Synaptic transmission at visualized sympathetic boutons: Stochastic interaction between acetylcholine and its receptors

Biophysical Journal

Volumn 72, Issue 4, 1997, Pages 1595-1606

  Bennett, M R ^a   Farnell, L ^a   Gibson, W G ^a   Lavidis, N A ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; CHOLINERGIC RECEPTOR;

ANIMAL TISSUE; ARTICLE; EXCITATORY POSTSYNAPTIC POTENTIAL; MOLECULAR DYNAMICS; NEUROTRANSMITTER RELEASE; NONHUMAN; RAT; RECEPTOR BINDING; SYMPATHETIC GANGLION; SYNAPTIC TRANSMISSION; SYSTEM ANALYSIS;

ANIMALIA;

EID: 0030938884     PISSN: 00063495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3495(97)78806-4     Document Type: Article

References (42)

1. Anglister, L., J. R. Stiles, and M. M. Salpeter. 1994. Acetylcholinesterase density and turnover number at frog neuromuscular junctions, with modelling of their role in synaptic function. Neuron. 12:783-794.
2. Bartol, T. M., Jr., B. R. Land, E. E. Salpeter, and M. M. Salpeter. 1991. Monte Carlo simulation of miniature endplate current generation in the vertebrate neuromuscular junction. Biophys. J. 59:1290-1307.
3. Bennett, M. R. 1995. The origin of Gaussian distributions of synaptic potentials. Prog. Neurobiol. 46:331-350.
4. Bennett, M. R., L. Farnell, W. G. Gibson, and S. Karunanithi. 1995a. Quantal transmission at purinergic junctions: stochastic interaction between ATP and its receptors. Biophys. J. 68:925-935.
5. Bennett, M. R., W. G. Gibson, and J. Robinson. 1995b. Probabilistic secretion of quanta: spontaneous release at active zones of varicosities, boutons and endplates. Biophys. J. 69:42-53.
6. Bennett, M. R., P. Jones, and N. A. Lavidis. 1986. The probability of quantal secretion along visualized terminal branches at amphibian (Bufo marinus) neuromuscular synapses. J. Physiol. (Lond.). 379:257-274.
7. Betz, W. J., F. Mao, and G. S. Bewick. 1992. Activity-dependent fluorescent staining and destaining of living vertebrate motor nerve terminals. J. Neurosci. 12:363-375.
8. Bornstein, J. C. 1978. Spontaneous multiquantal release at synapses in guinea-pig hypogastric ganglia: evidence that release can occur in bursts. J. Physiol. (Lond.). 282:375-398.
9. Busch, C., and B. Sakmann. 1990. Synaptic transmission in hippocampal neurons: numerical reconstruction of quantal IPSCs. Cold Spring Harb. Symp. Quant. Biol. 55:69-80.
10. de Groat, W. C., and A. M. Booth. 1993. Synaptic transmission in pelvic ganglia. In Nervous Control of the Urogenital System. C. A. Maggi, editor. Harwood Academic Publishers, Sydney.
11. Derkach, V. A., R. A. North, A. A. Selyanko, and V. I. Skok. 1987. Single channels activated by acetylcholine in rat superior cervical ganglion. J. Physiol. (Lond.). 388:141-151.
12. Derkach, V. A., A. A. Selyanko, and V. I. Skok. 1983. Acetylcholine-induced current fluctuations and fast excitatory post-synaptic currents in rabbit sympathetic neurones. J. Physiol. (Lond.). 336:511-526.
13. Dryer, S. E., and V. A. Chiappinelli. 1987. Analysis of quantal content and quantal conductance in two populations of neurons in the avian ciliary ganglion. Neuroscience. 20:905-910.
14. Edwards, F. A. 1991. LTP is a long term problem. Nature. 350:271-272.
15. Griffith. W. H., J. P. Gallagher, and P. Shinnick-Gallagher. 1980. An intracellular investigation of cat vesical pelvic ganglia. J. Neurophysiol. 43:343-354.
16. Hirst, G. D., and E. M. McLachlan. 1984. Post-natal development of ganglia in the lower lumbar sympathetic chain of the rat. J. Physiol. (Lond.). 349:119-134.
17. Khanin, R., H. Parnas, and L. Segel. 1994. Diffusion cannot govern the discharge of neurotransmitter in fast synapses. Biophys. J. 67:966-972.
18. Kuba, K., and S. Nishi. 1979. Characteristics of fast excitatory postsynaptic current in bullfrog sympathetic ganglion cells. Effects of membrane potential, temperature and Ca ions. Pflügers Arch. Eur. J. Physiol. 378:205-212.
19. Lavidis, N. A., and M. R. Bennett. 1992. Probabilistic secretion of quanta from visualized sympathetic nerve varicosities in mouse vas deferens. J. Physiol. (Lond.). 454:9-26.
20. Loring, R. H., D. W. Sah, S. C. Landis, and R. E. Zigmond. 1988. The ultrastructural distribution of putative nicotinic receptors on cultured neurons from the rat superior cervical ganglion. Neuroscience. 24:1071-1080.
21. 125I-toxin F binding sites on chick ciliary neurons: synaptic localization of a toxin that blocks ganglionic nicotinic receptors. J. Neurosci. 7:2153-2162.
22. MacDermott, A. B., E. A. Connor, V. E. Dionne, and R. L. Parsons. 1980. Voltage clamp study of fast excitatory synaptic currents in bullfrog sympathetic ganglion cells. J. Gen. Physiol. 75:39-60.
23. Margiotta, J. F., D. K. Berg, and V. E. Dionne. 1987. The properties and regulation of functional acetylcholine receptors on chick ganglion neurons. J. Neurosci. 7:3612-3622.
24. Martin, A. R., and G. Pilar. 1964. Quantal components of the synaptic potential in the ciliary ganglion of the chick. J. Physiol. (Lond.). 175: 1-16.
25. Mathie, A., S. G. Cull-Candy, and D. Colquhoun. 1991. Conductance and kinetic properties of single nicotinic acetylcholine receptor channels in rat sympathetic neurones. J. Physiol. (Lond.). 439:717-750.
26. Matthews-Bellinger, J., and M. M. Salpeter. 1978. Distribution of acetylcholine receptors at frog neuromuscular junctions with a discussion of some physiological implications. J. Physiol. (Lond.). 279:197-213.
27. Miledi, R., P. C. Molenaar, R. L. Polak, J. W. Tas, and T. van der Laaken. 1982. Neural and non-neural acetylcholine in the rat diaphragm. Proc. R. Soc. Lond. B. 214:153-168.
28. Rang, H. P. 1981. The characteristics of synaptic currents and responses to acetylcholine of rat submandibular ganglion cells. J. Physiol. (Lond.). 311:23-55.
29. Sargent, P. B. 1993. The diversity of neural nicotinic acetylcholine receptors. Annu. Rev. Neurosci. 16:403-443.
30. Sargent, P. B., and D. Z. Pang. 1988. Denervation alters the size, number, and distribution of clusters of acetylcholine receptor-like molecules on frog cardiac ganglion neurons. Neuron. 1:877-886.
31. Sargent, P. B., and D. Z. Pang. 1989. Acetylcholine receptor-like molecules are found in both synaptic and extrasynaptic clusters on the surface of neurones in the frog cardiac ganglion. J. Neurosci. 9:1062-1072.
32. Sigworth, F. J. 1980. The variance of sodium current fluctuations at the node of Ranvier. J. Physiol. (Lond.). 307:97-129.
33. Skok, V. I. 1987. Nicotinic acetylcholine receptors in the neurones of autonomic ganglia. J. Auton. Nerv. Syst. 21:91-99.
34. Stiles, J. R., D. van Helden, T. M. Bartol, E. E. Salpeter, and M. M. Salpeter. 1996. Miniature endplate current rise times less than 100 microseconds from improved dual recordings can be modeled with passive acetylcholine diffusion from a synaptic vesicle. Proc. Natl. Acad. Sci. USA. 93:5747-5752.
35. Streichert, L. C., and P. B. Sargent. 1989. Bouton ultrastructure and synaptic growth in a frog autonomic ganglion. J. Comp. Neurol. 281:159-168.
36. Tabatabai, N., A. M. Booth, and W. C. de Groat. 1986. Morphological and electrophysiological properties of pelvic ganglion cells in the rat. Brain Res. 382:61-70.
37. van der Kloot, W. 1995. The rise times of miniature endplate currents suggest that acetylcholine may be released over a period of time. Biophys. J. 69:148-154.
38. Warren, D., N. A. Lavidis, and M. R. Bennett. 1995a. Quantal secretion recorded from visualized boutons. Neurosci. Lett. 192:205-208.
39. Warren, D., N. A. Lavidis, and M. R. Bennett. 1995b. Quantal secretion recorded from visualized boutons on rat pelvic ganglion neurones. J. Auton. Nerv. Syst. 56:175-183.
40. Whittaker, V. P. 1990. Cholinergic synaptic vesicles are metabolically and biophysically heterogeneous even in resting terminals. Brain Res. 511: 113-121.
41. Yakota, R., and G. Burnstock. 1983. Synaptic organization of the pelvic ganglion in the guinea-pig. Cell Tissue Res. 232:379-397.
42. Yoshikami, D., and L. M. Okun. 1984. Staining of living presynaptic nerve terminals with selective fluorescent dyes. Nature. 310:53-56.