Mechanisms of the protective effects of urocortin on coronary endothelial function during ischemia-reperfusion in rat isolated hearts

British Journal of Pharmacology

Volumn 145, Issue 4, 2005, Pages 490-494

  Garcia Villalón, Angel Luis ^a   Amezquita, Yesika María ^a   Monge, Lius ^a   Fernández, Nuria ^a   Climent, Belén ^a   Sánchez, Ana ^a   Diéguez, Godofredo ^a  

^a UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

Author keywords

Coronary circulation; Endothelium; Ischemia reperfusion; Protein kinase C; Urocortin

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; ACETYLCHOLINE; CALCIUM CHANNEL BLOCKING AGENT; CHELERYTHRINE; GLIBENCLAMIDE; MECLOFENAMIC ACID; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; POTASSIUM CHANNEL BLOCKING AGENT; PROSTAGLANDIN SYNTHASE; PROTEIN KINASE C; PROTEIN KINASE C INHIBITOR; TETRYLAMMONIUM; UROCORTIN;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORONARY ARTERY; DRUG MECHANISM; ENZYME ACTIVATION; HEART FUNCTION; HEART MUSCLE ISCHEMIA; HEART MUSCLE PERFUSION; HEART PROTECTION; ISOLATED HEART; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; REPERFUSION INJURY; TIME SERIES ANALYSIS;

ACETYLCHOLINE; ALKALOIDS; ANIMALS; BENZOPHENANTHRIDINES; CARDIOVASCULAR AGENTS; CORTICOTROPIN-RELEASING HORMONE; CYCLOOXYGENASE INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIUM, VASCULAR; ENZYME INHIBITORS; GLYBURIDE; HEART; MALE; MECLOFENAMIC ACID; MYOCARDIAL REPERFUSION INJURY; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE; PERFUSION; PHENANTHRIDINES; PROTEIN KINASE C; RATS; RATS, SPRAGUE-DAWLEY; TETRAETHYLAMMONIUM; VASODILATOR AGENTS;

EID: 22044434305     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0706208     Document Type: Article

References (31)

1. BALE, T.L., CONTARINO, A., SMITH, G.W., CHAN, R., GOLD, L.H., SAWCHENKO, P.E., KOOB, G.F., VALE, W.W. & LEE, K.F. (2000). Mice deficient for corticotropin-releasing hormone receptor-2 display anxiety-like behaviour and are hypersensitive to stress. Nat. Genet., 24, 410-414.
2. BRAK, B.K., STEPHANOU, A., OKOSI, A., LAWRENCE, K.M., KNIGHT, R.A., MARBER, M.S. & LATCHMAN, D.S. (1999). CRH-like peptides protect cardiac myocytes from lethal ischaemic injury. Mol. Cell. Endocrinol., 158, 55-63.
3. BRAK, B.K., JONASSEN, A.K., STEPHANOU, A., SANTILLI, G., RAILSON, J., KNIGHT, R.A., YELLON, D.M. & LATCHMAN, D.S. (2000). Urocortin protects against ischemic and reperfusion injury via a MAPK-dependent pathway. J. Biol. Chem., 275, 8508-8514.
4. BRAR, B.K., STEPHANOU, A., KNIGHT, R. & LATCHMAN, D.S. (2002). Activation of protein kinase B/Akt by urocortin is essential for its ability to protect cardiac cells against hypoxia/reoxygenation-induced cell death. J. Mol. Cell. Cardiol., 34, 483-492.
5. GARCÍA-VILLALÓN, A.L., SANZ, E., MONGE, L., FERNÁNDEZ, N., CLIMENT, B. & DIÉGUEZ, G. (2004). Urocortin protects coronary endotelial function during ischemia-reperfusion: a brief communication. Exp. Biol. Med., 229, 118-120.
6. GORDON, J.M., DUSTING, G.J., WOODMAN, O.L. & RITCHIE, R.H. (2003). Cardioprotective action of CRF peptide urocortin against simulated ischemia in rat adult cardiomyocites. Am. J. Physiol. Heart Circ. Physiol., 284, H330-H336.
7. HUANG, Y., CHAN, F.L., LAU, C.W., TSANG, S.Y., HE, G.W., CHEN, Z.Y. & YAO, X. (2002). Urocortin-induced endothelium-dependent relaxation of rat coronary artery: role of nitric oxide and K+ channels. Br. J. Pharmacol., 135, 1467-1476.
8. HUANG, Y., CHAN, F.L., LAU, C.W., TSANG, S.Y., CHEN, Z.Y., HE, G.W. & YAO, X. (2003). Roles of cyclic AMP and Ca2+-activated K+ channels in endothelium-independent relaxation by urocortin in the rat coronary artery. Cardiovasc. Res., 57, 824-833.
9. HUANG, Y., YAO, X.Q., LAU, C.W., CHAN, Y.C., TSANG, S.Y. & CHAN, F.L. (2004). Urocortin and cardiovascular protection. Acta Pharmacol. Sin., 25, 257-265.
10. KIM, Y.D., FOMSGAARD, J.S., HEIM, K.F., RAMWELL, P.W., THOMAS, G., KAGAN, E., MOORE, S.P., COUGHLIN, S.S., KUWAHARA, M., ANALOUEI, A. & MYERS, A.K. (1992). Brief ischemia-reperfusion induces stunning of endothelium in canine coronary artery. Circulation, 85, 1473-1482.
11. KLONER, R.A., GANOTE, C.E. & JENNINGS, R.B. (1974). The 'no-reflow' phenomenon after temporary coronary occlusion in the dog. J. Clin. Invest., 54, 1496-1508.
12. KOURETAS, P.C., KIM, Y.D., CAHILL, P.A., MYERS, A.K., TO, L.N., WANG, Y.N., WALLACE, R.B., KRON, I.L. & HANNAN, R.L. (1998). Heparin preserves nitric oxide activity in coronary endothelium during ischemia-reperfusion injury. Ann. Thorac. Surg., 66, 1210-1215.
13. KU, D.D. (1982). Coronary vascular reactivity after acute myocardial ischemia. Science, 218, 576-578.
14. LAUDE, K., THUILLEZ, C. & RICHARD, V. (2001). Coronary endothelial dysfunction after ischemia and reperfusion: a new therapeutic target? Braz. J. Med. Biol. Res., 34, 1-7.
15. LAWRENCE, K.M., CHANALARIS, A., SCARABELLI, T., HUBANK, M., PASINI, E., TOWNSEND, P.A., COMINI, L., FERRARI, R., TINKER, A., STEPHANOU, A., KNIGHT, R.A. & LATCHMAN, D.S. (2002). K(ATP) channel gene expression is induced by urocortin and mediates its cardioprotective effect. Circulation, 106, 1556-1562.
16. LAWRENCE, K.M., SCARABELLI, T.M., TURTLE, L., CHANALARIS, A., TOWNSEND, P.A., CARROLL, C.J., HUBANK, M., STEPHANOU, A., KNIGHT, R.A. & LATCHMAN, D.S. (2003). Urocortin protects cardiac myocytes from ischemia/reperfusion injury by attenuating calcium-insensitive phospholipase A2 gene expression. FASEB J., 17, 2313-2315.
17. LAWRENCE, K.M., TOWNSEND, P.A., DAVIDSON, S.M., CARROLL, C.J., EATON, S., HUBANK, M., KNIGHT, R.A., STEPHANOU, A. & LATCHMAN, D.S. (2004). The cardioprotective effect of urocortin during ischaemia/reperfusion involves the prevention of mitochondrial damage. Biochem. Biophys. Res. Commun., 321, 479-486.
18. MACZEWSKI, M. & BERESEWICZ, A. (1998). The role of adenosine and ATP-sensitive potassium channels in the protection afforded by ischemic preconditioning against the post-ischemic endothelial dysfunction in guinea-pig hearts. J. Mol. Cell. Cardiol., 30, 1735-1747.
19. MIKI, I., SEYA, K., MOTOMURA, S. & FURUKAWA, K. (2004). Role of corticotropin-releasing factor receptor type 2beta in urocortin-induced vasodilation of rat aortas. J. Pharmacol. Sci., 96, 170-176.
20. NISHIKIMI, T., MIYATA, A., HORIO, T., YOSHIHARA, F., NAGAYA, N., TAKISHITA, S., YUTANI, C., MATSUO, H., MATSUOKA, H. & KANGAWA, K. (2000). Urocortin, a member of the corticotropin-releasing factor family, in normal and diseased heart. Am. J. Physiol. Heart. Circ. Physiol., 279, H3031-H3039.
21. PARKES, D.G., VAUGHAN, J., RIVIER, J., VALE, W. & MAY, C.N. (1997). Cardiac inotropic actions of urocortin in conscious sheep. Am. J. Physiol., 272, H2115-H2122.
22. SANZ, E., MONGE, L., FERNÁNDEZ, N., MARTÍNEZ, M.A., MARTÍNEZ-LEON, J.B., DIÉGUEZ, G. & GARCÍA- VILLALÓN, A.L. (2002). Relaxation by urocortin of human saphenous veins. Br. J. Pharmacol., 136, 90-94.
23. SANZ, E., FERNÁNDEZ, N., MONGE, L., CLIMENT, B., DIÉGUEZ, G. & GARCÍA-VILLALÓN, A.L. (2003). Relaxation by urocortin of rat renal arteries: effects of diabetes in males and females. Cardiovasc. Res., 58, 706-711.
24. SCARABELLI, T.M., PASINI, E., FERRARI, G., FERRARI, M., STEPHANOU, A., LAWRENCE, K., TOWNSEND, P., CHENSCARABELLI, C., GITTI, G., SARAVOLATZ, L., LATCHMAN, D., KNIGHT, R.A. & GARDIN, J.M. (2004). Warm blood cardioplegic arrest induces mitochondrial-mediated cardiomyocyte apoptosis associated with increased urocortin expression in viable cells. J. Thorac. Cardiovasc. Surg., 128, 364-371.
25. SCHULMAN, D., LATCHMAN, D.S. & YELLON, D.M. (2002). Urocortin protects the heart from reperfusion injury via upregulation of p42/p44 MAPK signaling pathway. Am. J. Physiol. Heart. Circ. Physiol., 283, H1481-H1488.
26. SUTHERLAND, F.J. & HEARSE, D.J. (2000). The isolated blood and perfusion fluid perfused heart. Pharmacol. Res., 41, 613-627.
27. TERUI, K., HIGASHIYAMA, A., HORIBA, N., FURUKAWA, K.I., MOTOMURA, S. & SUDA, T. (2001). Coronary vasodilation and positive inotropism by urocortin in the isolated rat heart. J. Endocrinol., 169, 177-183.
28. VAN BENTHUYSEN, K.M., MCMURTRY, I.F. & HORWITZ, L.D. (1987). Reperfusion after acute coronary occlusion in dogs impairs endothelium-dependent relaxation to acetylcholine and augments contractile reactivity in vitro. J. Clin. Invest., 79, 265-274.
29. VAUGHAN, J., DONALDSON, C., BITTENCOURT, J., PERRIN, M.H., LEWIS, K., SUTTON, S., CHAN, R., TURNBULL, A.V., LOVEJOY, D., RIVIER, C., RIVIER, J., SAWCHENKO, P. & VALE, W. (1995). Urocortin, a mammalian neuropeptide related to fish urotensin 1 and corticotropin-releasing factor. Nature, 378, 287-292.
30. WATANABE, F., OKI, Y., OZAWA, M., MASUZAWA, M., IWABUCHI, M., YOSHIMI, T., NISHIGUCHI, T., UNO, K. & SASANO, H. (1999). Urocortin in human placenta and maternal plasma. Peptides, 20, 205-209.
31. ZHOU, F.-W., LI, Y.-J., LU, R. & DENG, H.-W. (1999). Protection of calcitonin gene-related peptide-mediated preconditioning against coronary endothelial dysfunction induced by reperfusion in the isolated rat heart. Life Sci., 64, 1091-1097.