Neuroscience: Evidence for ectopic neurotransmission at a neuronal synapse

Science

Volumn 309, Issue 5733, 2005, Pages 446-451

  Coggan, Jay S ^a,c   Bartol, Thomas M ^a,c   Esquenazi, Eduardo ^c,e   Stiles, Joel R ^f,g   Lamont, Stephan ^c   Martone, Maryann E ^c,d   Berg, Darwin K ^e   Ellisman, Mark H ^c,d   Sejnowski, Terrence J ^a,b,c,e  

^a SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^f CARNEGIE MELLON UNIVERSITY   (United States)

^g UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPUTER SIMULATION; MATHEMATICAL MODELS; MONTE CARLO METHODS;

CHOLINERGIC SYNAPSES; ECTOPIC NEUROTRANSMISSION; POSTSYNAPTIC DENSITIES; PRESYNAPTIC ACTIVE ZONES;

NEUROLOGY;

NICOTINIC RECEPTOR; ACETYLCHOLINE; ACETYLCHOLINESTERASE; NICOTINIC RECEPTOR SUBUNIT ALPHA3;

NEUROLOGY;

ANIMAL CELL; ARTICLE; CHICKEN; CILIARY GANGLION; ELECTRON MICROSCOPY; MEMBRANE CURRENT; MONTE CARLO METHOD; NEUROTRANSMISSION; NEUROTRANSMITTER RELEASE; NONHUMAN; POSTSYNAPTIC MEMBRANE; PRESYNAPTIC MEMBRANE; PRIORITY JOURNAL; RECEPTOR DENSITY; STIMULUS RESPONSE; SYNAPSE VESICLE; SYNAPTIC TRANSMISSION; ALGORITHM; ANIMAL; BIOLOGICAL MODEL; CHICK EMBRYO; COMPUTER SIMULATION; DIFFUSION; EXCITATORY POSTSYNAPTIC POTENTIAL; IMAGE PROCESSING; MATHEMATICS; METABOLISM; PARASYMPATHETIC GANGLION; PATCH CLAMP; PHYSIOLOGY; PROBABILITY; SENSITIVITY AND SPECIFICITY; SYNAPSE; SYNAPTIC MEMBRANE; ULTRASTRUCTURE;

ANIMALIA;

ACETYLCHOLINE; ACETYLCHOLINESTERASE; ALGORITHMS; ANIMALS; CHICK EMBRYO; COMPUTER SIMULATION; DIFFUSION; EXCITATORY POSTSYNAPTIC POTENTIALS; GANGLIA, PARASYMPATHETIC; IMAGE PROCESSING, COMPUTER-ASSISTED; MATHEMATICS; MICROSCOPY, ELECTRON; MODELS, NEUROLOGICAL; MONTE CARLO METHOD; PATCH-CLAMP TECHNIQUES; PROBABILITY; RECEPTORS, NICOTINIC; SENSITIVITY AND SPECIFICITY; SYNAPSES; SYNAPTIC MEMBRANES; SYNAPTIC TRANSMISSION; SYNAPTIC VESICLES;

EID: 22244450050     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1108239     Document Type: Article

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41. Supported by: State of California TRDRP (J.S.C.); NSF IBM-9985964, NIH P01-NS044306, and NIH GM068630 (T.J.S., T.M.B., J.R.S.); NSF PHY-0225630 (T.J.S., T.M.B.); HHMI (T.J.S.); NIH P41-RR06009 and NIH P20-CM065805 (J.R.S.); NPACI NSF-ASC 97-5249 (T.J.S., T.M.B., M.H.E., M.E.M.); NIH NCRR RR040SO (M.H.E., M.E.M.); Human Brain Project DC03192 (M.H.E., M.E.M.); and NIH NS12601 and NS35469 (D.K.B.). We thank P. B. Sargent, C. F. Stevens, and R. Kerr for advice. We dedicate this work to the vision of the late Dr. Miriam Salpeter.