Investigation of glycine α-ketoamide HCV NS3 protease inhibitors: Effect of carboxylic acid isosteres

Bioorganic and Medicinal Chemistry Letters

Volumn 15, Issue 15, 2005, Pages 3487-3490

  Han, Wei ^a   Jiang, Xiangjun ^a   Hu, Zilun ^a   Wasserman, Zelda R ^a,b   Decicco, Carl P ^a  

^a BRISTOL MYERS SQUIBB   (United States)

^b Incyte Pharmaceuticals ^*  (United States)

Author keywords

HCV protease inhibitors

Indexed keywords

AMIDE; CARBOXYLIC ACID DERIVATIVE; PROTEINASE INHIBITOR; SULFONIC ACID DERIVATIVE; TETRAZOLE DERIVATIVE;

ARTICLE; DRUG DESIGN; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; HEPATITIS C VIRUS; IC 50;

AMIDES; BINDING SITES; CARBOXYLIC ACIDS; GLYCINE; HEPACIVIRUS; INHIBITORY CONCENTRATION 50; PROTEASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONIC ACIDS; TETRAZOLES; VIRAL NONSTRUCTURAL PROTEINS;

HEPATITIS C VIRUS;

EID: 21744454117     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2005.06.003     Document Type: Article

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