Possible role of autoantibodies against nephrin in an experimental model of chronic graft-versus-host disease

Clinical and Experimental Immunology

Volumn 141, Issue 2, 2005, Pages 215-222

  Nagahama, K ^a   Maru, K ^a   Kanzaki, S ^a   Chai, H L ^a   Nakai, T ^a   Miura, S ^a   Yamaguchi, A ^a   Yamanaka, S ^a   Nagashima, Y ^a   Aoki, Ichiro ^a  

^a YOKOHAMA CITY UNIVERSITY   (Japan)

Author keywords

Glomerulonephritis; Immune complex; Lupus nephritis; Nephrin; Slit diaphragm

Indexed keywords

AUTOANTIBODY; DNA ANTIBODY; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G ANTIBODY; NEPHRIN; POLYCLONAL ANTIBODY; SINGLE STRANDED DNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY TITER; ARTICLE; CHRONIC GRAFT VERSUS HOST DISEASE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; EXPERIMENTAL MODEL; GLOMERULONEPHRITIS; IMMUNE RESPONSE; IMMUNOBLOTTING; IMMUNOFLUORESCENCE MICROSCOPY; LUPUS ERYTHEMATOSUS NEPHRITIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEINURIA;

ANIMALS; AUTOANTIBODIES; CHRONIC DISEASE; DISEASE MODELS, ANIMAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; GLOMERULONEPHRITIS; GRAFT VS HOST DISEASE; IMMUNE COMPLEX DISEASES; LUPUS NEPHRITIS; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MICE, INBRED DBA; PROTEINURIA; RABBITS;

EID: 22344438986     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2249.2005.02838.x     Document Type: Article

References (22)

1. Busser BW, Adair BS, Erikson J, Laufer TM. Activation of diverse repertoires of autoreactive T cells enhances the loss of anti-dsDNA B cell tolerance. J Clin Invest 2003; 112:1361-71.
2. Bradley DS. Chronic graft versus host disease-associated autoimmune manifestations are independently regulated by different MHC class II loci. J Immunol 1994; 152:1960-9.
3. Treurniet RA, Bergijk EC, Baelde JJ, De Heer E, Hoedemaeker PJ, Bruijn JA. Gender-related influences on the development of chronic graft-versus-host disease-induced experimental lupus nephritis. Clin Exp Immunol 1993; 91:442-8.
4. Peutz-Kootstra CJ, Hansen K, De Heer E, Abrass CK, Bruijn JA. Differential expression of laminin chains and anti-laminin autoantibodies in experimental lupus nephritis. J Pathol 2000; 192:404-12.
5. Kestila M, Lenkkeri U, Mannikko M et al. Positionally cloned gene for a novel glomerular protein - nephrin - is mutated in congenital nephrotic syndrome. Mol Cell 1998; 1:575-82.
6. Tryggvason K, Wartiovaara J. Molecular basis of glomerular perm-selectivity. Curr Opin Nephrol Hypertens 2001; 10:543-9.
7. Mathieson PW. What has the immune system got against the glomerular podocyte? Clin Exp Immunol 2003; 134:1-5.
8. Rodewald R, Karnovsky MJ. Porous substructure of the glomerular slit diaphragm in the rat and mouse. J Cell Biol 1974; 60:423-33.
9. Putaala H. The murine nephrin gene is specifically expressed in kidney, brain and pancreas, inactivation of the gene leads to massive proteinuria and neonatal death. Hum Mol Genet 2001; 10:1-8.
10. Wang SX, Ahola H, Palmen T, Solin ML, Luimula P, Holthofer H. Recurrence of nephrotic syndrome after transplantation in CNF is due to autoantibodies to nephrin. Exp Nephrol 2001; 9:327-31.
11. Koop K, Eikmans M, Baelde HJ, Kawachi H, De Heer E, Paul LC, Bruijn JA. Expression of podocyte-associated molecules in acquired human kidney diseases. J Am Soc Nephrol 2003; 14:2063-71.
12. Yuan H, Takeuchi E, Taylor GA, McLaughlin M, Brown D, Salant DJ. Nephrin dissociates from actin, and its expression is reduced in early experimental membranous nephropathy. J Am Soc Nephrol 2002; 13:946-56.
13. Saran AM, Yuan H, Takeuchi E, McLaughlin M, Salant DJ. Complement mediates nephrin redistribution and actin dissociation in experimental membranous nephropathy. Kidney Int 2003; 64:2072-8.
14. Salant DJ, Darby C, Couser WG. Experimental membranous glomerulonephritis in rats. Quantitative studies of glomerular immune deposit formation in isolated glomeruli and whole animals. J Clin Invest 1980; 66:71-81.
15. Okubo T, Hagiwara E, Ohno S et al. Administration of an IL-12-encoding DNA plasmid prevents the development of chronic graft-versus-host disease (GVHD). J Immunol 1999; 162:4013-7.
16. Holzman LB, St John PL, Kovari IA, Verma R, Holthofer H, Abrahamson DR. Nephrin localizes to the slit pore of the glomerular epithelial cell. Kidney Int 1999; 56:1481-91.
17. Patrakka J, Ruotsalainen V, Reponen P, Qvist E, Laine J, Holmberg C, Tryggvason K, Jalanko H. Recurrence of nephrotic syndrome in kidney grafts of patients with congenital nephrotic syndrome of the Finnish type: role of nephrin. Transplantation 2002; 73:394-403.
18. Orikasa M, Matsui K, Oite T, Shimizu F. Massive proteinuria induced in rats by a single intravenous injection of a monoclonal antibody. J Immunol 1988; 141:807-14.
19. Topham PS, Kawachi H, Haydar SA et al. Nephritogenic mAb 5-1-6 is directed at the extracellular domain of rat nephrin. J Clin Invest 1999; 104:1559-66.
20. Aoki A, Ishigatsubo Y, Hagiwara E et al. Polyclonal B cell activation and antigen-specific stimulation in mice with chronic graft-versus-host reaction. Clin Immunol Immunopathol 1993; 66:254-9.
21. Aoki I, Aoki A, Otani M et al. A correlation between IgG class antibody production and glomerulonephritis in the murine chronic graft-versus-host reaction. Clin Immunol Immunopathol 1992; 63:34-8.
22. McCluskey J, Farris AD, Keech CL, Purcell AW, Rischmueller M, Kinoshita G, Reynolds P, Gordon TP. Determinant spreading, lessons from animal models and human disease. Immunol Rev 1998; 164:209-29.