Pathogenesis of secondary hyperparathyroidism

Kidney International, Supplement

Volumn 56, Issue 73, 1999, Pages

  Slatopolsky, Eduardo ^a   Brown, Alex ^a   Dusso, Adriana ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Calcitriol; Calcium; Chronic renal failure; Parathyroid hormone; Phosphorus

Indexed keywords

22 OXACALCITRIOL; CALCITRIOL; CALCIUM ION; CALCIUM SENSING RECEPTOR; PARATHYROID HORMONE; PHOSPHORUS; VITAMIN D; VITAMIN D RECEPTOR; CALCITRIOL RECEPTOR; CALCIUM;

ARTICLE; CALCIUM BLOOD LEVEL; CHRONIC KIDNEY FAILURE; DISEASE COURSE; HISTOPATHOLOGY; HORMONE SYNTHESIS; HUMAN; NONHUMAN; PARATHYROID HORMONE RELEASE; PARATHYROID HYPERPLASIA; PATHOGENESIS; PHOSPHATE INTAKE; PRIORITY JOURNAL; RECEPTOR DOWN REGULATION; SECONDARY HYPERPARATHYROIDISM; UREMIA; VITAMIN BLOOD LEVEL; VITAMIN D METABOLISM; ANIMAL; GENETICS; KIDNEY FAILURE; METABOLISM; PHYSIOLOGY; REVIEW; SECRETION;

ANIMALS; CALCIUM; HUMANS; HYPERPARATHYROIDISM, SECONDARY; KIDNEY FAILURE; PARATHYROID HORMONE; PHOSPHORUS; RECEPTORS, CALCITRIOL; VITAMIN D;

EID: 0033395674     PISSN: 00986577     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1755.1999.07304.x     Document Type: Article

References (38)

1. REISS E, CANTERBURY JM, EGDAHL RH: Measurement of serum parathyroid hormone in renal insufficiency. Trans Assoc Am Phys 81:104-115, 1968
2. ARNAUD CD: Hyperparathyroidism and renal failure. Kidney Int 4:89-95, 1973
3. 3 in the parathyroid glands of patient with renal failure. New Engl J Med 316:1577, 1987
4. 3 receptor in experimental uremia. Kidney Int 32:350-353, 1987
5. 3 receptors are decreased in parathyroid glands from chronically uremic dogs. Kidney Int 35:19-23, 1989
6. 3 results from ligand-induced stabilization. J Biol Chem 267:20082-20086, 1992
7. 3 inhibits parathyroid cell proliferation in experimental uremia. Kidney Int 35:1049-1056, 1989
8. 3 receptor density is associated with a more severe form of parathyroid hyperplasia in chronic uremia patients. J Clin Invest 92:1436-1443, 1993
9. GITTES RF, RADDE IC: Experimental model for hyperparathyroidism: Effect of excessive numbers of transplanted isologous parathyroid glands. J Urol 95:595-603, 1966
10. MAYER GP, HABENER JF, POTTS JT JR: Parathyroid hormone secretion in vivo, demonstration of calcium-independent, non-suppressible component of secretion. J Clin Invest 57:678-683, 1976
11. 3 and 22-oxacalcitriol prevented the decrease in vitamin D receptor content in the parathyroid glands of uremic rats. Kidney Int 50:34-39, 1996
12. PATEL SR, KE HQ, VANHOLDER R, HSU CH: Inhibition of nuclear uptake of calcitriol receptor by uremic ultrafiltrate. Kidney Int 46:129-133, 1994
13. PATEL SR, KE HQ, VANHOLDER R, KOENIG, RJ, HSU CH: Inhibition of calcitriol receptor binding to vitamin D response elements by uremic toxins. J Clin Invest 96:50-59, 1995
14. BROWN AJ, ZHONG M, FINCH L, RITTER C, MCCRACKEN R, MORRISSEY J, SLATOPOLSKY E: Rat calcium-sensing receptor is regulated by vitamin D but not by calcium. Ann Physiol Soc 230:F454-F460, 1996
15. BROWN EM, WILKSON RE, EASTMAN RC, PALLOTTA J, MAKYNICK SP: Abnormal regulation of parathyroid hormone release by calcium in secondary hyperparathyroidism due to chronic renal failure. J Clin Endocrinol Metab 54:172-179, 1982
16. BELLORIN-FONT E, MARTIN KJ, FEITAG JJ, ANDERSON C, SICARD G, SLATOPOLSKY E, KLAHR S: Altered adenylate cyclase kinetics in hyperfunctioning human parathyroid glands. Comparison with normal human and bovine parathyroid tissue. J Clin Endocrinol Metab 52:466-507, 1981
17. 2+ sensing receptor from bovine parathyroid. Nature 366:575-580, 1993
18. 2+ sensing receptor gene cause familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism. Cell 75:1297-1303, 1993
19. OKAZAKI T, ZAJAC JD, IGARASHI T, OGATA E, KRONENBERG HM: Negative regulatory elements in the human parathyroid hormone gene. J Biol Chem 266:21903-21910, 1991
20. KIFOR O, MOORE FD, WANG P, GOLDSTEIN M, VASSILER P, KIFOR I, HEBERT SC, BROWN EM: Reduced immunostaining for the extracellular Ca sensing receptor in primary and uremic secondary hyperparathyroidism. J Clin Endocrinol Metab 81:1598-1606, 1996
21. GOGUSEV JT DUCHAMBON P, HORY B, GIOVANNINI M, GOUREAU Y, SARFATI E, DRUEKE TB: Depressed expression of calcium receptor in parathyroid gland tissue of patient with hyperparathyroidism. Kidney Int 51:328-336, 1997
22. REISS E, CANTERBURY MJ, BERCOVITZ MA, KAPLAN EL: The role of phosphate in the secretion of parathyroid hormone in man. J Clin Invest 49:2146-2149, 1970
23. SLATOPOLSKY E, CAGLAR S, GRADOWSKA L, CANTERBURY JM, REISS E, BRICKER N: On the prevention of secondary hyperparathyroidism in experimental chronic renal disease using "proportional reduction" of dietary phosphorus intake. Kidney Int 2:147-151, 1972
24. RAIZ LG, NIEMANN I: Effect of phosphate calcium and magnesium on bone resorption and hormonal response in tissue culture. Endocrinology 85:446-452, 1969
25. LOPEZ-HILKER S, DUSSO A, RAPP N, MARTIN K, SLATOPOLSKY E: Phosphorus restriction reverses secondary hyperparathyroidism in chronic renal failure independent of changes in calcium and 1,25 dihydroxycholecalciferol. Am J Physiol 259:F432-F437, 1990
26. NAVEH-MANY T, RAHAMIMOV R, LIVNI N, SILVER J: Parathyroid cell proliferation in normal and chronic renal failure rats: the effects of calcium, phosphate and vitamin D. J Clin Invest 96:1786-1793, 1995
27. WANG Q, PALNITKAR S, PARFITT AM: Parathyroid cell proliferation in the rat: effect of age and of phosphate administration and recovery. Endocrinol 137:4558-4562, 1996
28. SLATOPOLSKY E, FINCH J, DENDA M, RITTER C, ZHONG A, DUSSO A, MACDONALD P, BROWN AJ: Phosphate restriction prevents parathyroid cell growth in uremic rats. High phosphate directly stimulates PTH secretion in vitro. J Clin Invest 97:2534-2540, 1996
29. KILAV R, SILVER J, NAVEH-MANY T: Parathyroid hormone gene expression in hypophosphatemia rats. J Clin Invest 96:327-333, 1995
30. ALMADEN Y, CANALEJO A, HERNANDEZ A, BALLESTEROS E, GARCIA-NAVARRO S, TORRES A, RODRIGUEZ M: Direct effect of phosphorus on parathyroid hormone secretion from whole rat parathyroid glands n vitro. J Bone Miner Res 11:970-976, 1996
31. NIELSEN PK, FELDT-RASMUSEN U, OLGAARD K: A direct effect of phosphate on PTH release from bovine parathyroid tissue slices but not from dispersed parathyroid cells. Nephrol Dial Transplant 11:1762-1768, 1996
32. YI H, FUKAGAWA M, YAMATO H, KUMAGAI M, WATANABE T, KUROKAWA K: Prevention of enhanced parathyroid hormone secretion, synthesis and hyperplasia by mild dietary phosphorus restriction in early chronic renal failure in rats: possible direct role of phosphorus. Nephron 70:242-248, 1995
33. DENDA M, FINCH J, SLATOPOLSKY E: Parathyroid hyperplasia and secondary hyperparathyroidism develop rapidly in experimental uremic rats. J Bone Miner Res 10:S276, 1995
34. ARNOLD A, KIM HG, GAZA RD, EDDY RL, FUKUSHIMA Y, BYERS MG, SHOWS TB, KRONENBERG HM: Molecular cloning and chromosome mapping of DNA rearranged with the parathyroid hormone gene in parathyroid adenoma. J Clin Invest 83:2034-2040, 1989
35. MOTOKURA T, BLOOM T, KIM TB, JUPPNER H, RUDERMAN JV, KRONENBERG HM, ARNOLD A: A novel cyclin encoded by a bell-candidate oncogene. Nature 350:512-515, 1991
36. ROSENBERG C, KIM HG, SHOWS TB, KRONENBERG HM, ARNOLD A: Rearrangement and over-expression of D11S287E, a candidate oncogene on chromosome 11q13 in benign parathyroid tumors. Oncogene 6:449-453, 1991
37. TATSUMI S, SEGAWA H, MORITA K, HAGA H, KOUDA T, YAMAMOTO H, INOUE Y, NII T, KATAI K, TAKETANI Y, MIYAMOTO K, TAKEDA E: Molecular cloning and hormone regulation of PiT-1, a sodium-dependent phosphate cotransporter from rat parathyroid glands. Endocrinology 139:1692-1699, 1998
38. MOLLEM E, KILAV R, SILVER J, NAVEH-MANY T: RNA-protein binding and post transcriptional regulation of parathyroid gene expression by calcium and phosphate. J Biol Chem 9:5253-5259, 1998