Periodic high-conductance states in spinal neurons during scratch-like network activity in adult turtles

Journal of Neuroscience

Volumn 25, Issue 27, 2005, Pages 6316-6321

  Alaburda, A ^a   Russo, R ^b   MacAulay, N ^c   Hounsgaard, J ^c  

^a VILNIUS UNIVERSITY   (Lithuania)

^b Facultad de Ciencias   (Uruguay)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Membrane conductance; Modulation; Motoneuron; Reflex; Spinal cord integrated preparation; Synaptic plasticity

Indexed keywords

2 AMINO 5 PHOSPHONOVALERIC ACID; 4 IODO 2,5 DIMETHOXYAMPHETAMINE; 6 CYANO 7 NITRO 2,3 QUINOXALINEDIONE; GLYCINE; LIDOCAINE ETHOBROMIDE; MUSCIMOL;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; INTERNEURON; MEMBRANE CONDUCTANCE; MOTONEURON; NERVE CELL; NERVE CELL PLASTICITY; NONHUMAN; PRIORITY JOURNAL; SPINAL CORD; TURTLE; VOLTAGE CLAMP;

ACTION POTENTIALS; ANIMALS; ELECTRIC STIMULATION; HINDLIMB; INTERNEURONS; MEMBRANE POTENTIALS; MOTOR NEURONS; NERVE NET; NEURAL CONDUCTION; PATCH-CLAMP TECHNIQUES; PHYSICAL STIMULATION; SPINAL CORD; SYNAPTIC TRANSMISSION; TURTLES;

EID: 21844469735     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.0843-05.2005     Document Type: Article

References (35)

1. Alaburda A, Hounsgaard J (2003) Metabotropic modulation of motoneurons by scratch-like spinal network activity. J Neurosci 23:8625-8629.
2. Alaburda A, Perrier JF, Hounsgaard J (2002) Mechanisms causing plateau potentials in spinal motoneurones. Adv Exp Med Biol 508:219-226.
3. Bernander O, Douglas RJ, Martin KA, Koch C (1991) Synaptic background activity influences spatiotemporal integration in single pyramidal cells. Proc Natl Acad Sci USA 88:11569-11573.
4. Borg-Graham LJ, Monier C, Fregnac Y (1998) Visual input evokes transient and strong shunting inhibition in visual cortical neurons. Nature 393:369-373.
5. Brecht M, Schneider M, Sakmann B, Margrie TW (2004) Whisker movements evoked by stimulation of single pyramidal cells in rat motor cortex. Nature 427:704-710.
6. Chance FS, Abbott LF, Reyes AD (2002) Gain modulation from background synaptic input. Neuron 35:773-782.
7. Delgado-Lezama R, Perrier JF, Nedergaard S, Svirskis G, Hounsgaard J (1997) Metabotropic synaptic regulation of intrinsic response properties of turtle spinal motoneurones. J Physiol (Lond) 504:97-102.
8. Destexhe A, Pare D (1999) Impact of network activity on the integrative properties of neocortical pyramidal neurons in vivo. J Neurophysiol 81:1531-1547.
9. Destexhe A, Rudolph M, Pare D (2003) The high-conductance state of neocortical neurons in vivo. Nat Rev Neurosci 4:739-751.
10. Grillner S (2003) The motor infrastructure: from ion channels to neuronal networks. Nat Rev Neurosci 4:573-586.
11. Hounsgaard J, Kiehn O, Mintz I (1988) Response properties of motoneurones in a slice preparation of the turtle spinal cord. J Physiol (Lond) 398:575-589.
12. Keifer J, Stein PS (1983) In vitro motor program for the rostral scratch reflex generated by the turtle spinal cord. Brain Res 266:148-151.
13. Kernell D (1999) Repetitive impulse firing in motoneurons: facts and perspectives. Prog Brain Res 123:31-37.
14. Llinas RR (1988) The intrinsic electrophysiological properties of mammalian neurons: insights into central nervous system function. Science 242:1654-1664.
15. Melby ECJ, Altman NH (1974) Handbook of laboratory animal science. Cleveland: CRC.
16. Mortin LI, Stein PS (1989) Spinal cord segments containing key elements of the central pattern generators for three forms of scratch reflex in the turtle. J Neurosci 9:2285-2296.
17. Mortin LI, Keifer J, Stein PS (1985) Three forms of the scratch reflex in the spinal turtle: movement analyses. J Neurophysiol 53:1501-1516.
18. Nusbaum MP, Beenhakker MP (2002) A small-systems approach to motor pattern generation. Nature 417:343-350.
19. Perrier JF, Hounsgaard J (2003) 5-HT2 receptors promote plateau potentials in turtle spinal motoneurons by facilitating an L-type calcium current. J Neurophysiol 89:954-959.
20. 2+ channels. Brain Res Brain Res Rev 40:223-229.
21. Prescott SA, De Koninck Y (2003) Gain control of firing rate by shunting inhibition: roles of synaptic noise and dendritic saturation. Proc Natl Acad Sci USA 100:2076-2081.
22. Rapp M, Yarom Y, Segev I (1992) The impact of parallel fiber background activity on the cable properties of the cerebellar Purkinje cells. Neural Comput 4:518-533.
23. Robertson GA, Stein PS (1988) Synaptic control of hindlimb motoneurones during three forms of the fictive scratch reflex in the turtle. J Physiol (Lond) 404:101-128.
24. Rosenberg ME (1986) Carapace and plastron sensitivity to touch and vibration in the tortoise (Testudo hermanni and T. graeca). J Zool 208:443-455.
25. Rudolph M, Destexhe A (2003) Characterization of subthreshold voltage fluctuations in neuronal membranes. Neural Comput 15:2577-2618.
26. Russo RE, Hounsgaard J (1996a) Plateau-generating neurones in the dorsal horn in an in vitro preparation of the turtle spinal cord. J Physiol (Lond) 493:39-54.
27. Russo RE, Hounsgaard J (1996b) Burst-generating neurones in the dorsal horn in an in vitro preparation of the turtle spinal cord. J Physiol (Lond) 493:55-66.
28. Russo RE, Hounsgaard J (1999) Dynamics of intrinsic electrophysiological properties in spinal cord neurones. Prog Biophys Mol Biol 72:329-365.
29. Shadlen MN, Newsome WT (1994) Noise, neural codes and cortical organization. Curr Opin Neurobiol 4:569-579.
30. Shu Y, Hasenstaub A, McCormick DA (2003) Turning on and off recurrent balanced cortical activity. Nature 423:288-293.
31. Stauffer EK, Stuart DG, McDonagh JC, Hornby TG, Reinking RM (2005) After hyperpolarization-firing rate relation of turtle spinal neurons. J Comp Physiol [A] 191:135-146.
32. Stein PS (2005) Neuronal control of turtle hindlimb motor rhythms. J Comp Physiol [A] 191:213-229.
33. Stein PS, Daniels-McQueen S (2002) Modular organization of turtle spinal interneurons during normal and deletion fictive rostral scratching. J Neurosci 22:6800-6809.
34. Svirskis G, Hounsgaard J (1998) Transmitter regulation of plateau properties in turtle motoneurons. J Neurophysiol 79:45-50.
35. Wilson WA, Goldner MM (1975) Voltage clamping with a single microelectrode. J Neurobiol 6:411-422.