Effect of mifepristone on proliferation and apoptosis of Ishikawa endometrial adenocarcinoma cells

Fertility and Sterility

Volumn 84, Issue 1, 2005, Pages 202-211

  Li, Aimin ^a   Felix, Juan C ^a   Minoo, Parviz ^a   Amezcua, Charles A ^a   Jain, John K ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

Apoptosis; CASP3 activation; Cell cycle; Ishikawa cells; Mifepristone; Proliferation

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; BROXURIDINE; CASPASE 3; FLUORESCEIN ISOTHIOCYANATE; GESTAGEN; LIPOCORTIN 5; MEDROXYPROGESTERONE ACETATE; MIFEPRISTONE; PROTEIN BAX;

ANALYTIC METHOD; APOPTOSIS; ARTICLE; CARCINOMA CELL; CELL CULTURE; CELL CYCLE G2 PHASE; CELL CYCLE S PHASE; CELL LABELING; CELL PROLIFERATION; CLINICAL RESEARCH; COLORIMETRY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOSOL; DRUG EFFECT; DRUG SCREENING; ENDOMETRIUM CARCINOMA; ENZYME ACTIVATION; FEMALE; FLOW CYTOMETRY; GROWTH INHIBITION; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE TEST; IN VITRO STUDY; LABORATORY TEST; MITOCHONDRION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; REPRODUCTIVE HEALTH; UNIVERSITY HOSPITAL;

ADENOCARCINOMA; APOPTOSIS; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; ENDOMETRIAL NEOPLASMS; FEMALE; HUMANS; MIFEPRISTONE;

EID: 22244471416     PISSN: 00150282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fertnstert.2005.01.126     Document Type: Article

References (60)

1. F.D. Anderson Selectivity and minimal androgenicity of norgestimate in monophasic and triphasic oral contraceptives Acta Obstet Gynecol Scand Suppl 156 1992 15 21
2. J.K. Findlay Future directions for research on endometrial bleeding Hum Reprod 11 Suppl 2 1996 179 183
3. G. Wang, S. Zheng, Z. Fan [The changes of sex steroid receptors and morphology in Norplant treated endometrium] Zhonghua Fu Chan Ke Za Zhi 33 1998 493 497
4. P. Zhu, X. Liu, H. Luo, Z. Gu, J. Cheng, R. Xu The effect of a levonorgestrel-releasing intrauterine device on human endometrial oestrogen and progesterone receptors after one year of use Hum Reprod 14 1999 970 975
5. T.M. Lau, J. Witjaksono, B. Affandi, P.A. Rogers Expression of progesterone receptor mRNA in the endometrium during the normal menstrual cycle and in Norplant users Hum Reprod 11 1996 2629 2634
6. S.M. Lu [Effect of levonorgestrel intrauterine device on human endometrial estrogen and progesterone receptors] Zhonghua Fu Chan Ke Za Zhi 26 1991 293 294 323
7. H.O. Critchley, H. Wang, R.L. Jones, R.W. Kelly, T.A. Drudy, A.E. Gebbie Morphological and functional features of endometrial decidualization following long-term intrauterine levonorgestrel delivery Hum Reprod 13 1998 1218 1224
8. S. Diaz, H.B. Croxatto, M. Pavez, H. Belhadj, J. Stern, I. Sivin Clinical assessment of treatments for prolonged bleeding in users of Norplant implants Contraception 42 1990 97 109
9. F. Alvarez-Sanchez, V. Brache, F. Thevenin, L. Cochon, A. Faundes Hormonal treatment for bleeding irregularities in Norplant implant users Am J Obstet Gynecol 174 1996 919 922
10. A.F. Glasier, H. Wang, J.E. Davie, R.W. Kelly, H.O. Critchley Administration of an antiprogesterone up-regulates estrogen receptors in the endometrium of women using Norplant a pilot study Fertil Steril 77 2002 366 372
11. L. Cheng, H. Zhu, A. Wang, F. Ren, J. Chen, A. Glasier Once a month administration of mifepristone improves bleeding patterns in women using subdermal contraceptive implants releasing levonorgestrel Hum Reprod 15 2000 1969 1972
12. R.N. Brogden, K.L. Goa, D. Faulds Mifepristone. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential Drugs 45 1993 384 409
13. C. Watts, N. Wilcken, J. Hamilton, K. Sweeney, E. Musgrove, R. Sutherland Mechanisms of antiestrogen, progestin/antiprogestin and retinoid inhibition of cell cycle progression in breast cancer cells J.P. Pasqualini B.S. Katzenellenbogen Molecular and Cellular Endocrinology 1995 Marcel Dekker New York
14. M. Thomas, J.D. Monet Combined effects of RU486 and tamoxifen on the growth and cell cycle phases of the MCF-7 cell line J Clin Endocrinol Metab 75 1992 865 870
15. E.A. Musgrove, R.L. Sutherland Effects of the progestin antagonist RU 486 on T-47D breast cancer cell cycle kinetics and cell cycle regulatory genes Biochem Biophys Res Commun 195 1993 1184 1190
16. H. Michna, M. Schneider, Y. Nishino, M.F. el Etreby, W.L. McGuire Progesterone antagonists block the growth of experimental mammary tumors in G0/G1 Breast Cancer Res Treat 17 1990 155 156
17. S. Tabibzadeh Signals and molecular pathways involved in apoptosis, with special emphasis on human endometrium Hum Reprod Update 1 1995 303 323
18. R.J. Rotello, R.C. Lieberman, R.B. Lepoff, L.E. Gerschenson Characterization of uterine epithelium apoptotic cell death kinetics and regulation by progesterone and RU 486 Am J Pathol 140 1992 449 456
19. H. Watanabe, H. Kanzaki, S. Narukawa, T. Inoue, H. Katsuragawa, Y. Kaneko, T. Mori Bcl-2 and Fas expression in eutopic and ectopic human endometrium during the menstrual cycle in relation to endometrial cell apoptosis Am J Obstet Gynecol 176 1997 360 368
20. Y. Otsuki, O. Misaki, O. Sugimoto, Y. Ito, Y. Tsujimoto, Y. Akao Cyclic bcl-2 gene expression in human uterine endometrium during menstrual cycle Lancet 344 1994 28 29
21. H.O. Critchley, S. Tong, S.T. Cameron, T.A. Drudy, R.W. Kelly, D.T. Baird Regulation of bcl-2 gene family members in human endometrium by antiprogestin administration in vivo J Reprod Fertil 115 1999 389 395
22. X.J. Tao, K.I. Tilly, D.V. Maravei, J.L. Shifren, S. Krajewski, J.C. Reed Differential expression of members of the bcl-2 gene family in proliferative and secretory human endometrium glandular epithelial cell apoptosis is associated with increased expression of bax J Clin Endocrinol Metab 82 1997 2738 2746
23. X. Peng, T. Maruo, H. Matsuo, S. Takekida, J. Deguchi Serum deprivation-induced apoptosis in cultured porcine granulosa cells is characterized by increased expression of p53 protein, Fas antigen and Fas ligand and by decreased expression of PCNA Endocr J 45 1998 247 253
24. P.A. Rogers, F. Lederman, D. Plunkett, B. Affandi Bcl-2, Fas and caspase 3 expression in endometrium from levonorgestrel implant users with and without breakthrough bleeding Hum Reprod 15 Suppl 3 2000 152 161
25. J. Carmichael, W.G. DeGraff, A.F. Gazdar, J.D. Minna, J.B. Mitchell Evaluation of a tetrazolium-based semiautomated colorimetric assay assessment of radiosensitivity Cancer Res 47 1987 943 946
26. K. Beppu, J. Jaboine, M.S. Merchant, C.L. Mackall, C.J. Thiele Effect of imatinib mesylate on neuroblastoma tumorigenesis and vascular endothelial growth factor expression J Natl Cancer Inst 96 2004 46 55
27. K.K. Kaulsay, T. Zhu, W. Bennett, K. Lee, P.E. Lobie The effects of autocrine human growth hormone (hGH) on human mammary carcinoma cell behavior are mediated via the hGH receptor Endocrinology 142 2001 767 777
28. L. Casciola-Rosen, A. Rosen, M. Petri, M. Schlissel Surface blebs on apoptotic cells are sites of enhanced procoagulant activity implications for coagulation events and antigenic spread in systemic lupus erythematosus Proc Natl Acad Sci U S A 93 1996 1624 1629
29. M. van Engeland, F.C. Ramaekers, B. Schutte, C.P. Reutelingsperger A novel assay to measure loss of plasma membrane asymmetry during apoptosis of adherent cells in culture Cytometry 24 1996 131 139
30. E.R. Weiss, M.H. Ducceschi, T.J. Horner, A. Li, C.M. Craft, S. Osawa Species-specific differences in expression of G-protein-coupled receptor kinase (GRK) 7 and GRK1 in mammalian cone photoreceptor cells implications for cone cell phototransduction J Neurosci 21 2001 9175 9184
31. X. Zhu, B. Brown, A. Li, A.J. Mears, A. Swaroop, C.M. Craft GRK1-dependent phosphorylation of S and M opsins and their binding to cone arrestin during cone phototransduction in the mouse retina J Neurosci 23 2003 6152 6160
32. M.F. El Etreby, Y. Liang, M.H. Johnson, R.W. Lewis Antitumor activity of mifepristone in the human LNCaP, LNCaP-C4, and LNCaP-C4-2 prostate cancer models in nude mice Prostate 42 2000 99 106
33. M.F. El Etreby, Y. Liang, R.W. Lewis Induction of apoptosis by mifepristone and tamoxifen in human LNCaP prostate cancer cells in culture Prostate 43 2000 31 42
34. M.F. El Etreby, Y. Liang Effect of antiprogestins and tamoxifen on growth inhibition of MCF-7 human breast cancer cells in nude mice Breast Cancer Res Treat 49 1998 109 117
35. M.F. El Etreby, Y. Liang, R.W. Wrenn, P.V. Schoenlein Additive effect of mifepristone and tamoxifen on apoptotic pathways in MCF-7 human breast cancer cells Breast Cancer Res Treat 51 1998 149 168
36. M.C. Kamradt, N. Mohideen, A.T. Vaughan RU486 increases radiosensitivity and restores apoptosis through modulation of HPV E6/E7 in dexamethasone-treated cervical carcinoma cells Gynecol Oncol 77 2000 177 182
37. C.C. Schneider, R.K. Gibb, D.D. Taylor, T. Wan, C. Gercel-Taylor Inhibition of endometrial cancer cell lines by mifepristone (RU 486) J Soc Gynecol Investig 5 1998 334 338
38. A.A. Murphy, M.H. Zhou, S. Malkapuram, N. Santanam, S. Parthasarathy, N. Sidell RU486-induced growth inhibition of human endometrial cells Fertil Steril 74 2000 1014 1019
39. J. Prange-Kiel, G.M. Rune, D. Wallwiener, L. Kiesel Inhibition of proliferation and differentiation by RU 486 in human endometrial stromal and epithelial cells in vitro Exp Clin Endocrinol Diabetes 108 2000 275 281
40. S. Han, N. Sidell RU486-induced growth inhibition of human endometrial cells involves the nuclear factor-kappa B signaling pathway J Clin Endocrinol Metab 88 2003 713 719
41. J.F. van Uem, J.G. Hsiu, C.F. Chillik, D.R. Danforth, A. Ulmann, E.E. Baulieu Contraceptive potential of RU 486 by ovulation inhibition: I. Pituitary versus ovarian action with blockade of estrogen-induced endometrial proliferation Contraception 40 1989 171 184
42. J.P. Wolf, J.G. Hsiu, T.L. Anderson, A. Ulmann, E.E. Baulieu, G.D. Hodgen Noncompetitive antiestrogenic effect of RU 486 in blocking the estrogen-stimulated luteinizing hormone surge and the proliferative action of estradiol on endometrium in castrate monkeys Fertil Steril 52 1989 1055 1060
43. J. Neulen, R.F. Williams, G.D. Hodgen RU 486 (mifepristone) induction of dose dependent elevations of estradiol receptor in endometrium from ovariectomized monkeys J Clin Endocrinol Metab 71 1990 1074 1075
44. R.M. Brenner, O.D. Slayden, H.O. Critchley Anti-proliferative effects of progesterone antagonists in the primate endometrium a potential role for the androgen receptor Reproduction 124 2002 167 172
45. E.A. Musgrove, C.S. Lee, A.L. Cornish, A. Swarbrick, R.L. Sutherland Antiprogestin inhibition of cell cycle progression in T-47D breast cancer cells is accompanied by induction of the cyclin-dependent kinase inhibitor p21 Mol Endocrinol 11 1997 54 66
46. A. Makrigiannakis, G. Coukos, M. Christofidou-Solomidou, S. Montas, C. Coutifaris Progesterone is an autocrine/paracrine regulator of human granulosa cell survival in vitro Ann N Y Acad Sci 900 2000 16 25
47. E.C. Svensson, E. Markstrom, R. Shao, M. Andersson, H. Billig Progesterone receptor antagonists Org 31710 and RU 486 increase apoptosis in human periovulatory granulosa cells Fertil Steril 76 2001 1225 1231
48. E.C. Svensson, E. Markstrom, M. Andersson, H. Billig Progesterone receptor-mediated inhibition of apoptosis in granulosa cells isolated from rats treated with human chorionic gonadotropin Biol Reprod 63 2000 1457 1464
49. Y. Zhang, G. Chen, Y. Liu, G. Fu [Apoptosis and expression of relative genes in early pregnant chorionic villi and decidua] Zhonghua Fu Chan Ke Za Zhi 37 2002 220 222
50. M. Tafani, D.A. Minchenko, A. Serroni, J.L. Farber Induction of the mitochondrial permeability transition mediates the killing of HeLa cells by staurosporine Cancer Res 61 2001 2459 2466
51. K.G. Wolter, Y.T. Hsu, C.L. Smith, A. Nechushtan, X.G. Xi, R.J. Youle Movement of Bax from the cytosol to mitochondria during apoptosis J Cell Biol 139 1997 1281 1292
52. G.W. Makin, B.M. Corfe, G.J. Griffiths, A. Thistlethwaite, J.A. Hickman, C. Dive Damage-induced Bax N-terminal change, translocation to mitochondria and formation of Bax dimers/complexes occur regardless of cell fate EMBO J 20 2001 6306 6315
53. T. Kohji, Y. Matsumoto Coexpression of Fas/FasL and Bax on brain and infiltrating T cells in the central nervous system is closely associated with apoptotic cell death during autoimmune encephalomyelitis J Neuroimmunol 106 2000 165 171
54. M. Enari, A. Hase, S. Nagata Apoptosis by a cytosolic extract from Fas-activated cells EMBO J 14 1995 5201 5208
55. S. Shimizu, Y. Eguchi, W. Kamiike, H. Matsuda, Y. Tsujimoto Bcl-2 expression prevents activation of the ICE protease cascade Oncogene 12 1996 2251 2257
56. Z.N. Oltvai, C.L. Milliman, S.J. Korsmeyer Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death Cell 74 1993 609 619
57. P.D. Feil, C.L. Clarke, P.G. Satyaswaroop Progestin-mediated changes in progesterone receptor forms in the normal human endometrium Endocrinology 123 1988 2506 2513
58. P.D. Feil, C.L. Clarke, P.G. Satyaswaroop Progesterone receptor structure and protease activity in primary human endometrial carcinoma Cancer Res 48 1988 1143 1147
59. C.L. Clarke, P.D. Feil, P.G. Satyaswaroop Progesterone receptor regulation by 17 beta-estradiol in human endometrial carcinoma grown in nude mice Endocrinology 121 1987 1642 1648
60. B.A. Lessey, A.O. Ilesanmi, A.J. Castelbaum, L. Yuan, S.G. Somkuti, K. Chwalisz Characterization of the functional progesterone receptor in an endometrial adenocarcinoma cell line (Ishikawa) progesterone-induced expression of the alpha1 integrin J Steroid Biochem Mol Biol 59 1996 31 39