Adverse effects of hyperphosphatemia on myocardial hypertrophy, renal function, and bone in rats with renal failure

Kidney International

Volumn 66, Issue 6, 2004, Pages 2237-2244

  Neves, Katia R ^a   Graciolli, Fabiana G ^a   Dos Reis, Luciene M ^a   Pasqualucci, Carlos A ^a   Moysés, Rosa M A ^a   Jorgetti, Vanda ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Chronic renal failure; Heart; Hyperphosphatemia; Phosphorus; Renal osteodystrophy; Vascular calcification

Indexed keywords

CREATININE; PHOSPHORUS;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL CALCIFICATION; BONE; BONE REMODELING; CONTROLLED STUDY; CREATININE BLOOD LEVEL; HEART VENTRICLE HYPERTROPHY; HISTOLOGY; HYPERPHOSPHATEMIA; IMPLANTATION; KIDNEY FAILURE; KIDNEY FUNCTION; MINIPUMP; MORPHOMETRICS; NEPHRECTOMY; NONHUMAN; PARATHYROIDECTOMY; PRIORITY JOURNAL; RAT; STATISTICAL SIGNIFICANCE; TRABECULAR BONE; UREMIA; VASCULAR FIBROSIS; ANIMAL; BLOOD; BODY WEIGHT; CARDIOMEGALY; CHRONIC KIDNEY FAILURE; DISORDERS OF MINERAL, ELECTROLYTE AND METAL METABOLISM; EATING; HEART MUSCLE; MALE; ORGAN SIZE; PATHOLOGY; RENAL OSTEODYSTROPHY; SECONDARY HYPERPARATHYROIDISM; WISTAR RAT;

ANIMALS; BODY WEIGHT; BONE AND BONES; CARDIOMEGALY; EATING; HYPERPARATHYROIDISM, SECONDARY; KIDNEY FAILURE, CHRONIC; MALE; MYOCARDIUM; ORGAN SIZE; PHOSPHORUS; PHOSPHORUS METABOLISM DISORDERS; RATS; RATS, WISTAR; RENAL OSTEODYSTROPHY;

EID: 21644453113     PISSN: 00852538     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1523-1755.2004.66013.x     Document Type: Article

References (21)

1. DELMEZ JA, SLATOPOLSKY E: Hyperphosphatemia: Its consequences and treatment in patients with chronic renal disease. Am J Kidney Dis 19:303-317, 1992
2. BLOCK GA, HULBERT-SHEARON TE, LEVIN NW, PORT FK: Association of serum phosphorus and calcium x phosphorus product with mortality risk in chronic hemodialysis patients: A national study. Am J Kidney Dis 31:607-617, 1998
3. SLATOPOLSKY E, BROWN A, DUSSO A: Pathogenesis of secondary hyperparathyroidism. Kidney Int 56(Suppl 73):S14-S19, 1999
4. NARANG R, RIDOUT D, NONIS C, KOONER JS: Serum calcium, phosphorus and albumin levels in relation to the angiographic severity of coronary artery disease. Int J Cardiol 27:73-79, 1997
5. LOOHMAN-ADHAM M: Role of phosphate retention in the progression of renal failure. J Lab Clin Med 122:16-26, 1993
6. BLOEMBERGEN WE: Cardiac disease in chronic uremia: Epidemiology. Adv Ren Replace Ther 4:185-193, 1997
7. US RENAL DATA SYSTEM: USRDS 1999 Annual Data of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, 1999 (www.med.umich.edu/usrds)
8. JONO S, MCKEE M, SHIOI A, et al: Phosphate regulation of vascular smooth muscle cell calcification. Circ Res 87:e10-e17, 2000
9. AMANN K, RITZ E, WIEST G, et al: A role of parathyroid hormone for the activation of cardiac fibroblasts in uremia. J Am Soc Nephrol 4:1814-1819, 1994
10. BERDUD I, MARTIN-MALO A, ALMADEN Y, et al: The PTH-calcium relationship during a range infused PTH doses in the parathyroidectomized rat. Calcif Tissue Int 62:457-461, 1998
11. GOUVEIA CH, JORGETTI V, BIANCO AC: Effects of thyroid hormone administration and estrogen deficiency on bone mass of female rats. J Bone Miner Res 12:2098-2107, 1997
12. PARFITT AM, DREZNER MK, GLORIEUX FH, et al: Bone histomorphometry Nomenclature Committee. J Bone Miner Res 6:595-610, 1987
13. GOODMAN WG, GOLDIN J, KUIZON BD, et al: Coronary artery calcification in young adults with end-stage renal disease who are undergoing dialysis. N Engl J Med 342:1478-1483, 2000
14. EJERBLAD S, ERIKSON I, JOHANSSON H: Uremic arterial disease. Scand J Urol Nephrol 13:161-169, 1979
15. WALLIN R, WAJIH N, TODD GREENWOOD G, SANE DC: Arterial calcification: A review of mechanisms, animals models, and the prospects for therapy. Med Res Rev 21:274-301, 2001
16. BORLE AB, CLARK I: Effects of phosphate-induced hyperparathyroidism and parathyroidectomy on rat kidney calcium in vivo. Am J Physiol 241:e136-e141, 1981
17. AMANN K, TORNIG J, KUGEL B, et al: Hyperphosphatemia aggravates cardiac fibrosis and microvascular disease in experimental uremia. Kidney Int 63:1296-1301, 2003
18. IBELS LS, ALFREY AC, HAUT L, HUFFER WE: Preservation of function in experimental renal disease by dietary restriction of phosphate. N Engl J Med 298:122-126, 1978
19. COZZOLINO M, DUSSO AS, LIAPIS H, et al: The effects of sevelamer hydrochloride and calcium carbonate on kidney calcification in uremic rats. J Am Soc Nephrol 13:2299-2308, 2002
20. SZABO A, FREESMEYER MG, ABENDROTH K, et al: Physiological doses of calcium regulatory hormones do not normalize bone cells in uremic rats. Eur J Clin Invest 29:529-535, 1999
21. BOVER J, JARA A, TRINDAD P, et al: Dynamics of skeletal resistance to parathyroid hormone in the rat: Effect of renal failure and dietary phosphorus. Bone 25:279-285, 1999