Sacred disease of our times: Failure of the infectious disease model of spongiform encephalopathy

Clinical and Investigative Medicine

Volumn 28, Issue 3, 2005, Pages 101-104

  McAlister, Vivian ^a,b  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

^b LONDON HEALTH SCIENCES CENTRE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AGRICULTURE; BRAIN INFECTION; BRAIN SPONGIOSIS; CANNIBALISM; CATTLE; DISEASE MODEL; DISEASE TRANSMISSION; GOAT; HEALTH CARE POLICY; HEALTH SURVEY; HUMAN; PREVALENCE; PRIORITY JOURNAL; REVIEW;

ANIMALS; BEHAVIOR; CANNIBALISM; COMMUNICABLE DISEASES; HISTORY, 18TH CENTURY; HISTORY, 20TH CENTURY; HISTORY, ANCIENT; HUMANS; MODELS, THEORETICAL; PRION DISEASES;

EID: 22144441721     PISSN: 0147958X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (16)

1. Anonymous. The Sacred Disease in Hippocrates, vol. 2, ed. W.H.S. Jones, Loeb Classical Library, London 1923, 169
2. http://www.asm.org/Media/index.asp?bid=21773 (accessed March 10, 2005)
3. Katscher F. It's Jakob's disease, not Creutzfeldt's. Nature 1998; 393: 11.
4. Brown P. Bradley R. 1755 and all that: a historical primer of transmissible spongiform encephalopathy BMJ 1998; 317: 1688-92.
5. Hope J, Reekie LJ, Hunter N et al. Fibrils from brains of cows with new cattle disease contain scrapie-associated protein. Nature 1988; 336: 390-2.
6. Gajdusek DC Unconventional viruses and the origin and disappearance of kuru. Science 1977; 197: 943-60
7. Prusiner S. Autobiography. http://www.nobel.se/medicine/laureates/1997/ prusi ner-autobio.html (accessed March 10, 2005)
8. Collins SJ, Lawson VA, Masters CL Transmissible spongiform encephalopathies. Lancet 2004; 363: 51-61
9. Will RG, Ironside JW, Zeidler M et al. A new variant of Creutzfeldt-Jakob disease in the UK. Lancet 1996; 347: 921-5.
10. Lawson VA, Priola SA, Meade-White K, Lawson M, Chesebro B. Flexible N-terminal region of prion protein influences conformation of protease-resistant prion protein isoforms associated with cross-species scrapie infection in vivo and in vitro. J Biol Chem. 2004; 279: 13689-95
11. Safar JG, Scott M, Monaghan J et al. Measuring prions causing bovine spongiform encephalopathy or chronic wasting disease by immunoassays and transgenic mice. Nat Biotechnol 2002; 20: 1147-50
12. Collinge J, Palmer MS, Sidle KC, et al. Unaltered susceptibility to BSE in transgenic mice expressing human prion protein. Nature 1995; 378: 779-83.
13. Carr RI, Zhou J, Ledingham D et al. Induction of transplantation tolerance by feeding or portal vein injection pretreatment of recipient with donor cells. Ann N Y Acad Sci. 1996; 778: 368-70.
14. Marsh RF. Bovine spongiform encephalopathy: a new disease of cattle? Arch Virol Suppl. 1993; 7: 255-9.
15. Buell JF, Beebe TM, Trofe et al. Donor transmitted malignancies. Ann Transplant 2004; 9: 53-6.
16. Deleault NR, Lucassen RW, Supattapone S. RNA molecules stimulate prion protein conversion. Nature 2003; 425: 717-20