The prognostic significance of the tumour infiltrating lymphocyte count in stage I testicular seminoma managed by surveillance

European Journal of Cancer

Volumn 38, Issue 15, 2002, Pages 2014-2019

  Parker, C ^a   Milosevic, M ^a   Panzarella, T ^b   Banerjee, D ^a   Jewett, M ^b   Catton, C ^a   Tew George, B ^a   Gospodarowicz, M ^a   Warde, P ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

Lymphocytes, tumour infiltrating; Prognosis; Seminoma

Indexed keywords

ADULT; AGE; ARTICLE; CANCER INVASION; CANCER RECURRENCE; CANCER STAGING; CARCINOGENESIS; CARDIOVASCULAR SYSTEM; CELL ASSAY; CLINICAL TRIAL; CONFIDENCE INTERVAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE ASSOCIATION; FOLLOW UP; HAZARD ASSESSMENT; HUMAN; LYMPH NODE; LYMPHOCYTE COUNT; LYMPHOCYTIC INFILTRATION; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROGNOSIS; RELAPSE; RETE TESTIS; SEMINOMA; STATISTICAL SIGNIFICANCE; TUMOR ASSOCIATED LEUKOCYTE;

ADULT; AGED; ANALYSIS OF VARIANCE; HUMANS; LYMPHOCYTE COUNT; LYMPHOCYTES, TUMOR-INFILTRATING; MALE; MIDDLE AGED; NEOPLASM RECURRENCE, LOCAL; PLOIDIES; PROGNOSIS; RISK FACTORS; SEMINOMA; TESTICULAR NEOPLASMS;

EID: 0036790750     PISSN: 09598049     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-8049(02)00235-6     Document Type: Article

References (33)

1. Ansell S.M., Stenson M., Habermann T.M., Jelinek D.F., Witzig T.E. Cd4+ T-cell immune response to large B-cell non-Hodgkin's lymphoma predicts patient outcome. J. Clin. Oncol. 19:2001;720-726.
2. Morita M., Kuwano H., Araki K.et al. Prognostic significance of lymphocyte infiltration following preoperative chemoradiotherapy and hyperthermia for esophageal cancer. Int. J. Radiat. Oncol. Biol Phys. 49:2001;1259-1266.
3. Schumacher K., Haensch W., Roefzaad C., Schlag P.M. Prognostic significance of activated CD8(+) T cell infiltrations within esophageal carcinomas. Cancer Res. 61:2001;3932-3936.
4. Mihm M.C. Jr., Clemente C.G., Cascinelli N. Tumor infiltrating lymphocytes in lymph node melanoma metastases. a histopathologic prognostic indicator and an expression of local immune response Lab. Invest. 74:1996;43-47.
5. Ropponen K.M., Eskelinen M.J., Lipponen P.K., Alhava E., Kosma V.M. Prognostic value of tumour-infiltrating lymphocytes (TILs) in colorectal cancer. J. Pathol. 182:1997;318-324.
6. Marrogi A.J., Munshi A., Merogi A.J.et al. Study of tumor infiltrating lymphocytes and transforming growth factor-beta as prognostic factors in breast carcinoma. Int. J. Cancer. 74:1997;492-501.
7. Torres A., Casanova J.F., Nistal M., Regadera J. Quantification of immunocompetent cells in testicular germ cell tumours. Histopathology. 30:1997;23-30.
8. Nakanoma T., Nakamura K., Deguchi N., Fujimoto J., Tazaki H., Hata J. Immunohistological analysis of tumour infiltrating lymphocytes in seminoma using monoclonal antibodies. Virchows Arch. A Pathol. Anat. Histopathol. 421:1992;409-413.
9. Bell D.A., Flotte T.J., Bhan A.K. Immunohistochemical characterization of seminoma and its inflammatory cell infiltrate. Hum. Pathol. 18:1987;511-520.
10. Hittmair A., Rogatsch H., Feichtinger H., Hobisch A., Mikuz G. Testicular seminomas are aneuploid tumors. Lab. Invest. 72:1995;70-74.
11. el-Naggar A.K., Ro J.Y., McLemore D., Ayala A.G., Batsakis J.G. DNA ploidy in testicular germ cell neoplasms. Histogenetic and clinical implications. Am. J. Surg. Pathol. 16:1992;611-618.
12. Fossa S.D., Nesland J.M., Pettersen E.O., Amellem O., Waehre H., Heimdal K. DNA ploidy in primary testicular cancer. Br. J. Cancer. 64:1991;948-952.
13. Mor Y, Leibovich I, Raviv G, et al. Testicular seminoma: clinical significance of nuclear deoxyribonucleic acid ploidy pattern as studied by flow cytometry [see comments]. J Urol 1995, 154, 1041-1043 [discussion 1044].
14. Nativ O., Winkler H.Z., Reiman H.R. Jr., Earle J.D., Lieber M.M. Primary testicular seminoma. prognostic significance of nuclear DNA ploidy pattern Eur. Urol. 31:1997;401-404.
15. Suzuki M., Hosaka Y., Matsushima H., Mizutani T., Kawabe K. Nuclear deoxyribonucleic acid ploidy of testicular tumors. peculiar features and clinical significance Urol. Int. 57:1996;203-208.
16. Warde P, Gospodarowicz MK, Banerjee D, et al. Prognostic factors for relapse in stage I testicular seminoma treated with surveillance. J Urol 1997, 157, 1705-1709 [discussion 1709-1710].
17. Hedley D.W., Friedlander M.L., Taylor I.W., Rugg C.A., Musgrove E.A. Method for analysis of cellular DNA content of paraffin-embedded pathological material using flow cytometry. J. Histochem. Cytochem. 31:1983;1333-1335.
18. Colett D. Modelling Survival Data in Medical Research. 1994;Chapman and Hall, London.
19. Holmes A.S., Klimberg I.W., Stonesifer K.J., Kramer B.S., Wajsman Z. Spontaneous regression of testicular seminoma. case report J. Urol. 135:1986;795-796.
20. Naseem S., Azzopardi A., Shrotri N., Mufti G.R. The shrinking seminoma - fact or fiction? Urol. Int. 65:2000;208-210.
21. Cohen E.M. Seminoma appearing as a retroperitoneal mass associated with a testicular scar. J. Am. Osteopath. Assoc. 75:1976;820-825.
22. Frisch M., Biggar R.J., Engels E.A., Goedert J.J. Association of cancer with AIDS-related immunosuppression in adults. JAMA. 285:2001;1736-1745.
23. Borre M., Hoyer M., Nerstrom B., Overgaard J. DNA ploidy and survival of patients with clinically localized prostate cancer treated without intent to cure. Prostate. 36:1998;244-249.
24. Pollack A., Troncoso P., Zagars G.K.et al. The significance of DNA-ploidy and S-phase fraction in node-positive (stage D1) prostate cancer treated with androgen ablation. Prostate. 31:1997;21-28.
25. Alderisio M., Cenci M., Valli C.et al. Nm23-H1 protein, DNA-ploidy and S-phase fraction in relation to overall survival and disease free survival in transitional cell carcinoma of the bladder. Anticancer Res. 18:1998;4225-4230.
26. Danesi D.T., Spano M., Fabiano A.et al. Flow cytometric DNA ploidy, p53, PCNA, and c-erbB-2 protein expressions as predictors of survival in surgically resected gastric cancer patients. Cytometry. 42:2000;27-34.
27. Salud A., Porcel J.M., Raikundalia B., Camplejohn R.S., Taub N.A. Prognostic significance of DNA ploidy, S-phase fraction, and P-glycoprotein expression in colorectal cancer. J Surg Oncol. 72:1999;167-174.
28. Susini T., Rapi S., Massi D.et al. Preoperative evaluation of tumor ploidy in endometrial carcinoma. an accurate tool to identify patients at risk for extrauterine disease and recurrence Cancer. 86:1999;1005-1012.
29. Hemmer J., Nagel E., Kraft K. DNA aneuploidy by flow cytometry is an independent prognostic factor in squamous cell carcinoma of the oral cavity. Anticancer Res. 19:1999;1419-1422.
30. Ben Arush M.W., Linn S., Ben-Izhak O.et al. Prognostic significance of DNA ploidy in childhood astrocytomas. Pediatr. Hematol. Oncol. 16:1999;387-396.
31. Bols B., Jensen L., Jensen A., Braendstrup O. Immunopathology of in situ seminoma. Int. J. Exp. Pathol. 81:2000;211-217.
32. Nouri A.M., Hussain R.F., Oliver R.T., Handy A.M., Bartkova I., Bodmer J.G. Immunological paradox in testicular tumours. the presence of a large number of activated T-cells despite the complete absence of MHC antigens Eur. J. Cancer. 29A:1993;1895-1899.
33. Thackray A.C., Crane W.A.J. Seminoma. Pugh R.C.B. Pathology of the Testis. 1976;164-168 Blackwell Scientific, Oxford.