-
1
-
-
0029687131
-
The three R's of Russell & Burch and the testing of biological products
-
Balls, M. & Straughan, D. W. (1996). The three R's of Russell & Burch and the testing of biological products. Dev Biol Stand 86, 8-11.
-
(1996)
Dev Biol Stand
, vol.86
, pp. 8-11
-
-
Balls, M.1
Straughan, D.W.2
-
2
-
-
0028069674
-
Proteolysis of SNAP-25 by types A and E botulinal neurotoxins
-
Binz, T., Blasi, J., Yamasaki, S., Baumeister, A., Link, E., Sudhof, T. C., Jahn, R. & Niemann, H. (1994). Proteolysis of SNAP-25 by types A and E botulinal neurotoxins. J Biol Chem 269, 1617-1620.
-
(1994)
J Biol Chem
, vol.269
, pp. 1617-1620
-
-
Binz, T.1
Blasi, J.2
Yamasaki, S.3
Baumeister, A.4
Link, E.5
Sudhof, T.C.6
Jahn, R.7
Niemann, H.8
-
3
-
-
0027219725
-
Botulinum neurotoxin A selectively cleaves the synaptic protein SNAP-25
-
Blasi, J., Chapman, E. R., Link, E., Binz, T., Yamasaki, S., De Camilli, P., Südhof, T. C., Niemann, H. & Jahn, R. (1993). Botulinum neurotoxin A selectively cleaves the synaptic protein SNAP-25. Nature 365, 160-163.
-
(1993)
Nature
, vol.365
, pp. 160-163
-
-
Blasi, J.1
Chapman, E.R.2
Link, E.3
Binz, T.4
Yamasaki, S.5
De Camilli, P.6
Südhof, T.C.7
Niemann, H.8
Jahn, R.9
-
4
-
-
0027199152
-
Sensitive enzyme-linked immunosorbent assay for detection of Clostridium botulinum neurotoxins A, B and E using signal amplification via enzyme-linked coagulation assay
-
Doellgast, G. J., Triscott, M. X., Beard, A. G., Bottoms, J. D., Cheng, T., Roh, B. H., Roman, M. G., Hall, P. A. & Brown, J. E. (1993). Sensitive enzyme-linked immunosorbent assay for detection of Clostridium botulinum neurotoxins A, B and E using signal amplification via enzyme-linked coagulation assay. J Clin Microbiol 31, 2402-2409.
-
(1993)
J Clin Microbiol
, vol.31
, pp. 2402-2409
-
-
Doellgast, G.J.1
Triscott, M.X.2
Beard, A.G.3
Bottoms, J.D.4
Cheng, T.5
Roh, B.H.6
Roman, M.G.7
Hall, P.A.8
Brown, J.E.9
-
5
-
-
0028935520
-
Immunological detection of Clostridium botulinum toxin type A in therapeutic preparations
-
Ekong, T. A. N., McLellan, K. & Sesardic, D. (1995). Immunological detection of Clostridium botulinum toxin type A in therapeutic preparations. J Immunol Methods 180, 181-191.
-
(1995)
J Immunol Methods
, vol.180
, pp. 181-191
-
-
Ekong, T.A.N.1
McLellan, K.2
Sesardic, D.3
-
6
-
-
1842415235
-
An alternative bioassay for botulinum neurotoxin type A based on its endopeptidase activity
-
Ekong, T. A. N., Gee, C., Blasi, J. & Sesardic, D. (1997). An alternative bioassay for botulinum neurotoxin type A based on its endopeptidase activity. Dev Anim Vet Sci 27, 1039-1045.
-
(1997)
Dev Anim Vet Sci
, vol.27
, pp. 1039-1045
-
-
Ekong, T.A.N.1
Gee, C.2
Blasi, J.3
Sesardic, D.4
-
7
-
-
0029780760
-
Tyrosine phosphorylation modulates the activity of clostridia neurotoxins
-
Ferrer-Montiel, A. V., Canaves, J. M., DasGupta, B. R., Wilson, M. C. & Montal, M. (1996). Tyrosine phosphorylation modulates the activity of clostridia neurotoxins. J Biol Chem 271, 18322-18325.
-
(1996)
J Biol Chem
, vol.271
, pp. 18322-18325
-
-
Ferrer-Montiel, A.V.1
Canaves, J.M.2
DasGupta, B.R.3
Wilson, M.C.4
Montal, M.5
-
8
-
-
0028558884
-
Differences in the protease activities of tetanus and botulinum B toxins revealed by the cleavage of vesicle-associated membrane protein and various sized fragments
-
Foran, P., Shone, C. C. & Dolly, J. O. (1994). Differences in the protease activities of tetanus and botulinum B toxins revealed by the cleavage of vesicle-associated membrane protein and various sized fragments. Biochemistry 33, 15365-15374.
-
(1994)
Biochemistry
, vol.33
, pp. 15365-15374
-
-
Foran, P.1
Shone, C.C.2
Dolly, J.O.3
-
9
-
-
0029874232
-
Botulinum neurotoxin C1 cleaves both syntaxin and SNAP-25 in intact and permeabilised chromaffin cells: Correlation with its blockade of catecholamine release
-
Foran, P., Lawrence, G. W., Shone, C. C., Foster, K. A. & Dolly, J. O. (1996). Botulinum neurotoxin C1 cleaves both syntaxin and SNAP-25 in intact and permeabilised chromaffin cells: correlation with its blockade of catecholamine release. Biochemistry 35, 2630-2636.
-
(1996)
Biochemistry
, vol.35
, pp. 2630-2636
-
-
Foran, P.1
Lawrence, G.W.2
Shone, C.C.3
Foster, K.A.4
Dolly, J.O.5
-
10
-
-
0027437516
-
Expression of biologically active C3a as fusion proteins
-
Fukuoka, Y., Tachibana, T. & Yasui, A. (1993). Expression of biologically active C3a as fusion proteins. Immunol Lett 38, 153-158.
-
(1993)
Immunol Lett
, vol.38
, pp. 153-158
-
-
Fukuoka, Y.1
Tachibana, T.2
Yasui, A.3
-
11
-
-
0029893774
-
Development of novel assays for botulinum type A and B neurotoxins based on their endopeptidase activity
-
Hallis, B., James, B. A. F. & Shone, C. C. (1996). Development of novel assays for botulinum type A and B neurotoxins based on their endopeptidase activity. J Clin Microbiol 34, 1934-1938.
-
(1996)
J Clin Microbiol
, vol.34
, pp. 1934-1938
-
-
Hallis, B.1
James, B.A.F.2
Shone, C.C.3
-
12
-
-
0020955120
-
Synapsin I (Protein I), a nerve terminal-specific phosphoprotein. III. Its association with synaptic vesicles studied in highly purified synaptic vesicle preparation
-
Huttner, W. B., Schiebler, W., Greengard, P. & de Camilli, P. (1983). Synapsin I (Protein I), a nerve terminal-specific phosphoprotein. III. Its association with synaptic vesicles studied in highly purified synaptic vesicle preparation. J Biol Chem 96, 1374-1388.
-
(1983)
J Biol Chem
, vol.96
, pp. 1374-1388
-
-
Huttner, W.B.1
Schiebler, W.2
Greengard, P.3
De Camilli, P.4
-
13
-
-
0025857556
-
Therapeutic uses of botulinum neurotoxin
-
Jankovic, J. & Brin, M. F. (1991). Therapeutic uses of botulinum neurotoxin. N Engl J Med 324, 1186-1194.
-
(1991)
N Engl J Med
, vol.324
, pp. 1186-1194
-
-
Jankovic, J.1
Brin, M.F.2
-
14
-
-
0028328247
-
Detection of botulinum toxin using an evanescent wave immunosensor
-
Kumar, P., Colston, J. T., Chambers, J. P., Rael, E. P. & Valdes, J. J. (1994). Detection of botulinum toxin using an evanescent wave immunosensor. Biosens Bioelectronics 9, 57-63.
-
(1994)
Biosens Bioelectronics
, vol.9
, pp. 57-63
-
-
Kumar, P.1
Colston, J.T.2
Chambers, J.P.3
Rael, E.P.4
Valdes, J.J.5
-
15
-
-
0014949207
-
Cleavage of structural proteins during the assembly of the head of bacteriophage T4
-
Laemmli, U. K. (1970). Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227, 680-685.
-
(1970)
Nature
, vol.227
, pp. 680-685
-
-
Laemmli, U.K.1
-
16
-
-
0028216482
-
A single mutation in the recombinant light chain of tetanus toxin abolishes its proteolytic activity and removes the toxicity seen after reconstitution with native heavy chain
-
Li, Y., Foran, P., Fairweather, N. F., de Paiva, A., Weller, U., Dougan, G. & Dolly, J. O. (1994). A single mutation in the recombinant light chain of tetanus toxin abolishes its proteolytic activity and removes the toxicity seen after reconstitution with native heavy chain. Biochemistry 33, 7014-7020.
-
(1994)
Biochemistry
, vol.33
, pp. 7014-7020
-
-
Li, Y.1
Foran, P.2
Fairweather, N.F.3
De Paiva, A.4
Weller, U.5
Dougan, G.6
Dolly, J.O.7
-
17
-
-
0027097028
-
Tetanus toxin action: Inhibition of neurotransmitter release linked to synaptobrevin proteolysis
-
Link, E., Edelmann, L., Chou, J. H., Binz, T., Yamasaki, S., Eisel, U., Baumert, M., Sudhof, T. C., Niemann, H. & Jahn, R. (1992). Tetanus toxin action: inhibition of neurotransmitter release linked to synaptobrevin proteolysis. Biochem Biophys Res Commun 189, 1017-1023.
-
(1992)
Biochem Biophys Res Commun
, vol.189
, pp. 1017-1023
-
-
Link, E.1
Edelmann, L.2
Chou, J.H.3
Binz, T.4
Yamasaki, S.5
Eisel, U.6
Baumert, M.7
Sudhof, T.C.8
Niemann, H.9
Jahn, R.10
-
18
-
-
0030245670
-
Therapeutic botulinum type A toxin: Factors affecting potency
-
McLellan, K., Gaines Das, G. E., Ekong, T. A. N. & Sesardic, D. (1996). Therapeutic botulinum type A toxin: factors affecting potency. Toxicon 34, 975-985.
-
(1996)
Toxicon
, vol.34
, pp. 975-985
-
-
McLellan, K.1
Gaines Das, G.E.2
Ekong, T.A.N.3
Sesardic, D.4
-
19
-
-
0027248876
-
Tetanus and botulinum neurotoxins: A new family of metalloproteases
-
Montecucco, C. & Schiavo, G. (1993). Tetanus and botulinum neurotoxins: a new family of metalloproteases. Trends Biochem Sci 18, 324-327.
-
(1993)
Trends Biochem Sci
, vol.18
, pp. 324-327
-
-
Montecucco, C.1
Schiavo, G.2
-
20
-
-
0029613765
-
The structure and function of tetanus and botulinum neurotoxins
-
Montecucco, C. & Schiavo, G. (1995). The structure and function of tetanus and botulinum neurotoxins. Q Rev Biophys 28, 423-472.
-
(1995)
Q Rev Biophys
, vol.28
, pp. 423-472
-
-
Montecucco, C.1
Schiavo, G.2
-
21
-
-
76549170704
-
The release of enzymes from Escherichia coli by osmotic shock and during the formation of spheroplasts
-
Neu, H. C. & Heppel, L. A. (1965). The release of enzymes from Escherichia coli by osmotic shock and during the formation of spheroplasts. J Biol Chem 240, 3685-3692.
-
(1965)
J Biol Chem
, vol.240
, pp. 3685-3692
-
-
Neu, H.C.1
Heppel, L.A.2
-
22
-
-
1842338490
-
Toxins and substrates: Structural requirements for formation of protein/substrate complexes
-
1996, Abstract 16
-
Niemann, H., Hayashi, T., Yamasaki, S., Neuenberg, P., Mannìer, P. & Binz, T. (1996). Toxins and substrates: structural requirements for formation of protein/substrate complexes. In Abstracts of the International Conference for Biomedical Aspects of Clostridial Neurotoxins, Oxford, UK, 1996, Abstract 16.
-
(1996)
Abstracts of the International Conference for Biomedical Aspects of Clostridial Neurotoxins, Oxford, UK
-
-
Niemann, H.1
Hayashi, T.2
Yamasaki, S.3
Neuenberg, P.4
Mannìer, P.5
Binz, T.6
-
23
-
-
0024828306
-
The identification of a novel synaptosomal-associated protein, SNAP-25, differentially expressed by neuronal subpopulations
-
Oyler, G. A., Higgins, G. A., Hart, R. A., Battenberg, E., Billinsgley, M., Bloom, F. E. & Wilson, M. C. (1989). The identification of a novel synaptosomal-associated protein, SNAP-25, differentially expressed by neuronal subpopulations. J Biol Chem 109, 3039-3052.
-
(1989)
J Biol Chem
, vol.109
, pp. 3039-3052
-
-
Oyler, G.A.1
Higgins, G.A.2
Hart, R.A.3
Battenberg, E.4
Billinsgley, M.5
Bloom, F.E.6
Wilson, M.C.7
-
24
-
-
0028964514
-
The median paralysis unit: A more pharmacologically relevant unit of biologic activity for botulinum toxin
-
Pearce, L. B., Borodic, G. E., Johnson, E. A., First, E. R. & MacCallum, R. D. (1995). The median paralysis unit: a more pharmacologically relevant unit of biologic activity for botulinum toxin. Toxicon 33, 217-227.
-
(1995)
Toxicon
, vol.33
, pp. 217-227
-
-
Pearce, L.B.1
Borodic, G.E.2
Johnson, E.A.3
First, E.R.4
MacCallum, R.D.5
-
25
-
-
0028090321
-
SNARE motif and neurotoxins
-
Rossetto, O., Schiavo, G., Montecucco, C., Poulain, B., Deloye, F., Lozzi, L. & Shone, C. C. (1994). SNARE motif and neurotoxins. Nature 372, 415-416.
-
(1994)
Nature
, vol.372
, pp. 415-416
-
-
Rossetto, O.1
Schiavo, G.2
Montecucco, C.3
Poulain, B.4
Deloye, F.5
Lozzi, L.6
Shone, C.C.7
-
26
-
-
0020286209
-
Clostridium botulinum toxins
-
Sakaguchi, G. (1983). Clostridium botulinum toxins. Pharmacol Ther 19, 165-194.
-
(1983)
Pharmacol Ther
, vol.19
, pp. 165-194
-
-
Sakaguchi, G.1
-
27
-
-
0026548114
-
Properties and use of botulinum toxin and other microbial neurotoxins in medicine
-
Schantz, E. J. & Johnson, E. A. (1992). Properties and use of botulinum toxin and other microbial neurotoxins in medicine. Microbiol Rev 56, 80-99.
-
(1992)
Microbiol Rev
, vol.56
, pp. 80-99
-
-
Schantz, E.J.1
Johnson, E.A.2
-
28
-
-
0026497466
-
Tetanus and botulinum B neurotoxins block transmitter release by proteolytic cleavage of synaptobrevin
-
Schiavo, G., Benfenati, F., Poulain, B., Rossetto, O., de Laureto, P. P., DasGupta, B. R. & Montecucco, C. (1992). Tetanus and botulinum B neurotoxins block transmitter release by proteolytic cleavage of synaptobrevin. Nature 359, 832-835.
-
(1992)
Nature
, vol.359
, pp. 832-835
-
-
Schiavo, G.1
Benfenati, F.2
Poulain, B.3
Rossetto, O.4
De Laureto, P.P.5
DasGupta, B.R.6
Montecucco, C.7
-
29
-
-
0027438184
-
Botulinum neurotoxins serotypes A and E cleave SNAP-25 at distinct COOH-terminal peptide bonds
-
Schiavo, G., Santucci, A., DasGupta, B. R., Mehta, P. P., Jontes, J., Benfenati, F., Wilson, C. W. & Montecucco, C. (1993a). Botulinum neurotoxins serotypes A and E cleave SNAP-25 at distinct COOH-terminal peptide bonds. FEBS Lett 335, 99-103.
-
(1993)
FEBS Lett
, vol.335
, pp. 99-103
-
-
Schiavo, G.1
Santucci, A.2
DasGupta, B.R.3
Mehta, P.P.4
Jontes, J.5
Benfenati, F.6
Wilson, C.W.7
Montecucco, C.8
-
30
-
-
0027366557
-
Identification of the nerve terminal targets of botulinum neurotoxin serotypes A, D, and E
-
Schiavo, G., Rossetto, O., Catsicas, S., de Laureto, P. P., DasGupta, B. R. & Montecucco, C. (1993b). Identification of the nerve terminal targets of botulinum neurotoxin serotypes A, D, and E. J Biol Chem 268, 23784-23787.
-
(1993)
J Biol Chem
, vol.268
, pp. 23784-23787
-
-
Schiavo, G.1
Rossetto, O.2
Catsicas, S.3
De Laureto, P.P.4
DasGupta, B.R.5
Montecucco, C.6
-
31
-
-
0029560840
-
Proteolysis of synthetic peptides by type A botulinum neurotoxin
-
Schmidt, J. J. & Bostian, K. A. (1995). Proteolysis of synthetic peptides by type A botulinum neurotoxin. J Protein Chem 14, 703-708.
-
(1995)
J Protein Chem
, vol.14
, pp. 703-708
-
-
Schmidt, J.J.1
Bostian, K.A.2
-
32
-
-
0029952424
-
Refinement and validation of an alternative bioassay for potency testing of therapeutic botulinum type A toxin
-
Sesardic, D., McLellan, K., Ekong, T. A. N. & Gaines Das, R. (1996). Refinement and validation of an alternative bioassay for potency testing of therapeutic botulinum type A toxin. Pharmacol Toxicol 78, 283-288.
-
(1996)
Pharmacol Toxicol
, vol.78
, pp. 283-288
-
-
Sesardic, D.1
McLellan, K.2
Ekong, T.A.N.3
Gaines Das, R.4
-
33
-
-
0028065415
-
Peptide substrate specificity and properties of the zinc-endopeptidase activity of botulinum type B neurotoxin
-
Shone, C. C. & Roberts, A. K. (1994). Peptide substrate specificity and properties of the zinc-endopeptidase activity of botulinum type B neurotoxin. Eur J Biochem 225, 263-270.
-
(1994)
Eur J Biochem
, vol.225
, pp. 263-270
-
-
Shone, C.C.1
Roberts, A.K.2
-
34
-
-
0021869121
-
Monoclonal antibody-based immunoassay for type A Clostridium botulinum toxin is comparable to the mouse bioassay
-
Shone, C. C., Wilton-Smith, P., Appleton, N., Hambleton, P., Modi, N., Gatley, S. & Melling, J. (1985). Monoclonal antibody-based immunoassay for type A Clostridium botulinum toxin is comparable to the mouse bioassay. Appl Environ Microbiol 50, 63-67.
-
(1985)
Appl Environ Microbiol
, vol.50
, pp. 63-67
-
-
Shone, C.C.1
Wilton-Smith, P.2
Appleton, N.3
Hambleton, P.4
Modi, N.5
Gatley, S.6
Melling, J.7
-
35
-
-
0019619833
-
The origin, structure and pharmacological activity of botulinum toxin
-
Simpson, L. L. (1981). The origin, structure and pharmacological activity of botulinum toxin. Pharmacol Rev 33, 155-188.
-
(1981)
Pharmacol Rev
, vol.33
, pp. 155-188
-
-
Simpson, L.L.1
-
36
-
-
0030052207
-
Immunochemical characterization of type A botulinum neurotoxin in its purified and complexed forms
-
Singh, B. R., Lopes, T. & Silvia, M. A. (1996). Immunochemical characterization of type A botulinum neurotoxin in its purified and complexed forms. Toxicon 34, 267-275.
-
(1996)
Toxicon
, vol.34
, pp. 267-275
-
-
Singh, B.R.1
Lopes, T.2
Silvia, M.A.3
-
37
-
-
0030271329
-
A sensitive and rapid fluorescence-based assay for determination of tetanus toxin peptidase activity
-
Soleilhac, J.-M., Cornille, F., Martin, L., Lenoir, C., Fournie-Zaluski, M.-C. & Roques, B. P. (1996). A sensitive and rapid fluorescence-based assay for determination of tetanus toxin peptidase activity. Anal Biochem 241, 120-127.
-
(1996)
Anal Biochem
, vol.241
, pp. 120-127
-
-
Soleilhac, J.-M.1
Cornille, F.2
Martin, L.3
Lenoir, C.4
Fournie-Zaluski, M.-C.5
Roques, B.P.6
-
38
-
-
0027413655
-
SNAP receptors implicated in vesicle targeting and fusion
-
Söllner, T., Whiteheart, S. W., Brunner, M., Erjument-Bromage, H., Geromanos, S., Tempst, P. & Rothman, J. E. (1993). SNAP receptors implicated in vesicle targeting and fusion. Nature 362, 318-324.
-
(1993)
Nature
, vol.362
, pp. 318-324
-
-
Söllner, T.1
Whiteheart, S.W.2
Brunner, M.3
Erjument-Bromage, H.4
Geromanos, S.5
Tempst, P.6
Rothman, J.E.7
-
39
-
-
0009482260
-
Electrophoretic transfer from polyacrylamide gels to nitrocellulose sheets: Procedure and some applications
-
Towbin, H., Staehelin, T. & Gordon, J. (1979). Electrophoretic transfer from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc Natl Acad Sci USA 76, 4350-4354.
-
(1979)
Proc Natl Acad Sci USA
, vol.76
, pp. 4350-4354
-
-
Towbin, H.1
Staehelin, T.2
Gordon, J.3
-
40
-
-
0029891288
-
Substrate residues N-terminal to the cleavage site of botulinum type B neurotoxin play a role in determining the specificity of its endopeptidase activity
-
Wictome, M., Rossetto, O., Montecucco, C. & Shone, C. C. (1996). Substrate residues N-terminal to the cleavage site of botulinum type B neurotoxin play a role in determining the specificity of its endopeptidase activity. FEBS Lett 386, 133-136.
-
(1996)
FEBS Lett
, vol.386
, pp. 133-136
-
-
Wictome, M.1
Rossetto, O.2
Montecucco, C.3
Shone, C.C.4
-
41
-
-
0029980484
-
Clostridial neurotoxins and substrate proteolysis in intact neurones: Botulinum neurotoxin C acts on synaptosomal-associated protein of 25 kDa
-
Williamson, L. C., Halpern, J. L., Montecucco, C., Brown, J. E. & Neale, E. A. (1996). Clostridial neurotoxins and substrate proteolysis in intact neurones: Botulinum neurotoxin C acts on synaptosomal-associated protein of 25 kDa. J Biol Chem 271, 7694-7699.
-
(1996)
J Biol Chem
, vol.271
, pp. 7694-7699
-
-
Williamson, L.C.1
Halpern, J.L.2
Montecucco, C.3
Brown, J.E.4
Neale, E.A.5
|