In situ measurement of free zinc in an ischemia model and cell culture using a ratiometric fluorescence-based biosensor

Progress in Biomedical Optics and Imaging - Proceedings of SPIE

Volumn 5692, Issue , 2005, Pages 51-59

  Zeng, Hui Hui ^a   Bozym, Rebecca A ^a   Rosenthal, Robert E ^a   Fiskum, Gary ^a   Cotto Cumba, Cynthia ^a   Westerberg, Nissa ^b   Fierke, Carol A ^b   Stoddard, Andrea ^b   Cramer, Michele L ^a   Frederickson, C J ^c   Thompson, Richard ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

^c NeuroBioTex Inc   (United States)

Author keywords

Apoptosis; Brain; Carbonic anhydrase; Fiber optic sensor; Fluorescence biosensor; Stroke; Zinc

Indexed keywords

APOPTOSIS; CARBONIC ANHYDRASE; FLUORESCENCE BIOSENSORS; STROKE;

BIOSENSORS; BRAIN; DIALYSIS; ENZYMES; FIBER OPTIC SENSORS; FLUORESCENCE; RADIOMETRY; ZINC;

CELL CULTURE;

EID: 21844471774     PISSN: 16057422     EISSN: None     Source Type: Conference Proceeding    
DOI: 10.1117/12.614168     Document Type: Conference Paper

References (33)

1. Frederickson, C. J., Klitenick, M. A., Manton, W. I. & Kirkpatrick, J. B. Cytoarchitectonic distribution of zinc in the hippocampus of man and the rat. Brain Research 273, 335-339 (1983).
2. Frederickson, C. J., Suh, S. W., Silva, D., Frederickson, C. J. & Thompson, R. B. Importance of zinc in the central nervous system: the zinc-containing neuron. Journal of Nutrition (Supplement) 130, 1471S-1483S (2000).
3. Yokoyama, M., Koh, J. & Choi, D. W. Brief exposure to zinc is toxic to cortical neurons. Neuroscience Letters 71, 351-355 (1986).
4. Frederickson, C. J. & Bush, A. I. Synaptically released zinc: Physiological functions and pathological effects. Bio Metals 14, 353 - 366 (2001).
5. Tonder, N., Johansen, F. F., Frederickson, C. J., Zimmer, J. & Diemer, N. H. Possible role of zinc in the selective degeneration of dentate hilar neurons after cerebral ischemia in the adult rat. Neuroscience Letters 109, 247-252 (1990).
6. Koh, J. Y. et al. The role of zinc in selective neuronal death after transient global cerebral ischemia. Science 272, 1013-1016 (1996).
7. Frederickson, C. J. The neurobiology of zinc and of zinc-containing neurons. International Review of Neurobiology 31, 145-238 (1989).
8. Bozym, R. A. et al. in Proceedings of the SPIE Conference on Advanced Biomedical and Clinical Diagnostic Systems II(eds. Cohn, G. E., Grundfest, W. S., Benaron, D. A. & Vo-Dinh, T.) (SPIE, Bellingham, WA, 2004).
9. Finney, L. A. & O'Halloran, T. V. Transition metal speciation in the cell: insights from the chemistry of metal ion receptors. Science 300, 931 - 936 (2003).
10. Lee, J. Y., Cole, T. B., Palmiter, R. D. & Koh, J. Y. Accumulation of zinc in degenerating hippocampal neurons of ZnT3-null mice after seizures: evidence against synaptic vesicle origin. Journal of Neuroscience 20, RC79 (2000).
11. Frederickson, C. J., Maret, W. & Cuajungco, M. P. Zinc and excitotoxic brain injury: a new model. The Neuroscientist 10, 18 - 25 (2004).
12. Truong-Tran, A. Q., Carter, J., Ruffin, R. E. & Zalewski, P. D. The role of zinc in caspase activation and apoptotic cell death. BioMetals 14, 315 - 330 (2001).
13. Prasad, A. S. & Oberleas, D. Zinc in human serum: evidence for an amino acid-bound fraction. Journal of Laboratory and Clinical Medicine, 1006 (1968).
14. Berg, J. M. & Shi, Y. The galvanization of biology: a growing appreciation for the roles of zinc. Science 271, 1081-1085 (1996).
15. Bertini, I., Sigel, A. & Sigel, H. (eds.) Handbook on Metalloproteins (Marcel Dekker, New York, 2001).
16. Hunt, J. B., Rhee, M. J. & Storm, C. B. A rapid and convenient preparation of apocarbonic anhydrase. Analytical Biochemistry 79, 614-617 (1977).
17. Hunt, J. A., Ahmed, M. & Fierke, C. A. Metal binding specificity in carbonic anhydrase is influenced by conserved Hydrophobic amino acids. Biochemistry 38, 9054-9060 (1999).
18. Liu, Y. et al. Normoxic ventilation after cardiac arrest reduces oxidation of brain lipids and improves neurological outcome. Stroke 29, 1679 - 1686 (1998).
19. Campbell, R. E. et al. A monomeric red fluorescent protein. Proceedings of the National Academy of Sciences 99, 7877 - 7882 (2002).
20. Thompson, R. B. & Jones, E. R. Enzyme-based fiber optic zinc biosensor. Analytical Chemistry 65, 730-734 (1993).
21. Thompson, R. B., Ge, Z., Patchan, M. W., Huang, C.-c. & Fierke, C. A. Fiber optic biosensor for Co(II) and Cu(II) based on fluorescence energy transfer with an enzyme transducer. Biosensors and Bioelectronics 11, 557-564 (1996).
22. Zeng, H. H. et al. Real-time determination of picomolar free Cu(II) in seawater using a fluorescence-based fiber optic biosensor. Analytical Chemistry 75, 6807 - 6812 (2003).
23. Fierke, C. A. & Thompson, R. B. Fluorescence-based biosensing of zinc using carbonic anhydrase. BioMetals 14, 205 - 222 (2001).
24. Henary, M. M., Wu, Y. & Fahrni, C. J. Zinc(II)-selective ratiometric fluorescent sensors based on inhibition of excited state intramolecular proton transfer. Chemistry in Europe Journal 10, 3015 - 3025 (2004).
25. Thompson, R. B., Jr., W. O. W., Maliwal, B. P., Fierke, C. A. & Frederickson, C. J. Fluorescence microscopy of stimulated Zn(II) release from organotypic cultures of mammalian hippocampus using a carbonic anhydrase-based biosensor system. Journal of Neuroscience Methods 96, 35-45 (2000).
26. Thompson, R. B., Levine, M. & Kondracki, L. Component selection for fiber optic fluorometry. Applied Spectroscopy 44, 117-122 (1990).
27. Lindskog, S. et al. in The Enzymes (ed. Boyer, P. D.) 587-665 (Academic Press, New York, 1971).
28. Thompson, R. B. et al. Fluorescent zinc indicators for neurobiology. Journal of Neuroscience Methods 118, 63 - 75 (2002).
29. Miyawaki, A. et al. Fluorescent indicators for Ca2+ based on green fluorescent proteins and calmodulin. Nature 388, 882-887 (1997).
30. Choi, D. W. & Koh, J. Y. Zinc and brain injury. Annual Review of Neuroscience 21, 347-375 (1998).
31. Suh, S. W., Thompson, R. B. & Frederickson, C. J. Loss of vesicular zinc and appearance of perikaryal zinc after seizures induced by pilocarpine. Neuroreport 12, 1523 - 1525 (2001).
32. Suh, S. W. et al. Release of synaptic zinc is substantially depressed by conventional brain slice preparations. Brain Research 879, 7-12 (2000).
33. Cherny, R. A. et al. Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice. Neuron 30, 665 - 676 (2001).