The type 2 vascular endothelial growth factor receptor recruits insulin receptor substrate-1 in its signalling pathway

Biochemical Journal

Volumn 368, Issue 1, 2002, Pages 49-56

  Senthil, Duraisamy ^a   Ghosh Choudhury, Goutam ^b   Bhandari, Basant K ^a   Kasinath, Balakuntalam S ^a  

^a Mays Cancer Center at UT Health San Antonio   (United States)

^b Education and Clinical Center   (United States)

Author keywords

Antisense oligonucleotide; Epithelial cell; Phosphoinositide 3 kinase (PI 3 kinase); Protein synthesis; Tyrosine phosphorylation

Indexed keywords

CELLS; ENZYME KINETICS; ENZYMES; INSULIN;

PHOSPHORYLATION;

BIOCHEMISTRY;

ANTISENSE OLIGONUCLEOTIDE; INSULIN RECEPTOR SUBSTRATE 1; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN P85; PROTEIN SUBUNIT; PROTEIN TYROSINE KINASE; VASCULOTROPIN RECEPTOR;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME ACTIVITY; IMMUNOPRECIPITATION; KIDNEY EPITHELIUM; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; RAT; RECEPTOR BINDING; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; CELL LINE, TRANSFORMED; DNA, ANTISENSE; ENDOTHELIAL GROWTH FACTORS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LYMPHOKINES; MICE; PHOSPHOPROTEINS; PHOSPHORYLATION; SIGNAL TRANSDUCTION; TYROSINE; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2; VASCULAR ENDOTHELIAL GROWTH FACTORS;

ANIMALIA;

EID: 2242419082     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20020137     Document Type: Article

References (27)

1. Connolly, D. T., Olander, J. V., Heuvelman, D., Nelson, R., Monsell, R., Siegel, N., Haymore, B. L., Leimgruber, R. and Feder, J. (1989) Human vascular permeability factor. Isolation from U937 cells. J. Biol. Chem. 264, 20017-20024
2. Zachary, I. and Gliki, G. (2001) Signaling transduction mechanisms mediating biological actions of the vascular endothelial growth factor family. Cardiovasc. Res. 49, 568-581
3. Cross, M. J. and Claesson-Welsh, L. (2001) FGF and VEGF function in angiogenesis: Signalling pathways, biological responses and therapeutic inhibition. Trends Pharmacol. Sci. 22, 201-207
4. Dougher-Vermazen, M., Hulmes, J. D., Bohlen, P. and Terman, B. I. (1994) Biological activity and phosphorylation sites of the bacterially expressed cytosolic domain of the KDR VEGF-receptor. Biochem. Biophys. Res. Commun. 205, 728-738
5. Guo, D., Jia, Q., Song, H.-Y., Warren, R. S. and Donner, D. B. (1995) Vascular endothelial cell growth factor promotes tyrosine phosphorylation of mediators of signal transduction that contain SH2 domains. J. Biol. Chem. 270, 6729-6733
6. Kroll, J. and Waltenberger, J. (1997) The vascular endothelial growth factor receptor KDR activates multiple signal transduction pathways in porcine aortic endothelial cells. J. Biol. Chem. 272, 32521-32527
7. Gerber, H. P., McMurtrey, A., Kowalski, J., Yan, M., Keyt, B. A., Dixit, V. and Ferrara, N. (1998) Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3′-kinase/Akt signal transduction pathway. Requirement for flk-1/kdr activation. J. Biol. Chem. 273, 30336-30343
8. Takahashi, T. and Shibuya, M. (1997) The 230 kDa mature form of KDR/Flk-1 (VEGF receptor-2) activates the PLC-γ pathway and partially induces mitotic signals in NIH3T3 fibroblasts. Oncogene 14, 2079-2089
9. Kanno, S., Oda, N., Abe, M., Terai, Y., Ito, M., Shitara, K., Tabayashi, K., Shibuya, M. and Sato, Y. (2000) Roles of two VEGF receptors, Flt-1 and KDR, in the signal transduction of VEGF effects in human vascular endothelial cells. Oncogene 19, 2138-2146
10. Wu, L. W., Mayo, L. D., Dunbar, J. D., Kessler, K. M., Baerwald, M. R., Jaffe, E. A., Wang, D., Warren, R. S. and Donner, D. B. (2000) Utilization of distinct signaling pathways by receptors for vascular endothelial cell growth factor and other mitogens in the induction of endothelial cell proliferation. J. Biol. Chem. 275, 5096-5103
11. White, M. F. and Yenush, L. (1998) The IRS-signaling system: A network of docking proteins that mediate insulin and cytokine action. Curr. Top. Microbiol. Immunol. 228, 179-208
12. Cunningham, S. A., Waxham, M. N., Arrate, P. M. and Brock, T. A. (1995) Interaction of the Flt-1 tyrosine kinase receptor with the p85 subunit of phosphatidylinositol 3-kinase. J. Biol. Chem. 270, 20254-20257
13. Bhandari, B., Feliers, D., Senthil, D., Gingras, A.-C., Abboud, H. E., Ghosh Choudhury, G., Sonenberg, N. and Kasinath, B. S. (2001) Insulin regulation of protein translation repressor 4E-BP1 an elF4E binding protein, in renal epithelial cells. Kidney Int. 59, 866-875
14. Haverty, T. P., Kelly, C. J., Hines, W. H., Amenta, P. S., Watanabe, M., Harper, R. A., Kefalides, N. A. and Neilson, E. G. (1988) Characterization of a renal tubular epithelial cell line which secretes the autologous target antigen of autoimmune experimental interstitial nephritis. J. Cell. Biol. 107, 1359-1368
15. Feliers, D., Duraisamy, S., Faulkner, J. L., Duch, J., Lee, A. V., Abboud, H. E., Choudhury, G. G. and Kasinath, B. S. (2001) Activation of renal signaling pathways in db/db mice with type 2 diabetes. Kidney Int. 60, 495-504
16. Wallace, W. C., Akar, C. A., Lyons, W. E., Kole, H. K., Egan, J. M. and Wolozin, B. (1997) Amyloid precursor protein requires the insulin signaling pathway for neurotrophic activity. Brain Res. Mol. Brain Res. 52, 213-227
17. Senthil, D., Faulkner, J. L., Choudhury, G. G., Abboud, H. E. and Kasinath, B. S. (2001) Angiotensin II inhibits insulin-stimulated phosphorylation of eukaryotic initiation factor 4E-binding protein-1 in proximal tubular epithelial cells. Biochem. J. 360, 87-95
18. Millauer, B., Wizigmann-Voos, S., Schnurch, H., Martinez, R., Moller, N. P., Risau, W. and Ullrich, A. (1993) High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis. Cell 72, 835-846
19. Keegar, A. D., Nelms, K., White, M., Wang, L. M., Pierce, J. H. and Paul, W. E. (1994) An IL-4 receptor region containing an insulin receptor motif is important for IL-4-mediated IRS-1 phosphorylation and cell growth. Cell 76, 811-820
20. Matthews, W., Jordan, C. T., Gavin, M., Jenkins, N. A., Copeland, N. G. and Lemischka, I. R. (1991) A receptor tyrosine kinase cDNA isolated from a population of enriched primitive hematopoietic cells and exhibiting close genetic linkage to c-kit. Proc. Natl. Acad. Sci. U.S.A. 88, 9026-9030
21. Sawka-Verhelle, D., Deckert, S. T., White, M. F. and Obberghen, E. V. (1996) Insulin receptor substrate-2 binds to the insulin receptor through its phosphotyrosine-binding domain and through a newly identified domain comprising amino acids 591-786. J. Biol. Chem. 271, 5980-5983
22. He, W., Craparo, A., Zhu, Y., O'Neill, T. J., Wang, L. M., Pierce, J. H. and Gustafson, T. A. (1996) Interaction of insulin receptor substrate-2 (IRS-2) with the insulin and insulin-like growth factor I receptors. J. Biol. Chem. 271, 11641-11645
23. Dayanir, V., Meyer, R. D., Lashkari, K. and Rahimi, N. (2001) Identification of tyrosine residues in vascular endothelial growth factor receptor-2/FLK-1 involved in activation of phosphatidylinositol 3-kinase and cell proliferation. J. Biol. Chem. 276, 17686-17692
24. Jiang, B. H., Zheng, J. Z., Aoki, M. and Vogt, P. K. (2000) Phosphatidylinositol 3-kinase signaling mediates angiogenesis and expression of vascular endothelial growth factor in endothelial cells. Proc. Natl. Acad. Sci. U.S.A. 97, 1749-1753
25. Fulton, D., Gratton, J. P., McCabe, T. J., Fontana, J., Fujio, Y., Walsh, K., Franke, T. F., Papapetropoulos, A. and Sessa, W. C. (1999) Regulation of endothelium-derived nitric oxide production by the protein kinase Akt. Nature (London) 399, 597-601
26. Dimmeler, S., Dernbach, E. and Zeiher, A. M. (2000) Phosphorylation of the endothelial nitric oxide synthase at Ser-1177 is required for VEGF-induced endothelial cell migration. FEBS Lett. 477, 258-262
27. Mendez, R., Myers, Jr, M. G., White, M. F. and Rhoads, R. E. (1996) Stimulation of protein synthesis, eukaryotic translation initiation factor 4E phosphorylation, and PHAS-I phosphorylation by insulin requires insulin receptor substrate 1 and phosphatidylinositol 3-kinase. Mol. Cell. Biol. 16, 2857-2864