Heme oxygenase-1 messenger RNA expression is induced in peripheral blood mononuclear cells of pediatric cancer patients with systemic inflammatory response syndrome

Pediatric Critical Care Medicine

Volumn 5, Issue 6, 2004, Pages 554-560

  Schmidt, Jeffrey E ^a   Morgan, Jim I ^a   Rodriguez Galindo, Carlos ^a   Webb, David L ^a   Liang, Hua ^a   Tamburro, Robert F ^a  

^a UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

Author keywords

Bilirubin; Carbon monoxide; Carboxyhemoglobin; Heme oxygenase 1; Sepsis; Systemic inflammatory response syndrome

Indexed keywords

BILIRUBIN; CARBOXYHEMOGLOBIN; HEME OXYGENASE; HEME OXYGENASE 1; HMOX1 PROTEIN, HUMAN; MEMBRANE PROTEIN; MESSENGER RNA;

ADOLESCENT; ARTICLE; BIOSYNTHESIS; BLOOD; CANCER CENTER; CHILD; CLINICAL TRIAL; ENZYMOLOGY; FEMALE; GENETICS; HUMAN; INFANT; MALE; MONONUCLEAR CELL; NEOPLASM; PRESCHOOL CHILD; PROSPECTIVE STUDY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME;

ADOLESCENT; BILIRUBIN; CANCER CARE FACILITIES; CARBOXYHEMOGLOBIN; CHILD; CHILD, PRESCHOOL; FEMALE; HEME OXYGENASE (DECYCLIZING); HEME OXYGENASE-1; HUMANS; INFANT; LEUKOCYTES, MONONUCLEAR; MALE; MEMBRANE PROTEINS; NEOPLASMS; PROSPECTIVE STUDIES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME;

EID: 21644479280     PISSN: 15297535     EISSN: 19473893     Source Type: Journal    
DOI: 10.1097/01.PCC.0000144709.87365.F0     Document Type: Article

References (41)

1. Angus DC, Linde-Zwirble WT, Lidicker J, et al: Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care. Crit Care Med 2001; 29:1303-1310
2. Bone RC, Balk RA, Cerra FB, et al: Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Crit Care Med 1992; 20:864-874
3. Hotchkiss RS, Karl IE: The pathophysiology and treatment of sepsis. N Engl J Med 2003; 348:138-150
4. Bernard GR, Vincent J-L, Laterre P-F, et al: Efficacy and safety of recombinant human activated protein C for severe sepsis. N Engl J Med 2001; 344:699-709
5. Matthay MA: Severe sepsis-A new treatment with both anticoagulant and anti-inflammatory properties. N Engl J Med 2001; 344: 759-762
6. Otterbein LE, Sylvester SL, Choi AM: Hemoglobin provides protection against lethal endotoxemia in rats: The role for heme oxygenase- 1. Am J Respir Cell Mol Biol 1995; 13: 595-601
7. Hashiba T, Suzuki M, Nagashima Y, et al: Adenovirus-mediated transfer of heme oxygenase- 1 cDNA attenuates severe lung injury induced by the influenza virus in mice. Gene Ther 2001; 8:1499-1507
8. Willis D, Moore AR, Frederick R, et al: Heme oxygenase: A novel target for the modulation of the inflammatory response. Nat Med 1996; 2:87-90
9. Stocker R, Yamamoto Y, McDonagh AF, et al: Bilirubin is an antioxidant of possible physiological importance. Science 1987; 235: 1043-1046
10. Nakagami T, Toyomura K, Kinoshita T, et al: A beneficial role of bile pigments as an endogenous tissue protector: Anti-complement effects of biliverdin and conjugated bilirubin. Biochim Biophys Acta 1993; 1158:189-193
11. Llesuy SF, Tomaro ML: Heme oxygenase and oxidative stress. Evidence of involvement of bilirubin as physiological protector against oxidative damage. Biochim Biophys Acta 1994; 1223:9-14
12. Yamaguchi T, Horio F, Hashizume T, et al: Bilirubin is oxidized in rats treated with endotoxin and acts as a physiological antioxidant synergistically with ascorbic acid in vivo. Biochem Biophys Res Commun 1995; 214:11-19
13. Downard PJ, Wilson MA, Spain DA, et al: Heme-oxygenase-dependent carbon monoxide production is a hepatic adaptive response to sepsis. J Surg Res 1997; 71:7-12
14. Otterbein LE, Mantell LL, Choi AMK: Carbon monoxide provides protection against hyperoxic lung injury. Am J Physiol 1999; 276: L688-L694
15. Otterbein LE, Bach FJ, Alam J, et al: Carbon monoxide has anti-inflammatory effects involving the mitogen-Activated protein kinase pathway. Nat Med 2000; 6:422-428
16. Sarady JK, Otterbein SL, Liu F, et al: Carbon monoxide modulates endotoxin-induced production of granulocyte macrophage colonystimulating factor in macrophages. Am J Respir Cell Mol Biol 2002; 27:739-745
17. Lee TS, Chau LY: Heme oxygenase-1 mediates the anti-inflammatory effect of interleukin- 10 in mice. Nat Med 2002; 8:240-246
18. Tenhunen R, Marver HS, Schmid R: The enzymatic conversion of heme to bilirubin by microsomal heme oxygenase. Proc Natl Acad Sci USA 1968; 61:748-755
19. Trakshel GM, Maines MD: Multiplicity of heme oxygenase isozymes. HO-1 and HO-2 are different molecular species in rat and rabbit. J Biol Chem 1989; 264:1323-1328
20. Maines MD: The heme oxygenase system: A regulator of second messenger gases. Annu Rev Pharmacol Toxicol 1997; 37:514-554
21. McCoubrey WK, Huang TJ, Maines MD: Isolation and characterization of a cDNA from the rat brain that encodes hemoprotein heme oxygenase-3. Eur J Biochem 1997; 247: 725-732
22. Cantoni L, Rossi C, Rizzardini M, et al: In- terleukin-1 and tumour necrosis factor induce hepatic haem oxygenase. Biochem J 1991; 279:891-894
23. Motterlini R, Foresti R, Intaglietta M, et al: NO-mediated activation of heme oxygenase: Endogenous cytoprotection against oxidative stress to endothelium. Am J Physiol 270: H107-H114
24. Banks JG, Foulis AK, Ledingham IMcA, et al: Liver function in septic shock. J Clin Pathol 1982; 35:1249-1252
25. Roelofsen H, Schoemaker B, Bakker C, et al: Impaired hepatocanalicular organic anion transport in endotoxemic rats. Am J Physiol 269:G427-G434
26. Douzinas EE, Vamvasakis E, Rigas K, et al: Bile canaliculi are defective in hepatic involvement of organ failure and recovery of liver function is due to their secondary regeneration. Intensive Care Med 1996; 22: 553-558
27. Zegdi R, Perrin D, Burdin M, et al: Increased endogenous carbon monoxide production in severe sepsis. Intensive Care Med 2002; 28: 793-796
28. Shahin AA, Tamburro RF, Schmidt JE: Carboxyhemoglobin in pediatric sepsis and the systemic inflammatory response syndrome. Clinical Intensive Care 2000; 11:311-317
29. Hunter K, Mascia M, Eudaric P, et al: Evidence that carbon monoxide is a mediator of critical illness. Cell Mol Biol 1994; 40: 507-510
30. Moncure M, Grathwaite KC, Samaha E, et al: Carboxyhemoglobin elevation in trauma victims. J Trauma 1999; 46:424-427
31. Yachie A, Toma T, Mizuno K, et al: Heme oxygenase-1 production by peripheral blood monocytes during acute inflammatory illnesses of children. Exp Biol Med 2003; 228: 550-556
32. Stordeur P, Poulin LF, Cracium L, et al: Cytokine mRNA quantification by real-time PCR. J Immunol Methods 259):55-64, 2002
33. Horii A, Smith PF, Darlington CL: Application of real-time quantitative polymerase chain reaction to quantification of glutamate receptor gene expression in the vestibular brainstem and cerebellum. Brain Res Brain Res Protoc 2002; 9:77-83
34. Crouser ED, Julian MW, Blaho DV, et al: Endotoxin-induced mitochondrial damage correlates with impaired respiratory activity. Crit Care Med 2002; 30:276-284
35. Westphal M, Weber TP, Meyer J, et al: Affinity of carbon monoxide to hemoglobin increases at low oxygen fractions. Biochem Biophys Res Commun 2002; 295:975-977
36. Weaver LK, Hopkins RO, Chan KJ, et al: Hyperbaric oxygen for acute carbon monoxide poisoning. N Engl J Med 2002; 347: 1057-1067
37. Suzuki T, Takahashi T, Yamasaki A, et al: Tissue-specific gene expression of heme oxygenase- 1 (HO-1) and non-specific deltaaminolevulinate synthase (ALAS-N) in a rat model of septic multiple organ dysfunction syndrome. Biochem Pharmacol 2000; 60: 275-283
38. Raju VS, Maines MD: Coordinated expression and mechanism of induction of HSP32 (heme oxygenase-1) mRNA by hyperthermia in rat organs. Biochim Biophys Acta 1994; 1217:273-280
39. Deramaudt TB, da Silva JL, Remy P, et al: Negative regulation of human heme oxygenase in microvessel endothelial cells by dexamethasone. Proc Soc Exp Biol Med 1999; 222:185-193
40. Schmidt JE, Mertz K, Morgan JI: Regulation of heme oxygenase-1 expression by dopamine in cultured C6 glioma and primary astrocytes. Brain Res Mol Brain Res 1999; 73: 50-59
41. Allen E, Pettigrew A, Frank D, et al: Alterations in dopamine clearance and catechol- O-methyltransferase activity by dopamine infusions in children. Crit Care Med 1997; 25: 181-189