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Volumn 9, Issue 1, 2005, Pages 2-7

Keloids: An old problem still searching for a solution

Author keywords

Future trends; Keloids; Pathophysiology; Racial susceptibility; Treatment modalities

Indexed keywords

3 AMINOPROPIONITRILE; ALPHA TOCOPHEROL; ALPHA2B INTERFERON; ANALGESIC AGENT; ANTIBIOTIC AGENT; ANTINEOPLASTIC AGENT; ANTIPRURITIC AGENT; ASIATICOSIDE; BLEOMYCIN; CHLORMETHINE; COLCHICINE DERIVATIVE; CORTICOSTEROID; CORTICOTROPIN; DEXAMETHASONE; DEXTRAN SULFATE; FLUOROURACIL; GAMMA INTERFERON; HYALURONIDASE; HYDROQUINONE DERIVATIVE; IMIQUIMOD; INTERFERON; MANNOSE 6 PHOSPHATE; METHOTREXATE; PENICILLAMINE; PEPSIN A; RETINOIC ACID; SILICON; SNAKE VENOM; STEROID; THIOTEPA; TRANSFORMING GROWTH FACTOR BETA ANTIBODY; TRANSFORMING GROWTH FACTOR BETA3; TRIAMCINOLONE; TRIAMCINOLONE ACETONIDE; VERAPAMIL; ZINC OXIDE;

EID: 21644452545     PISSN: 17441625     EISSN: 17441633     Source Type: Journal    
DOI: 10.1111/j.1744-1633.2005.00226.x     Document Type: Review
Times cited : (18)

References (53)
  • 1
    • 0037377119 scopus 로고    scopus 로고
    • Role of IGF system of mitogens in the induction of fibroblast proliferation by keloid-derived keratinocytes in vitro
    • Phan TT, Lim IJ, Bay BH et al. Role of IGF system of mitogens in the induction of fibroblast proliferation by keloid-derived keratinocytes in vitro. Am. J. Physiol. Cell Physiol. 2003; 284: C860-C869.
    • (2003) Am. J. Physiol. Cell Physiol. , vol.284
    • Phan, T.T.1    Lim, I.J.2    Bay, B.H.3
  • 2
    • 2442655265 scopus 로고    scopus 로고
    • Medical and surgical therapies for keloids
    • Kelly AP. Medical and surgical therapies for keloids. Dermol. Ther. 2004; 17: 212-18.
    • (2004) Dermol. Ther. , vol.17 , pp. 212-218
    • Kelly, A.P.1
  • 3
    • 0025308160 scopus 로고
    • Keloids: A review of the literature
    • Datubo-Brown DD. Keloids: a review of the literature. Br. J. Plast. Surg. 1990; 43: 70-7.
    • (1990) Br. J. Plast. Surg. , vol.43 , pp. 70-77
    • Datubo-Brown, D.D.1
  • 4
    • 1042289600 scopus 로고    scopus 로고
    • Elevated vascular endothelial growth factor in keloids: Relevance to tissue fibrosis
    • Le AD, Zhang Q, Wu Y et al. Elevated vascular endothelial growth factor in keloids: relevance to tissue fibrosis. Cells Tissues Organs 2004; 176: 87-94.
    • (2004) Cells Tissues Organs , vol.176 , pp. 87-94
    • Le, A.D.1    Zhang, Q.2    Wu, Y.3
  • 7
    • 21644477848 scopus 로고    scopus 로고
    • Wound healing, keloids
    • Available from: URL: [onlineεMedicine.com. Inc.]
    • Newsome RE, Langton K, Jansen D. Wound healing, keloids. eMedicine Specialties 2003; 1-11 Available from: URL: [onlineεMedicine.com. Inc.].
    • (2003) EMedicine Specialties , pp. 1-11
    • Newsome, R.E.1    Langton, K.2    Jansen, D.3
  • 8
    • 0035205678 scopus 로고    scopus 로고
    • Scar contractures, hypertrophic scars, and keloids
    • Brissett AE, Sherris DA. Scar contractures, hypertrophic scars, and keloids. Arch. Facial Plast. Surg. 2001; 17: 263-72.
    • (2001) Arch. Facial Plast. Surg. , vol.17 , pp. 263-272
    • Brissett, A.E.1    Sherris, D.A.2
  • 10
    • 0014815854 scopus 로고
    • Biological basis for the treatment of keloids and hypertrophic scars
    • Peacock EE, Madden JW, Trier WC. Biological basis for the treatment of keloids and hypertrophic scars. South. Med. J. 1970; 63: 755-60.
    • (1970) South. Med. J. , vol.63 , pp. 755-760
    • Peacock, E.E.1    Madden, J.W.2    Trier, W.C.3
  • 11
    • 0042164838 scopus 로고    scopus 로고
    • Keloid in Iraqi patients: A clinicohistopathologic study
    • Sharquie KE, Al-Dhalimi MA. Keloid in Iraqi patients: a clinicohistopathologic study. Dermatol. Surg. 2003; 29: 847-51.
    • (2003) Dermatol. Surg. , vol.29 , pp. 847-851
    • Sharquie, K.E.1    Al-Dhalimi, M.A.2
  • 12
    • 0019122781 scopus 로고
    • The biology and control of surface overhealing
    • Cohen IK, McCoy BJ. The biology and control of surface overhealing. World J. Surg. 1980; 4: 289-95.
    • (1980) World J. Surg. , vol.4 , pp. 289-295
    • Cohen, I.K.1    McCoy, B.J.2
  • 13
    • 0016707690 scopus 로고
    • Genetic studies on keloid
    • Omo-Dare P. Genetic studies on keloid. J. Natl. Med. Assoc. 1975; 67: 428-32.
    • (1975) J. Natl. Med. Assoc. , vol.67 , pp. 428-432
    • Omo-Dare, P.1
  • 14
    • 1242330339 scopus 로고    scopus 로고
    • Description of site specific morphology of keloid phenotypes in an Afrocarribean population
    • Bayat A, Fergusson MW, McGrouther DA. Description of site specific morphology of keloid phenotypes in an Afrocarribean population. Br. J. Plast. Surg. 2004; 57: 122-33.
    • (2004) Br. J. Plast. Surg. , vol.57 , pp. 122-133
    • Bayat, A.1    Fergusson, M.W.2    McGrouther, D.A.3
  • 15
    • 0003326337 scopus 로고
    • The pathology of keloid scars
    • Khan S. The pathology of keloid scars. Surgery 1988; 54: 1299-301.
    • (1988) Surgery , vol.54 , pp. 1299-1301
    • Khan, S.1
  • 16
    • 0021827463 scopus 로고
    • Biochemical composition of the connective tissue in keloids and analysis of collagen metabolism in keloid fibroblast cultures
    • Abergel RP, Pizzurro D, Meeker CAJ et al. Biochemical composition of the connective tissue in keloids and analysis of collagen metabolism in keloid fibroblast cultures. J. Invest. Dermatol. 1985; 84: 384-90.
    • (1985) J. Invest. Dermatol. , vol.84 , pp. 384-390
    • Abergel, R.P.1    Pizzurro, D.2    Meeker, C.A.J.3
  • 17
    • 0018349618 scopus 로고
    • Growth kinetics and collagen synthesis of normal skin, normal scar and keloid fibroblasts in vitro
    • Diegelmann RF, Cohen IK, McCoy BJ. Growth kinetics and collagen synthesis of normal skin, normal scar and keloid fibroblasts in vitro. J. Cell. Physiol. 1979; 98: 341.
    • (1979) J. Cell. Physiol. , vol.98 , pp. 341
    • Diegelmann, R.F.1    Cohen, I.K.2    McCoy, B.J.3
  • 18
    • 0019983359 scopus 로고
    • Collagenase in keloid biopsies and fibroblasts
    • McCoy BJ, Cohen IK. Collagenase in keloid biopsies and fibroblasts. Connect. Tissue Res. 1982; 9: 181-5.
    • (1982) Connect. Tissue Res. , vol.9 , pp. 181-185
    • McCoy, B.J.1    Cohen, I.K.2
  • 19
    • 0006551350 scopus 로고
    • Collagen metabolism in keloid and hypertrophic scar
    • Longacre JJ, ed. Springfield: Charles C. Thomas
    • Cohen IK, Diegelmann RF, Keiser HR. Collagen metabolism in keloid and hypertrophic scar. In: Longacre JJ, ed. The Ultrastructure of Collagen. Springfield: Charles C. Thomas, 1976; 199-212.
    • (1976) The Ultrastructure of Collagen , pp. 199-212
    • Cohen, I.K.1    Diegelmann, R.F.2    Keiser, H.R.3
  • 20
    • 0015725758 scopus 로고
    • Collagen degradation in cultured keloid and hypertrophic scar tissue
    • Milsom JP, Craig RDP. Collagen degradation in cultured keloid and hypertrophic scar tissue. Br. J. Dermatol. 1973; 89: 635-43.
    • (1973) Br. J. Dermatol. , vol.89 , pp. 635-643
    • Milsom, J.P.1    Craig, R.D.P.2
  • 21
    • 0014976044 scopus 로고
    • Human skin collagenase, the role of serum alpha globulins in the control of activity in vivo and in vitro
    • Eisen AZ, Bauer EA, Jeffrey JJ. Human skin collagenase, the role of serum alpha globulins in the control of activity in vivo and in vitro. Proc. Natl. Acad. Sci. USA 1971; 168: 248.
    • (1971) Proc. Natl. Acad. Sci. USA , vol.168 , pp. 248
    • Eisen, A.Z.1    Bauer, E.A.2    Jeffrey, J.J.3
  • 23
    • 0020196322 scopus 로고
    • Delayed type hypersensitivity reaction to cutaneous antigen in keloid
    • Mukherjee A, Mukherjee A, Saha KC. Delayed type hypersensitivity reaction to cutaneous antigen in keloid. Indian J. Dermatol. 1982; 27: 125-30.
    • (1982) Indian J. Dermatol. , vol.27 , pp. 125-130
    • Mukherjee, A.1    Mukherjee, A.2    Saha, K.C.3
  • 25
    • 0018689821 scopus 로고
    • Does an immune reaction to sebum in wounds cause keloid scars?
    • Yagi KI, Dafalla AA, Osman AA. Does an immune reaction to sebum in wounds cause keloid scars? Br. J. Plast. Surg. 1979; 32: 223-5.
    • (1979) Br. J. Plast. Surg. , vol.32 , pp. 223-225
    • Yagi, K.I.1    Dafalla, A.A.2    Osman, A.A.3
  • 26
    • 0020701989 scopus 로고
    • Immunofluorescence finding in haematoporphyrin-induced keloid
    • Nunzi E, Parodi A, Rebora A. Immunofluorescence finding in haematoporphyrin-induced keloid. Br. J. Dermatol. 1983; 108: 263-6.
    • (1983) Br. J. Dermatol. , vol.108 , pp. 263-266
    • Nunzi, E.1    Parodi, A.2    Rebora, A.3
  • 28
    • 0020454456 scopus 로고
    • Studies on immunologic aspects of keloids and hypertrophic scars
    • Janssen de Limpens AM, Cormane RH. Studies on immunologic aspects of keloids and hypertrophic scars. Arch. Dermatol. Res. 1982; 274: 259-66.
    • (1982) Arch. Dermatol. Res. , vol.274 , pp. 259-266
    • Janssen de Limpens, A.M.1    Cormane, R.H.2
  • 29
    • 0018424935 scopus 로고
    • Immunoglobulin, complement and histocompatibility antigen studies in keloids patients
    • Cohen IK, McCoy BJ, Mohanakumars T, Diegelmann RF. Immunoglobulin, complement and histocompatibility antigen studies in keloids patients. Plast. Reconstr. Surg. 1979; 63: 689-95.
    • (1979) Plast. Reconstr. Surg. , vol.63 , pp. 689-695
    • Cohen, I.K.1    McCoy, B.J.2    Mohanakumars, T.3    Diegelmann, R.F.4
  • 32
    • 0037273159 scopus 로고    scopus 로고
    • Hypertrophic scars and keloids: Etiology and management
    • Alster TS, Tanzi EL. Hypertrophic scars and keloids: etiology and management. Am. J. Clin. Dermatol. 2003; 4: 235-43.
    • (2003) Am. J. Clin. Dermatol. , vol.4 , pp. 235-243
    • Alster, T.S.1    Tanzi, E.L.2
  • 33
    • 0030051516 scopus 로고    scopus 로고
    • Adjunct therapies to surgical management of keloids
    • Berman B, Bieley HC. Adjunct therapies to surgical management of keloids. Dermatol. Surg. 1996; 22: 126-30.
    • (1996) Dermatol. Surg. , vol.22 , pp. 126-130
    • Berman, B.1    Bieley, H.C.2
  • 34
    • 0032410066 scopus 로고    scopus 로고
    • The treatment of hypertrophic scars and keloids
    • Berman B, Flores F. The treatment of hypertrophic scars and keloids. Eur. J. Dermatol. 1998; 8: 591-5.
    • (1998) Eur. J. Dermatol. , vol.8 , pp. 591-595
    • Berman, B.1    Flores, F.2
  • 35
    • 0019100087 scopus 로고
    • Keloids: A prospective study of 57 cases
    • Sharma BC. Keloids: a prospective study of 57 cases. Med. J. Zambia 1980; 14: 66-9.
    • (1980) Med. J. Zambia , vol.14 , pp. 66-69
    • Sharma, B.C.1
  • 36
    • 0141619237 scopus 로고    scopus 로고
    • Imiquimod 5% cream for keloid management
    • Berman B, Villa A. Imiquimod 5% cream for keloid management. Dermatol. Surg. 2003; 29: 1050-1.
    • (2003) Dermatol. Surg. , vol.29 , pp. 1050-1051
    • Berman, B.1    Villa, A.2
  • 37
    • 0016780123 scopus 로고
    • Alteration of hypertrophic scar induced by mechanical pressure
    • Kischer CW, Shetlar MR, Shetlar CL. Alteration of hypertrophic scar induced by mechanical pressure. Arch. Dermatol. 1975; 111: 60-4.
    • (1975) Arch. Dermatol. , vol.111 , pp. 60-64
    • Kischer, C.W.1    Shetlar, M.R.2    Shetlar, C.L.3
  • 38
    • 0017137772 scopus 로고
    • Postoperative irradiation in the prevention of keloids
    • Levy DS, Salter MM, Roth RE. Postoperative irradiation in the prevention of keloids. Am. J. Roentgenol. 1976; 127: 509-10.
    • (1976) Am. J. Roentgenol. , vol.127 , pp. 509-510
    • Levy, D.S.1    Salter, M.M.2    Roth, R.E.3
  • 39
    • 0017065771 scopus 로고
    • Keloid scars: A new method of treatment combining surgery with interstitial radiotherapy
    • Malaker A, Ellis F, Paine CH. Keloid scars: a new method of treatment combining surgery with interstitial radiotherapy. Clin. Radiol. 1976; 27: 179-83.
    • (1976) Clin. Radiol. , vol.27 , pp. 179-183
    • Malaker, A.1    Ellis, F.2    Paine, C.H.3
  • 40
    • 0029075231 scopus 로고
    • Superficial X-ray therapy in keloid management: A retrospective study of 24 cases and literature review
    • Norris JE. Superficial X-ray therapy in keloid management: a retrospective study of 24 cases and literature review. Plast. Recontr. Surg. 1995; 95: 1051-5.
    • (1995) Plast. Recontr. Surg. , vol.95 , pp. 1051-1055
    • Norris, J.E.1
  • 41
    • 0028310542 scopus 로고
    • A short course postoperative radiotherapy regime for keloid scars in Nigeria
    • Durosinmi-Etti FA, Olasinde TA, Solarin EO. A short course postoperative radiotherapy regime for keloid scars in Nigeria. West Afr. J. Med. 1994; 13: 17-19.
    • (1994) West Afr. J. Med. , vol.13 , pp. 17-19
    • Durosinmi-Etti, F.A.1    Olasinde, T.A.2    Solarin, E.O.3
  • 42
    • 0029287582 scopus 로고
    • Treatment of so-called keloid with excision and postoperative electron irradiation
    • Mitsuhashi K, Miyashita T. Treatment of so-called keloid with excision and postoperative electron irradiation. J. Nippon Med. Sch. 1995; 62: 186-95.
    • (1995) J. Nippon Med. Sch. , vol.62 , pp. 186-195
    • Mitsuhashi, K.1    Miyashita, T.2
  • 43
    • 0029884029 scopus 로고    scopus 로고
    • Cushing's syndrome in postburn children following intralesional triamcinolone injection
    • Ritota PC, Lo AK. Cushing's syndrome in postburn children following intralesional triamcinolone injection. Ann. Plast. Surg. 1996; 36: 508-11.
    • (1996) Ann. Plast. Surg. , vol.36 , pp. 508-511
    • Ritota, P.C.1    Lo, A.K.2
  • 44
    • 0034518779 scopus 로고    scopus 로고
    • Laser treatment of hypertrophic scars, keloids, and striae
    • Alster TS, Handrick C. Laser treatment of hypertrophic scars, keloids, and striae. Semin. Cutan. Med. Surg. 2000; 19: 287-92.
    • (2000) Semin. Cutan. Med. Surg. , vol.19 , pp. 287-292
    • Alster, T.S.1    Handrick, C.2
  • 45
    • 0029024449 scopus 로고
    • Vitamin E added silicon gel sheets for treatment of hypertrophic scars and keloids
    • Palmieri G, Gozzi G, Palmieri G. Vitamin E added silicon gel sheets for treatment of hypertrophic scars and keloids. Int. J. Dermatol. 1995; 34: 506-9.
    • (1995) Int. J. Dermatol. , vol.34 , pp. 506-509
    • Palmieri, G.1    Gozzi, G.2    Palmieri, G.3
  • 46
    • 0018898441 scopus 로고
    • Treating keloids by surgery and methotrexate
    • (Letter)
    • Onwukwe MF. Treating keloids by surgery and methotrexate (Letter). Arch. Dermatol. 1980; 116: 158.
    • (1980) Arch. Dermatol. , vol.116 , pp. 158
    • Onwukwe, M.F.1
  • 47
    • 0034791601 scopus 로고    scopus 로고
    • The effects of a single dose 5-Fluorouracil on keloid scars: A clinical trial of timed wound irrigation after intralesional excision
    • Uppal RS, Khan U, Kakar S, Talas G, Chapman P, McGrunther DA. The effects of a single dose 5-Fluorouracil on keloid scars: a clinical trial of timed wound irrigation after intralesional excision. Plast. Recontr. Surg. 2001; 108: 1218-24.
    • (2001) Plast. Recontr. Surg. , vol.108 , pp. 1218-1224
    • Uppal, R.S.1    Khan, U.2    Kakar, S.3    Talas, G.4    Chapman, P.5    McGrunther, D.A.6
  • 48
    • 0035142536 scopus 로고    scopus 로고
    • Bleomycin in the treatment of keloids and hypertrophic scars by multiple needle punctures
    • Espana A, Solano T, Quintanilla E. Bleomycin in the treatment of keloids and hypertrophic scars by multiple needle punctures. Dermatol. Surg. 2001; 27: 23-7.
    • (2001) Dermatol. Surg. , vol.27 , pp. 23-27
    • Espana, A.1    Solano, T.2    Quintanilla, E.3
  • 49
    • 0021108738 scopus 로고
    • Ultrasound therapy for keloids
    • (Letter)
    • Walker JJ. Ultrasound therapy for keloids (Letter). S. Afr. Med. J. 1983; 64: 270.
    • (1983) S. Afr. Med. J. , vol.64 , pp. 270
    • Walker, J.J.1
  • 50
    • 0029807849 scopus 로고    scopus 로고
    • Keloid excision and recurrence prophylaxis via intradermal interferon-gamma injections: A pilot study
    • Broker BJ, Rosen D, Amsberry J et al. Keloid excision and recurrence prophylaxis via intradermal interferon-gamma injections: a pilot study. Laryngoscope 1996; 106: 1497-501.
    • (1996) Laryngoscope , vol.106 , pp. 1497-1501
    • Broker, B.J.1    Rosen, D.2    Amsberry, J.3
  • 51
    • 0030203935 scopus 로고    scopus 로고
    • Treatment of earlobe keloids with surgery plus adjuvant intralesional verapamil and pressure earrings
    • Lawrence WT. Treatment of earlobe keloids with surgery plus adjuvant intralesional verapamil and pressure earrings. Ann. Plast. Surg. 1996; 37: 167-9.
    • (1996) Ann. Plast. Surg. , vol.37 , pp. 167-169
    • Lawrence, W.T.1
  • 52
    • 0034852841 scopus 로고    scopus 로고
    • Intralesional cryosurgery using lumbar puncture and/or hypodermic needles for large, bulky, recalcitrant keloids
    • Gupta S, Kumar B. Intralesional cryosurgery using lumbar puncture and/or hypodermic needles for large, bulky, recalcitrant keloids. Int. J. Dermatol. 2001; 40: 349-53.
    • (2001) Int. J. Dermatol. , vol.40 , pp. 349-353
    • Gupta, S.1    Kumar, B.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.