CD2-SLFA3/T11TS interaction facilitates immune activation and glioma regression by apoptosis

Cancer Biology and Therapy

Volumn 3, Issue 11, 2004, Pages 1121-1128

  Sarkar, Susobhan ^a   Ghosh, Anirban ^a   Mukherjee, Joydeep ^a   Chaudhuri, Samares ^b   Chaudhuri, Swapna ^a  

^a INSTITUTE OF POST GRADUATE MEDICAL EDUCATION AND RESEARCH   (India)

^b CALCUTTA SCHOOL OF TROPICAL MEDICINE   (India)

Author keywords

Apoptosis; CD2 SLFA3 interaction; Glioma; Immunotherapy; Lymphocytes; Microglia

Indexed keywords

CD2 ANTIGEN; DNA FRAGMENT; EXTRACHROMOSOMAL DNA; GLYCOPROTEIN; GLYCOPROTEIN T11TS; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; UNCLASSIFIED DRUG; ETHYLNITROSOUREA; LYMPHOCYTE ANTIGEN RECEPTOR; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 3; MUTAGENIC AGENT; PHOSPHATIDYLSERINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN CELL; CANCER IMMUNOTHERAPY; CYTOPLASM; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; GLIOMA; IMMUNOMODULATION; IMMUNOPOTENTIATION; IMMUNOTHERAPY; LYMPHOCYTE; MACROPHAGE; MAJOR HISTOCOMPATIBILITY COMPLEX; MALE; MICROGLIA; NEWBORN; NONHUMAN; PERIPHERAL LYMPHOCYTE; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN ANALYSIS; PURIFICATION; RAT; RECEPTOR DOWN REGULATION; SHEEP ERYTHROCYTE; STAINING; TUMOR REGRESSION; ANIMAL; BRAIN TUMOR; CYTOLOGY; DRUG EFFECT; ERYTHROCYTE; GENE; IMMUNOLOGY; ISOLATION AND PURIFICATION; METABOLISM; PHYSIOLOGY; PROTEIN BINDING; ROSETTE FORMATION; SHEEP;

ANIMALS; ANTIGENS, CD2; ANTIGENS, CD58; APOPTOSIS; BRAIN NEOPLASMS; ERYTHROCYTES; ETHYLNITROSOUREA; FEMALE; FLOW CYTOMETRY; GENES, MHC CLASS I; GLIOMA; LYMPHOCYTES; MACROPHAGES; MALE; MICROGLIA; MUTAGENS; PHOSPHATIDYLSERINES; PROTEIN BINDING; RATS; RECEPTORS, ANTIGEN, T-CELL; ROSETTE FORMATION; SHEEP;

EID: 22144490892     PISSN: 15384047     EISSN: 15558576     Source Type: Journal    
DOI: 10.4161/cbt.3.11.1214     Document Type: Article

References (44)

1. Sarkar S, Begum Z, Dutta SK, Dutta S, Chaudhuri S, Chaudhuri Swapna. Sheep form of lecocyte function antigen-3 (T11TS) exerts immunostimulatory and anti-tumor activity against experimental brain tumor. A new approach to biological response modifier therapy. J Exp Clin Cancer Res 2002; 21:95-106.
2. Begum Z, Ghosh A, Sarkar S, Mukherjee J, Mazumdar M, Sarkar P, Chaudhuri Swapna. Documentation of immune profile of microglia through cell surface marker study in glioma model primed by a novel cell surface glycopeptide T11TS/SLFA3. Glycoconj J 2004; In press.
3. Mukherjee J, Dutta S, Sarker S, Begum Z, Ghosh A, Chaudhuri S, Chaudhuri Swapna. Preclinical changes in immunoreactivity and cellular architecture during the progressive development of intracranial neoplasms and an immunotherapeutic schedule with a novel biological response modifier, the T11TS/SLFA-3. Asian Pacific J Cancer Prev 2002; 3:325-37.
4. Siliciano RF, Pratt J C, Schmidt RE, Ritz J, Reinherz EL. Activation of cytolytic T lymphocyte and natural killer cell function through the T11 sheep erythrocyte binding protein. Nature 1985; 317:428-30.
5. Meuer SC, Roux MM, Schraven B. The alternative pathway of T cell activation: Biology, pathophysiology and perspectives for immunopharmacology. Clin Immunol Immunopathol 1989; 50:133-9.
6. Dustin ML, Oiszowy MW, Holdorf AD, Li J, Bromley S, Desai N, Widder P, et al. A novel adapter protein orchestrates receptor patterning and cytoskeletal polarity in T cell contacts. Cell 1998; 94:667-77.
7. Hunig T, Tiefenthaler G, Mitnacht R, Kohler C, Lottspeich F, Meuer S. The "erythrocyte receptor" of T-lymphocytes and T11 target structure (T11TS): Complementary cell interaction molecules involved in T cell activation. Behring Inst Mitt 1987; 81:31-40.
8. Sun Z J, Dotsch V, Kim M, Li J, Reinherz EL, Wagner G. Functional glycan-free adhesion domain of human cell surface receptor CD58: Design, production and NMR studies. EMBO J 1999; 18:2941-49.
9. Grakoui A, Bromley SK, Sumen C, Davis MM, Shaw S, Allen PM, Dustin ML: The immunological synapse: A molecular machine controlling T cell activation. Science 1999; 285:221-7.
10. Wild MK, Cambiaggi A, Brown MH, Davies EA, Ohno H, Saito P, van der Merwe PA. Dependence of T cell antigen recognition on the dimensions of an accessory receptor ligand complex. J Exp Med 1999; 190:31-41.
11. Bierer BE, Peterson A, Gorga JC, Herrmann SH, Burakoff SJ. Synergistic T cell activation via the physiological ligands for CD2 and the T cell receptor. J Exp Med 1988; 168:1145-56.
12. Bachmann MF, Barner M, Kopf M. CD2 sets quantitative threshold in T cell activation. J Exp Med 1999; 190:1383-91.
13. nd edition. London: Academic Press, 1997:613.
14. Sedgwick JD, Ford L, Foulcher E, Airriess R. Central nervous system microglial cell activation and proliferation follows direct interaction with tissue infiltrating T cell blasts. J Immunol 1998; 160:5320-30.
15. Badie B, Schartner J. Role of microglia in glioma biology. Microsc Res Tech 2001; 54:106-13.
16. Flugel A, Labeur MS, Grasbon-Frodl EM, Kreutzberg GW, Graeber MB. Microglia only weakly present glioma antigen to cytotoxic T cells. Int J Dev Neurosci 1999; 17:547-56.
17. Badie B, Bartley B, Schartner J. Differential expression of MHC class II and B7 costimulatory molecules by microglia in rodent gliomas. J Neuroimmunol 2002; 133:39-45.
18. Aloisi F, Serafini B, Adorini L. Glia-T cell Dialogue. J Neuroimmunol 2000; 107:111-7.
19. Parney IF, Farr-Jones MA, Chang J, et al. Human glioma immunobiology in vitro: Implications for immunogen therapy. Neurosurgery 2000; 46:1169-78.
20. Liu Y, Ng K, Lillehei KO. Cell mediated immunotherapy: A new approach to the treatment of malignant glioma. Cancer Control 2003; 10:138-47.
21. Zwaal RFA, Schroit A. Pathophysiologic implication of membrane phospholipids asymmetry in blood cells. Blood 1997; 89:1121-32.
22. Green DR. Apoptotic pathways: The roads to ruin. Cell 1998 94:695-8.
23. Lantos PL. Chemical induction of tumors in nervous system. In: Thomas, GT(ed): NeuroOncology, New York: Churchill Livingstone, 1993:85-107.
24. Maniatis T, Frirsch EF, Sambrook J. Molecular Cloning: A laboratory manual. Cold Spring Harber Laborator, 1982.
25. Baines D. Analysis of purity. In: Simon Roe, ed.: Proptein purification techniques. 2nd ed. New York: Oxford University Press, 2001: 45.
26. Chaudhuri Swapna, Sinha A, Sengupta A, Chaudhuri S. Sheep erythrocytes provide metabolic triggers for tumor phagocytosis in polymorphonuclear neutrophils: A possible mechanism of tumor inhibition in mice. Biochem Int 1991; 23:231-41.
27. Fischer HG, Reichmann G. Brain dendritic cells and macrophage/microglia in central nervous system inflammation. J Immunol 2001; 166:2717-26.
28. Begum Z, Sarkar S, Mukherjee J, Ghosh A, Chaudhuri S, Chaudhuri Swapna. Evaluation of anti-tumor property of specific BRMs in experimental glioma by assessing the microglial cell functional and phenotypic modulations. Cancer Biol Ther 2003; 2:356-63.
29. Kitao T, Takeshita M, Hottori K. Studies on glycopeptide release by trypsin from from sheep erythrocytes. J Immunol 1976; 117:310-2.
30. Fox DA, Hussey RE, Fitzgerald KA, Bensussan D, Daley JF, Schlossman SF, et al. Activation of human thymocytes via 50 Kd T11 sheep erythrocytes binding protein induces the expression of interleukin 2 receptors on both T3+ and T3- populations. J Immunol 1985; 134:330-5.
31. Koestner A, Swenberg JA, Wechsler W. Transplacental production with ethylnitrosourea of neoplasms of the nervous system in Sprague-Dawley rats. AMJ Pathol 1971; 63:37-9.
32. Kleihues P, Meer I, Wrestler OD, Bamberg M. Formation and repair of O-alkylated DNAbases: Role in neurocarcinogenesis and chemotherapy. In Grundmann, E (ed): Cancer campaign Vol-10: Experimental Neurooncology, Brain Tumor and Pain Therapy. New York: Gustav Fischer, Stuttgart 1987:1-17.
33. Alberola-Ila J, Places L, de la Calle O, Romero M, Yague J, Gallart T, et al. Stimulation through the TCR/CD3 complex upregulates the CD2 surface expression on human T lymphocytes. J Immunol 1991; 146:1085-92.
34. Cannella B, Cross AH, Raine CS. Adhesion related molecules in the central nervous system: Upregulation correlates with inflammatory cell influx during relapsing experimental autoimmune encephalomyelitis. Lab Invest 1991; 65:23-31.
35. Dustin ML, Golan DE, Zhu DM, Miller JM, Meier W, Davies EA, et al. Low affinity interaction of human or rat T cell adhesion molecule CD2 with its ligand aligns adhering membranes to achieve high physiological affinity. J Biol Chem 1997; 272:30889-98.
36. Guiner SL, Drean EL, Labarriere N, Fontenean JF, Viret C, Diez E, et al. LFA-3 costimulates cytokine secretion by cytotoxic T lymphocytes by providing a TCR independent activation signal. Eur J Immunol 1998; 28:1322-3348.
37. Tanaka N, Abe H, Yogita H, Okumura K, Nakamura M, Sugamura K. Itk, a T cell specific tyrosin kinase, is required for CD2-mediated interleukin-2 promoter activation in the human Tcell line. Eur J Immunol 1997; 27:834-41.
38. Van de Wiel-van Kemenada E, Te Velde AA, De Boer AJ, Weening RS, Fischer A, Borst J, et al. Botk LFA-1 positive and -deficient T cell clones require the CD2/LFA3 interaction for specific cytolytic activation. Eur J Immunol 1992; 22:1467-75.
39. Martin SJ, Reutelingsperger CP, McGahon AJ, Rader JA, van Schie RC, LaFace DM, et al. Early distribution of phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: Inhibition by overexpression of Bcl-2 and Abl. J Exp Med 1995; 182:1545-56.
40. Somersan S, Bharadwaj N. Tethering and tickling: a new role for the phosphatidylserine receptor. J Cell Biol 2001; 155:501-4.
41. Sadok VA, Cathelineau A, Daleka DL, Henson PM, Bratton DL. Loss of phospholipids asymmetry and surface exposure of phosphatidylserine is required for phagocytosis of apoptotic cells by macrophages and fibroblasts. J Biol Chem 2001; 276:1071-7.
42. Muir D, Varon S, Manthorpe M. An enzyme linked immunosorbant assay for bromodeoxyuridine incorporation using fixed microcultures. Anal Biochem 1990; 195:377-82.
43. Zunkeler B, Carson RE, Olson J, Blasberg RG, DeVroom H, Lutz RJ, et al. Quantification and Phermacokynetics of blood-brain-barrier disruption in humans. J Neurosurge 1996; 85:1056-65.
44. Cardon-Cardo C, O'Brien JP, Boccia J, Casals D, Bertino JR, Melamed MR. Expression of multi-drug resistant gene product (P-glycoprotein) in human normal and tumor tissues. J Histochem Cytochem 1990; 38:1277-87.