Characterization and modulation by drugs of sheep liver microsomal flavin monooxygenase activity

Cell Biochemistry and Function

Volumn 23, Issue 4, 2005, Pages 245-251

  Demirdöǧen, Birsen Can ^a   Adali, Orhan ^a  

^a MIDDLE EAST TECHNICAL UNIVERSITY   (Turkey)

Author keywords

Chlorpromazine; Drug metabolism; Flavin monooxygenase; Imipramine; Methimazole; Sheep

Indexed keywords

CHLORPROMAZINE; CHOLIC ACID; DETERGENT; EMULGEN 913; FLAVIN MONOOXYGENASE; FLAVINE ADENINE NUCLEOTIDE; IMIPRAMINE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; THIAMAZOLE; TRITON X 100; UNCLASSIFIED DRUG; UNSPECIFIC MONOOXYGENASE;

ANIMAL CELL; ANIMAL TISSUE; CATALYSIS; CONCENTRATION RESPONSE; CONFERENCE PAPER; CONTROLLED STUDY; DRUG METABOLISM; ENZYME ACTIVITY; ENZYME ANALYSIS; IMMUNOCHEMISTRY; LIVER MICROSOME; NONHUMAN; OXIDATION; PRIORITY JOURNAL; SHEEP; SPECTROPHOTOMETRY; WESTERN BLOTTING;

ANIMALS; ANTIDEPRESSIVE AGENTS, TRICYCLIC; ANTIPSYCHOTIC AGENTS; ANTITHYROID AGENTS; CHLORPROMAZINE; CHOLATES; DETERGENTS; IMIPRAMINE; LIVER; METHIMAZOLE; MICROSOMES, LIVER; NADP; OCTOXYNOL; OXIDATION-REDUCTION; OXYGENASES; SHEEP;

OVIS ARIES;

EID: 22244433167     PISSN: 02636484     EISSN: None     Source Type: Journal    
DOI: 10.1002/cbf.1145     Document Type: Conference Paper

References (32)

1. Sum CY, Kasper CB. Mixed function amine oxidase of the rat hepatocyte nuclear envelope. Biochem Pharmacol 1982; 31: 69-73.
2. Schlenk D. Occurrence of flavin-containing monooxygenase in non-mammalian eukaryotic organism. Comp Biochem Physiol C 1998; 121: 185-195.
3. Hodgson E, Cherrington NJ, Philpot RM, Rose RL. Biochemical aspects of flavin-containing monooxygenases (FMOs). In Molecular and Applied Aspects of Oxidative Drug Metabolizing Enzymes, Arinç E, et al. (eds). Nato ASI Series, Plenum Publishers: New York, 1999; 55-70.
4. Attar M, Dong D, Ling KH, Tang-Liu DD. Cytochrome P450 2C8 and flavin-containing monooxygenases are involved in the metabolism of tazarotenic acid in humans. Drug Metab Dispos 2003; 31: 476-481.
5. Hodgson E, Blake BL, Levi PE, et al. Flavin-containing monooxygenases: substrate specificity and complex metabolic pathways. In Molecular Aspects of Oxidative Drug Metabolizing Enzymes: Their Significance in Environmental Toxicology, Chemical Carcinogenesis and Health, Arinç E, Schenkman JB, Hodgson E (eds). Nato ASI Series, Plenum Publishers: New York, 1995; 225-235.
6. Ziegler DM. Flavin-containing monooxygenases: catalytic mechanism and substrate specificities. Drug Metab Rev 1988; 19: 1-32.
7. Bhamre S, Bhagwat SV, Shankar SK, Boyd MR, Ravindranath V. Flavin-containing monooxygenase mediated metabolism of psychoactive drugs by human brain microsomes. Brain Res 1995; 672: 276-280.
8. Kupfer D, Dehal SS. Tamoxifen metabolism by microsomal cytochrome P450 and Flavin-containing monooxygenase. In Methods In Enzymology (Vol. 272), Johnson EF, Waterman MR (eds). Academic Press, Inc: San Diego, 1996; 152-163.
9. Stormer E, Roots I, Brockmoller J. Benzydamine N-oxidation as an index reaction reflecting FMO activity in human liver microsomes and impact of FMO3 polymorphisms on enzyme activity. Br J Clin Pharmacol 2000; 50: 553-561.
10. Parkinson A. Biotransformation of xenobiotics. In Casarett & Doul's Toxicology: The Basic Science of Poisons (5th edn), Klaassen CD (ed.). McGraw-Hill: New York, 1996; 113-186.
11. Cashman JR. Structural and catalytic properties of the mammalian flavin-containing monooxygenase. Chem Res Toxicol 1995; 8: 165-181.
12. Elfarra AA. Potential role of the flavin-containing monooxygenases in the metabolism of endogenous compounds. Chem - Biol Inter 1995; 96: 47-55.
13. Dolphin CT, Janmohammed A, Smith RL, Shephard EA, Phillips IR. Compound heterozygosity for missense mutations in the flavin-containing monooxygenase 3 (FMO3) gene in patients with fish-odour syndrome. Pharmacogenetics 2000; 10: 799-807.
14. Mitchell SC, Smith RL. Trimethylaminuria: the fish malodor syndrome. Drug Metab Dispos 2001; 29: 517-521.
15. Cashman JR, Zhang J. Interindividual differences of human flavin-containing monooxygenase 3: genetic polymorphisms and functional variation. Drug Metab Dispos 2002; 30: 1043-1052.
16. Philpot RM, Biagini CP, Carver GT, Overby LH, Wyatt MK, Itagaki K. Expression and regulation of flavin-containing monooxygenases. In Molecular and Applied Aspects of Oxidative Drug Metabolizing Enzymes, Arinç E, et al. (eds). Plenum: New York, 1999; 71-79.
17. Kruger SK, Yueh M-F, Martin SR, Pereira CB, Williams DE. Characterization of expressed full-length and truncated FMO2 from rhesus monkey. Drug Metab Dispos 2001; 29: 693-700.
18. Tynes RE, Philpot RM. Tissue and species-dependent expression of multiple forms of mammalian microsomal flavin-containing monooxygenase. Mol Pharmacology 1987; 31: 569-574.
19. Rouer E, Rouet P, Delpech M, Leroux JP. Purification and comparison of liver microsomal flavin-containing monooxygenase from normal and streptozotocin-diabetic rats. Biochem Pharmacol 1988; 37: 3455-3459.
20. Williams DE, Meyer HH, Dutchuk MS. Distinct pulmonary and hepatic forms of flavin-containing monooxygenase in sheep. Comp Biochem Physiol 1989; 93B: 465-470.
21. Falls JG, Cherrington NJ, Clements KM, et al. Molecular cloning, sequencing, and expression in Eschericia coli of mouse flavin-containing monooxygenase 3 (FMO3): comparison with the human isoform. Arch Biochem Biophys 1997; 347: 9-18.
22. Iscan MY, Arinc E. Comparison of highly purified sheep liver and lung NADPH-cytochrome P-450 reductases by the analysis of kinetic and catalytic properties. Int J Biochem 1988; 20: 1189-1196.
23. Lowry OH, Rosebrough NJ, Farr AL, Randal RJ. Protein measurement with Folin phenol reagent. J Biol Chem 1951; 193: 265-275.
24. Dixit A, Roche TE. Spectrophotometric assay of the flavin-containing monooxygenase and changes in its activity in female mouse liver with nutritional and diurnal conditions. Arch Biochem Biophys 1984; 233: 50-63.
25. Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970; 227: 680-684.
26. Ey PL, Ashman LK. The use of alkaline phosphatase-conjugated anti-immunoglobulin with immunoblots for determining the specificity of monoclonal antibodies to protein mixtures. In Methods in Enzymology (Vol. 121), Langone JJ, Vunakis HV (eds). Academic Press: New York, 1986; 497-509.
27. Tynes RE, Hodgson E. Catalytic activity and substrate specificity of the flavin-containing monooxygenase in microsomal systems: characterization of the hepatic, pulmonary and renal enzymes of the mouse, rabbit, and rat. Arch Biochem Biophys 1985; 240: 77-93.
28. Sum CY, Kasper CB. Mixed function amine oxidase of the rat hepatocyte nuclear envelope. Biochem Pharmacol 1982; 31: 69-73.
29. Ziegler DM, Poulsen LL, McKee EM. Interaction of primary amines with a mixed-function amine oxidase isolated from pig liver microsomes. Xenobiotics 1971; 1: 523-531.
30. Adah O, Carver GC, Philpot RM. Modulation of human flavin-containing monooxygenase 3 activity by tricyclic antidepressants and other agents: importance of residue 428. Arch Biochem Biophys 1998; 358: 92-97.
31. Narimatsu S, Yamamoto S, Kato R, Masubuchi Y, Hone T. Contribution of flavin-containing monooxygenase and cytochrome P450 to imipramine N-oxidation in rat hepatic microsomes. Biol Pharm Bull 1999; 22: 567-571.
32. Longin-Sauvageon C, Lattard V, Lilaz-Michel C, Buronfosse T, Beneoit E. Expression of two different FMOs in sheep liver. Drug Metab Dispos 1998; 26: 284-287.