Reg protein: A possible mediator of gastrin-induced mucosal cell growth

Journal of Gastroenterology

Volumn 35, Issue SUPPL. 12, 2000, Pages 52-56

  Chiba, Tsutomu ^a   Fukui, Hirokazu ^a   Kinoshita, Yoshikazu ^b  

^a KYOTO UNIVERSITY   (Japan)

^b SHIMANE UNIVERSITY   (Japan)

Author keywords

Enterochromaffin like cell; Gastrin; Gastrin receptor; Reg

Indexed keywords

GASTRIN; GENE PRODUCT; INTRINSIC FACTOR; MESSENGER RNA; REG PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; CELL CULTURE; CELL GROWTH; CELL PROLIFERATION; CONFERENCE PAPER; ENTEROCHROMAFFIN CELL; GENE EXPRESSION; HYPERGASTRINEMIA; MALE; MUCOSA CELL; NONHUMAN; PRIORITY JOURNAL; RAT; STOMACH FUNDUS; STOMACH MUCOSA;

ANIMALS; CALCIUM-BINDING PROTEINS; CELL DIVISION; GASTRIC MUCOSA; GASTRINS; GENE EXPRESSION REGULATION; LITHOSTATHINE; MALE; NERVE TISSUE PROTEINS; RATS; RECEPTORS, CHOLECYSTOKININ; RNA, MESSENGER;

EID: 0034056876     PISSN: 09441174     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (21)

1. Waldum HL, Sandvik AK, Brenna E, Petersen H. Gastrinhistamine sequence in the regulation of gastric acid secretion. Gut 1991;32:698-704.
2. Chiba T, Fisher SK, Park J, Seguin EB, Agranoff BW, Yamada T. Carbamoylcholine and gastrin induce inositol lipid turnover in canine gastric parietal cells. Am J Physiol 1988;255:G99-105.
3. Carney JA, Go VEW, Fairbanks VF, Moore SB, Alport EC, Nora FE. The syndrome of gastric argyrophil carcinoid tumors and nonantral gastric atrophy. Ann Intern Med 1983;99:761-6.
4. Solcia E, Capella C, Flocca R, Rindi G, Rosai J. Gastric argyrophil carcinoidosis in paitents with Zollinger-Ellison syndrome due to type I multiple endocrine neoplasia: a newly recognized association. Am J Surg Pathol 1990;14:503-13.
5. Larson H, Carlsson E, Mattsson H. Plasma gastrin and gastric enterochromaffin-like cell activation and proliferation: studies with omeprazole and ranitidine in intact and antrectomized rats. Gastroenterology 1986;90:391-9.
6. Bordi C, Cocconi G, Togni R, Vezzadini P, Missale G. Gastric endocrine cell proliferation: association with Zollinger-Ellison syndrome. Arch Pathol 1974;98:274-9.
7. Wang TC, Koh TJ, Varro A, Cahill RJ, Dangler CA, Fox JG, et al. Proecessing and proliferative effects of human progastrin in transgenic mice. J Clin Invest 1996;98:1918-29.
8. Gray MR, Darnton SJ, Hunt JA, Irlam RW, Nemeth J, Wallace HM. Accelerated gastric epithelial proliferation. Gut 1995;36: 522-7.
9. Asahara M, Kinoshita Y, Nakata H, Matsushima Y, Naribayashi Y, Nakamura A, et al. Gastrin receptor genes are expressed in gastric parietal and enterochromaffin-like cells of Mastomys natalensis. Dig Dis Sci 1994;39:2149-56.
10. Kawanami C, Fukui H, Kinoshita Y, Nakata H, Asahara M, Matsushima Y, et al. Regenerating gene expression in normal gastric mucosa and indomethacin-induced mucosal lesions of the rat. J Gastroenterol 1997;32:12-18.
11. Asahara M, Mushiake S, Shimada S, Fukui H, Kinoshita Y, Kawanami C, et al. Reg gene expression is increased in rat gastric enterochromaffin-like cells follwing water immersion stress. Gastroenterology 1996;111:45-55.
12. Fukui H, Kinoshita Y, Maekawa T, Okada A, Waki S, Hassan MDS, et al. Regenerating gene protein may mediate gastric mucosal proliferation induced by hypergastrinemia in rats. Gastroenterology 1998;115:1483-93.
13. Yonemura Y, Takashima T, Miwa K, Miyazaki I, Yamamoto H, Okamoto H. Amelioration of diabetes mellitus in partially depancreatised rats by poly(ADP-ribose) synthetase inhibitors. Diabetes 1984;33:401-4.
14. Terazono K, Yamamoto H, Takasawa S, Shiga K, Yamamura Y, Tochino Y, et al. A novel gene activated in regenerating islets. J Biol Chem 1988;263:2111-14.
15. Rouquier S, Verdier JM, Iovanna J, Dagorn JC, Giorgi D. Rat pancreatic stone protein messenger RNA. J Biol Chem 1991;266: 786-91.
16. Kimura N, Yonekura H, Okamoto H, Nagura H. Expression of human regenerating gene mRNA and its product in normal and neoplastic human pancreas. Cancer 1992;70:1857-63.
17. Watanabe T, Yonekura H, Terazono K, Yamamoto H, Okamoto H. Complete nucleotide sequence of human reg gene and its expression in normal and tumoral tissues: the Reg protein, pancreatic stone protein, and pancreatic thread protein are one and the same product of the gene. J Biol Chem 1990;265:7432-9.
18. Chiba T, Kinoshita Y, Sawada M, Kishi K, Baba A, Hoshino E. The role of endogenous gastrin in the development of enterochromaffin-like (ECL) cell carcinoid tumors in Mastomys natalensis: a study with the specific gastrin receptor antagonist AG-041R. Yale J Biol Med 1999 (in press).
19. Kinoshita Y, Nakata H, Kishi K, Kawanami C, Sawada M, Chiba T. Comparison of the signal transduction pathways activated by gastrin in enterochromaffin-like and parietal cells. Gastroenterology 1998;115:93-100.
20. Kinoshita Y, Hassan S, Nakata H, Asahara M, Matsushima Y, Kawanami C, et al. Establishment of primary epithelial cell culture from elutriated rat gastric mucosal cells. J Gastroenterol 1995;30:135-41.
21. Karam SM, Leblond CP. Dynamics of epithelial cells in the corpus of the mouse stomach. Anal Rec 1993;236:259-79.