Family-based association tests for different family structures using pooled DNA

Annals of Human Genetics

Volumn 69, Issue 4, 2005, Pages 429-442

  Zou, Guohua ^a,b   Zhao, Hongyu ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b CHINESE ACADEMY OF SCIENCES   (China)

Author keywords

DNA pooling; Family structure; Family based association study; Measurement error; Sample size

Indexed keywords

DNA;

ANALYTICAL ERROR; ARTICLE; DISEASE MODEL; FAMILY STUDY; GENETIC ASSOCIATION; GENETIC MODEL; HUMAN; PRIORITY JOURNAL; SAMPLE SIZE; SIMULATION; STATISTICAL ANALYSIS;

COMPUTER SIMULATION; DNA; FEMALE; GENETICS, MEDICAL; HUMANS; MALE; MODELS, GENETIC; NUCLEAR FAMILY; RESEARCH DESIGN; SAMPLE SIZE; SELECTION BIAS;

EID: 22244491647     PISSN: 00034800     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1529-8817.2005.00164.x     Document Type: Article

References (18)

1. Allen, A., Rathouz, P. & Satten, G. (2003) Informative missingness in genetic association studies: case-parent designs. Am J Hum Genet 72, 671-680.
2. Bader, J., Bansal, A. & Sham, P. (2001) Efficient SNP-based tests of association for quantitative phenotypes using pooled DNA. GeneScreen 1, 143-150.
3. Bader, J. & Sham, P. (2002) Family-based association tests for quantitative traits using pooled DNA. Eur J Hum Genet 10, 870-878.
4. Bengtsson, B. O. & Thomson, G. (1981) Measuring the strength of associations between HLA antigens and diseases. Tissue Antigens 18, 356-363.
5. Buetow, K. H., Edmonson, M., MacDonald, R., Clifford, P., Yip, P., Kelley, J., Little, D. P., Strausberg, R., Koester, H., Cantor, C. R. & Braun, A. (2001) High-throughput development and characterization of a genomewide collection of gene-based single nucleotide polymorphism markers by chip-based matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Proc Natl Acad Sci USA 98, 581-584.
6. Grupe, A., Germer, S., Usuka, J., Aud, D., Belknap, J. K., Klein, R. F., Ahluwalia, M. K., Higuchi, R. & Peltz, G. (2001) In silico mapping of complex disease-related traits in mice. Science 292, 1915-1918.
7. Ito, T., Chiku, S., Inoue, E., Tomita, M., Morisaki, T., Morisaki, H. & Kamatani, N. (2003) Estimation of haplotype frequencies, linkage-disequilibrium measures, and combination of haplotype copies in each pool by use of pooled DNA data. Am J Hum Genet 72, 384-398.
8. Jawaid, A., Bader, J., Purcell, S., Cherny, S. & Sham, P. (2002) Optimal selection strategies for QTL mapping using pooled DNA samples. Eur J Hum Genet 10, 125-132.
9. Le, Hellard S., Ballereau, S.J., Visscher, P. M., Torrance, H. S., Pinson, J., Morris, S. W., Thomson, M. L., Semple, C. A., Muir, W. J., Blackwood, D. H., Porteous, D. J. & Evans, K. L. (2002) SNP genotyping on pooled DNAs: comparison of genotyping technologies and a semi automated method for data storage and analysis. Nucleic Acids Res 30 e74.
10. Lipkin, E., Mosig, M. O., Darvasi, A., Ezra, E., Shalom, A., Friedmann, A. & Soller, M. (1998) Quantitative trait locus mapping in dairy cattle by means of selective milk DNA pooling using dinucleotide microsatellite markers: analysis of milk protein percentage. Genetics 149, 1557-1567.
11. Michelmore, R., Paran, I. & Kesseli, R. (1991) Identification of marker linked to disease resistance gene by bulk segregant analysis: a rapid method to detect markers in specific genomic regions using segregating populations. Proc Natl Acad Sci USA 88, 9828-9832.
12. Risch, N. & Merikangas, K. (1996) The future of genetic studies of complex human diseases. Science 273, 1516-1517.
13. Risch, N. & Teng, J. (1998) The relative power of family-based and case-control designs for linkage disequilibrium studies of complex human diseases. Genome Res 8, 1273-1288.
14. Sham, P., Bader, J., Craig, I., O'Donovan, M. & Owen, M. (2002) DNA pooling: a tool for large-scale association studies. Nature Reviews Genetics 3, 862-871.
15. Stephan, F. F. (1945) The expected value and variance of the reciprocal and other negative powers of a positive Bernoulli variate. Ann Math Statist 16, 50-61.
16. Xu, C., Donnelly, C., Montgomery, D., Allan, C. & Purvis, I. (1999) Determination of SNP allele frequency by a DNA pooling method. Am J Hum Genet, 65, 2577.
17. Wang, S., Kidd, K. K. & Zhao, H. (2003) On the use of DNA pooling to estimate haplotype frequencies. Genet Epidemiol 24, 74-82.
18. Zou, G. & Zhao, H. (2004) The impacts of errors in individual genotyping and DNA pooling on association studies. Genet Epidemiol 26, 1-10.