Response-surface analysis of exposure-duration relationships: The effects of hyperthermia on embryonic development of the rat in vitro

Toxicological Sciences

Volumn 69, Issue 2, 2002, Pages 391-399

  Kimmel, G L ^a   Williams, P L ^b   Claggett, T W ^c   Kimmel, C A ^a  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^b HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^c CHARLES RIVER LABORATORIES   (United States)

Author keywords

Developmental toxicity; Dose duration; Dose rate; Haber's law; Heat shock; Hyperthermia; Rat; Risk assessment; Whole embryo culture

Indexed keywords

ANALYTIC METHOD; ANIMAL TISSUE; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; EMBRYO; EMBRYO DEVELOPMENT; HYPERTHERMIA; IN VITRO STUDY; NONHUMAN; ORGANOGENESIS; RAT; RESPONSE SURFACE METHOD; THERMAL EXPOSURE;

ALGORITHMS; ANIMALS; EMBRYO; EMBRYONIC AND FETAL DEVELOPMENT; FEMALE; FEVER; MODELS, STATISTICAL; PREGNANCY; PROBABILITY; RATS; RATS, SPRAGUE-DAWLEY; SOMITES; TEMPERATURE; TIME FACTORS;

ANIMALIA; HABER;

EID: 0036772994     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/69.2.391     Document Type: Article

References (23)

1. Box, G. E. P., and Draper, N. (1987). Empirical Model-Building and Response Surfaces. Wiley, Philadelphia.
2. Bushnell, P. J. (1997). Concentration-time relationships for the effects of inhaled trichlorethylene on signal behavior in rats. Fundam. Appl. Toxicol. 36, 30-38.
3. Crofton, K. M., Padilla, S., Tilson, H. A., Anthony, D. C., Raymer, J. H., and MacPhail, R. C. (1996). The impact of dose rate on the neurotoxicity of acrylamide: The interaction of administered dose, target tissue concentrations, tissue damage, and functional effects. Toxicol. Appl. Pharmacol. 139, 163-176.
4. Cuff, J. M., Kimmel, G. L., Kimmel, C. A., Heredia, D. J., Tudor, N., and Chen, J. (1993). Relationship between abnormal somite development and axial skeletal defects in rats following heat exposure. Teratology 48, 259-266.
5. Eastern Research Group (1998). Summary of the U.S. EPA Workshop on the Relationship Between Exposure Duration and Toxicity. Prepared for the U. S. Environmental Protection Agency, Risk Assessment Forum, Washington, D.C., under Contract No. 68-D5-0028. Available from: Technical Information Staff, (202-564-3261).
6. Edwards, M. J. (1986). Hyperthermia as a teratogen: A review of experimental studies and their clinical significance. Teratog. Carcinog. Mutagen. 6, 563-582.
7. Edwards, M. J., Shiota, K., Smith, M. S., and Walsh, D. A. (1995). Hyperthermia and birth defects. Reprod. Toxicol. 9, 411-425.
8. Germaine, M.-A., Webster, W. S., and Edwards, M. J. (1985). Hyperthermia as a teratogen: Parameters determining hyperthermia-induced head defects in the rat. Teratology 31, 265-272.
9. Graham, J. M., Jr., Edwards, M. J., and Edwards, M. J. (1998). Teratogen update: Gestational effects of maternal hyperthermia due to febrile illnesses and resultant patterns of defects in humans. Teratology 58, 209-221.
10. Jarabek, A. M. (1995). Consideration of temporal toxicity challenges current default assumptions. Inhalation Toxicol. 7, 927-946.
11. Kimmel, C. A., Cuff, J. M., Kimmel, G. L., Heredia, D. J., Tudor, N., Silverman, P. M., and Chen, J. (1993a). Skeletal development following heat exposure in the rat. Teratology 47, 229-242,
12. Kimmel, G. L. (1995). Exposure-duration relationships: The risk assessment process for health effects other than cancer. Inhalation Toxicol. 7, 873-880.
13. Kimmel, G. L., Cuff, J. M., Kimmel, C. A., Heredia, D. J., Tudor, N., and Silverman, P. M. (1993b). Embryonic development in vitro following short-duration exposure to heat. Teratology 47, 243-251.
14. Mirkes, P. E. (1985). Effects of acute exposures to elevated temperatures on rat embryo growth and development in vitro. Teratology 32, 259-266.
15. Pierano, W. B., Mattie, D., and Smith, P. (1995). Proceedings of the conference on temporal aspects in risk assessment for noncancer endpoints. Inhalation Toxicol. 7, 837-1029.
16. Scharfstein, D. O., and Williams, P. L. (1994). Design of developmental toxicity studies for assessing joint effects of dose and duration. Risk Anal. 14, 1057-107.
17. Shiota, K. (1988). Induction of neural tube defects and skeletal malformations in mice following brief hyperthermia in utero. Biol. Neonate 53, 86-97.
18. U.S. EPA (1991). Guidelines for developmental toxicity risk assessment. Fed. Regist. 56, 63798-63826.
19. Walsh, D. A., Klein, N. W., Hightower, L. E., and Edwards, M. J. (1987). Heat shock and thermotolerance during early rat embryo development. Teratology 36, 181-191.
20. Weller, E., Long, N., Smith, A., Williams, P., Ravi, S., Gill, J., Henessey, R., Skornik, W., Brain, J., Kimmel, C., Kimmel, G., Holmes, L., and Ryan, L. (1999). Dose-rate effects of ethylene oxide exposure on developmental toxicity. Toxicol. Sci. 50, 259-270,
21. Williams, P. L., Molenbergs, G., and Lipsitz, S. (1996). Analysis of multiple ordinal outcomes in developmental toxicity studies. J. Agricultural Biol. Environ. Stat. 1, 1-25.
22. Witschi, H. (1999). Some notes on the history of Haber's Law. Toxicol. Sci. 50, 164-168.
23. Witschi, H. (1997). The story of the man who gave us Haber's Law. Inhalation Toxicol. 9, 201-209.