The CD34 epitope is expressed in neoplastic and malformative lesions associated with chronic, focal epilepsies

Acta Neuropathologica

Volumn 97, Issue 5, 1999, Pages 481-490

  Blümcke, Ingmar ^a   Giencke, Kai ^a   Wardelmann, Eva ^a   Beyenburg, Stefan ^a   Kral, Thomas ^a   Sarioglu, Nanette ^b   Pietsch, Torsten ^a   Wolf, Helmut K ^c   Schramm, Johannes ^a   Elger, Christian E ^a   Wiestler, Otmar D ^a  

^a UNIVERSITY HOSPITAL BONN   (Germany)

^b HUMBOLDT UNIVERSITY   (Germany)

^c UNIVERSITY MEDICAL CENTER MAINZ   (Germany)

Author keywords

Epilepsy; Ganglioglioma; Malformation; Stem cell; Tumor

Indexed keywords

CD34 ANTIGEN; EPITOPE; PROTEIN S 100;

ADOLESCENT; ADULT; ANTIGEN EXPRESSION; ARTICLE; ASTROCYTOMA; BRAIN MALFORMATION; BRAIN TUMOR; CONTROLLED STUDY; FOCAL EPILEPSY; GLIOMA; HAMARTOMA; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; INTRACTABLE EPILEPSY; MAJOR CLINICAL STUDY; MALIGNANT TERATOMA; NERVE CELL DIFFERENTIATION; NEURULATION; OLIGODENDROGLIOMA; PRIORITY JOURNAL; STEM CELL; TEMPORAL LOBE; TEMPORAL LOBE EPILEPSY;

ADOLESCENT; ADULT; ANTIGENS, CD34; CHRONIC DISEASE; EPILEPSIES, PARTIAL; EPITOPES; HUMANS; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; MIDDLE AGED;

EID: 0345040135     PISSN: 00016322     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004010051017     Document Type: Article

References (42)

1. Allen IV, McQuaid S, McMahon J, Crangle K, McConnell R (1996) The expression of the endothelial cell antigen CD34 in demyelinating disease. Neuropathol Appl Neurobiol 22:101-107
2. Armstrong DD (1993) The neuropathology of temporal lobe epilepsy. J Neuropathol Exp Neurol 52:433-443
3. Berg MJ, Schifitto G, Powers JM, Martinez-Capolino C, Fong CT, Myers GJ, Epstein LG, Walsh CA (1998) X-linked female band heterotopia-male lissencephaly syndrome. Neurology 50: 1143-1146
4. Brodsky M, Lombroso PJ (1998) Molecular mechanisms of developmental disorders. Dev Psychopathol 10:1-20
5. Brown J, Greaves MF, Molgaard HV (1991) The gene encoding the stem cell antigen, CD34, is conserved in mouse and expressed in haemopoietic progenitor cell lines, brain, and embryonic fibroblasts. Int Immunol 3:175-184
6. Carneiro SS, Scheithauer BW, Nascimento AG, Hirose T, Davis DH (1996) Solitary fibrous tumor of the meninges: a lesion distinct from fibrous meningioma. A clinicopathologic and immunohistochemical study. Am J Clin Pathol 106:217-224
7. Celio MR, Blümcke I (1994) Perineuronal nets - a specialized form of extracellular matrix in the adult nervous system. Brain Res Rev 19:128-145
8. De Silva U, D'Arcangelo E, Braden VV, Chen J, Miao GG, Curran T, Green ED (1997) The human reelin gene: isolation, sequencing and mapping on chromosome 7. Genome Res 7: 157-164
9. Des Portes V, Pinard JM, Billuart P, Vinet MC, Koulakoff A, Carrie A, Gelot A, Dupuis E, Motte J, Berwald-Netter Y, Catala M, Kahn A, Beldjord C, Chelly J (1998) A novel CNS gene required for neuronal migration and involved in X-linked subcortical laminar heterotopia and lissencephaly syndrome. Cell 92:51-61
10. Eng LF, Ghirnikar RS (1994) GFAP and astrogliosis. Brain Pathol 4:229-237
11. Enzinger FM, Weiss SW (1995) CD34. In: Enzinger FM, Weiss SW (eds) Soft tissue tumors, 3rd edn. Mosby, St. Louis, pp 150-151
12. Flint A, Weiss SW (1995) CD-34 and keratin expression distinguishes solitary fibrous tumor (fibrous mesothelioma) of pleura from desmoplastic mesothelioma. Hum Pathol 26: 428-431
13. Gleeson JG, Allen KM, Fox JW, Lamperti ED, Berkovic S, Scheffer I, Cooper EC, Dobyns WB, Minnerath SR, Ross ME, Walsh CA (1998) Doublecortin, a brain-specific gene mutated in human X-linked lissencephaly and double cortex syndrome, encodes a putative signaling protein. Cell 92:63-72
14. Gräber MB, Streit WJ (1990) Microglia: immune network in the CNS. Brain Pathol 1:2-5
15. Howell BW, Hawkes R, Soriano P, Cooper JA (1997) Neuronal position in the developing brain is regulated by mouse disabled-1. Nature 389:733-737
16. Kahn HJ, Marks A, Thom H, Baumal R (1982) Role of antibody to S-100 protein in diagnostic pathology. Am J Clin Pathol 79:341-347
17. Kalaria RN, Kroon SN (1992) Expression of leukocyte antigen CD34 by brain capillaries in Alzheimer's disease and neurologically normal subjects. Acta Neuropathol 84:606-612
18. Kettenmann H (1994) Electrophysiological behavior of microglia. Neuropathol Appl Neurobiol 20:177-178
19. Kettenmann H, Ilschner S (1993) Physiological properties of microglia. Clin Neuropathol 12:306-307
20. Lin G, Finger E, Gutierrez Ramos JC (1995) Expression of CD34 in endothelial cells, hematopoietic progenitors and nervous cells in fetal and adult mouse tissues. Eur J Immunol 25: 1508-1516
21. Morris SM, Albrecht U, Reiner O, Eichele G, Yu-Lee L (1998) The lissencephaly gene product Lis 1, a protein involved in neu ronal migration, interacts with a nuclear movement protein, NudC. Curr Biol 8:603-606
22. Navratil E, Couvelard A, Rey A, Henin D, Scoazec JY (1997) Expression of cell adhesion molecules by microvascular endothelial cells in the cortical and subcortical regions of the normal human brain: an immunohistochemical analysis. Neuropathol Appl Neurobiol 23:68-80
23. Nora FE, Scheithauer BW (1996) Primary epithelioid hemangioendothelioma of the brain. Am J Surg Pathol 20:707-714
24. Platten M, Meyer Puttlitz B, Blümcke I, Waha A, Wolf HK, Nothen MM, Louis DN, Sampson JR, Deimling A von (1997) A novel splice site associated polymorphism in the tuberous sclerosis 2 (TSC2) gene may predispose to the development of sporadic gangliogliomas. J Neuropathol Exp Neurol 56:806-810
25. Prayson RA, Estes ML, Morris HH (1993) Coexistence of neoplasia and cortical dysplasia in patients presenting with seizures. Epilepsia 34:609-615
26. Reiner O, Lombroso PJ (1998) Development of the cerebral cortex. II. Lissencephaly. J Am Acad Child Adolesc Psychiatry 37:231-232
27. Reiner O, Carrozzo R, Shen Y, Wehnert M, Faustinella F, Dobyns WB, Caskey CT, Ledbetter DH (1993) Isolation of a Miller-Dieker lissencephaly gene containing G-protein betasubunit-like repeats. Nature 364:717-721
28. Scott MA, Gordon MY (1995) In search of the haemopoietic stem cell. Br J Haematol 90:738-743
29. Sreenan JJ, Prayson RA (1997) Gliosarcoma. A study of 13 tumors, including p53 and CD34 immunohistochemistry. Arch Pathol Lab Med 121:129-133
30. Sutherland DR, Marsh JCW, Davidson J, Baker MA, Keating A, Mellors A (1992) Differential sensitivity of CD34 epitopes to cleavage by pasteurella haemolytica glycoprotease: implications for purification of CD34 positive progenitor cells. Exp Hematol 20:590-599
31. Sutherland DR, Stewart AK, Keating A (1993) CD34 antigen: molecular features and potential clinical applications. Stem Cells 3:50-57
32. Tamsen A, Silverman JS (1995) GIST. Am J Surg Pathol 19: 1444-1445
33. Toyama J, Kasuya H, Higuchi S, Kondo H, Naganuma Y, Uchiyama M (1998) Familial neuronal migration disorder: subcortical laminar heterotopia in a mother and pachygyria in the son. Am J Med Genet 75:481-484
34. Van de Rijn M, Lombard CM, Rouse RV (1994) Expression of CD34 by solitary fibrous tumors of the pleura, mediastinum, and lung (see comments). Am J Surg Pathol 18:814-820
35. Weiss SW, Nickoloff BJ (1993) CD-34 is expressed by a distinctive cell population in peripheral nerve, nerve sheath tumors, and related lesions. Am J Surg Pathol 17:1039-1045
36. Wickenhäuser C, Thiele J, Kümmel T, Fischer R (1995) Hematopoitic stem cells of the human. Function and morphology. Pathologe 16:1-10
37. Wiestler OD, Siebenthal K von, Schmitt HP, Feiden W, Kleihues P (1989) Distribution and immunoreactivity of cerebral micro-hamartomas in bilateral acoustic neurofibromatosis (neurofibromatosis 2). Acta Neuropathol 79:137-143
38. Wolf HK, Wiestler OD (1993) Surgical pathology of chronic epileptic seizure disorders. Brain Pathol 3:371-380
39. Wolf HK, Zentner J, Hufnagel A, Campos MG, Schramm J, Elger CE, Wiestler OD (1993) Surgical pathology of chronic epileptic seizure disorders: experience with 63 specimens from extratemporal corticectomies, lobectomies and functional hemispherectomies. Acta Neuropathol 86:466-472
40. Wolf HK, Campos MG, Zentner J, Hufnagel A, Schramm J, El-ger CE, Wiestler OD (1993) Surgical pathology of temporal lobe epilepsy. Experience with 216 cases. J Neuropathol Exp Neurol 52:499-506
41. Wolf HK, Wellmer J, Müller MB, Wiestler OD, Hufnagel A, Pietsch T (1995) Glioneuronal malformative lesions and dysembryoplastic neuroepithelial tumors in patients with chronic pharmacoresistant epilepsies. J Neuropathol Exp Neurol 54: 245-254
42. Young PE, Baumhueter S, Lasky LA (1995) The sialomucin CD34 is expressed on hematopoietic cells and blood vessels during murine development. Blood 85:96-105