Effects of hyperthermia and boric acid on skeletal development in rat embryos

Birth Defects Research Part B - Developmental and Reproductive Toxicology

Volumn 74, Issue 3, 2005, Pages 268-276

  Harrouk, Wafa A ^a   Wheeler, Kellylynn E ^b,d   Kimmel, Gary L ^c,e   Hogan, Karen A ^c   Kimmel, Carole A ^c,e  

^a CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^b OAK RIDGE INSTITUTE FOR SCIENCE AND EDUCATION   (United States)

^c U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^d Gene Logic Inc   (United States)

^e Kimmel and Associates   (United States)

Author keywords

Boric acid; Combination exposure; Development; Hyperthermia; Rat; Segmentation defects; Skeleton

Indexed keywords

BORIC ACID;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; BONE DEVELOPMENT; EMBRYO; FEMALE; GENDER; HYPERTHERMIA; LUMBAR VERTEBRA; MALE; NONHUMAN; PERINATAL PERIOD; PRIORITY JOURNAL; RAT; RIB MALFORMATION; SKELETON MALFORMATION; VERTEBRA; VERTEBRA MALFORMATION;

ABNORMALITIES, DRUG-INDUCED; ANIMALS; BONE AND BONES; BORIC ACIDS; EMBRYO; FEMALE; FETUS; HEAT; INSECTICIDES; MALE; RATS; RATS, SPRAGUE-DAWLEY; SPINE;

ANIMALIA;

EID: 21744462923     PISSN: 15429733     EISSN: None     Source Type: Journal    
DOI: 10.1002/bdrb.20047     Document Type: Article

References (17)

1. Augustine-Rauch KA, Zhang QJ, Leonard JL, Chadderton A, Welsh MJ, Rami HK, Thompson M, Gaster L, Wier PJ, 2004. Evidence for a molecular mechanism of teratogenicity of SB-236057, a 5-HT1B receptor inverse agonist that alters axial formation. Birth Defects Res 70:789-807.
2. Beaudoin AR. 1978. Teratogenicity of sodium arsenate in rats. Teratology 10:153-158.
3. Breen JG, Claggett TW, Kimmel GL, Kimmel CA. 1999. Heat shock during rat embryo development in vitro results in decreased mitosis and abundant cell death. Reprod Toxicol 12:31-39.
4. Burgess R, Rawls A, Brown D, Bradley A, Olson EN. 1996. Requirement of the paraxis gene for somite formation and musculoskeletal patterning. Nature 384:570-573.
5. Cherrington JW, Chernoff N. 2002. Period of vertebral sensitivity to boric acid in CD-1 mice in utero. Reprod Toxicol 16:237-243.
6. Connelly LE, Rogers JM. 1997. Methanol causes posteriorization of cervical vertebrae in mice. Teratology 55:138-144.
7. Cuff JM, Kimmel GL, Kimmel CA, Heredia DJ, Tudor N, Chen J. 1993. The relationship between abnormal somite development and thoracic skeletal defects in rats following heat exposure. Teratology 48:259-266.
8. Haseman JK, Kupper LL. 1979. Analysis of dichotomous response data from certain toxicological experiments. Biometrics 35:281-293.
9. Heindel JJ, Price CJ, Schwetz BA. 1994. Developmental toxicity of boric acid in mice, rats and rabbits. Environ Health Perspect 102:107-112.
10. Kimmel CA, Cuff JM, Kimmel GL, Heredia DJ, Tudor N, Silverman PM, Chen J. 1993. Skeletal development following heat exposure in the rat. Teratology 47:229-242.
11. Kimmel GL, Williams PL, Claggett TW, Kimmel CA. 2002. Response-surface analysis of exposure-duration relationships: the effects of hyperthermia on embryonic development of the rat in vitro. Toxicol Sci 69:391-393.
12. Li ZL, Chisaka O, Koseki H, Akasaka T, Ishibashi M, Shiota K. 1997. Heat shock-induced homeotic transformations of the axial skeleton and associated shifts of Hox gene expression domains in mouse embryos. Reprod Toxicol 11:761-770.
13. Li ZL, Shiota K. 1999. Stage-specific homeotic vertebral transformations in mouse fetuses induced by maternal hyperthermia during somitogenesis. Dev Dyn 216:336-348.
14. Moore JA, an Expert Scientific Committee. 1997. An assessment of boric acid and borax using the IEHR evaluative process for assessing human developmental and reproductive toxicity of agents. Reprod Toxicol 11:123-160.
15. Narotsky MG, Schmid JE, Andrews JE, Kavlock RJ. 1998. Effects of boric acid on axial skeletal development in rats. Biol Trace Elem Res 66:373-394.
16. Nelson BK. 1994. Interactions in developmental toxicology: a literature review and terminology proposal. Teratology 49:33-71.
17. Wery N, Narotsky MG, Pacico N, Kavlock RJ, Picard JJ, Gofflot F. 2003. Defects in cervical vertebrae in boric acid-exposed rat embryos are associated with anterior shifts of Hox gene expression domains. Birth Defects Res A Clin Mol Teratol 67:59-67.