The transcriptional activator ClgR controls transcription of genes involved in proteolysis and DNA repair in Corynebacterium glutamicum

Molecular Microbiology

Volumn 57, Issue 2, 2005, Pages 576-591

  Engels, Sabine ^a   Ludwig, Carsten ^a   Schweitzer, Jens Eric ^a   Mack, Christina ^a   Bott, Michael ^a   Schaffer, Steffen ^b  

^a FORSCHUNGSZENTRUM JÜLICH   (Germany)

^b EVONIK INDUSTRIES AG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CLGR PROTEIN; DNA; ENDOPEPTIDASE LA; MITOMYCIN C; REGULATOR PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CLGR GENE; CORYNEBACTERIUM GLUTAMICUM; DNA BINDING; DNA DAMAGE; DNA REPAIR; DNA SEQUENCE; ENZYME SUBSTRATE; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; NONHUMAN; PLASMID; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PURIFICATION; REGULON; STRUCTURAL GENE; TRANSCRIPTION INITIATION; ULTRAVIOLET IRRADIATION; WESTERN BLOTTING;

BACTERIAL PROTEINS; BASE SEQUENCE; CORYNEBACTERIUM GLUTAMICUM; DNA DAMAGE; DNA FOOTPRINTING; DNA REPAIR; DNA, BACTERIAL; ENDOPEPTIDASE CLP; GENE DELETION; GENE EXPRESSION REGULATION, BACTERIAL; MITOMYCIN; MOLECULAR SEQUENCE DATA; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PEPTIDE HYDROLASES; PROTEASE LA; PROTEIN BINDING; REGULATORY SEQUENCES, NUCLEIC ACID; REGULON; RNA, BACTERIAL; RNA, MESSENGER; TRANS-ACTIVATORS; ULTRAVIOLET RAYS;

CORYNEBACTERIUM GLUTAMICUM; STREPTOMYCES LIVIDANS;

EID: 22144447873     PISSN: 0950382X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2958.2005.04710.x     Document Type: Article

References (35)

1. Abe, S., Takayama, K., and Kinoshita, S. (1967) Taxonomical studies on glutamic acid producing bacteria. J Gen Appl Microbiol 13: 279-301.
2. Alonso, J.C., Shirahige, K., and Ogasawara, N. (1990) Molecular cloning, genetic characterization and DNA sequence analysis of the recM region of Bacillus subtilis. Nucleic Acids Res 18: 6771-6777.
3. Arsene, F., Tomoyasu, T., and Bukau, B. (2000) The heat shock response of Escherichia coli. Int J Food Microbiol 55: 3-9.
4. Bellier, A., and Mazodier, P. (2004) ClgR, a novel regulator of clp and Ion expression in Streptomyces. J Bacteriol 186: 3238-3248.
5. Busby, S., and Ebright, R.H. (1999) Transcription activation by catabolite activator protein (CAP). J Mol Biol 293: 199-213.
6. Cremer, J., Eggeling, L., and Sahm, H. (1990) Cloning of the dapA dapB cluster of the lysine-secreting bacterium Corynebacterium glutamicum. Mol Gen Genet 220: 478-480.
7. Eikmanns, B.J., Kleinertz, E., Liebl, W., and Sahm, H. (1991) A family of Corynebacterium glutamicum/Escherichia coli shuttle vectors for cloning, controlled gene expression, and promoter probing. Gene 102: 93-98.
8. Engels, S., Schweitzer, J.E., Ludwig, C., Bott, M., and Schaffer, S. (2004) clpC and clpP1P2 gene expression in Corynebacterium glutamicum is controlled by a regulatory network involving the transcriptional regulators ClgR and HspR as well as the ECF sigma factor σH. Mol Microbiol 52: 285-302.
9. Hanahan, D. (1985) Techniques for transformation of E. coli. In DNA Cloning, Vol. 1. Glover, D.M. (ed.). Oxford: IRL Press, pp. 109-135.
10. Hillen, W., and Berens, C. (1994) Mechanisms underlying expression of Tn 10 encoded tetracycline resistance. Annu Rev Microbiol 48: 345-369.
11. Jakoby, M., Ngouto-Nkili, C.E., and Burkovski, A. (1999) Construction and application of new Corynebacterium glutamicum vectors. Biotechnol Techniques 13: 437-441.
12. Jenal, U., and Hengge-Aronis, R. (2003) Regulation by proteolysis in bacterial cells. Curr Opin Microbiol 6: 163-172.
13. Kanatani, A., Masuda, T., Shimoda, T., Misoka, F., Lin, X.S., Yoshimoto, T., and Tsuru, D. (1991) Protease II from Escherichia coli, sequencing and expression of the enzyme gene and characterization of the expressed enzyme. J Biochem (Tokyo) 110: 315-320.
14. Kihara, A., Akiyama, Y., and Ito, K. (1996) A protease complex in the Escherichia coli plasma membrane: HflKC (HflA) forms a complex with FtsH (HflB), regulating its proteolytic activity against SecY. EMBO J 15: 6122-6131.
15. Krüger, E., and Hecker, M. (1998) The first gene of the Bacillus subtilis clpC operon, ctsR, encodes a negative regulator of its own operon and other class III heat shock genes. J Bacteriol 180: 6681-6688.
16. Krüger, E., Zühlke, D., Witt, E., Ludwig, H., and Hecker, M. (2001) Clp-mediated proteolysis in Gram-positive bacteria is autoregulated by the stability of a repressor. EMBO J 20: 852-863.
17. Lange, C., Rittmann, D., Wendisch, V.F., Bott, M., and Sahm, H. (2003) Global expression profiling and physiological characterization of Corynebacterium glutamicum grown in the presence of L-valine. Appl Environ Microbiol 69: 2521-2532.
18. Lim, K., Tempczyk, A., Parsons, J.F., Bonander, N., Toedt, J., Kelman, Z., et al. (2003) Crystal structure of YbaB from Haemophilus influenzae (HI0442), a protein of unknown function coexpressed with the recombinational DNA repair protein RecR. Proteins 50: 375-379.
19. Morimatsu, K., and Kowalczykowski, S.C. (2003) RecFOR proteins load RecA protein onto gapped DNA to accelerate DNA strand exchange: a universal step of recombinational repair. Mol Cell 11: 1337-1347.
20. Mostertz, J., Scharf, C., Hecker, M., and Homuth, G. (2004) Transcriptome and proteome analysis of Bacillus subtilis gene expression in response to superoxide and peroxide stress. Microbiology 150: 497-512.
21. 1. Arch Microbiol 175: 282-294.
22. Pelaez, A.I., Ribas-Aparicio, R.M., Gomez, A., and Rodicio, M.R. (2001) Structural and functional characterization of the recR gene of Streptomyces. Mol Genet Genomics 265: 663-672.
23. Quillardet, P., Rouffaud, M.A., and Bouige, P. (2003) DNA array analysis of gene expression in response to UV irradiation in Escherichia coli. Res Microbiol 154: 559-572.
24. Rhodius, V.A., and Busby, S.J. (1998) Positive activation of gene expression. Curr Opin Microbiol 1: 152-159.
25. Sambrook, J., Fritsch, E.F., and Maniatis, T. (1989) Molecular Cloning. A Laboratory Manual. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press.
26. Schäfer, A., Tauch, A., Jäger, W., Kalinowski, J., Thierbach, G., and Pühler, A. (1994) Small mobilizable multi-purpose cloning vectors derived from the Escherichia coli plasmids pK18 and pK19: selection of defined deletions in the chromosome of Corynebacterium glutamicum. Gene 145: 69-73.
27. Schaffer, S., Weil, B., Nguyen, V.D., Dongmann, G., Günther, K., Nickolaus, M., et al. (2001) A high-resolution reference map for cytoplasmic and membrane-associated proteins of Corynebacterium glutamicum. Electrophoresis 22: 4404-4422.
28. Schägger, H., and von Jagow, G. (1987) Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa. Anal Biochem 166: 368-379.
29. Schägger, H., and von Jagow, G. (1991) Blue native electrophoresis for isolation of membrane protein complexes in enzymatically active form. Anal Biochem 199: 223-231.
30. Skerra, A., and Schmidt, T.G. (2000) Use of the Strep-Tag and streptavidin for detection and purification of recombinant proteins. Methods Enzymol 326: 271-304.
31. Strösser, J., Lüdke, A., Schaffer, S., Krämer, R., Burkovski, A. (2004) Regulation of GlnK activity: modification, membrane sequestration and proteolysis as regulatory principles in the network of nitrogen control in Corynebacterium glutamicum. Mol Microbiol 54: 132-147.
32. Tavernarakis, N., Driscoll, M., Kyrpides, N.C. (1999) The SPFH domain: implicated in regulating targeted protein turnover in stomatins and other membrane-associated proteins. Trends Biochem Sci 24: 425-427.
33. Tomoyasu, T., Mogk, A., Langen, H., Goloubinoff, P., and Bukau, B. (2001) Genetic dissection of the roles of chaperones and proteases in protein folding and degradation in the Escherichia coli cytosol. Mol Microbiol 40: 397-413.
34. 32- specific promoters during heat shock. J Bacteriol 178: 5719-5731.
35. Yeung, T., Mullin, D.A., Chen, K.S., Craig, E.A., Bardwell, J.C., and Walker, J.R. (1990) Sequence and expression of the Escherichia coli recR locus. J Bacteriol 172: 6042-6047.