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Volumn 5, Issue SUPPL. 1, 2005, Pages

Epidermal growth factor receptor as a target for chemotherapy

Author keywords

Cetuximab; Erlotinib; Gefitinib; Matuzumab; Monoclonal antibodies; Panitumumab; Tyrosine kinase inhibitors

Indexed keywords

ANTINEOPLASTIC AGENT; CETUXIMAB; EPIDERMAL GROWTH FACTOR RECEPTOR; ERLOTINIB; GEFITINIB; MONOCLONAL ANTIBODY; PANITUMUMAB; QUINAZOLINE DERIVATIVE;

EID: 21744450766     PISSN: 15330028     EISSN: None     Source Type: Journal    
DOI: 10.3816/CCC.2005.s.003     Document Type: Article
Times cited : (71)

References (57)
  • 2
    • 10644281265 scopus 로고    scopus 로고
    • Capecitabine: The new generation of fluoropyrimidines in colorectal cancer
    • Iqbal S, Lenz HJ. Capecitabine: the new generation of fluoropyrimidines in colorectal cancer. Exp Rev Anticancer Ther 2004; 4:947-955.
    • (2004) Exp Rev Anticancer Ther , vol.4 , pp. 947-955
    • Iqbal, S.1    Lenz, H.J.2
  • 3
    • 0034712536 scopus 로고    scopus 로고
    • Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: A multicentre randomised trial
    • Douillard JY, Cunningham D, Roth AD, et al. Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: a multicentre randomised trial. Lancet 2000; 355:1041-1047.
    • (2000) Lancet , vol.355 , pp. 1041-1047
    • Douillard, J.Y.1    Cunningham, D.2    Roth, A.D.3
  • 4
    • 0033874892 scopus 로고    scopus 로고
    • Leucovorin and fluorouracil with or without oxaliplatin as first-line treatment in advanced colorectal cancer
    • de Gramont A, Figer A, Seymour M, et al. Leucovorin and fluorouracil with or without oxaliplatin as first-line treatment in advanced colorectal cancer. J Clin Oncol 2000; 18:2938-2947.
    • (2000) J Clin Oncol , vol.18 , pp. 2938-2947
    • de Gramont, A.1    Figer, A.2    Seymour, M.3
  • 5
    • 3242720345 scopus 로고    scopus 로고
    • Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer
    • Cunningham D, Humblet Y, Siena S, et al. Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer. N Engl J Med 2004; 351:337-345.
    • (2004) N Engl J Med , vol.351 , pp. 337-345
    • Cunningham, D.1    Humblet, Y.2    Siena, S.3
  • 6
    • 0036362181 scopus 로고    scopus 로고
    • Why the epidermal growth factor receptor? The rationale for cancer therapy
    • Baselga J. Why the epidermal growth factor receptor? The rationale for cancer therapy. Oncologist 2002; 7(suppl 4):2-8.
    • (2002) Oncologist , vol.7 , Issue.SUPPL. 4 , pp. 2-8
    • Baselga, J.1
  • 7
    • 0036500831 scopus 로고    scopus 로고
    • Monoclonal antibodies to target epidermal growth factor receptor-positive tumors: A new paradigm for cancer therapy
    • Herbst RS, Shin DM. Monoclonal antibodies to target epidermal growth factor receptor-positive tumors: a new paradigm for cancer therapy. Cancer 2002; 94:1593-1611.
    • (2002) Cancer , vol.94 , pp. 1593-1611
    • Herbst, R.S.1    Shin, D.M.2
  • 8
    • 0034773992 scopus 로고    scopus 로고
    • The EGFR family and its ligands in human cancer. signalling mechanisms and therapeutic opportunities
    • Yarden Y. The EGFR family and its ligands in human cancer. signalling mechanisms and therapeutic opportunities. Eur J Cancer 2001; 37(suppl 4):S3-S8.
    • (2001) Eur J Cancer , vol.37 , Issue.SUPPL. 4
    • Yarden, Y.1
  • 10
    • 0028955388 scopus 로고
    • Epidermal growth factor-related peptides and their receptors in human malignancies
    • Salomon DS, Brandt R, Ciardiello F, et al. Epidermal growth factor-related peptides and their receptors in human malignancies. Crit Rev Oncol Hematol 1995; 19:183-232.
    • (1995) Crit Rev Oncol Hematol , vol.19 , pp. 183-232
    • Salomon, D.S.1    Brandt, R.2    Ciardiello, F.3
  • 11
    • 0027415146 scopus 로고
    • The prognostic significance of proliferating cell nuclear antigen, epidermal growth factor receptor, and mdr gene expression in colorectal cancer
    • Mayer A, Takimoto M, Fritz E, et al. The prognostic significance of proliferating cell nuclear antigen, epidermal growth factor receptor, and mdr gene expression in colorectal cancer. Cancer 1993; 71:2454-2460.
    • (1993) Cancer , vol.71 , pp. 2454-2460
    • Mayer, A.1    Takimoto, M.2    Fritz, E.3
  • 12
    • 0023788201 scopus 로고
    • Increased epidermal growth factor receptor in multidrug-resistant human neuroblastoma cells
    • Meyers MB, Shen WP, Spengler BA, et al. Increased epidermal growth factor receptor in multidrug-resistant human neuroblastoma cells. J Cell Biochem 1988; 38:87-97.
    • (1988) J Cell Biochem , vol.38 , pp. 87-97
    • Meyers, M.B.1    Shen, W.P.2    Spengler, B.A.3
  • 13
    • 4143076078 scopus 로고    scopus 로고
    • Targeting the epidermal growth factor receptor
    • El-Rayes BF, LoRusso PM. Targeting the epidermal growth factor receptor. Br J Cancer 2004; 91:418-24.
    • (2004) Br J Cancer , vol.91 , pp. 418-424
    • El-Rayes, B.F.1    LoRusso, P.M.2
  • 14
    • 1842791537 scopus 로고    scopus 로고
    • Pharmacokinetic and pharmacodynamic properties of EGFR inhibitors under clinical investigation
    • Thomas SM, Grandis JR. Pharmacokinetic and pharmacodynamic properties of EGFR inhibitors under clinical investigation. Cancer Treat Rev 2004; 30:255-268.
    • (2004) Cancer Treat Rev , vol.30 , pp. 255-268
    • Thomas, S.M.1    Grandis, J.R.2
  • 15
    • 0034722889 scopus 로고    scopus 로고
    • The EGF receptor family as targets for cancer therapy
    • Mendelsohn J, Baselga J. The EGF receptor family as targets for cancer therapy. Oncogene 2000; 19:6550-6565.
    • (2000) Oncogene , vol.19 , pp. 6550-6565
    • Mendelsohn, J.1    Baselga, J.2
  • 16
    • 0028819660 scopus 로고
    • Biological efficacy of a chimeric antibody to the epidermal growth factor receptor in a human tumor xenograft model
    • Goldstein NI, Prewett M, Zuklys K, et al. Biological efficacy of a chimeric antibody to the epidermal growth factor receptor in a human tumor xenograft model. Clin Cancer Res 1995; 1:1311-1318.
    • (1995) Clin Cancer Res , vol.1 , pp. 1311-1318
    • Goldstein, N.I.1    Prewett, M.2    Zuklys, K.3
  • 17
    • 84898699439 scopus 로고    scopus 로고
    • ERBITUX® Cetuximab, package insert, New York, NY: Im-Clone Systems Incorporated; Princeton, NJ: Bristol-Myers Squibb; June 2004
    • ERBITUX® (Cetuximab) [package insert]. New York, NY: Im-Clone Systems Incorporated; Princeton, NJ: Bristol-Myers Squibb; June 2004.
  • 18
    • 0002823211 scopus 로고    scopus 로고
    • Cetuximab (IMC-C225) plus irinotecan (CPT-11) is active in CPT-11-refractory colorectal cancer (CRC) that expresses epidermal growth factor receptor (EGFR)
    • Abstract
    • Saltz L, Rubin M, Hochster H, et al. Cetuximab (IMC-C225) plus irinotecan (CPT-11) is active in CPT-11-refractory colorectal cancer (CRC) that expresses epidermal growth factor receptor (EGFR). Proc Am Soc Clin Oncol 2001; 20:3a (Abstract #7).
    • (2001) Proc Am Soc Clin Oncol , vol.20 , Issue.7
    • Saltz, L.1    Rubin, M.2    Hochster, H.3
  • 19
    • 2142641698 scopus 로고    scopus 로고
    • Phase II trial of cetuximab in patients with refractory colorectal cancer that expresses the epidermal growth factor receptor
    • Saltz LB, Meropol NJ, Loehrer PJ Sr, et al. Phase II trial of cetuximab in patients with refractory colorectal cancer that expresses the epidermal growth factor receptor. J Clin Oncol 2004; 22:1201-1208.
    • (2004) J Clin Oncol , vol.22 , pp. 1201-1208
    • Saltz, L.B.1    Meropol, N.J.2    Loehrer Sr, P.J.3
  • 20
    • 3543053772 scopus 로고    scopus 로고
    • Activity of cetuximab in patients with colorectal cancer refractory to both irinotecan and oxaliplatin
    • Abstract
    • Lenz HJ, Mayer RJ, Gold PJ, et al. Activity of cetuximab in patients with colorectal cancer refractory to both irinotecan and oxaliplatin. Proc Am Soc Clin Oncol 2004; 23:248 (Abstract #3510).
    • (2004) Proc Am Soc Clin Oncol , vol.23 , Issue.3510 , pp. 248
    • Lenz, H.J.1    Mayer, R.J.2    Gold, P.J.3
  • 21
    • 84898691978 scopus 로고    scopus 로고
    • Tabernero M, Van Cutsem E, Sastre J, et al. An international phase II study of cetuximab in combination with oxaliplatin/5-fluorouracil (5-FU)/folinic acid (FA) (FOLFOX-4) in the first-line treatment of patients with metastatic colorectal cancer (CRC) expressing epidermal growth factor receptor (EGFR): Preliminary results. Proc Am Soc Clin Oncol 2004; 23:248 (Abstract #3512).
    • Tabernero M, Van Cutsem E, Sastre J, et al. An international phase II study of cetuximab in combination with oxaliplatin/5-fluorouracil (5-FU)/folinic acid (FA) (FOLFOX-4) in the first-line treatment of patients with metastatic colorectal cancer (CRC) expressing epidermal growth factor receptor (EGFR): Preliminary results. Proc Am Soc Clin Oncol 2004; 23:248 (Abstract #3512).
  • 22
    • 0001407137 scopus 로고    scopus 로고
    • Erbitux (IMC-C225) plus weekly irinotecan (CPT-11), fluorouracil (5FU) and leucovorin (LV) in colorectal cancer (CRC) that expresses the epidermal growth factor receptor (EGFR)
    • Abstract
    • Rosenberg AH, Loehrer PJ, Needle MN, et al. Erbitux (IMC-C225) plus weekly irinotecan (CPT-11), fluorouracil (5FU) and leucovorin (LV) in colorectal cancer (CRC) that expresses the epidermal growth factor receptor (EGFR). Proc Am Soc Clin Oncol 2002; 21:135a (Abstract #536).
    • (2002) Proc Am Soc Clin Oncol , vol.21 , Issue.536
    • Rosenberg, A.H.1    Loehrer, P.J.2    Needle, M.N.3
  • 23
    • 84898695247 scopus 로고    scopus 로고
    • Folprecht G, Lutz MP, Schoeffski P, et al. Pharmacokinetic (PK) evaluation of cetuximab in combination with weekly irinotecan (CPT-11) and 24h infusional 5-FU/folinic acid (FA) as first line treatment in patients (pts) with epidermal growth factor receptor (EGFR)-positive metastatic colorectal cancer (MCRC). Proc Am Soc Clin Oncol 2003; 22:222 (Abstract #890).
    • Folprecht G, Lutz MP, Schoeffski P, et al. Pharmacokinetic (PK) evaluation of cetuximab in combination with weekly irinotecan (CPT-11) and 24h infusional 5-FU/folinic acid (FA) as first line treatment in patients (pts) with epidermal growth factor receptor (EGFR)-positive metastatic colorectal cancer (MCRC). Proc Am Soc Clin Oncol 2003; 22:222 (Abstract #890).
  • 24
    • 84898691771 scopus 로고    scopus 로고
    • Rougier P, Raoul JL, Van Laethem JL, et al. Cetuximab+FOLFIRI as first-line treatment for metastatic colorectal CA. Proc Am Soc Clin Oncol 2004; 23:248 (Abstract #3513).
    • Rougier P, Raoul JL, Van Laethem JL, et al. Cetuximab+FOLFIRI as first-line treatment for metastatic colorectal CA. Proc Am Soc Clin Oncol 2004; 23:248 (Abstract #3513).
  • 25
    • 0035724536 scopus 로고    scopus 로고
    • Cutaneous side-effects in cancer patients treated with the antiepidermal growth factor receptor antibody C225
    • Busam KJ, Capodieci P, Motzer R, et al. Cutaneous side-effects in cancer patients treated with the antiepidermal growth factor receptor antibody C225. Br J Dermatol 2001; 144:1169-1176.
    • (2001) Br J Dermatol , vol.144 , pp. 1169-1176
    • Busam, K.J.1    Capodieci, P.2    Motzer, R.3
  • 26
    • 2942588651 scopus 로고    scopus 로고
    • The humanized monoclonal anti-EGFR antibody EMD72000 potently inhibits the growth of EGFR-expressing human tumor xenografts insensitive to chemotherapeutic drugs
    • Abstract
    • Burger AM, Heiss NS, Kreysch H, et al. The humanized monoclonal anti-EGFR antibody EMD72000 potently inhibits the growth of EGFR-expressing human tumor xenografts insensitive to chemotherapeutic drugs. Proc Am Assoc Cancer Res 2003; 44:1139 (Abstract #5719).
    • (2003) Proc Am Assoc Cancer Res , vol.44 , Issue.5719 , pp. 1139
    • Burger, A.M.1    Heiss, N.S.2    Kreysch, H.3
  • 27
    • 1542344622 scopus 로고    scopus 로고
    • Phase I study of the humanized antiepidermal growth factor receptor monoclonal antibody EMD72000 in patients with advanced solid tumors that express the epidermal growth factor receptor
    • Vanhoefer U, Tewes M, Rojo F, et al. Phase I study of the humanized antiepidermal growth factor receptor monoclonal antibody EMD72000 in patients with advanced solid tumors that express the epidermal growth factor receptor. J Clin Oncol 2004; 22:175-184.
    • (2004) J Clin Oncol , vol.22 , pp. 175-184
    • Vanhoefer, U.1    Tewes, M.2    Rojo, F.3
  • 28
    • 0347615106 scopus 로고    scopus 로고
    • A phase I PK and serial tumor and skin pharmacodynamic (PD) study of weekly (q1w), every 2-week (q2w) or every 3-week (q3w) 1-hour (h) infusion EMD72000, a humanized monoclonal anti-epidermal growth factor receptor (EGFR) antibody, in patients (pt) with advanced tumors
    • Abstract
    • Tabernero J, Rojo F, Jimenez E, et al. A phase I PK and serial tumor and skin pharmacodynamic (PD) study of weekly (q1w), every 2-week (q2w) or every 3-week (q3w) 1-hour (h) infusion EMD72000, a humanized monoclonal anti-epidermal growth factor receptor (EGFR) antibody, in patients (pt) with advanced tumors. Proc Am Soc Clin Oncol 2003; 22:192 (Abstract #770).
    • (2003) Proc Am Soc Clin Oncol , vol.22 , Issue.770 , pp. 192
    • Tabernero, J.1    Rojo, F.2    Jimenez, E.3
  • 29
    • 10744221013 scopus 로고    scopus 로고
    • Preclinical and clinical evaluations of ABX-EGF, a fully human anti-epidermal growth factor receptor antibody
    • Foon KA, Yang XD, Weiner LM, et al. Preclinical and clinical evaluations of ABX-EGF, a fully human anti-epidermal growth factor receptor antibody. Int J Radiat Oncol Biol Phys 2004; 58:984-990.
    • (2004) Int J Radiat Oncol Biol Phys , vol.58 , pp. 984-990
    • Foon, K.A.1    Yang, X.D.2    Weiner, L.M.3
  • 30
    • 0035117355 scopus 로고    scopus 로고
    • Development of ABX-EGF, a fully human anti-EGF receptor monoclonal antibody, for cancer therapy
    • Yang XD, Jia XC, Corvalan JR, et al. Development of ABX-EGF, a fully human anti-EGF receptor monoclonal antibody, for cancer therapy. Crit Rev Oncol Hematol 2001; 38:17-23.
    • (2001) Crit Rev Oncol Hematol , vol.38 , pp. 17-23
    • Yang, X.D.1    Jia, X.C.2    Corvalan, J.R.3
  • 31
    • 0012679970 scopus 로고    scopus 로고
    • ABX-EGF, a fully human anti-epidermal growth factor receptor (EGFR) monoclonal antibody (mAb) in patients with advanced cancer: Phase 1 clinical results
    • Abstract
    • Figlin RA, Belldegrun AS, Crawford J, et al. ABX-EGF, a fully human anti-epidermal growth factor receptor (EGFR) monoclonal antibody (mAb) in patients with advanced cancer: phase 1 clinical results. Proc Am Soc Clin Oncol 2002; 21:10a (Abstract #35).
    • (2002) Proc Am Soc Clin Oncol , vol.21 , Issue.35
    • Figlin, R.A.1    Belldegrun, A.S.2    Crawford, J.3
  • 32
    • 6344272498 scopus 로고    scopus 로고
    • ABX-EGF monotherapy in patients (pts) with metastatic colorectal cancer (mCRC): An updated analysis
    • Abstract
    • Hecht JR, Patnaik A, Malik I, et al. ABX-EGF monotherapy in patients (pts) with metastatic colorectal cancer (mCRC): an updated analysis. Proc Am Soc Clin Oncol 2004; 23:248 (Abstract #3511).
    • (2004) Proc Am Soc Clin Oncol , vol.23 , Issue.3511 , pp. 248
    • Hecht, J.R.1    Patnaik, A.2    Malik, I.3
  • 33
    • 4143050397 scopus 로고    scopus 로고
    • Safety, pharmacokinetics, and activity of ABX-EGF, a fully human anti-epidermal growth factor receptor monoclonal antibody in patients with metastatic renal cell cancer
    • Rowinsky EK, Schwartz GH, Gollob JA, et al. Safety, pharmacokinetics, and activity of ABX-EGF, a fully human anti-epidermal growth factor receptor monoclonal antibody in patients with metastatic renal cell cancer. J Clin Oncol 2004; 22:3003-3015.
    • (2004) J Clin Oncol , vol.22 , pp. 3003-3015
    • Rowinsky, E.K.1    Schwartz, G.H.2    Gollob, J.A.3
  • 34
    • 0032695910 scopus 로고    scopus 로고
    • Inhibition of epidermal growth factor receptor-associated tyrosine phosphorylation in human carcinomas with CP-358,774: Dynamics of receptor inhibition in situ and antitumor effects in athymic mice
    • Pollack VA, Savage DM, Baker DA, et al. Inhibition of epidermal growth factor receptor-associated tyrosine phosphorylation in human carcinomas with CP-358,774: dynamics of receptor inhibition in situ and antitumor effects in athymic mice. J Pharmacol Exp Ther 1999; 291:739-748.
    • (1999) J Pharmacol Exp Ther , vol.291 , pp. 739-748
    • Pollack, V.A.1    Savage, D.M.2    Baker, D.A.3
  • 35
    • 0035398631 scopus 로고    scopus 로고
    • Phase I and pharmacologic study of OSI-774, an epidermal growth factor receptor tyrosine kinase inhibitor, in patients with advanced solid malignancies
    • Hidalgo M, Siu LL, Nemunaitis J, et al. Phase I and pharmacologic study of OSI-774, an epidermal growth factor receptor tyrosine kinase inhibitor, in patients with advanced solid malignancies. J Clin Oncol 2001; 19:3267-3279.
    • (2001) J Clin Oncol , vol.19 , pp. 3267-3279
    • Hidalgo, M.1    Siu, L.L.2    Nemunaitis, J.3
  • 36
    • 0345636045 scopus 로고    scopus 로고
    • Phase II study of erlotinib (OSI-774) in patients with metastatic colorectal cancer
    • Abstract
    • Oza AM, Townsley CA, Siu LL, et al. Phase II study of erlotinib (OSI-774) in patients with metastatic colorectal cancer. Proc Am Soc Clin Oncol 2003; 22:196 (Abstract #785).
    • (2003) Proc Am Soc Clin Oncol , vol.22 , Issue.785 , pp. 196
    • Oza, A.M.1    Townsley, C.A.2    Siu, L.L.3
  • 37
    • 30044452229 scopus 로고    scopus 로고
    • Phase II study of capecitabine, oxaliplatin and erlotinib in previously treated patients with metastatic colorectal cancer (MCRC)
    • Abstract
    • Meyerhardt A, Xhu A, Enzinger PC, et al. Phase II study of capecitabine, oxaliplatin and erlotinib in previously treated patients with metastatic colorectal cancer (MCRC). Proc Am Soc Clin Oncol 2004; 23:265 (Abstract #3580).
    • (2004) Proc Am Soc Clin Oncol , vol.23 , Issue.3580 , pp. 265
    • Meyerhardt, A.1    Xhu, A.2    Enzinger, P.C.3
  • 38
    • 4444238981 scopus 로고    scopus 로고
    • Results of a phase III trial of erlotinib (OSI-774) combined with cisplatin and gemcitabine (GC) chemotherapy in advanced non-small cell lung cancer (NSCLC)
    • Abstract
    • Gatzemeier U, Pluzanska A, Szczesna A, et al. Results of a phase III trial of erlotinib (OSI-774) combined with cisplatin and gemcitabine (GC) chemotherapy in advanced non-small cell lung cancer (NSCLC). Proc Am Soc Clin Oncol 2004; 23:617 (Abstract #7010).
    • (2004) Proc Am Soc Clin Oncol , vol.23 , Issue.7010 , pp. 617
    • Gatzemeier, U.1    Pluzanska, A.2    Szczesna, A.3
  • 39
    • 24944440830 scopus 로고    scopus 로고
    • TRIBUTE - A phase III trial of erlotinib HCl (OSI-774) combined with carboplatin and paclitaxel (CP) chemotherapy in advanced non-small cell lung cancer (NSCLC)
    • Abstract
    • Herbst RS, Prager D, Hermann R, et al. TRIBUTE - A phase III trial of erlotinib HCl (OSI-774) combined with carboplatin and paclitaxel (CP) chemotherapy in advanced non-small cell lung cancer (NSCLC). Proc Am Soc Clin Oncol 2004; 23:617 (Abstract #7011).
    • (2004) Proc Am Soc Clin Oncol , vol.23 , Issue.7011 , pp. 617
    • Herbst, R.S.1    Prager, D.2    Hermann, R.3
  • 40
    • 84898691225 scopus 로고    scopus 로고
    • Shepherd FA, Pereira J, Ciuleanu TE, et al. A randomized placebo-controlled trial of erlotinib in patients with advanced non-small cell lung cancer (NSCLC) following failure of 1st line or 2nd line chemotherapy. A National Cancer Institute of Canada Clinical Trials Group (NCIC CTG) trial. Proc Am Soc Clin Oncol 2004; 23:18 (Abstract #7022).
    • Shepherd FA, Pereira J, Ciuleanu TE, et al. A randomized placebo-controlled trial of erlotinib in patients with advanced non-small cell lung cancer (NSCLC) following failure of 1st line or 2nd line chemotherapy. A National Cancer Institute of Canada Clinical Trials Group (NCIC CTG) trial. Proc Am Soc Clin Oncol 2004; 23:18 (Abstract #7022).
  • 41
    • 0345205996 scopus 로고    scopus 로고
    • Rash severity is predictive of increased survival with erlotinib HCl
    • Abstract
    • Clark GM, Pérez-Soler R, Siu L, et al. Rash severity is predictive of increased survival with erlotinib HCl. Proc Am Soc Clin Oncol 2003; 22:196 (Abstract #786).
    • (2003) Proc Am Soc Clin Oncol , vol.22 , Issue.786 , pp. 196
    • Clark, G.M.1    Pérez-Soler, R.2    Siu, L.3
  • 42
    • 0033763084 scopus 로고
    • Iressa') as an anticancer agent
    • Baselga J, Averbuch SD. ZD1839 ('Iressa') as an anticancer agent. Drugs 2000; 60(suppl 1):33-40.
    • (1839) Drugs , vol.60 , Issue.SUPPL. 1 , pp. 33-40
    • Baselga, J.1    Averbuch, S.Z.2
  • 43
    • 6444230253 scopus 로고    scopus 로고
    • A phase II study of gefitinib in combination with FOLFOX-4 (IFOX) in patients with metastatic colorectal cancer
    • Abstract
    • Fisher GA, Kuo T, Cho CD, et al. A phase II study of gefitinib in combination with FOLFOX-4 (IFOX) in patients with metastatic colorectal cancer. Proc Am Soc Clin Oncol 2004; 23:249 (Abstract #3514).
    • (2004) Proc Am Soc Clin Oncol , vol.23 , Issue.3514 , pp. 249
    • Fisher, G.A.1    Kuo, T.2    Cho, C.D.3
  • 44
    • 0012381722 scopus 로고    scopus 로고
    • Multi-institutional randomized phase II trial of gefitinib for previously treated patients with advanced non-small-cell lung cancer
    • Fukuoka M, Yano S, Giaccone G, et al. Multi-institutional randomized phase II trial of gefitinib for previously treated patients with advanced non-small-cell lung cancer. J Clin Oncol 2003; 21:2237-2246.
    • (2003) J Clin Oncol , vol.21 , pp. 2237-2246
    • Fukuoka, M.1    Yano, S.2    Giaccone, G.3
  • 45
    • 0142055937 scopus 로고    scopus 로고
    • Efficacy of gefitinib, an inhibitor of the epidermal growth factor receptor tyrosine kinase, in symptomatic patients with non-small cell lung cancer: A randomized trial
    • Kris MG, Natale RB, Herbst RS, et al. Efficacy of gefitinib, an inhibitor of the epidermal growth factor receptor tyrosine kinase, in symptomatic patients with non-small cell lung cancer: a randomized trial. JAMA 2003; 290:2149-2158.
    • (2003) JAMA , vol.290 , pp. 2149-2158
    • Kris, M.G.1    Natale, R.B.2    Herbst, R.S.3
  • 46
    • 1542503746 scopus 로고    scopus 로고
    • Gefitinib in combination with gemcitabine and cisplatin in advanced non-small-cell lung cancer: A phase III trial - INTACT 1
    • Giaccone G, Herbst RS, Manegold C, et al. Gefitinib in combination with gemcitabine and cisplatin in advanced non-small-cell lung cancer: a phase III trial - INTACT 1. J Clin Oncol 2004; 22:777-784.
    • (2004) J Clin Oncol , vol.22 , pp. 777-784
    • Giaccone, G.1    Herbst, R.S.2    Manegold, C.3
  • 47
    • 1542713370 scopus 로고    scopus 로고
    • Gefitinib in combination with paclitaxel and carboplatin in advanced non-small-cell lung cancer: A phase III trial - INTACT 2
    • Herbst RS, Giaccone G, Schiller JH, et al. Gefitinib in combination with paclitaxel and carboplatin in advanced non-small-cell lung cancer: a phase III trial - INTACT 2. J Clin Oncol 2004; 22:785-794.
    • (2004) J Clin Oncol , vol.22 , pp. 785-794
    • Herbst, R.S.1    Giaccone, G.2    Schiller, J.H.3
  • 48
    • 12744280441 scopus 로고    scopus 로고
    • Skin rash and good performance status (PS) predicts improved survival with gefitinib for patients with advanced non-small cell lung cancer (NSCLC)
    • Abstract
    • Mohamed MK, Ramalingam S, Lin Y et al. Skin rash and good performance status (PS) predicts improved survival with gefitinib for patients with advanced non-small cell lung cancer (NSCLC). Proc Am Soc Clin Oncol 2004; 23:617 (Abstract #7097).
    • (2004) Proc Am Soc Clin Oncol , vol.23 , Issue.7097 , pp. 617
    • Mohamed, M.K.1    Ramalingam, S.2    Lin, Y.3
  • 49
    • 2342471392 scopus 로고    scopus 로고
    • Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
    • Lynch TJ, Bell DW, Sordella R, et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med 2004; 350:2129-2139.
    • (2004) N Engl J Med , vol.350 , pp. 2129-2139
    • Lynch, T.J.1    Bell, D.W.2    Sordella, R.3
  • 50
    • 2342624080 scopus 로고    scopus 로고
    • EGFR mutations in lung cancer: Correlation with clinical response to gefitinib therapy
    • Paez JG, Janne PA, Lee JC, et al. EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Science 2004; 304:1497-1500.
    • (2004) Science , vol.304 , pp. 1497-1500
    • Paez, J.G.1    Janne, P.A.2    Lee, J.C.3
  • 51
    • 13244251062 scopus 로고    scopus 로고
    • CYFRA 21-1 level predicts survival in non-small-cell lung cancer patients receiving gefitinib as third-line therapy
    • Barlesi F, Tchouhadjian C, Doddoli C, et al. CYFRA 21-1 level predicts survival in non-small-cell lung cancer patients receiving gefitinib as third-line therapy. Br J Cancer 2004; 92:13-14.
    • (2004) Br J Cancer , vol.92 , pp. 13-14
    • Barlesi, F.1    Tchouhadjian, C.2    Doddoli, C.3
  • 52
    • 0030697807 scopus 로고    scopus 로고
    • PD153035, a tyrosine kinase inhibitor, prevents epidermal growth factor receptor activation and inhibits growth of cancer cells in a receptor number-dependent manner
    • Bos M, Mendelsohn J, Kim YM, et al. PD153035, a tyrosine kinase inhibitor, prevents epidermal growth factor receptor activation and inhibits growth of cancer cells in a receptor number-dependent manner. Clin Cancer Res 1997; 3:2099-2106.
    • (1997) Clin Cancer Res , vol.3 , pp. 2099-2106
    • Bos, M.1    Mendelsohn, J.2    Kim, Y.M.3
  • 53
    • 0033863510 scopus 로고    scopus 로고
    • RAS transformation causes sustained activation of epidermal growth factor receptor and elevation of mitogen-activated protein kinase in human mammary epithelial cells
    • Martinez-Lacaci I, Kannan S, De Santis M, et al. RAS transformation causes sustained activation of epidermal growth factor receptor and elevation of mitogen-activated protein kinase in human mammary epithelial cells. Int J Cancer 2000; 88:44-52.
    • (2000) Int J Cancer , vol.88 , pp. 44-52
    • Martinez-Lacaci, I.1    Kannan, S.2    De Santis, M.3
  • 54
    • 4744363900 scopus 로고    scopus 로고
    • Phase I/II trial evaluating the anti-VEGF MAb bevacizumab in combination with erlotinib, a HER1/EGFR-TK inhibitor, for patients with recurrent non-small cell lung cancer
    • Abstract
    • Sandler AB, Blumenschein GR, Henderson T, et al. Phase I/II trial evaluating the anti-VEGF MAb bevacizumab in combination with erlotinib, a HER1/EGFR-TK inhibitor, for patients with recurrent non-small cell lung cancer. Proc Am Soc Clin Oncol 2004; 23:127 (Abstract #2000).
    • (2000) Proc Am Soc Clin Oncol , vol.2004 , Issue.23 , pp. 127
    • Sandler, A.B.1    Blumenschein, G.R.2    Henderson, T.3
  • 57
    • 27644569112 scopus 로고    scopus 로고
    • A pilot feasibility study of gefitinib (ZD1839) and celecoxib in metastatic GI tumors
    • Abstract
    • Yamaguchi NH, Mayer IA, Malzyner A, et al. A pilot feasibility study of gefitinib (ZD1839) and celecoxib in metastatic GI tumors. Proc Am Soc Clin Oncol 2004; 23:216 (Abstract #3086).
    • (2004) Proc Am Soc Clin Oncol , vol.23 , Issue.3086 , pp. 216
    • Yamaguchi, N.H.1    Mayer, I.A.2    Malzyner, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.