메뉴 건너뛰기




Volumn 5, Issue 1, 2005, Pages 57-60

The rTS signaling pathway as a target for drug development

Author keywords

Acyl homocysteine lactone; Antisense RNA; Growth regulation; Thymidylate synthase

Indexed keywords

ANTINEOPLASTIC AGENT; COMPLEMENTARY RNA; FLUOROURACIL; GENE PRODUCT; HOMOSERINE; LACTONE; MESSENGER RNA; METHOTREXATE; RALTITREXED; THYMIDYLATE SYNTHASE; THYMIDYLATE SYNTHASE ALPHA; THYMIDYLATE SYNTHASE BETA; THYMIDYLATE SYNTHASE INHIBITOR; UNCLASSIFIED DRUG; RECOMBINANT PROTEIN;

EID: 21844472275     PISSN: 15330028     EISSN: None     Source Type: Journal    
DOI: 10.3816/CCC.2005.n.017     Document Type: Article
Times cited : (7)

References (27)
  • 1
    • 23244464739 scopus 로고    scopus 로고
    • Thymidylate synthase: A critical target in cancer therapy?
    • Rustum YM. Thymidylate synthase: a critical target in cancer therapy? Front Biosci 2004; 9:2467-2473.
    • (2004) Front Biosci , vol.9 , pp. 2467-2473
    • Rustum, Y.M.1
  • 2
    • 0036087483 scopus 로고    scopus 로고
    • Thymidylate synthase expression as a predictor of clinical response to fluoropyrimidine-based chemotherapy in advanced colorectal cancer
    • Aschele C, Lonardi S, Monfardini S. Thymidylate synthase expression as a predictor of clinical response to fluoropyrimidine-based chemotherapy in advanced colorectal cancer. Cancer Treat Rev 2002; 28:27-47.
    • (2002) Cancer Treat Rev , vol.28 , pp. 27-47
    • Aschele, C.1    Lonardi, S.2    Monfardini, S.3
  • 3
    • 0037386688 scopus 로고    scopus 로고
    • Is the measurement of thymidylate synthase to determine suitability for treatment with 5-fluoropyrimidines ready for prime time?
    • Bertino JR, Banerjee D. Is the measurement of thymidylate synthase to determine suitability for treatment with 5-fluoropyrimidines ready for prime time? Clin Cancer Res 2003; 9:1235-1239.
    • (2003) Clin Cancer Res , vol.9 , pp. 1235-1239
    • Bertino, J.R.1    Banerjee, D.2
  • 4
    • 0027174556 scopus 로고
    • Cloning and characterization of a naturally occurring antisense RNA to human thymidylate synthase mRNA
    • Dolnick BJ. Cloning and characterization of a naturally occurring antisense RNA to human thymidylate synthase mRNA. Nucleic Acids Res 1993; 21:1747-1752.
    • (1993) Nucleic Acids Res , vol.21 , pp. 1747-1752
    • Dolnick, B.J.1
  • 5
    • 33646549851 scopus 로고    scopus 로고
    • Homo sapiens RTS (RTS) gene, complete eds, alternatively spliced
    • (GenBank)
    • Dolnick B, Su J. Homo sapiens RTS (RTS) gene, complete eds, alternatively spliced (GenBank, 2000).
    • (2000)
    • Dolnick, B.1    Su, J.2
  • 6
    • 33646545625 scopus 로고    scopus 로고
    • Fluoropyrimidines in cancer therapy
    • Rustum YM, ed. Totowa, NJ: Humana Press
    • Dolnick BJ. Fluoropyrimidines in cancer therapy. In: Rustum YM, ed. Cancer Drug Discovery and Development. Totowa, NJ: Humana Press; 2003:83-91.
    • (2003) Cancer Drug Discovery and Development , pp. 83-91
    • Dolnick, B.J.1
  • 7
    • 0005901567 scopus 로고    scopus 로고
    • Regulation of thymidylate synthase mRNA levels by RNA editing
    • Dolnick BJ. Regulation of thymidylate synthase mRNA levels by RNA editing. Proc Am Assoc Cancer Res 2000; 41:945.
    • (2000) Proc Am Assoc Cancer Res , vol.41 , pp. 945
    • Dolnick, B.J.1
  • 9
    • 0029987653 scopus 로고    scopus 로고
    • Alternate splicing of the rTS gene product and its overexpression in a 5-fluorouracil-resistant cell line
    • Dolnick BJ, Black AR. Alternate splicing of the rTS gene product and its overexpression in a 5-fluorouracil-resistant cell line. Cancer Res 1996; 56:3207-3210.
    • (1996) Cancer Res , vol.56 , pp. 3207-3210
    • Dolnick, B.J.1    Black, A.R.2
  • 10
    • 0030866784 scopus 로고    scopus 로고
    • Recent advances in the study of rTS proteins. rTS expression during growth and in response to thymidylate synthase inhibitors in human tumor cells
    • Dolnick BJ, Lu K, Yin MB, et al. Recent advances in the study of rTS proteins. rTS expression during growth and in response to thymidylate synthase inhibitors in human tumor cells. Adv Enzyme Regul 1997; 37:95-109.
    • (1997) Adv Enzyme Regul , vol.37 , pp. 95-109
    • Dolnick, B.J.1    Lu, K.2    Yin, M.B.3
  • 11
    • 0030041335 scopus 로고    scopus 로고
    • Expression of rTS correlates with altered growth regulation of thymidylate synthase
    • Black AR, Dolnick BJ. Expression of rTS correlates with altered growth regulation of thymidylate synthase. Cancer Res 1996; 56:700-705.
    • (1996) Cancer Res , vol.56 , pp. 700-705
    • Black, A.R.1    Dolnick, B.J.2
  • 12
    • 0037130121 scopus 로고    scopus 로고
    • Natural antisense (rTSalpha) RNA induces site-specific cleavage of thymidylate synthase mRNA
    • Chu J, Dolnick BJ. Natural antisense (rTSalpha) RNA induces site-specific cleavage of thymidylate synthase mRNA. Biochimica et Biophysica Acta 2002; 1587:183-193.
    • (2002) Biochimica Et Biophysica Acta , vol.1587 , pp. 183-193
    • Chu, J.1    Dolnick, B.J.2
  • 13
    • 33646575850 scopus 로고    scopus 로고
    • Natural antisense (rTSalpha) RNA mediated down-regulation of thymidylate synthase gene expression
    • [doctoral dissertation]. Buffalo, NY: State University of New York
    • Chu J. Natural antisense (rTSalpha) RNA mediated down-regulation of thymidylate synthase gene expression [doctoral dissertation]. Buffalo, NY: State University of New York; 1999.
    • (1999)
    • Chu, J.1
  • 14
    • 12244275645 scopus 로고    scopus 로고
    • Widespread occurrence of antisense transcription in the human genome
    • Yelin R, Dahary D, Sorek R, et al. Widespread occurrence of antisense transcription in the human genome. Nat Biotechnol 2003; 21:379-386.
    • (2003) Nat Biotechnol , vol.21 , pp. 379-386
    • Yelin, R.1    Dahary, D.2    Sorek, R.3
  • 15
    • 0037382909 scopus 로고    scopus 로고
    • Antisense starts making more sense
    • Carmichael GG. Antisense starts making more sense. Nat Biotechnol 2003; 21:371-372.
    • (2003) Nat Biotechnol , vol.21 , pp. 371-372
    • Carmichael, G.G.1
  • 16
    • 0028030535 scopus 로고
    • Sensing starvation: A homoserine lactone--dependent signaling pathway in Escherichia coli
    • Huisman G, Kolter R. Sensing starvation: a homoserine lactone--dependent signaling pathway in Escherichia coli. Science 1994; 265:537-539.
    • (1994) Science , vol.265 , pp. 537-539
    • Huisman, G.1    Kolter, R.2
  • 17
    • 0029651191 scopus 로고
    • A functionally diverse enzyme superfamily that abstracts the alpha protons of carboxylic acids
    • Babbitt PC, Mrachko GT, Hasson MS, et al. A functionally diverse enzyme superfamily that abstracts the alpha protons of carboxylic acids. Science 1995; 267:1159-1161.
    • (1995) Science , vol.267 , pp. 1159-1161
    • Babbitt, P.C.1    Mrachko, G.T.2    Hasson, M.S.3
  • 19
    • 0035876148 scopus 로고    scopus 로고
    • The languages of bacteria
    • Schauder S, Bassler BL. The languages of bacteria. Genes Dev 2001; 15:1468-1480.
    • (2001) Genes Dev , vol.15 , pp. 1468-1480
    • Schauder, S.1    Bassler, B.L.2
  • 20
    • 0029980095 scopus 로고    scopus 로고
    • Enzymatic synthesis of a quorum-sensing autoinducer through use of defined substrates
    • More MI, Finger LD, Stryker JL, et al. Enzymatic synthesis of a quorum-sensing autoinducer through use of defined substrates. Science 1996; 272:1655-1658.
    • (1996) Science , vol.272 , pp. 1655-1658
    • More, M.I.1    Finger, L.D.2    Stryker, J.L.3
  • 21
    • 84898689888 scopus 로고    scopus 로고
    • Modulation of cell cycle genes and tumor cell growth by acyl-homoserine lactones
    • Dolnick BJ, Angelino NJ, Dolnick R, et al. Modulation of cell cycle genes and tumor cell growth by acyl-homoserine lactones. Proc Am Assoc Cancer Res 2003; 44.
    • (2003) Proc Am Assoc Cancer Res , pp. 44
    • Dolnick, B.J.1    Angelino, N.J.2    Dolnick, R.3
  • 22
    • 0037220642 scopus 로고    scopus 로고
    • Detection of thymidylate synthase modulators by a novel screening assay
    • Wu Q, Dolnick BJ. Detection of thymidylate synthase modulators by a novel screening assay. Mol Pharmacol 2003; 63:167-173.
    • (2003) Mol Pharmacol , vol.63 , pp. 167-173
    • Wu, Q.1    Dolnick, B.J.2
  • 23
    • 0030111238 scopus 로고    scopus 로고
    • The role of thymidylate synthase as an RNA binding protein
    • Chu E, Allegra CJ. The role of thymidylate synthase as an RNA binding protein. Bioessays 1996; 18:191-198.
    • (1996) Bioessays , vol.18 , pp. 191-198
    • Chu, E.1    Allegra, C.J.2
  • 24
    • 0030472807 scopus 로고    scopus 로고
    • The role of thymidylate synthase in cellular regulation
    • Chu E, Allegra CJ. The role of thymidylate synthase in cellular regulation. Adv Enzyme Regul 1996; 36:143-163.
    • (1996) Adv Enzyme Regul , vol.36 , pp. 143-163
    • Chu, E.1    Allegra, C.J.2
  • 25
    • 0034653284 scopus 로고    scopus 로고
    • Characterization of a cis-acting regulatory element in the protein coding region of thymidylate synthase mRNA
    • Lin X, Parsels LA, Voeller DM, et al. Characterization of a cis-acting regulatory element in the protein coding region of thymidylate synthase mRNA. Nucleic Acids Res 2000; 28:1381-1389.
    • (2000) Nucleic Acids Res , vol.28 , pp. 1381-1389
    • Lin, X.1    Parsels, L.A.2    Voeller, D.M.3
  • 26
    • 0025990937 scopus 로고
    • Autoregulation of human thymidylate synthase messenger RNA translation by thymidylate synthase
    • Chu E, Koeller DM, Casey JL, et al. Autoregulation of human thymidylate synthase messenger RNA translation by thymidylate synthase. Proc Natl Acad Sci U S A 1991; 88:8977-8981.
    • (1991) Proc Natl Acad Sci U S A , vol.88 , pp. 8977-8981
    • Chu, E.1    Koeller, D.M.2    Casey, J.L.3
  • 27
    • 0037413582 scopus 로고    scopus 로고
    • Synthetic analogues of the bacterial (quorum sensing) molecule N-(3-oxododecanoyl)-L-homoserine lactone as immune modulators
    • Chabra SR, Harty C, Hooi DS, et al. Synthetic analogues of the bacterial (quorum sensing) molecule N-(3-oxododecanoyl)-L-homoserine lactone as immune modulators. J Med Chem 2003; 46:97-104.
    • (2003) J Med Chem , vol.46 , pp. 97-104
    • Chabra, S.R.1    Harty, C.2    Hooi, D.S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.