Cytoprotection against ischemia-induced DNA cleavages and cell injuries in the rat liver by pro-vitamin C via hydrolytic conversion into ascorbate

Molecular and Cellular Biochemistry

Volumn 252, Issue 1-2, 2003, Pages 17-23

  Eguchi, Masahiro ^a,b   Miyazaki, Takashi ^c   Masatsuji Kato, Eiko ^d   Tsuzuki, Toshi ^d   Oribe, Tomohiro ^a   Miwa, Nobuhiko ^a  

^a PREFECTURAL UNIVERSITY OF HIROSHIMA   (Japan)

^b KITASATO UNIVERSITY   (Japan)

^c SAITAMA MEDICAL UNIVERSITY   (Japan)

^d Showa Denko Materials Co   (Japan)

Author keywords

Ascorbyl radical; DNA cleavage; Hepatic injuries; Ischemia reperfusion; Pro vitamin C; Reactive oxygen species

Indexed keywords

ALANINE AMINOTRANSFERASE; ANTIOXIDANT; ASCORBIC ACID; ASCORBIC ACID DERIVATIVE; ASPARTATE AMINOTRANSFERASE; CELL NUCLEUS DNA; DNA; LIVER ENZYME; REACTIVE OXYGEN METABOLITE; SCAVENGER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERY CLAMP; ARTICLE; AUTOOXIDATION; CELL DAMAGE; CELL DEGENERATION; CELL PROTECTION; CELL VACUOLE; CONTROLLED STUDY; DNA CLEAVAGE; DNA STRAND; DRUG BLOOD LEVEL; DRUG DECOMPOSITION; DRUG HYDROLYSIS; ELECTRON SPIN RESONANCE; ENZYME INHIBITION; ENZYME RELEASE; LIVER ISCHEMIA; LIVER SURGERY; MALE; NICK END LABELING; NONHUMAN; PORTAL VEIN; RAT; REPERFUSION INJURY; SYMPTOM; TIME;

ANIMALS; ASCORBIC ACID; CYTOPROTECTION; DNA; ELECTRON SPIN RESONANCE SPECTROSCOPY; HYDROLYSIS; IN SITU NICK-END LABELING; LIVER; MALE; RATS; RATS, WISTAR; REPERFUSION INJURY; SUGAR ACIDS;

ANIMALIA;

EID: 0041691777     PISSN: 03008177     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1025567400384     Document Type: Article

References (22)

1. Xia Y, Zweier JL: Substrate control of free radical generation from xanthine oxidase in the postischemic heart. J Biol Chem 270: 18797-18803, 1995
2. Ozaki M, Fuchinoue S, Teraoka S, Ota K: The in vivo cytoprotection of ascorbic acid against ischemia/reoxygenation injury of rat liver. Arch Biochem Biophys 318: 439-445, 1995
3. Maramag C, Menon M, Balaji KC, Reddy PG, Laxmanan S: Effect of vitamin C on prostate cancer cells in vitro: Effect on cell number, viability, and DNA synthesis. Prostate 32: 188-195, 1997
4. Nagao N, Nakayama T, Etoh T, Saiki I, Miwa N: Tumor invasion is inhibited by phosphorylated ascorbate via enrichment of intracellular vitamin C and decreasing of oxidative stress. J Cancer Res Clin Oncol 126: 511-518, 2000
5. Kageyama K, Yamada R, Otani S, Hasuma T, Miwa N: Abnormal cell morphology and cytotoxicity induced by phosphoascorbyl palmitate, but not by ascorbic acid, or upon combined hyperthermia. Anticancer Res 19: 4321-4326, 1999
6. Saitoh Y, Nagao N, O'Uchida R, Yamane T, Kageyama K, Muto N, Miwa N: Moderately controlled transport of ascorbate into aortic endothelial cells against slowdown of the cell cycle, decreasing of the concentration or increasing of coexistent glucose as compared with dehydroascorbate. Mol Cell Biochem 173: 43-50, 1997
7. +-dependent L-ascorbic acid transporters. Nature 399: 70-75, 1999
8. Kumano Y, Sakamoto T, Egawa M, Tanaka M, Yamamoto I: Enhancing effect of 2-O-alpha-D-glucopyranosyl-L-ascorbic acid, a stable ascorbic acid derivative, on collagen synthesis. Biol Pharm Bull 21: 662-666, 1998
9. Fujiwara M, Nagao N, Monden K, Misumi M, Kageyama K, Yamamoto K, Miwa N: Enhanced protection against peroxidation-induced mortality of aortic endothelial cells by ascorbic acid-2-O-phosphate abundantly accumulated in the cell as the dephosphorylated form. Free Radic Res 27: 97-104, 1997
10. Kanatate T, Nagao N, Sugimoto M, Kageyama K, Fujimoto T, Miwa N: Differential susceptibility of epidermal keratinocytes and neuroblastoma cells to cytotoxicity of ultraviolet-B light irradiation prevented by the oxygen radical-scavenger ascorbate-2-phosphate but not by ascorbate. Cell Mol Biol Res 41: 561-567, 1995
11. Frei B, England L, Ames BN: Ascorbate is an outstanding antioxidant in human blood plasma. Proc Natl Acad Sci USA 86: 6377-6381, 1989
12. Frei B, Stocker R, Ames BN: Antioxidant defenses and lipid peroxidation in human blood plasma. Proc Natl Acad Sci USA 85: 9748-9752, 1988
13. Kane DJ, Sarafian TA, Anton R, Hahn H, Gralla EB, Valentine JS, Ord T, Bredesen DE: Bcl-2 inhibition of neural death: Decreased generation of reactive oxygen species. Science 262: 1274-1277, 1993
14. Hashimoto Y, Itoh K, Nishida K, Okano T, Miyazawa Y, Okinaga K: Rapid superoxide production by endothelial cells and their injury upon reperfusion. J Surg Res 57: 693-697, 1994
15. Mizukami Y, Kobayashi S, Uberall F, Hellbert K, Kobayashi N, Yoshida K: Nuclear mitogen-activated protein kinase activation by protein kinase czeta during reoxygenation after ischemic hypoxia. J Biol Chem 275: 19921-19927, 2000
16. Bohles H: Antioxidative vitamins in prematurely and maturely born infants. Int J Vitamin Nutr Res 67: 321-328, 1997
17. Kukreja RC, Hess ML: The oxygen free radical system: From equations through membrane-protein interactions to cardiovascular injury and protection. Cardiovasc Res 26: 641-655, 1992
18. Simpson PJ, Lucchesi BR: Free radicals and myocardial ischemia and reperfusion injury. J Lab Clin Med 110: 13-30, 1987
19. Togashi H, Shinzawa H, Yong H, Takahashi T, Noda H, Oikawa K, Kamada H: Ascorbic acid radical, superoxide, and hydroxyl radical are detected in reperfusion injury of rat liver using electron spin resonance spectroscopy. Arch Biochem Biophys 308: 1-7, 1994
20. Enari M, Sakahira H, Yokoyama H, Okawa K, Iwamatsu A, Nagata S: A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD. Nature 391, 20-21, 1998
21. Nakagawa T, Zhu H, Morishima N, Li E, Xu J, Yankner BA, Yuan J: Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta. Nature 403: 98-103, 2000
22. Furumoto K, Inoue E, Nagao N, Hiyama E, Miwa N: Age-dependent telomere shortening is slowed down by enrichment of intracellular vitamin C via suppression of oxidative stress. Life Sci 63: 935-948, 1998