Intercomparison of apoptosis morphology with active dna cleavage on single cells in vitro and on testis tumours

Journal of Pathology

Volumn 185, Issue 4, 1998, Pages 419-426

  Abend, M ^a   Schmelz, H U ^b   Kraft, K ^b   Rhein, A P ^a   Van Beuningen, D ^a   Sparwasser, C ^b  

^a Sanitatsakademie der Bundeswehr   (Germany)

^b Military Hospital Ulm   (Germany)

Author keywords

Apoptosis; HL 60 cells; Laser scanning microscopy; TdT; Testis tumour

Indexed keywords

APOPTOSIS; ARTICLE; CELL STRAIN HL 60; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; DNA CLEAVAGE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOFLUORESCENCE MICROSCOPY; PRIORITY JOURNAL; TESTIS TUMOR;

APOPTOSIS; DNA FRAGMENTATION; DNA, NEOPLASM; HUMANS; LEUKEMIA, MYELOID; MALE; MICROSCOPY, CONFOCAL; MICROSCOPY, FLUORESCENCE; TESTICULAR NEOPLASMS; TESTIS; TUMOR CELLS, CULTURED;

EID: 0031846964     PISSN: 00223417     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1096-9896(199808)185:4<419::AID-PATH126>3.0.CO;2-B     Document Type: Article

References (18)

1. Glücksmann A. Cell deaths in normal vertebrate ontogeny. Biol Rev Camb Philos Soc 1951; 26: 59-86.
2. Kerr JFR, Wyllie AH, Currie AR. Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer 1972; 26: 239-257.
3. Houge G, Doskeland SO. Divergence towards a dead end? Cleavage of the divergent domains of ribosomal RNA in apoptosis. Experientia 1996; 10: 963-967.
4. Zhivotovsky B, Burgess DH, Orrenius S. Proteases in apoptosis. Experientia 1996; 10: 968-978.
5. Lavin MF, Watters D, Song Q. Role of protein kinase activity in apoptosis. Experientia 1996; 10: 979-994.
6. Wyllie AH, Morris RG, Smith AL, Dunlop D. Chromatin cleavage in apoptosis: association with condensed chromatin morphology and dependence on macromolecular synthesis. J Pathol 1984; 142: 67-77.
7. Gorczyca W, Tuziak T, Kram A, Melamed MR, Darzynkiewicz Z. Detection of apoptosis-associated DNA strand breaks in fine-needle aspiration biopsies by in situ end labelling of fragmented DNA. Cytometry 1994; 15: 169-175.
8. Czader M, Mazur J, Pettersson M, et al. Prognostic significance of proliferative and apoptotic fractions in low grade follicle center cell-derived non-Hodgkin's lymphomas. Cancer 1996; 77: 1180-1188.
9. Li WC, Kuszak JR, Wang GM, Wu ZQ, Spector A. Calcimycin-induced lens epithelial cell apoptosis contributes to cataract formation. Exp Eye Res 1995; 61: 91-98.
10. Shoji Y, Saegusa M, Takano Y, Ohbu M, Okayasu I. Correlation of apoptosis with tumour cell differentiation, progression, and HPV infection in cervical carcinoma. J Clin Pathol 1996; 49: 134-138.
11. Charriaut-Marlangue C, Ben-Ari Y. A cautionary note on the use of the TUNEL stain to determine apoptosis. Neur Rep 1995; 7: 61-64.
12. Grasl-Kraupp B, Ruttkay-Nedecky B, Koudelka H, Bukowska K, Bursch W, Schulte-Hermann R. In situ detection of fragmented DNA (TUNEL assay) fails to discriminate among apoptosis, necrosis, and autolytic cell death: a cautionary note. Hepatology 1995; 21: 1465-1468.
13. Chang GQ, Gaitan A, Hao Y, Wong F. Correlation of DNA fragmentation and chromatin condensation in apoptotic nuclei of the Ser 6 mouse retina. Microsc Res Tech 1997; 36: 123-129.
14. Obcrhammer F, Wilson JW, Dive C, et al. Apoptotic death in epithelial cells: cleavage of DNA to 300 and/or 50 kb fragments prior to or in the absence of internucleosomal fragmentation. EMBO J 1993; 12: 3679-3684.
15. Collins RJ, Harmon BV, Gobe GC, Kerr JFR. Internucleosomal DNA cleavage should not be the sole criterion for identifying apoptosis. Int J Radial Biol 1992; 61: 451-453.
16. Migheli A, Attanasio A, Shiffer D. Ultrastructural detection of DNA strand breaks in apoptotic neural cells by in situ end-labelling techniques. J Pathol 1995; 176: 27-35.
17. Ashwell JD, Berger NA, Cidlowski JA, Lane DP, Korsmeyer SJ. Coming to terms with death: apoptosis in cancer and immune development. Immunol Today 1994; 15: 147-151.
18. Isaacs JT. Advances and controversies in the study of programmed cell death/apoptosis in the development of and therapy for cancer. Curr Opin Oncol 1994; 6: 82-89.