Cytoprotection of vascular endotheliocytes by phosphorylated ascorbate through suppression of oxidative stress that is generated immediately after post-anoxic reoxygenation or with alkylhydroperoxides

Journal of Cellular Biochemistry

Volumn 93, Issue 4, 2004, Pages 653-663

  Saitoh, Yasukazu ^a,b   Miwa, Nobuhiko ^a  

^a PREFECTURAL UNIVERSITY OF HIROSHIMA   (Japan)

^b Ophtecs Corporation   (Japan)

Author keywords

Anoxia and reoxygenation; Cell death; L ascorbic acid 2 O phosphate; Reactive oxygen species; Tert butyl hydroperoxide

Indexed keywords

ALKYLHYDROPEROXIDE; ASCORBIC ACID 2 PHOSPHATE; CYTOCHROME C; HYDROPEROXIDE DERIVATIVE; SUPEROXIDE; UNCLASSIFIED DRUG; ANTIOXIDANT; ASCORBATE-2-PHOSPHATE; ASCORBIC ACID; DRUG DERIVATIVE; REACTIVE OXYGEN METABOLITE; TERT BUTYL HYDROPEROXIDE;

ANOXIA; ARTICLE; CELL DEATH; CELL PROTECTION; CELL VIABILITY; OXIDATIVE PHOSPHORYLATION; OXIDATIVE STRESS; PRIORITY JOURNAL; REOXYGENATION; ANIMAL; CATTLE; CELL HYPOXIA; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; ENDOTHELIUM CELL; HUMAN; METABOLISM; PHYSIOLOGY; UMBILICAL VEIN; VASCULAR ENDOTHELIUM;

ANIMALS; ANTIOXIDANTS; ASCORBIC ACID; CATTLE; CELL DEATH; CELL HYPOXIA; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; HUMANS; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; TERT-BUTYLHYDROPEROXIDE; UMBILICAL VEINS;

EID: 21744436493     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.20245     Document Type: Article

References (36)

1. Adams JD, Mukherjee SK, Klaidman LK, Chang ML, Yasharel R. 1996. Apoptosis and oxidative stress in the aging brain. Ann NY Acad Sci 786:135-151.
2. Antonenkov VD, Sies H. 1992. Ascorbate-dependent capacity of dialysed rat liver cytosol to prevent nonenzymatic lipid peroxidation. Biol Chem Hoppe Seyler 373:1111-1116.
3. Bissell MJ, Hatie C, Farson DA, Schwarz RI, Soo WJ. 1980. Ascorbic acid inhibits replication and infectivity of avian RNA tumor virus. Proc Natl Acad Sci USA 77:2711-2715.
4. Bunce GE, Kinoshita J, Horwitz J. 1990. Nutritional factors in cataract. Annu Rev Nutr 10:233-254.
5. Cepinskas G, Lush CW, Kvietys PR. 1999. Anoxia/reoxygenation-induced tolerance with respect to polymorphonuclear leukocyte adhesion to cultured endothelial cells. A nuclear factor-kappaB-mediated phenomenon. Circ Res 84:103-112.
6. Chance B, Sies H, Boveris A. 1979. Hydroperoxide metabolism in mammalian organs. Physiol Rev 59:527-605.
7. Eguchi M, Miyazaki T, Masatsuji-Kato E, Tsuzuki T, Oribe T, Miwa N. 2003a. Cytoprotection against ischemia-induced DNA cleavages and cell injuries in the rat liver by pro-vitamin C via hydrolytic conversion into ascorbate. Mol Cell Biochem 252:17-23.
8. Eguchi M, Monden K, Miwa N. 2003b. Role of MAPK phosphorylation in cytoprotection by pro-vitamin C against oxidative stress-induced injuries in cultured cardiomyoblasts and perfused rat heart. J Cell Biochem 90:219-226.
9. Enstrom JE, Kanim LE, Klein MA. 1992. Vitamin C intake and mortality among a sample of the United States population. Epidemiology 3:194-202.
10. Frei B. 1999. On the role of vitamin C and other antioxidants in atherogenesis and vascular dysfunction. Proc Soc Exp Biol Med 222:196-204.
11. Frei B, Stocker R, Ames BN. 1988. Antioxidant defenses and lipid peroxidation in human blood plasma. Proc Natl Acad Sci USA 85:9748-9752.
12. Fujiwara M, Nagao N, Monden K, Misumi M, Kageyama K, Yamamoto K, Miwa N. 1997. Enhanced protection against peroxidation-induced mortality of aortic endothelial cells by ascorbic acid-2-O-phosphate abundantly accumulated in the cell as the dephosphorylated form. Free Radic Res 27:97-104.
13. Furumoto K, Inoue E, Nagao N, Hiyama E, Miwa N. 1998. Age-dependent telomere shortening is slowed down by enrichment of intracellular vitamin C via suppression of oxidative stress. Life Sci 63:935-948.
14. Gey KF, Stahelin HB, Puska P, Evans A. 1987. Relationship of plasma level of vitamin C to mortality from ischemic heart disease. Ann NY Acad Sci 498:110-123.
15. Halliwell B, Gutteridge JM. 1990. The antioxidants of human extracellular fluids. Arch Biochem Biophys 280: 1-8.
16. Halliwell B, Gutteridge JM. 1994. Oxygen toxicity, oxygen radicals, transition metals and disease. Biochem J 219: 1-14.
17. Halliwell B, Gutteridge JM, Cross CE. 1992. Free radicals, antioxidants, and human disease: Where are we now? J Lab Clin Med 119:598-620.
18. Hata R, Senoo H. 1989. L-ascorbic acid 2-phosphate stimulates collagen accumulation, cell proliferation, and formation of a three-dimensional tissuelike substance by skin fibroblasts. J Cell Physiol 138:8-16.
19. Kageyama K, Onoyama Y, Otani S, Matsui-Yuasa I, Nagao N, Miwa N. 1995. Enhanced inhibitory effects of hyperthermia combined with ascorbic acid on DNA synthesis in Ehrlich ascites tumor cells grown at a low cell density. Cancer Biochem Biophys 14:273-280.
20. Kanatate T, Nagao N, Sugimoto M, Kageyama K, Fujimoto T, Miwa N. 1995. Differential susceptibility of epidermal keratinocytes and neuroblastoma cells to cytotoxicity of ultraviolet-B light irradiation prevented by the oxygen radical-scavenger ascorbate-2-phosphate but not by ascorbate. Cell Mol Biol Res 41:561-567.
21. Kelly FJ. 1998. Use of antioxidants in the prevention and treatment of disease. J Int Fed Clin Chem 10:21-23.
22. Kumar M, Liu GJ, Floyd RA, Grammas P. 1996. Anoxic injury of endothelial cells increases production of nitric oxide and hydroxyl radicals. Biochem Biophys Res Commun 219:497-501.
23. Leung PY, Miyashita K, Young M, Tsao CS. 1993. Cytotoxic effect of ascorbate and its derivatives on cultured malignant and nonmalignant cell lines. Anticancer Res 13:475-480.
24. Liu P, Xu B, Cavalieri TA, Hock CE. 2002. Age-related difference in myocardial function and inflammation in a rat model of myocardial ischemia-reperfusion. Cardiovasc Res 56:443-453.
25. Makar TK, Nedergaard M, Preuss A, Gelbard AS, Perumal AS, Cooper AJ. 1994. Vitamin E, ascorbate, glutathione, glutathione disulfide, and enzymes of glutathione metabolism in cultures of chick astrocytes and neurons: Evidence that astrocytes play an important role in antioxidative processes in the brain. J Neurochem 62: 45-53.
26. McCord JM. 1987. Oxygen-derived free radicals: A link between reperfusion injury and inflammation. Fed Proc 46:2402-2406.
27. Nagao N, Nakayama T, Etoh T, Saiki I, Miwa N. 2000. Tumor invasion is inhibited by phosphorylated ascorbate via enrichment of intracellular vitamin C and decreasing of oxidative stress. J Cancer Res Clin Oncol 126:511-518.
28. Niki E. 1991. Selected vitamins, minerals, and functional consequences of maternal malnutrition. In: World Review of Nutrition and Dietetics 64:1-30.
29. Saitoh Y, Nagao N, O'Uchida R, Yamane T, Kageyama K, Muto N, Miwa N. 1997. Moderately controlled transport of ascorbate into aortic endothelial cells against slow-down of the cell cycle, decreasing of the concentration or increasing of coexistent glucose as compared with dehydroascorhate. Mol Cell Biochem 173:43-50.
30. Saitoh Y, Ouchida R, Kayasuga A, Miwa N. 2003a. Antiapoptotic defense of bcl-2 gene against hydroperoxide-induced cytotoxicity together with suppressed lipid peroxidation, enhanced ascorbate uptake, and upregulated Bcl-2 protein. J Cell Biochem 89:321-334.
31. Saitoh Y, Ouchida R, Miwa N. 2003b. Bcl-2 prevents hypoxia/reoxygenation- induced cell death through suppressed generation of reactive oxygen species and upregulation of Bcl-2 proteins. J Cell Biochem 90:914-924.
32. Takenaga M, Igarashi R, Nakayama T, Mizushima Y. 1999. Lecithinized ascorbic acid (PC-AS) effectively inhibits murine pulmonary metastasis. Anticancer Res 19:1085-1091.
33. Varma SD, Richards RD. 1988. Ascorbic acid and the eye lens. Ophthalmic Res 20:164-173.
34. Wells WW, Rocque PA, Xu DP, Meyer EB, Charamella LJ, Dimitrov NV. 1995. Ascorbic acid and cell survival of adriamycin resistant and sensitive MCF-7 breast tumor cells. Free Radic Biol Med 18:699-708.
35. Wu S, Tamaki N, Nagashima T, Yamaguchi M. 1998. Reactive oxygen species in reoxygenation injury of rat brain capillary endothelial cells. Neurosurgery 43:577-583.
36. Zweier JL, Broderick R, Kuppusamy P, Thompson-Gorman S, Lutty GA. 1994. Determination of the mechanism of free radical generation in human aortic endothelial cells exposed to anoxia and reoxygenation. J Biol Chem 269: 24156-24162.