Engineered skin substitutes: Practices and potentials

Clinics in Dermatology

Volumn 23, Issue 4, 2005, Pages 403-412

  Supp, Dorothy M ^a   Boyce, Steven T ^b  

^a SHRINERS HOSPITALS FOR CHILDREN   (United States)

^b UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOBRANE;

ARTICLE; BURN; CELL CULTURE; HUMAN; HUMAN TISSUE; PATIENT; PRIORITY JOURNAL; SKIN AUTOGRAFT; SKIN CELL; SKIN GRAFT; TISSUE REPAIR; WOUND DRESSING; WOUND HEALING; WOUND HEALING IMPAIRMENT;

HUMANS; SKIN TRANSPLANTATION; SKIN, ARTIFICIAL; WOUND HEALING;

EID: 22044437561     PISSN: 0738081X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.clindermatol.2004.07.023     Document Type: Article

References (100)

1. Burn Incidence and Treatment in the United States: 1999 Fact Sheet 1999 The Burn Foundation Philadelphia (PA)
2. J.K. Rose, and D.N. Herndon Advances in the treatment of burn patients Burns 23 1997 S19 S26
3. D.N. Herndon, R.E. Barrow, and R.L. Rutan A comparison of conservative versus early excision. Therapies in severely burned patients Ann Surg 209 1989 547 552
4. R.B. Fratianne, and C.P. Brandt Improved survival of adults with extensive burns J Burn Care Rehabil 18 1997 347 351
5. T.J. Phillips Chronic cutaneous ulcers: etiology and epidemiology J Invest Dermatol 102 1994 38S 41S
6. T. Philips, B. Santon, A. Provan, and R. Lew A study of the impact of leg ulcers on quality of life: financial, social, and psychologic implications J Am Acad Dermatol 31 1994 49 53
7. V. Falanga Chronic wounds: pathophysical and experimental considerations J Invest Deramtol 100 1993 721 725
8. T.J. Phillips, and B.A. Gilchrest Cultured epidermal grafts in the treatment of leg ulcers Adv Dermatol 5 1990 33 48
9. F.V. Bittencourt, A.A. Marghoob, and A.W. Kopf Large congenital melanocytic nevi and the risk of development of malignant melanoma and neurocutaneous melanocytosis Pediatrics 106 2000 736 741
10. J. Uitto, and L. Pulkkinen Molecular genetics of heritable blistering disorders Arch Dermatol 137 2001 1458 1461
11. A.F. Falabella, L.A. Schachner, and I.C. Valencia The use of tissue-engineered skin (Apligraf) to treat a newborn with epidermolysis bullosa Arch Dermatol 135 1999 1219 1222
12. A.F. Falabella, I.C. Valencia, and W.H. Eaglstein Tissue-engineered skin (Apligraf) in the healing of patients with epidermolysis bullosa wounds Arch Dermatol 136 2000 1225 1230
13. M.N. Tavis, N.W. Thornton, and R.H. Bartlett A new composite skin prosthesis Burns 7 1980 123 130
14. G.F. Purdue, J.L. Hunt, and R.W. Gillespie Biosynthetic skin substitute versus frozen human cadaver allograft for temporary coverage of excised burn wounds J Trauma 27 1987 155 157
15. S. Lal, R.E. Barrow, and S.E. Wolf Biobrane improves wound healing in burned children without increased risk of infection Shock 14 2000 314 318
16. J.M. Arevalo, and J.A. Lorente Skin coverage with Biobrane biomaterial for the treatment of patients with toxic epidermal necrolysis J Burn Care Rehabil 20 1999 406 410
17. I.V. Yannas, and J.F. Burke Design of an artifical skin I. Basic design principles J Biomed Mater Res 14 1980 65 81
18. I.V. Yannas, J.F. Burke, and P.L. Gordon Design of an artificial skin II. Control of chemical composition J Biomed Mater Res 14 1980 107 131
19. D. Heimbach, A. Luterman, and J.F. Burke Artificial dermis for major burns; a multi-center randomized clinical trial Ann Surg 208 1988 313 320
20. R.L. Sheridan, M. Hegarty, and R.G. Tompkins Artificial skin in massive burns-results to ten years Eur J Plast Surg 17 1994 91 93
21. D.M. Heimbach, G.D. Warden, and A. Luterman Multicenter postapproval clinical trial of Integra Dermal Regeneration Template for burn treatment J Burn Care Rehabil 24 2003 42 48
22. D. Wisser, and J. Steffes Skin replacement with a collagen based dermal substitute, autologous keratinocytes and fibroblasts in burn trauma Burns 29 2003 375 380
23. J. Kopp, N.E. Magnus, and A. Rubben Radical resection of giant congenital melanocyte nevus and reconstruction with meek-graft covered Integra dermal template Dermatol Surg 29 2003 653 657
24. D. Wainwright, M. Madden, and A. Luterman Clinical evaluation of an acellular allograft dermal matrix in full-thickness burns J Burn Care Rehabil 17 1996 124 136
25. R. Sheridan, R. Choucair, and M. Donelan Acellular allodermis in burns surgery: 1-year results of a pilot trial J Burn Care Rehabil 19 1998 528 530
26. N.G. Menon, E.D. Rodrigues, and C.K. Byrnes Revascularization of human acellular dermis in full-thickness abdominal wall reconstruction in the rabbit model Ann Plast Surg 50 2003 523 527
27. R.R. Lorenz, R.L. Dean, and D.B. Hurley Endoscopic reconstruction of anterior and middle cranial fossa defects using acellular dermal allograft Laryngoscope 113 2003 496 501
28. J. Noordenbos, C. Dore, and J.F. Hansbrough Safety and efficacy of TransCyte for the treatment of partial-thickness burns J Burn Care Rehabil 20 1999 275 281
29. J.F. Hansbrough, D.W. Mozingo, and G.P. Kealey Clinical trials of a biosynthetic temporary skin replacement, Dermagraft-transitional covering, compared with cryopreserved human cadaver skin for temporary coverage of excised burn wounds J Burn Care Rehabil 18 1997 43 51
30. G.F. Purdue, J.L. Hunt, and J.M. Still Jr A multicenter clinical trial of a biosynthetic skin replacement, Dermagraft-TC, compared with cryopreserved human cadaver skin for temporary coverage of excised burn wounds J Burn Care Rehabil 18 1997 52 57
31. M.L. Cooper, J.F. Hansbrough, and R.L. Spielvogel In vivo optimization of a living dermal substitute employing cultured human fibroblasts on a biodegradable polyglycolic or polyglactin mesh Biomaterials 12 1991 243 248
32. J.F. Hansbrough, C. Dore, and W.B. Hansbrough Clinical trials of a living dermal tissue replacement placed beneath meshed, split-thickness skin grafts on excised wounds J Burn Care Rehabil 13 1992 519 529
33. J.R. Hanft, and M.S. Surprenant Healing of chronic foot ulcers in diabetic patients treated with a human fibroblast-derived dermis J Foot Ankle Surg 41 2002 291 299
34. W.H. Eaglstein, M. Iriondo, and K. Laszlo A composite skin substitute (Graftskin) for surgical wounds: a clinical experience Dermatol Surg 21 1995 839 843
35. V. Falanga, D.J. Margolis, and O. Alvarez Rapid healing of venous ulcers and lack of clinical rejection with an allogeneic cultured human skin equivalent Arch Dermatol 134 1998 293 300
36. H.H. Sams, J. Chen, and L.E. King Graftskin treatment of difficult to heal diabetic foot ulcers: one center's experience Dermatol Surg 28 2002 698 703
37. M.P. Curran, and G.L. Plosker Bilayered bioengineered skin substitute (Apligraf): a review of its use in the treatment of venous leg ulcers and diabetic foot ulcers BioDrugs 16 2002 439 455
38. T.J. Phillips, J. Manzoor, and A. Rojas The longevity of a bilayered skin substitute after application to venous ulcers Arch Dermatol 138 2002 1079 1081
39. O.R. Ozerdem, S.A. Wolfe, and D. Marshall Use of skin substitutes in pediatric patients J Craniofac Surg 14 2003 517 520
40. D.P. Fivenson, L. Scherschun, and L.V. Cohen Apligraf in the treatment of severe mitten deformity associated with recessive dystrophic epidermolysis bullosa Plast Reconstr Surg 112 2003 584 588
41. R. Stephens, K. Wilson, and P. Silverstein A premature infant with skin injury successfully treated with bilayered cell matrix Ostomy/Wound Manage 48 2002 34 38
42. J. Still, P. Glat, and P. Silverstein The use of a collagen spong/living cell composite material to treat donor sites in burn patients Burns 29 2003 837 841
43. C.C. Compton Current concepts in pediatric burn care: the biology of cultured epithelial autografts: an eight-year study in pediatric burn patients Eur J Pediatr Surg 2 1992 216 222
44. R. Gobet, M. Raghunath, and S. Altermatt Efficacy of cultured epithelial autografts in pediatric burns and reconstructive surgery Surgery 121 1997 654 661
45. H. Carsin, P. Ainaud, and H. Le Bever Cultured epithelial autografts in extensive burn coverage of severely traumatized patients: a five year single-center experience with 30 patients Burns 26 2000 379 387
46. J.S. Yang, R.M. Lavker, and T.T. Sun Upper human hair follicle contains a subpopulation of keratinocytes with superior in vitro proliferative potential J Invest Dermatol 101 2003 652 659
47. A. Limat, D. Mauri, and T. Hunziker Successful treatment of chronic leg ulcers with epidermal equivalents generated from cultured autologous outer root sheath cells J Invest Dermatol 107 1996 128 315
48. M.C. Higham, R. Dawson, and M. Szabo Development of a stable chemically defined surface for the culture of human keratinocytes under serum-free conditions for clinical use Tissue Eng 9 2003 919 930
49. S.T. Boyce, M.J. Goretsky, and D.G. Greenhalgh Comparative assessment of cultured skin substitutes and native skin autograft for treatment of full-thickness burns Ann Surg 222 1995 743 752
50. S.T. Boyce, R. Glatter, and W.J. Kitzmiller Treatment of chronic wounds with cultured cells and biopolymers: a pilot study Wounds 7 1995 24 29
51. D. Passaretti, D. Billmire, and R. Kagan Autologous cultured skin substitutes conserve donor site autograft in elective treatment of congenital giant melanocyte nevus Plast Reconstr Surg 114 2004 1523 1528
52. J.F. Hansbrough, S.T. Boyce, and M.L. Cooper Burn wound closure with cultured autologous keratinocytes and fibroblasts attached to a collagen-glycosaminoglycan substrate JAMA 262 1989 2125 2130
53. S.T. Boyce, D.G. Greenhalgh, and R.J. Kagan Skin anatomy and antigen expression after burn wound closure with composite grafts of cultured skin cells and biopolymers Plast Reconstr Surg 91 1993 632 641
54. S.T. Boyce, R.J. Kagan, and N.A. Meyer The 1999 Clinical Research Award. Cultured skin substitutes combined with Integra to replace native skin autograft and allograft for closure of full-thickness burns J Burn Care Rehabil 20 1999 453 461
55. J.G. Rheinwald, and H. Green Formation of a keratinizing epithelium in culture by a cloned cell line derived from a teratoma Cell 6 1975 317 330
56. J.G. Rheinwald, and H. Green Serial cultivation of strains of human epidermal keratinocytes: the formation of keratinizing colonies from single cells Cell 6 1975 331 343
57. S.T. Boyce, and R.G. Ham Cultivation, frozen storage, and clonal growth of normal human epidermal keratinocytes in serum-free media J Tissue Cult Methods 9 1985 83 93
58. S.T. Boyce Methods for serum-free culture of keratinocytes and transplantation of collagen-GAG based composite grafts J.R. Morgan M. Yarmush Methods in tissue engineering 1998 Humana Press Inc. Totowa (NJ) 365 389
59. S.T. Boyce, R.J. Kagan, and K.P. Yakuboff Cultured skin substitutes reduce donor skin harvesting for closure of excised, full-thickness burns Ann Surg 235 2002 269 279
60. M.L. Cooper, J.A. Laxer, and J.F. Hansbrough The cytotoxic effects of commonly used topical antimicrobial agents on human fibroblasts and keratinocytes J Trauma 31 1991 775 782
61. O. Damour, S.Z. Hua, and F. Lasne Cytotoxicity evaluation of antiseptics and antibiotics on cultured fibroblasts and keratinocytes Burns 18 1992 479 485
62. S.T. Boyce, and R.G. Ham Calcium-regulated differentiation of normal human epidermal keratinocytes in chemically defined clonal culture and serum-free serial culture J Invest Dermatol 81 1983 33S 40S
63. S.T. Boyce, and J.F. Hansbrough Biologic attachment, growth, and differentiation of cultured human epidermal keratinocytes on a graftable collagen and chondroitin-6-sulfate substrate Surgery 103 1988 421 431
64. S.T. Boyce, and M.L. Williams Lipid supplemented medium induces lamellar bodies and precursors of barrier lipids in cultured analogues of human skin J Invest Dermatol 101 1993 180 184
65. M. Prunieras, M. Regnier, and D.T. Woodley Methods for cultivation of keratinocytes at the air-liquid interface J Invest Dermatol 81 1983 28S 33S
66. M. Ponec, J. Kempenaar, and A. Weerheim Triglyceride metabolism in human keratinocytes cultured at the air-liquid interface Arch Dermatol Res 287 1995 723 730
67. A.P. Supp, R.R. Wickett, and V.B. Swope Incubation of cultured skin substitutes in reduced humidity promotes cornification in vitro and stable engraftment in athymic mice Wound Repair Regen 7 1999 226 237
68. S.T. Boyce, A.P. Supp, and V.B. Swope Vitamin C regulates keratinocyte viability, epidermal barrier, and basement membrane formation in vitro, and reduces wound contraction after grafting of cultured skin substitutes J Invest Dermatol 118 2002 565 572
69. S.T. Boyce, and I.A. Holder Selection of topical antimicrobial agents for cultured skin for burns by combined assessment of cellular cytotoxicity and antimicrobial activity Plast Reconstr Surg 92 1993 493 500
70. S.T. Boyce, M.D. Harriger, and A.P. Supp Effective management of microbial contamination in cultured skin substitutes after grafting to athymic mice Wound Repair Regen 5 1997 191 197
71. S.T. Boyce, A.P. Supp, and M.D. Harriger Topical nutrients promote engraftment and inhibit wound contraction of cultured skin substitutes in athymic mice J Invest Dermatol 104 1995 345 349
72. A.F. Black, F. Berthod, and N. L'Heureux In vitro reconstruction of a human capillary-like network in a tissue-engineered skin equivalent FASEB J 12 1998 1331 1340
73. J.S. Schechner, A.K. Nath, and L. Zheng In vivo formation of complex microvessels lined by human endothelial cells in an immunodeficient mouse Proc Natl Acad Sci U S A 97 2000 9191 9196
74. D.M. Supp, K. Wilson-Landy, and S.T. Boyce Human dermal microvascular endothelial cells form vascular analogs in cultured skin substitutes after grafting to athymic mice FASEB J 16 2002 797 804
75. P.S. Sahota, J.L. Burn, and M. Heaton Development of a reconstructed human skin model for angiogenesis Wound Repair Regen. 11 2003 275 284
76. M.J. Pollman, L. Naumovski, and G.H. Gibbons Endothelial cell apoptosis in capillary network remodeling J Cell Physiol 178 1999 359 370
77. J.E. Nor, J. Christensen, and D.J. Mooney Vascular endothelial growth factor (VEGF)-mediated angiogenesis is associated with enhanced endothelial cell survival and induction of Bcl-2 expression Am J Pathol 154 1999 375 384
78. Z.A. Abdel-Malek Endocrine factors as effectors of integumental pigmentation Dermatol Clin 6 1988 175 183
79. J.J. Nordlund, Z.A. Abdel-Malek, and R.E. Boissy Pigment cell biology: an historical review J Invest Dermatol 92 1989 53S 60S
80. S.T. Boyce, A.P. Supp, and M.D. Harriger Surface electrical capacitance as a noninvasive index of epidermal barrier in cultured skin substitutes in athymic mice J Invest Dermatol 107 1996 82 87
81. M.D. Harriger, G.D. Warden, and D.G. Greenhalgh Pigmentation and microanatomy of skin regenerated from composite grafts of cultured cells and biopolymers applied to full-thickness burn wounds Transplantation 59 1995 702 707
82. V.B. Swope, A.P. Supp, and J.R. Cornelius Regulation of pigmentation in cultured skin substitutes by cytometric sorting of melanocytes and keratinocytes J Invest Dermatol 109 1997 289 295
83. M. Seiberg Keratinocyte-melanocyte interactions during melanosome transfer Pigment Cell Res 14 2001 236 242
84. M. Tasatmali, J. Ancans, and A.J. Thody Melanocyte function and its control by melanocortin peptides J Histochem Cytochem 50 2002 125 133
85. J.R. Morgan, Y. Barrandon, and H. Green Expression of an exogenous growth hormone gene in transplantable human epidermal cells Science 237 1987 1476 1479
86. E.S. Fenjves Approaches to gene transfer in keratinocytes J Invest Dermatol 103 1994 70S 75S
87. D.M. Supp, A.P. Supp, and S.M. Bell Enhanced vascularization of cultured skin substitutes genetically modified to overexpress vascular endothelial growth factor J Invest Dermatol 114 2000 5 13
88. D.M. Supp, and S.T. Boyce Overexpression of vascular endothelial growth factor accelerates early vascularization and improves healing of genetically modified cultured skin substitutes J Burn Care Rehabil 23 2002 10 20
89. E. Dellambra, J. Vailly, and G. Pellegrini Corrective transduction of human epidermal stem cells in laminin-5-dependent junctional epidermolysis bullosa Hum Gene Ther 9 1998 1359 1370
90. J. Vailly, L. Gagnouz-Palacios, and E. Dell'Ambra Corrective gene transfer of keratinoyctes from patients with junctional epidermolysis bullosa restores assembly of hemidesmosomes in reconstructed epithelia Gene Ther 5 1998 1322 1332
91. P.B. Robbins, Q. Lin, and J.B. Goodnough In vivo restoration of laminin 5 beta 3 expression and function in junctional epidermolysis bullosa Proc Natl Acad Sci U S A 98 2001 5193 5198
92. E.S. Fenjves, D.A. Gordon, and L.K. Pershing Systematic distribution of apolipoprotein E secreted by grafts of epidermal keratinocytes: implications for epidermal function and gene therapy Proc Natl Acad Sci U S A 86 1989 8803 8807
93. E.S. Fenjves, J. Smith, and S. Zaradic Systemic delivery of secreted protein by grafts of epidermal keratinocytes: prospects for keratinocyte gene therapy Hum Gene Ther 5 1994 1241 1248
94. P.M. Vogt, S. Thompson, and C. Andree Genetically modified keratinocytes transplanted to wounds reconstitute the epidermis Proc Natl Acad Sci U S A 91 1994 9307 9311
95. U.B. Jensen, T.G. Jensen, and P.K. Jensen Gene transfer into cultured human epidermis and its transplantation onto immunodeficient mice: an experimental model for somatic gene therapy J Invest Dermatol 103 1994 391 394
96. A.J. Gerrard, D.L. Hudson, and G.G. Brownlee Towards gene therapy for haemophilia B using primary human keratinocytes Nat Genet 3 1993 180 183
97. S.M. Page, and G.G. Brownlee An ex vivo keratinocyte model for gene therapy of hemophilia B J Invest Dermatol 108 1997 139 145
98. S.J. White, S.M. Page, and P. Margaritis Long-term expression of human clotting factor IX from retrovirally transduced primary human keratinocytes in vivo Hum Gene Ther 9 2002 1187 1195
99. F. Lonnqvist, L. Nordfors, and M. Schalling Leptin and its potential role in human obesity J Intern Med 245 1999 643 652
100. F. Larcher, M. Del Rio, and F. Serrano A cutaneous gene therapy approach to human leptin deficiencies: correction of the murine ob/ob phenotype using leptin-targeted keratinocyte grafts FASEB J 15 2001 1529 1538