Retinoic acid and its 4-oxo metabolites are functionally active in human skin cells in vitro

Journal of Investigative Dermatology

Volumn 125, Issue 1, 2005, Pages 143-153

  Baron, Jens Malte ^a   Heise, Ruth ^a   Blaner, William S ^b   Neis, Mark ^a   Joussen, Sylvia ^a   Dreuw, Alexandra ^a   Marquardt, Yvonne ^a   Saurat, Jean Hilaire ^c   Merk, Hans F ^a   Bickers, David R ^b   Jugert, Frank K ^b  

^a UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

^b College of Physicians and Surgeons ^*  (United States)

^c GENEVA UNIVERSITY HOSPITALS   (Switzerland)

Author keywords

Dermal fibroblasts; Epidermal keratinocytes; Functional proteomics; Gene expression profile

Indexed keywords

4 OXOALITRETINOIN; 4 OXOISOTRETINOIN; 4 OXORETINOIC ACID; ALITRETINOIN; CALCIUM BINDING PROTEIN; COMPLEMENTARY DNA; CORTICOSTEROID; CYCLOOXYGENASE 2; CYTOKERATIN; DRUG METABOLITE; FATTY ACID BINDING PROTEIN; FILAGGRIN; HYDROCORTISONE; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 1BETA; ISOTRETINOIN; PHOSPHORUS 32; PLASMINOGEN ACTIVATOR INHIBITOR 2; RETINOIC ACID; RNA; STROMELYSIN 2; THROMBOSPONDIN 1; TISSUE PLASMINOGEN ACTIVATOR; UNCLASSIFIED DRUG; VASCULOTROPIN C;

ARTICLE; DERMIS; DNA MICROARRAY; EPIDERMIS; FIBROBLAST; FUNCTIONAL PROTEOMICS; GENE EXPRESSION; HUMAN; HUMAN CELL; ISOTOPE LABELING; KERATINOCYTE; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; SKIN CELL; TWO DIMENSIONAL GEL ELECTROPHORESIS;

EID: 22144447135     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1111/j.0022-202X.2005.23791.x     Document Type: Article

References (61)

1. Asselineau D, Dale BA, Bernard BA: Filaggrin production by cultured human epidermal keratinocytes and its regulation by retinoic acid. Differentiation 45:221-229, 1990
2. Axel DI, Frigge A, Dittmann J, et al: All-trans retinoic acid regulates proliferation, migration, differentiation, and extracellular matrix turnover of human arterial smooth muscle cells. Cardiovasc Res 49:851-862, 2001
3. Balmer JE, Blomhoff R: Gene expression regulation by retinoic acid. J Lipid Res 43:1773-1808, 2002
4. Beard RL, Chandraratna RAS: RAR-selective ligands: Receptor subtype and function selectivity. In: Nau H, Blaner WS (eds). The Handbook of Experimental Pharmacology, The Retinoids. Heidelberg: Springer Verlag, 1999; p 185-235
5. Blaner WS: Cellular metabolism and actions of 13-cis-retinoic acid. J Am Acad Dermatol 45:129-135, 2001
6. Bodey B, Bodey B Jr, Siegel SE, Kaiser HE: Matrix metalloproteinase expression in malignant melanomas: Tumor-extracellular matrix interactions in invasion and metastasis. In Vivo 15:57-64, 2001
7. Bosio A, Knörr C, Janssen U, Gebel S, Haussmann HJ, Müller T: Kinetics of gene expression profiling in Swiss 3T3 cells exposed to aqueous extracts of cigarette smoke. Carcinogenesis 23:741-748, 2002
8. Braungart E, Magdolen V, Degitz K: Retinoic acid upregulates the plasminogen activator system in human epidermal keratinocytes. J Invest Dermatol 116:778-784, 2001
9. Broers JLV, Machiels BM, Kuijpers HJH, Smedts F, van den Kieboom R, Raymond Y, Ramaekers FCS: A- and B-type lamins are differentially expressed in normal human tissues histochem. Cell Biol 107:505-517, 1997
10. Chambon P: The retinoid signaling pathway: Molecular and genetic analyses. Semin Cell Biol 5:115-125, 1994
11. Chambon P: A decade of molecular biology of retinoic acid receptors. FASEB J 10:940-954, 1996
12. Chawla A, Repa JJ, Evans RM, Mangelsdorf DJ: Nuclear receptors and lipid physiology: Opening the X-files. Science 294:1866-1870, 2001
13. Clagett-Dame M, DeLuca HF: The role of vitamin A in mammalian reproduction and embryonic development. Annu Rev Nutr 22:347-381, 2002
14. Daberkow RL, White BR, Cederberg RA, Griffin JB, Zempleni J: Monocarboxylate transporter 1 mediates biotin uptake in human peripheral blood mononuclear cells. J Nutr 133:2703-2706, 2003
15. Daly TJ, Weston WL: Retinoid effects on fibroblast proliferation and collagen synthesis in vitro and on fibrotic disease in vivo. J Am Acad Dermatol 15:900-902, 1986
16. Diaz BV, Lenoir MC, Ladoux A, Frelin C, Demarchez M, Michel S: Regulation of vascular endothelial growth factor expression in human keratinocytes by retinoids. J Biol Chem 275:642-650, 2000
17. Eberwine J: Amplification of mRNA populations using aRNA generated from immobilized oligo(dT)-T7 primed cDNA. Biotechniques 20:584-591, 1996
18. Fisher GJ, Talwar HS, Lin J, Voorhees JJ: Molecular mechanisms of photoaging in human skin in vivo and their prevention by all-trans retinoic acid. Photochem Photobiol 69:154-157, 1999
19. Fray MJ, Dickinson RP, Muggins JP, Occleston NL: A potent, selective inhibitor of matrix metalloproteinase-3 for the topical treatment of chronic dermal ulcers. J Med Chem 46:3514-3525, 2003
20. Garcia CK, Li X, Luna J, Francke U: cDNA cloning of the human monocarboxylate transporter 1 and chromosomal localization of the SLC16A1 locus to 1p13.2-p12. Genomics 23:500-503, 1994
21. Gatto H, Richard MH, Viac J, Charveron M, Schmitt D: Effects of retinoic acid on interleukin-1 alpha and -1 beta expression by normal human keratinocytes cultured in defined medium. Skin Pharmacol 6:10-19, 1993
22. Goldman RD, Gruenbaum Y, Moir RD, Shumaker DK, Spann TP: Nuclear lamins: Building blocks of nuclear architecture. Genes Dev 16:533-547, 2002
23. Green H, Easly K, Iuchi S: Marker succession during the development of keratinocytes from cultured human embryonic stem cells. Proc Natl Acad Sci USA 100:15625-15630, 2003
24. Gudas LJ, Sporn MB, Roberts AB: Cellular biology and biochemistry of the retinoids. In: Sporn MB, Roberts AB, Goodman DS (eds). The Retinoids: Biology, Chemistry, and Medicine, 2nd edn. New York: Raven Press, 1994; p 443-520
25. Ha MK, Chung KY, Lee JH, Bang D, Park YK, Lee KH: Expression of psoriasis-associated fatty acid-binding protein in senescent human dermal microvascular endothelial cells. Exp Dermatol 13:543-550, 2004
26. Holaska JM, Wilson KL, Mansharamani M: The nuclear envelope, lamins and nuclear assembly. Curr Opin Cell Biol 14:357-364, 2002
27. Hoyos B, Imam A, Chua R, et al: The cysteine-rich regions of the regulatory domains of Raf and protein kinase C as retinoid receptors. J Exp Med 192:835-845, 2000
28. Imam A, Hoyos B, Swenson C, Levi E, Chua R, Viriya E, Hammerling U: Retinoids as ligands and coactivators of protein kinase C alpha. FASEB J 15:28-30, 2001
29. Kanekura T, Higashi Y, Kanzaki T: Inhibitory effects of 9-cis-retinoic acid and pyrrolidinedithiocarbamate on cyclooxygenase (COX)-2 expression and cell growth in human skin squamous carcinoma cells. Cancer Lett 161:177-183, 2000
30. Karlsson T, Vahlquist A, Kedishvili N, Torma H: 13-cis-retinoic acid competitively inhibits 3 alpha-hydroxysteroid oxidation by retinol dehydrogenase RoDH-4: A mechanism for its anti-androgenic effects in sebaceous glands? Biochem Biophys Res Commun 303:273-278, 2003
31. Koehler-Stec EM, Simpson IA, Vannucci SJ, Landschulz KT, Landschulz WH: Monocarboxylate transporter expression in mouse brain. Am J Physiol 275:516-524, 1998
32. Korichneva I, Waka J, Hammerling U: Regulation of cardiac mitochondrial membrane potential by retinoids. J Pharmacol Exp Ther 305:426-433, 2003
33. Krampert M, Bloch W, Sasaki T, et al: Activities of the matrix metalloproteinase stromelysin-2 (MMP-10) in matrix degradation and keratinocyte organization in wounded skin. Mol Biol Cell 15:5242-5254, 2004
34. Kurlandsky SB, Duell EA, Kang S, Voorhees JJ, Fisher GJ: Auto-regulation of retinoic acid biosynthesis through regulation of retinol esterification in human keratinocytes. J Biol Chem 271:15346-15352, 1996
35. Leite-Browning ML, McCawley LJ, Choi OH, Mathsian LM, Ochieng J: Interactions of alpha2-HS-glycoprotein (fetuin) with MMP-3 and murine squamous cell carcinoma cells. Int J Oncol 21:965-971, 2002
36. Madsen P, Rasmussen HH, Leffers H, Honore B, Celis JE: Molecular cloning and expression of a novel keratinocyte protein (psoriasis-associated fatty acid-binding protein [PA-FABP]) that is highly up-regulated in psoriatic skin and that shares similarity to fatty acid-binding proteins. J Invest Dermatol 99:299-305, 1992
37. Mangelsdorf DJ, Borgmeyer U, Heyman RA, et al: Characterization of three RXR genes that mediate the action of 9-cis-retinoic acid. Genes Dev 6: 329-334, 1992
38. Mangelsdorf DJ, Thummel C, Beato M, et al: The nuclear receptor superfamily: The second decade. Cell 83:835-839, 1995
39. Mangelsdorf DJ, Umesono K, Evans RM: The retinoid receptors. In: Sporn MB, Roberts AV, Goodman DS (eds). The Retinoids, Biology, Chemistry, and Medicine, 2nd edn. New York: Raven Press, 1994; p 319-350
40. Mommers JM, van Rossum MM, van Erp PE, van De Kerkhof PC: Changes in keratin 6 and keratin 10 (co-)expression In lesional and symptomless skin of spreading psoriasis. Dermatology 201:15-20, 2000
41. Myhre AM, Takahashi N, Blomhoff R, Brertman TR, Norum KR: Retinoylation of proteins in rat liver, kidney, and lung in vivo. J Lipid Res 37:1971-1977, 1996
42. O'Farrell PH: High resolution two-dimensional electrophoresis of proteins. J Biol Chem 250:4007-4021, 1975
43. Ogawa A, Maeguchi M, Uchida Y, Yoshioka T, Kawashima M, Muraki T: Effect of tazarotene, an acetylenic retinoid, on human dermal fibroblast. Jpn J Pharmacol 76:317-319, 1998
44. Peck GL, DiGiovanna JJ: Synthetic retinoids in dermatology. In: Sporn MB, Roberts AB, Goodman DS (eds). The Retinoids: Biology, Chemistry, and Medicine, 2nd Edition. New York: Raven Press Ltd., 1994; p 631-658
45. Peck SM, Chargin L, Sobotka H: Keratosis follicularis (Darier's disease)-a vitamin A-deficiency disease. Arch Dermatol Syphilol 43:223, 1949
46. Poumay Y, Herphelin F, Smits P, De Potter IY, Pittelkow MR: High-cell-density phorbol ester and retinoic acid upregulate involucrin and downregulate suprabasal keratin 10 in autocrine cultures of human epidermal keratinocytes. Mol Cell Biol Res Commun 2:138-144, 1999
47. Radominska-Pandya A, Chen G, Czernik PJ, Little JM, Samokyszyn VM, Carter CA, Nowak G: Direct interaction of all-trans-retinoic acid with protein kinase C (PKC). J Biol Chem 275:22324-22330, 2000
48. Roos TC, Jugert FK, Merk HF, Bickers DR: Retinoid metabolism in the skin. Pharmacol Rev 50:315-333, 1998
49. Ross SA, McCaffery PJ, Drager UC, De Luca LM: Retinoids in embryonal development. Physiol Rev 80:1021-1054, 2000
50. Shroot B, Gibson DFC, Lu XP: Retinoic receptor-selective agonists and their action in skin. In: Nau H, Blaner WS (eds). The Handbook of Experimental Pharmacology, The Retinoids. Springer Verlag, Heidelberg: 1999; p 539-559
51. Shumaker DK, Kuczmarski E, Goldman RD: The nucleoskeleton: Lamins and actin are major players in essential nuclear functions. Curr Opin Cell Biol 15:358-366, 2003
52. Takahashi N, Breitman TR: Covalent modification of proteins by ligands of steroid hormone receptors. Proc Natl Acad Sci USA 89:10807-10811, 1992
53. Takahashi N, Jetten AM, Breitman TR: Retinoylation of cytokeratins in normal human epidermal keratinocytes. Biochem Biophys Res Commun 180: 393-400, 1991a
54. Takahashi N, Liapi C, Anderson WB, Breitman TR: Retinoylation of the cAMP-binding regulatory subunits of type II cAMP-dependent protein kinases in HL60 cells. Arch Biochem Biophys 290:293-302, 1991b
55. Tilli CM, Ramaekers FC, Broers JL, Hutchison CJ, Neumann HA: Lamin expression in normal human skin, actinic keratosis, squamous cell carcinoma and basal cell carcinoma. Br J Dermatol 148:102-109, 2003
56. van Rossum MM, Mommers JM, van de Kerkhof PC, van Erp PE: Coexpression of keratins 13 and 16 in human keratinocytes indicates association between hyperproliferation-associated and retinoid-induced differentiation. Arch Dermatol Res 292:16-20, 2000
57. Virtanen M, Torma H, Vahlquist A: Keratin 4 upregulation by retinoic acid in vivo: A sensitive marker for retinoid bioactivity in human epidermis. J Invest Dermatol 114:487-493, 2000
58. 2+ influx regulates growth plate chondrocyte maturation and apoptosis. J Biol Chem 278:3762-3769, 2003
59. Zolfaghari R, Ross AC: Lecithin:retinol acyltransferase from mouse and rat liver: cDNA cloning and liver specific regulation by dietary vitamin A and retinoic acid. J Lipid Res 41:2024-2034, 2000
60. Zolfaghari R, Ross AC: Lecithin:retinol acyltransferase expression is regulated by dietary vitamin A and exogenous retinoic acid in the lung of adult rats. J Nutr 132:1160-1164, 2002
61. Zouboulis CC: Retinoids-which dermatological indications will benefit in the near future? Skin Pharmacol Appl Skin Physiol 14:303-315, 2001