Combined use of omeprazole and a novel antioxidative cytoprotectant for the treatment of peptic ulcer: Facilitation of ulcer healing in experimental animals

Arzneimittel-Forschung/Drug Research

Volumn 55, Issue 7, 2005, Pages 387-393

  Kim, Ju Mi ^a   Choi, Seul Min ^a   Kim, Dong Hwan ^a   Oh, Tae Young ^a   Ahn, Byoung Ok ^a   Kwon, Jong Won ^a   Kim, Won Bae ^a  

^a Dong A Pharmaceutical Company   (South Korea)

Author keywords

Anti ulcer drugs; Artemisia asiatica nakai, anti ulcer effect, extract; CAS 73590 58 6; DA 9601, anti ulcer effect, combined treatment, rat; Omeprazole, anti ulcer effect, combined treatment, rat; Peptic ulcer; Reflux esophagitis

Indexed keywords

ACETIC ACID; ALCOHOL; ANTIULCER AGENT; ARTEMISIA ASIATICA NAKAI; DA 9601; GLUTATHIONE; INDOMETACIN; MERCAPTAMINE; OMEPRAZOLE; PLANT EXTRACT; PROSTAGLANDIN E2; PROTON PUMP INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTEMISIA; ARTICLE; CELL PROTECTION; CONTROLLED STUDY; DRUG FORMULATION; GASTRITIS; GASTROESOPHAGEAL REFLUX; HISTOPATHOLOGY; LIPID PEROXIDATION; MALE; NONHUMAN; PEPTIC ULCER; RAT; REFLUX ESOPHAGITIS; ULCER HEALING;

EID: 22544463362     PISSN: 00044172     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0031-1296877     Document Type: Article

References (43)

1. Chan, F. K. L., Leung, W. K., Peptic-ulcer disease. Lancet 360, 933 (2002)
2. Sivri, B., Trends in peptic ulcer pharmacotherapy. Fundam. Clin. Pharmacol. 18, 23 (2004)
3. Wolfe, M. M., Soll, A. H., The physiology of gastric acid secretion. N. Engl. J. Med. 319, 1707 (1988)
4. Feldman, M., Richardson, C. T., Total 24-hour gastric acid secretion in patients with duodenal ulcer. Comparison with normal subjects and effects of cimetidine and parietal cell vagotomy. Gastroenterology 90, 540 (1986)
5. Ahtaridis, G., Snape, W. J. Jr., Cohen, S., Lower esophageal sphincter pressure as an index of gastroesophageal acid reflux. Dig. Dis. Sci. 26, 993 (1981)
6. Kahrilas, P. J., GERD pathophysiology: the importance of acid control. Rev. Gastroenterol. Mex. 68, 14 (2003)
7. Lee, J. S., Oh, T. Y., Ahn, B. O. et al., Involvement of oxidative stress in experimentally induced reflux esophagitis and Barrett's esophagus: clue for the chemoprevention of esophageal carcinoma by antioxidants. Mutat. Res. 480/481, 189 (2001)
8. Wetscher, G. J., Hinder, R. A., Bagchi, D. et al., Reflux esophagitis in humans is mediated by oxygen-derived free radicals. Am. J. Surg. 170, 552 (1995a)
9. Wetscher, G. J., Perdikis, G., Kretchmar, D. H. et al., Esophagitis in Sprague-Dawley rats is mediated by free radicals. Dig. Dis. Sci. 40, 1297 (1995b)
10. Spiro, H. M., Peptic ulcer: Moynihan's or Marshall's disease? Lancet 352, 645 (1998)
11. Anon., Current European concepts in the management of Helicobacter pylori infection. The Maastricht Consensus Report. European Helicobacter pylori Study Group. Gut 41, 8 (1997)
12. Anon., NIH Consensus Conference. Helicobacter pylori in peptic ulcer disease. NIH Consensus Development Panel on Helicobacter pylori in Peptic Ulcer Disease. JAMA 272, 65 (1994)
13. Grayson, M. L., Eliopoulos, G. M., Ferraro, M. J. et al., Effect of varying pH on the susceptibility of Campylobacter pylori to antimicrobial agents. Eur. J. Clin. Microbiol. Infect Dis. 8, 888 (1989)
14. Hunt, R. H., pH and Hp - gastric acid secretion and Helicobacter pylori: implications for ulcer healing and eradication of the organism. Am. J. Gastroenterol. 88, 481 (1993)
15. Sachs, G., Shin, J. M., Munson, K. et al., Review article: the control of gastric acid and Helicobacter pylori eradication. Aliment. Pharmacol. Ther. 14, 1383 (2000)
16. Vanderhoff, B. T., Tahboub, R. M., Proton pump inhibitors: an update. Am. Fam. Physician. 66, 273 (2002)
17. Huang, J. Q., Hunt, R. H., Pharmacological and pharmacodynamic essentials of H(2)-receptor antagonists and proton pump inhibitors for the practising physician. Best Pract. Res. Clin. Gastroenterol. 15, 355 (2001)
18. Kobayashi, T., Ohta, Y., Inui, K. et al., Protective effect of omeprazole against acute gastric mucosal lesions induced by compound 48/80, a mast cell degranulator, in rats. Pharmacol. Res. 46, 75 (2002)
19. Biswas, K., Bandyopadhyay, U., Chattopadhyay, I. et al., A novel antioxidant and antiapoptotic role of omeprazole to block gastric ulcer through scavenging of hydroxyl radical. J. Biol. Chem. 278, 10993 (2003)
20. Kelly, J. P., Kaufman, D. W., Jurgelon, J. M. et al., Risk of aspirin-associated major upper-gastrointestinal bleeding with enteric-coated or buffered product. Lancet 348, 1413 (1996)
21. Lichtenberger, L. M., Wang, Z. M., Romero, J. J. et al., Non-steroidal anti-inflammatory drugs (NSAIDs) associate with zwitterionic phospholipids: insight into the mechanism and reversal of NSAID-induced gastrointestinal injury. Nat. Med. 1, 154 (1995)
22. Wallace, J. L., Nonsteroidal anti-inflammatory drugs and gastroenteropathy: the second hundred years. Gastroenterology 112, 1000 (1997)
23. Andrews, F. J., Malcontenti-Wilson, C., O'Brien, P. E., Effect of nonsteroidal anti-inflammatory drugs on LFA-1 and ICAM-1 expression in gastric mucosa. Am. J. Physiol. 266, G657 (1994)
24. Wallace, J. L., Keenan, C. M., Granger, D. N., Gastric ulceration induced by nonsteroidal anti-inflammatory drugs is a neutrophil-dependent process. Am. J. Physiol. 259, G462 (1990)
25. Lehmann, F. S., Hildebrand, P., Beglinger, C., New molecular targets for treatment of peptic ulcer disease. Drugs 63, 1785 (2003)
26. Hahm, K. B., Kim, J. H., You, B. M. et al., Induction of apoptosis with an extract of Artemisia asiatica attenuates the severity of cerulein-induced pancreatitis in rats. Pancreas 17, 153 (1998)
27. Pihan, G., Regillo, C., Szabo, S., Free radicals and lipid peroxidation in ethanol- or aspirin-induced gastric mucosal injury. Dig. Dis. Sci. 32, 1395 (1987)
28. Oh, T. Y., Lee, J. S., Ahn, B. O. et al., Oxidative stress is more important than acid in the pathogenesis of reflux oesophagitis in rats. Gut 49, 364 (2001)
29. Takagi, K., Okabe, S., Saziki, R., A new method for the production of chronic gastric ulcer in rats and the effect of several drugs on its healing. Jpn. J. Pharmacol. 19, 418 (1969)
30. Robert, A., Nezamis, J. E., Lancaster, C. et al., Cytoprotection by prostaglandins in rats. Prevention of gastric necrosis produced by alcohol, HCl, NaOH, hypertonic NaCl, and thermal injury. Gastroenterology 77, 433 (1979)
31. Galunska, B., Marazova, K., Tankova, T. et al., Effects of paracetamol and propacetamol on gastric mucosal damage and gastric lipid peroxidation caused by acetylsalicylic acid (ASA) in rats. Pharmacol. Res. 46, 141 (2002)
32. Urushidani, T., Okabe, S., Takeuchi, K. et al., Effects of various amino acids on indomethacin-induced gastric ulcers in rats. Jpn. J. Pharmacol. 27, 316 (1977)
33. Okabe, S., Pfeiffer, C. J., Chronicity of acetic acid ulcer in the rat stomach. Am. J. Dig. Dis. 17, 619 (1972)
34. Szabo, S., Duodenal ulcer disease. Animal model: cysteamine-induced acute and chronic duodenal ulcer in the rat. Am. J. Pathol. 93, 273 (1978)
35. Ohkawa, H., Ohishi, N. and Yagi, K., Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal. Biochem. 95, 351 (1979)
36. Lowry, O. H., Rosebrough, N. J., Farr, A. L., Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193, 265 (1951)
37. Oh, T. Y., Hahm, K. B., Lee, K. J. et al., Beneficial effects of DA-9601, extract of Artemisia asiatica, in the TNB-induced experimental colitis in the rat. J. Appl. Pharmacol. 5, 165 (1997a)
38. Oh, T. Y., Ryu, B. K., Ko, J. I. et al., Protective effect of DA-9601, an extract of Artemisia herba, against naproxen-induced gastric damage in arthritic rats. Arch. Pharm. Res. 20, 414 (1997b)
39. Blandizzi, C., Gherardi, G., Natale, G. et al., Protective action of omeprazole against gastric mucosal injury induced by hemorrhagic shock in rats. Dig. Dis. Sci. 39, 2109 (1994)
40. Ohara, S., Murayama, N., Kuwata, H. et al., Effects of omeprazole on rat gastric mucus glycoproteins with acetylsalicylic acid-induced gastric damage. Arch. Int. Pharmacodyn. Ther. 296, 192 (1988)
41. Wandall, J. H., Effects of omeprazole on neutrophil chemotaxis, super oxide production, degranulation, and translocation of cytochrome b-245. Gut 33, 617 (1992)
42. Lapenna, D., de Gioia, S., Ciofani, G. et al., Antioxidant properties of omeprazole. FEBS Lett. 382, 189 (1996)
43. Suzuki, M., Mori, M., Miura, S. et al., Omeprazole attenuates oxygen-derived free radical production from human neutrophils. Free Radic. Biol. Med. 21, 727 (1996)