Neuropathological spectrum of cortical dysplasia in children with severe focal epilepsies

Acta Neuropathologica

Volumn 110, Issue 1, 2005, Pages 1-11

  Hildebrandt, Michelle ^a   Pieper, Tom ^b   Winkler, Peter ^c   Kolodziejczyk, Dieter ^d   Holthausen, Hans ^b   Blümcke, Ingmar ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b Epilepsy Center for Children and Adolescents   (Germany)

^c Olgaspital ^*  (Germany)

^d Clinic for Neurosurgery and Neuroradiology   (Germany)

Author keywords

Brain; Development; Epilepsy; Focal cortical dysplasia; Neuropathology

Indexed keywords

ADOLESCENT; ANATOMICAL VARIATION; ARTICLE; AUTOPSY; BRAIN BIOPSY; BRAIN DEVELOPMENT; CELL COUNT; CELL STRUCTURE; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; CORTICAL DYSPLASIA; DISEASE SEVERITY; FEMALE; FOCAL EPILEPSY; GLIOSIS; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; MALE; NERVE CELL GROWTH; NEUROANATOMY; NEUROPATHOLOGY; ONSET AGE; PERIKARYON; PERINATAL PERIOD; PRIORITY JOURNAL; STATISTICAL SIGNIFICANCE; WHITE MATTER;

ADOLESCENT; ADULT; ASTROCYTES; BRAIN DISEASES; CHILD; CHILD, PRESCHOOL; EPILEPSY; FEMALE; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; IMMUNOHISTOCHEMISTRY; MAGNETIC RESONANCE IMAGING; MALE; MICROGLIA; NEOCORTEX; NEURONS;

EID: 22244447175     PISSN: 00016322     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00401-005-1016-6     Document Type: Article

References (52)

1. Andres M, Andre VM, Nguyen S, Salamon N, Cepeda C, Levine MS, Leite JP, Neder L, Vinters HV, Mathern GW (2005) Human cortical dysplasia and epilepsy: An ontogenetic hypothesis based on volumetric MRI and NeuN neuronal density and size measurements. Cereb Cortex 15:194-210 10.1093/ cercor/bhh122
2. Arai N, Umitsu R, Komori T, Hayashi M, Kurata K, Nagata J, Tamagawa K, Mizutani T, Oda M, Morimatsu Y (2003) Peculiar form of cerebral microdysgenesis characterized by white matter neurons with perineuronal and perivascular glial satellitosis: A study using a variety of human autopsied brains. Pathol Int 53:345-352 10.1046/j.1440-1827.2003.01480.x
3. Becker AJ, Urbach H, Scheffler B, Baden T, Normann S, Lahl R, Pannek HW, Tuxhorn I, Elger CE, Schramm J, Wiestler OD, Blumcke I (2002) Focal cortical dysplasia of Taylor's balloon cell type: Mutational analysis of the TSC1 gene indicates a pathogenic relationship to tuberous sclerosis. Ann Neurol 52:29-37 10.1002/ana.10251
4. Bentivoglio M, Tassi L, Pech E, Costa C, Fabene PF, Spreafico R (2003) Cortical development and focal cortical dysplasia. Epileptic Disord 5 Suppl 2:S27-S34
5. Blumcke I, Giencke K, Wardelmann E, Beyenburg S, Kral T, Sarioglu N, Pietsch T, Wolf HK, Schramm J, Elger CE, Wiestler OD (1999) The CD34 epitope is expressed in neoplastic and malformative lesions associated with chronic, focal epilepsies. Acta Neuropathol 97:481-490 10.1007/ s004010051017
6. Blumcke I, Schewe JC, Normann S, Brustle O, Schramm J, Elger CE, Wiestler OD (2001) Increase of nestin-immunoreactive neural precursor cells in the dentate gyrus of pediatric patients with early-onset temporal lobe epilepsy. Hippocampus 11:311-321 10.1002/hipo.1045
7. Bothwell S, Meredith GE, Phillips J, Staunton H, Doherty C, Grigorenko E, Glazier S, Deadwyler SA, O'Donovan CA, Farrell M (2001) Neuronal hypertrophy in the neocortex of patients with temporal lobe epilepsy. J Neurosci 21:4789-800 1:CAS:528:DC%2BD3MXks1aktr8%3D
8. Braak H (1980) Architectonics of the human telencephalic cortex. Springer, Berlin
9. Buxhoeveden DP, Casanova MF (2002) The minicolumn and evolution of the brain. Brain Behav Evol 60:125-151 10.1159/000065935
10. Buxhoeveden DP, Switala AE, Roy E, Casanova MF (2000) Quantitative analysis of cell columns in the cerebral cortex. J Neurosci Methods 97:7-17 10.1016/S0165-0270(99)00192-2
11. Casanova MF, Buxhoeveden DP, Cohen M, Switala AE, Roy EL (2002) Minicolumnar pathology in dyslexia. Ann Neurol 52:108-110 10.1002/ ana.10226
12. Catania KC (2002) Barrels, stripes, and fingerprints in the brain - Implications for theories of cortical organization. J Neurocytol 31:347-538 10.1023/A:1024186329012
13. Cepeda C, Hurst RS, Flores-Hernandez J, Hernandez-Echeagaray E, Klapstein GJ, Boylan MK, Calvert CR, Jocoy EL, Nguyen OK, Andre VM, Vinters HV, Ariano MA, Levine MS, Mathern GW (2003) Morphological and electrophysiological characterization of abnormal cell types in pediatric cortical dysplasia. J Neurosci Res 72:472-486 10.1002/jnr.10604
14. Chun JJ, Shatz CJ (1989) Interstitial cells of the adult neocortical white matter are the remnant of the early generated subplate neuron population. J Comp Neurol 282:555-569 10.1002/cne.902820407
15. Clusmann H, Schramm J, Kral T, Helmstaedter C, Ostertun B, Fimmers R, Haun D, Elger CE (2002) Prognostic factors and outcome after different types of resection for temporal lobe epilepsy. J Neurosurg 97:1131-1141 12450036
16. Crino PB, Trojanowski JQ, Dichter MA, Eberwine J (1996) Embryonic neuronal markers in tuberous sclerosis: Single-cell molecular pathology. Proc Natl Acad Sci USA 93:14152-14157 10.1073/pnas.93.24.14152
17. Del Rio JA, Heimrich B, Borrell V, Forster E, Drakew A, Alcantara S, Nakajima K, Miyata T, Ogawa M, Mikoshiba K, Derer P, Frotscher M, Soriano E (1997) A role for Cajal-Retzius cells and reelin in the development of hippocampal connections. Nature 385:70-74 10.1038/385070a0
18. Diehl B, Najm I, LaPresto E, Prayson R, Ruggieri P, Mohamed A, Ying Z, Lieber M, Babb T, Bingaman W, Luders HO (2004) Temporal lobe volumes in patients with hippocampal sclerosis with or without cortical dysplasia. Neurology 62:1729-1735 1:STN:280:DC%2BD2c3mtVarug%3D%3D
19. Emery JA, Roper SN, Rojiani AM (1997) White matter neuronal heterotopia in temporal lobe epilepsy: A morphometric and immunohistochemical study. J Neuropathol Exp Neurol 56:1276-1282 1:STN:280:DyaK1c%2FnsFWqtQ%3D%3D
20. Fauser S, Becker A, Schulze-Bonhage A, Hildebrandt M, Tuxhorn I, Pannek HW, Lahl R, Schramm J, Blumcke I (2004) CD34-immunoreactive balloon cells in cortical malformations. Acta Neuropathol 108:272-278 10.1007/ s00401-004-0889-0
21. Fauser S, Schulze-Bonhage A, Honegger J, Carmona H, Huppertz HJ, Pantazis G, Rona S, Bast T, Strobl K, Steinhoff BJ, Korinthenberg R, Rating D, Volk B, Zentner J (2004) Focal cortical dysplasias: Surgical outcome in 67 patients in relation to histological subtypes and dual pathology. Brain 127:2406-2418 10.1093/brain/awh277
22. Haas CA, Dudeck O, Kirsch M, Huszka C, Kann G, Pollak S, Zentner J, Frotscher M (2002) Role for reelin in the development of granule cell dispersion in temporal lobe epilepsy. J Neurosci 22:5797-5802 1:CAS:528:DC%2BD38XlsFOjs78%3D
23. Hader WJ, Mackay M, Otsubo H, Chitoku S, Weiss S, Becker L, Snead OC, 3rd, Rutka JT (2004) Cortical dysplastic lesions in children with intractable epilepsy: Role of complete resection. J Neurosurg 100:110-117 14758938
24. Hilbig A, Babb TL, Najm I, Ying Z, Wyllie E, Bingaman W (1999) Focal cortical dysplasia in children. Dev Neurosci 21:271-280 10.1159/000017406
25. Jones EG (2000) Microcolumns in the cerebral cortex. Proc Natl Acad Sci USA 97:5019-5021 10.1073/pnas.97.10.5019
26. Kasper BS, Stefan H, Buchfelder M, Paulus W (1999) Temporal lobe microdysgenesis in epilepsy versus control brains. J Neuropathol Exp Neurol 58:22-28 1:STN:280:DyaK1M7jvF2isg%3D%3D
27. Kasper BS, Stefan H, Paulus W (2003) Microdysgenesis in mesial temporal lobe epilepsy: A clinicopathological study. Ann Neurol 54:501-506 10.1002/ana.10694
28. Kloss S, Pieper T, Pannek H, Holthausen H, Tuxhorn I (2002) Epilepsy surgery in children with focal cortical dysplasia (FCD): Results of long-term seizure outcome. Neuropediatrics 33:21-26 10.1055/s-2002-23595
29. Kuzniecky RI, Barkovich AJ (2001) Malformations of cortical development and epilepsy. Brain Dev 23:2-11 10.1016/S0387-7604(00)00195-9
30. Marin-Padilla M (1999) Developmental neuropathology and impact of perinatal brain damage. III. Gray matter lesions of the neocortex. J Neuropathol Exp Neurol 58:407-429 1:STN:280:DyaK1M3mtVaksQ%3D%3D
31. Meencke HJ (1983) The density of dystrophic neurons in the white matter of the gyrus frontalis inferior in epilepsies. J Neurol 230:171-181 10.1007/BF00313628
32. Meencke HJ, Janz D (1984) Neuropathological findings in primary generalized epilepsy: A study of eight cases. Epilepsia 25:8-21 1:STN:280:BiuC3cfisFw%3D
33. Mischel PS, Nguyen LP, and Vinters HV (1995) Cerebral cortical dysplasia associated with pediatric epilepsy. Review of neuropathologic features and proposal for a grading system. J Neuropathol Exp Neurol 54:137-153 1:STN:280:ByqC1c3hsFc%3D
34. Mountcastle VB (1997) The columnar organization of the neocortex. Brain 120:701-722 10.1093/brain/120.4.701
35. Nishikawa S, Goto S, Hamasaki T, Yamada K, Ushio Y (2002) Involvement of reelin and Cajal-Retzius cells in the developmental formation of vertical columnar structures in the cerebral cortex: Evidence from the study of mouse presubicular cortex. Cereb Cortex 12:1024-1030 10.1093/ cercor/12.10.1024
36. Palmini A, Najm I, Avanzini G, Babb T, Guerrini R, Foldvary-Schaefer N, Jackson G, Luders HO, Prayson R, Spreafico R, Vinters HV (2004) Terminology and classification of the cortical dysplasias. Neurology 62:S2-S8 1:STN:280:DC%2BD2c7ksVektQ%3D%3D
37. Riederer BM (1992) Differential phosphorylation of some proteins of the neuronal cytoskeleton during brain development. Histochem J 24:783-790 10.1007/BF01046350
38. Riederer B, Matus A (1985) Differential expression of distinct microtubule-associated proteins during brain development. Proc Natl Acad Sci USA 82:6006-6009 1:CAS:528:DyaL2MXltl2gsrs%3D
39. Riederer BM, Porchet R, Marugg RA (1996) Differential expression and modification of neurofilament triplet proteins during cat cerebellar development. J Comp Neurol 364:704-717 10.1002/ (SICI)1096-9861(19960122)364:4<704::AID-CNE8>3.0.CO;2-7
40. Rojiani AM, Emery JA, Anderson KJ, Massey JK (1996) Distribution of heterotopic neurons in normal hemispheric white matter: A morphometric analysis. J Neuropathol Exp Neurol 55:178-183 1:STN:280:BymC2snitFA%3D
41. Sisodiya SM (2000) Surgery for malformations of cortical development causing epilepsy. Brain 123:1075-1091 10.1093/brain/123.6.1075
42. Spreafico R, Battaglia G, Arcelli P, Andermann F, Dubeau F, Palmini A, Olivier A, Villemure JG, Tampieri D, Avanzini G, Avoli M (1998) Cortical dysplasia: An immunocytochemical study of three patients. Neurology 50:27-36 1:STN:280:DyaK1c7gtlKqsg%3D%3D
43. Tassi L, Colombo N, Garbelli R, Francione S, Lo Russo G, Mai R, Cardinale F, Cossu M, Ferrario A, Galli C, Bramerio M, Citterio A, Spreafico R (2002) Focal cortical dysplasia: Neuropathological subtypes, EEG, neuroimaging and surgical outcome. Brain 125:1719-1732 10.1093/ brain/awf175
44. Taylor DC, Falconer MA, Bruton CJ, Corsellis JA (1971) Focal dysplasia of the cerebral cortex in epilepsy. J Neurol Neurosurg Psychiatry 34:369-387 1:STN:280:CS2D3cfjtFQ%3D
45. Thom M, Sisodiya S, Harkness W, Scaravilli F (2001) Microdysgenesis in temporal lobe epilepsy. A quantitative and immunohistochemical study of white matter neurones. Brain 124:2299-2309 10.1093/brain/124.11.2299
46. Thom M, Harding BN, Lin WR, Martinian L, Cross H, Sisodiya SM (2003) Cajal-Retzius cells, inhibitory interneuronal populations and neuropeptide Y expression in focal cortical dysplasia and microdysgenesis. Acta Neuropathol 105:561-569 1:CAS:528:DC%2BD3sXjsVGrsr0%3D
47. Urbach H, Scheffler B, Heinrichsmeier T, Oertzen J von, Kral T, Wellmer J, Schramm J, Wiestler OD, Blumcke I (2002) Focal cortical dysplasia of Taylor's balloon cell type: A clinicopathological entity with characteristic neuroimaging and histopathological features, and favorable postsurgical outcome. Epilepsia 43:33-40 10.1046/ j.1528-1157.2002.38201.x
48. Volterra A, Steinhauser C (2004) Glial modulation of synaptic transmission in the hippocampus. Glia 47:249-257 10.1002/glia.20080
49. Widman G, Lehnertz K, Urbach H, Elger CE (2000) Spatial distribution of neuronal complexity loss in neocortical lesional epilepsies. Epilepsia 41:811-817 1:STN:280:DC%2BD3czlslKksA%3D%3D
50. Wolf HK, Buslei R, Schmidt-Kastner R, Schmidt-Kastner PK, Pietsch T, Wiestler OD, Blumcke I (1996) NeuN: A useful neuronal marker for diagnostic histopathology. J Histochem Cytochem 44:1167-1171 1:CAS:528:DyaK28XmtVylsL8%3D
51. Wolf HK, Roos D, Blumcke I, Pietsch T, Wiestler OD (1996) Perilesional neurochemical changes in focal epilepsies. Acta Neuropathol 91:376-384 10.1007/s004010050439
52. Zecevic N, Rakic P (2001) Development of layer I neurons in the primate cerebral cortex. J Neurosci 21:5607-5619 1:CAS:528:DC%2BD3MXlsV2gtrY%3D