Administration of a peptide inhibitor of α4-integrin inhibits the development of experimental autoimmune uveitis

Investigative Ophthalmology and Visual Science

Volumn 46, Issue 6, 2005, Pages 2056-2063

  Martín, Andrea P ^a,b   Vieira De Moraes, Luciana ^a   Tadokoro, Carlos E ^a   Commodaro, Alessandra G ^a   Urrets Zavalia, Enrique ^c   Rabinovich, Gabriel A ^d   Urrets Zavalia, Julio ^c   Rizzo, Luiz V ^a,e   Serra, Horacio M ^b  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b UNIVERSIDAD NACIONAL DE CÓRDOBA   (Argentina)

^c UNIVERSIDAD CATÓLICA DE CÓRDOBA   (Argentina)

^d HOSPITAL DE CLÍNICAS JOSÉ DE SAN MARTÍN   (Argentina)

^e MCT   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA4 INTEGRIN; ALPHA4 INTEGRIN INHIBITOR; CELL ADHESION MOLECULE; CYTOKINE; FREUND ADJUVANT; GAMMA INTERFERON; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2A; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 18; INTERLEUKIN 4; INTERLEUKIN 5; INTERPHOTORECEPTOR RETINOID BINDING PROTEIN; PHENYLACETYLLEUCYLASPARTYLPHENYLALANYLMORPHOLINEAMIDE; PROTEIN INHIBITOR; UNCLASSIFIED DRUG; EYE PROTEIN; IMMUNOGLOBULIN G; OLIGOPEPTIDE; PEPTIDE FRAGMENT; PHENYLACETYL LEUCYL ASPARTYL PHENYLALANYL PROLINEAMIDE; PHENYLACETYL-LEUCYL-ASPARTYL-PHENYLALANYL-PROLINEAMIDE; RETINOL BINDING PROTEIN; RETINOL-BINDING GLYCOPROTEIN; VERY LATE ACTIVATION ANTIGEN 4;

ADOPTIVE TRANSFER; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY RESPONSE; ARTICLE; AUTOIMMUNE DISEASE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DELAYED HYPERSENSITIVITY; DNA SYNTHESIS; ENZYME LINKED IMMUNOSORBENT ASSAY; HISTOPATHOLOGY; INFLAMMATORY CELL; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; OPHTHALMOSCOPY; PRIORITY JOURNAL; STATISTICAL ANALYSIS; UVEITIS; VASCULAR ENDOTHELIUM; ANIMAL; BLOOD; DISEASE MODEL; DRUG ANTAGONISM; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; PATHOLOGY; T LYMPHOCYTE;

ADOPTIVE TRANSFER; ANIMALS; AUTOIMMUNE DISEASES; CYTOKINES; DISEASE MODELS, ANIMAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; EYE PROTEINS; HYPERSENSITIVITY, DELAYED; IMMUNOGLOBULIN G; INTEGRIN ALPHA4BETA1; LYMPHOCYTE ACTIVATION; MICE; OLIGOPEPTIDES; PEPTIDE FRAGMENTS; RETINOL-BINDING PROTEINS; T-LYMPHOCYTES; UVEITIS, POSTERIOR;

EID: 22144485975     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: 10.1167/iovs.04-0418     Document Type: Article

References (62)

1. Caspi RR, Roberge FG, McAllister CG, et al. T cell lines mediating experimental autoimmune uveoretinitis (EAU) in the rat. J Immunol. 1986;136:928-933.
2. Gery I, Mochizuki M, Nussenblatt RB. Retinal specific antigens and immunopathogenic processes they provoke. In: Osborne NN, Chader GJ, eds. Progress in Retinal Research. Oxford, UK: Pergamon Press, 1986;75-109.
3. Forrester JV. Uveitis pathogenesis. Lancet. 1991;338:1498-1501.
4. Caspi RR, Chan CC, Fujino Y, et al. Recruitment of antigen-nonspecific cells plays a pivotal role in the pathogenesis of a T cell-mediated organ-specific autoimmune disease, experimental autoimmune uveoretinitis. J Neuroimmunol. 1993;47:177-188.
5. Chan CC, Caspi RR, Ni M, et al. Pathology of experimental autoimmune uveoretinitis in mice. J Autoimmun. 1990;3:247-255.
6. Caspi RR, Chan CC, Leake WC, Higuchi M, Wiggert B, Chader GJ. Experimental autoimmune uveoretinitis in mice: induction by a single eliciting event and dependence on quantitative parameters of immunization. J Autoimmun. 1990;3:237-246.
7. Springer TA. Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. Cell. 1994;76:301-3l4.
8. Springer TA. Traffic signals on endothelium for lymphocyte recirculation and leukocyte emigration. Annu Rev Physiol. 1995;57:827-872.
9. Prendergast RA, Iliff CE, Coskuncan NM, et al. T cell traffic and the inflammatory response in experimental autoimmune uveoretinitis. Invest Ophthalmol Vis Sci. 1998;39:754-762.
10. Devine L, Lightman S, Greenwood J. Lymphocyte migration across the anterior and posterior blood-retinal barrier in vitro. Cell Immunol. 1996;168:267-275.
11. Devine L, Lightman SL, Greenwood J. Role of LFA-1, ICAM-1, VLA-4 and VCAM-1 in lymphocyte migration across retinal pigment epithelial monolayers in vitro. Immunology. 1996;88:456-462.
12. Greenwood J. The blood-retinal barrier in experimental autoimmune uveitis (EAU): a review. Curr Eye Res. 1992;11(suppl):25-32.
13. Atalla L, Linker-Israeli M, Steinman L, Rao NA. Inhibition of autoimmune uveitis by anti-CD4+antibody. Invest Ophthalmol Vis Sci. 1990;31:1264-1270.
14. Jiang H, Lumsden L, Forrester JV. Macrophages and dendritic cells in IRBP-induced experimental autoimmune uveoretinitis in B10RIII Mice. Invest Ophthalmol Vis Sci. 1999;40:3177-3185.
15. Baron JL, Madri JA, Ruddle NH, Hashim G, Janeway CA Jr. Surface expression of α 4 integrin by CD4 T cells is required for their entry into the brain parenchyma. J Exp Med. 1993;177:57-68.
16. Steffen BJ, Butcher EC, Engelhardt B. Evidence for involvement of ICAM-1 and VCAM-1 in lymphocyte interaction with endothelium in experimental autoimmune encephalomyelitis in the central nervous system in the SJL/J mouse. Am J Pathol. 1994;145:189-201.
17. Brocke S, Piercy C, Steinman L, Weissman IL, Veromaa T. Antibodies to CD44 and integrin α4, but not L-selectin, prevent central nervous system inflammation and experimental encephalomyelitis by blocking secondary leukocyte recruitment. Proc Natl Acad Sci USA. 1999;96:6896-6901.
18. Yednock T, Cannon C, Fritz LC, Sanchez-Madrid F, Steinman L, Karin N. Prevention of experimental autoimmune encephalomyelitis by antibodies against alpha 4 beta 1 integrin. Nature. 1992;356:63-66.
19. La Heij E, Kiujpers RW, Baarsma S, Kijlstra A, van der Weiden M, Mooy CM. Adhesion molecules in iris biopsy specimens from patients with uveitis. Br J Ophthalmol. 1998;82:432-437.
20. Hill TA, Stanford MR, Graham EM, Dumonde DC, Brown KA. A new method for studying the selective adherence of blood lymphocytes to the microvasculature of human retina. Invest Ophthalmol Vis Sci. 1997;38:2608-2618.
21. Hill TA, Stanford MR, Graham EM, Dumonde DC, Brown KA. A new method for studying the selective adherence of blood lymphocytes to the microvasculature of human retina. Invest Ophthalmol Vis Sci. 1997;38:2608-2618.
22. Whitcup SM, DeBarge LR, Caspi RR, Harning R, Nussenblatt RB, Chan CC. Monoclonal antibodies against ICAM-1 (CD54) and LFA-1 (CD11a/CD18) inhibit experimental autoimmune uveitis. Clin Immunol Immunopathol. 1993;67:143-150.
23. Devine L, Lightman SL, Greenwood J. Role of LFA-1, ICAM-1, VLA-4 and VCAM-1 in lymphocyte migration across retinal pigment epithelial monolayers in vitro. Immunology. 1996;88:456-462.
24. Wayner EA, Garcia-Pardo A, Humphries MJ, McDonald JA, Carter WG. Identification and characterization of the T lymphocyte adhesion receptor for an alternative cell attachment domain (CS-1) in plasma fibronectin. J Cell Biol. 1989;109:1321-1330.
25. Elices MJ, Osborn L, Takada Y, Crouse C, Luhowskyj S, Hemler ME. VCAM-1 on activated endothelium interacts with the leukocyte integrin VLA-4 at a site distinct from the VLA-4/fibronectin binding site. Cell. 1990;60:577-584.
26. Van der Laan LJW, De Groot CJA, Elices MJ, Dijkstra CD. Extracellular matrix proteins expressed by human adult astrocytes in vivo and in vitro: an astrocyte surface protein containing the CS1 domain contributes to binding of lymphoblasts. J Neurosci Res. 1997;50:539-548.
27. Wahl S, Allen J, Hines K, Imamichi T, Wahl A, Furcht L. Synthetic fibronectin peptides suppress arthritis in rats by interrupting leukocyte adhesion and recruitment. J Clin Invest. 1994;94:655-662.
28. Martín AP, Ortiz S, Cabalier MED, et al. Vascular endothelium express CS-1 fibronectin in allergic contact dermatitis. J Cutan Pathol. 2002;29:347-353.
29. May MJ, Entwistle G, Humphries MJ, Ager A. VCAM-1 is a CS1 peptide-inhibitable adhesion molecule expressed by lymph node high endothelial. J Cell Sci. 1993;106:109-119.
30. Makarem R, Newham P, Askari JA, Green LJ, Clements J, Edwards M. Competitive binding of vascular cell adhesion molecule-1 and the HepII/IIICS domain of fibronectin to the integrin α4β1. J Biol Chem. 1994;269:4005-4011.
31. Clements JM, Newham P, Shepherd M, Gilbert R, Dudgeon TJ, Lindsey A. Identification of a key integrin-binding sequence in VCAM-1 homologous to the LDV active site in fibronectin. J Cell Sci. 1994;107:2127-2135.
32. Kuijpers TW. Pathophysiological aspects of VLA-4 interactions and possibilities for therapeutical interventions. Springer Semin Immunopathol. 1995;16:379-389.
33. Lobb RR, Hemler ME. The pathophysiologic role of α4 integrins in vivo. J Clin Invest. 1994;94:1722-1728.
34. Molossi S, Elices M, Arrhenius T, Diaz R, Coulber C, Rabinovitch M. Blockade of very late antigen-4 integrin binding to fibronectin with connecting segment-1 peptide reduces accelerated coronary arteriopathy in rabbit cardiac allografts. J Clin Invest. 1995;95:2601-2610.
35. Tamraz S, Arrhenius T, Chien A, Forrest MJ, Gaeta FCA, He Y-B. Treatment of delay-type hypersensitivity with inhibitors of the VLA-4 integrin. Springer Semin Immunopathol. 1995;16:437-441.
36. 4 integrins on experimental allergic encephalomyelitis in Lewis rats. J Neurosci Res. 2002;67:191-199.
37. Rizzo LV, Silver P, Wiggert B, et al. Establishment and characterization of a murine CD4+ T cell line and clone that induce experimental autoimmune uveoretinitis in B10.A mice. J Immunol. 1996;156:1654-1660.
38. Silver PB, Rizzo LV, Chan CC, Donoso LA, Wiggert B, Caspi RR. Identification of a major pathogenic epitope in the human IRBP molecule recognized by mice of the H-2r haplotype. Invest Ophthalmol Vis Sci. 1995;36:946-954.
39. Caspi RR, Roberge FG, Chan CC, et al. A new model of autoimmune disease: experimental autoimmune uveoretinitis induced in mice with two different retinal antigens. J Immunol. 1988;140:1490-1495.
40. Rizzo LV, DeKruyff RH, Umetsu DT, Caspi RR. Regulation of the interaction between Th1 and Th2 T cell clones to provide help for antibody production in vivo. Eur J Immunol. 1995;25:708-716.
41. Snedecor GW, Cochran WG. Statistical Methods. Ames, IA: Iowa State University Press; 1967:248.
42. Saoudi A, Kuhn J, Huygen K, et al. TH2 activated cells prevent experimental autoimmune uveoretinitis, a TH1-dependent autoimmune disease. Eur J Immunol. 1993;23:3096-3103.
43. Sun B, Rizzo LV, Sun SH, Caspi RR. Genetic susceptibility to experimental autoimmune uveitis involves more than a predisposition to generate a Th1-like or a Th2-like response. J Immunol. 1997;159:1004-1011.
44. Caspi RR, Grubbs BG, Chan CC, Chader GJ, Wiggert B. Genetic control of susceptibility to experimental autoimmune uveoretinitis in the mouse model: concomitant regulation by MHC and non-MHC genes. J Immunol. 1992;148:2384-2388.
45. Hara Y, Caspi RR, Wiggert B, Chan CC, Wilbanks GA, Streilein JW. Suppression of experimental autoimmune uveitis in mice by induction of anterior chamber-associated immune deviation with interphotoreceptor retinoid-binding protein. J Immunol. 1992;148:1685-1692.
46. Hara Y, Caspi RR, Wiggert B, Chan CC, Streilen JW. Use of ACAID to suppress interphotoreceptor retinoid binding protein-induced experimental autoimmune uveitis. Curr Eye Res. 1992;11(suppl):97-100.
47. Thurau SR, Chan CC, Nussenblatt RB, Caspi RR. Oral tolerance in a murine model of relapsing experimental autoimmune uveoretinitis (EAU): induction of protective tolerance in primed animals. Clin Exp Immunol. 1997;109:370-376.
48. Rizzo LV, Miller-Rivero NE, Chan CC, Wiggert B, Nussenblatt RB, Caspi RR. Interleukin 2 treatment potentiates induction of oral tolerance in a murine model of autoimmunity. J Clin Inv. 1994;94:1668-1672.
49. Clegg DO, Mullick LH, Wingerd KL, et al. Adhesive events in retinal development and function: the role of integrin receptors. Results Probl Cell Differ. 2000;31:141-156.
50. Rose DM, Han J, Ginsberg MH. Alpha4 integrins and the immune response. Immunol Rev. 2002;186:118-124.
51. Rose DM, Grabovsky V, Alon R, Ginsberg MH. The affinity of integrin alpha(4)beta(1) governs lymphocyte migration. J Immunol. 2001;167:2824-2830.
52. Micallef M, Ohtsuki T, Kohno K, et al. Interferon-γ-inducing factor enhances T helper 1 cytokine production by stimulated human T cells: synergism with interleukin-12 for interferon-γ production. Eur J Immunol. 1996;26:1647-1651.
53. Zhang T, Kawakami K, Qureshi MH, Okamura H, Kurimoto M, Saito A. Interleukin-12 (IL-12) and IL-18 synergistically induce the fungicidal activity of murine peritoneal exudates cells against Cryptococcus neoformans through production of gamma interferon by natural killer cells. Infect Immun. 1997;65:3594-3599.
54. Morel JC, Park CC, Woods JM, Koch AE. A novel role for interleukin-18 in adhesion molecule induction through NF kappa B and phosphatidylinositol (PI) 3-kinase-dependent signal transduction pathways. J Biol Chem. 2001;276:37069-37075.
55. Canella B, Gaupp S, Tilton RG, Raine CS. Differential efficacy of a synthetic antagonist of VLA-4 during the course of chronic relapsing experimental autoimmune encephalomyelitis. J Neurosci Res. 2003;71:407-416.
56. Ando K, Fujino Y, Mochizuki M. Effects of monoclonal antibodies directed at cell surface molecules on murine experimental autoimmune uveoretinitis. Graefes Arch Clin Exp Ophthalmol. 1999;237:848-854.
57. McIntyre BW, Woodsite DG, Caruso DA, Wooten DK, Simon SI, Neelamegham S. Regulation of human T lymphocyte coactivation with an α 4 integrin antagonist peptide. J Immunol. 1997;158:4180-4186.
58. Platts KE, Benson MT, Rennie IG, Sharrard RM, Rees RC. Cytokine modulation of adhesion molecule expression on human retinal pigment epithelial cells. Invest Ophthalmol Vis Sci. 1995;36:2262-2269.
59. Silver PB, Hathcock KS, Chan CC, Wiggert B, Caspi RR. Blockade of costimulation through B7/CD28 inhibits experimental autoimmune uveoretinitis, but does not induce long-term tolerance. J Immunol. 2000;165:5041-5047.
60. Jones LS, Rizzo LV, Agarwal RK, et al. IFN-γ-deficient mice development experimental autoimmune uveitis in the context of a deviant effector response. J Immunol. 1997;158:5997-6005.
61. Fujikawa LS, Chan CC, McAllister C, et al. Retinal vascular endothelium expresses fibronectin and class II histocompatibility complex antigens in experimental autoimmune uveitis. Cell Immunol. 1987;106:139-150.
62. Wang J, Lin WL, Essner E, Shichi H, Yelian FD. Ultrastructural and immunocytochemical studies of iris vessels in rats with experimental autoimmune uveoretinitis. Curr Eye Res. 1994;13:747-754.