The KPNA3 gene may be a susceptibility candidate for schizophrenia

Neuroscience Research

Volumn 52, Issue 4, 2005, Pages 342-346

  Wei, Jun ^a   Hemmings, Gwynneth P ^a  

^a Schizophrenia Assoc of Gt Britain   (United Kingdom)

Author keywords

Association study; Chromosome 13; HTR2A; KPNA3; Schizophrenia; Single nucleotide polymorphisms (SNPs)

Indexed keywords

ADULT; ALLELE; ARTICLE; CHROMOSOME 13Q; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE PREDISPOSITION; ETHNIC GROUP; FAMILY; FATHER; FEMALE; GENE; GENE LOCUS; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; HAPLOTYPE; HUMAN; KPNA3 GENE; MAJOR CLINICAL STUDY; MALE; MOTHER; PRIORITY JOURNAL; PROGENY; SCHIZOPHRENIA; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; ALLELES; ALPHA KARYOPHERINS; CHI-SQUARE DISTRIBUTION; FAMILY HEALTH; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; HAPLOTYPES; HUMANS; MALE; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; POLYMORPHISM, SINGLE NUCLEOTIDE; SCHIZOPHRENIA;

EID: 21444442419     PISSN: 01680102     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neures.2005.04.005     Document Type: Article

References (40)

1. H.M. Abdolmaleky, S.V. Faraone, S.J. Glatt, and M.T. Tsuang Meta-analysis of association between the T102C polymorphism of the 5HT2a receptor gene and schizophrenia Schizophr. Res. 67 2004 53 62
2. A.M. Addington, M. Gornick, A.L. Sporn, N. Gogtay, D. Greenstein, M. Lenane, P. Gochman, N. Baker, R. Balkissoon, R.K. Vakkalanka, D.R. Weinberger, R.E. Sraub, and J.L. Rapoport Polymorphisms in the 13q33.2 gene G72/G30 are associated with childhood-onset schizophrenia and psychosis not otherwise specified Biol. Psychiatry 55 2004 976 980
3. M.J. Arranz, M.W. Lin, J. Powell, R. Kerwin, and D. Collier 5-HT 2a receptor T102C polymorphism and schizophrenia Lancet 347 1996 1831 1832
4. J.A. Badner, and E.S. Gershon Meta-analysis of whole-genome linkage scans of bipolar disorder and schizophrenia Mol. Psychiatry 7 2002 405 411
5. J.-L. Blouin, B.A. Dombroski, S.K. Nath, V.K. Lasseter, P.S. Wolyniec, G. Nestadt, M. Thornquist, G. Ullrich, J. McGrath, L. Kasch, M. Lamacz, M.G. Thomas, C. Gehrig, U. Radhakrishna, S.E. Snyder, K.G. Balk, K. Neufeld, K.L. Swartz, N. DeMarchi, G.N. Papadimitriou, D.G. Dikeos, C.N. Stefanis, A. Chakravarti, B. Childs, B. Childs, D.E. Housman, H.H. Kazazian, S.E. Antonarakis, and A.E. Pulver Schizophrenia susceptibility loci on chromosomes 13q32 and 8p21 Nat. Genet. 20 1998 70 73
6. L.M. Brzustowicz, W.G. Honer, E.W. Chow, D. Little, J. Hogan, K. Hodgkinson, and A.S. Bassett Linkage of familial schizophrenia to chromosome 13q32 Am. J. Hum. Genet. 65 1999 1096 1103
7. N.J. Camp, S.L. Neuhausen, J. Tiobech, A. Polloi, H. Coon, and M. Myles-Worsley Genome-wide multipoint linkage analysis of seven extended Palauan pedigrees with schizophrenia, by a Markov-chain Monte Carlo method Am. J. Hum. Genet. 69 2001 1278 1289
8. C.H. Chen, Y.R. Lee, F.C. Wei, F.J. Koong, H.G. Hwu, and K.J. Hsiao Lack of allelic association between 102T/C polymorphism of serotonin receptor type 2A gene and schizophrenia in Chinese Psychiatr. Genet. 7 1997 35 38
9. R.Y. Chen, P. Sham, E.Y. Chen, T. Li, E.F. Cheung, T.C. Hui, C.L. Kwok, F. Lieh-Mak, J.H. Zhao, D. Collier, and R. Murrray No association between T102C polymorphism of serotonin-2A receptor gene and clinical phenotypes of Chinese schizophrenic patients Psychiatry Res. 105 2001 175 185
10. I. Chumakov, M. Blumenfeld, O. Guerassimenko, L. Cavarec, M. Palicio, H. Abderrahim, L. Bougueleret, C. Barry, H. Tanaka, P. La Rosa, A. Puech, N. Tahri, A. Cohen- Akenine, S. Delabrosse, S. Lissarrague, F.-P. Picard, K. Maurice, L. Essioux, P. Millasseau, P. Grel, V. Debailleul, A.-M. Simon, D. Caterina, I. Dufaure, K. Malekzadeh, M. Belova, J.-J. Luan, M. Bouilot, J.-L. Sambucy, G. Primas, M. Saumier, N. Boubkiri, S. Martin-Saumier, M. Nasroune, H. Peixoto, A. Delaye, V. Pinchot, M. Bastucci, S. Guillou, M. Chevillon, R. Sainz-Fuertes, S. Meguenni, J. Aurich-Costa, D. Cherif, A. Gimalac, C. Van Duijn, D. Gauvreau, G. Ouelette, I. Fortier, J. Realson, T. Sherbatich, N. Riazanskaia, E. Rogaev, P. Raeymaekers, J. Aerssens, F. Konings, W. Luyten, F. Macciardi, P.C. Sham, R.E. Straub, D.R. Weinberger, N. Cohen, and D. Cohen Genetic and physiological data implicating the new human gene G72 and the gene for D-amino acid oxidase in schizophrenia Proc. Natl. Acad. Sci. U.S.A. 99 2002 13675 13680
11. P.M. Czerski, A. Leszczynska-Rodziewicz, M. Dmitrzak-Weglarz, P. Kapelski, S. Godlewski, J. Rybakowski, and J. Hauser Association analysis of serotonin 2A receptor gene T102C polymorphism and schizophrenia World J. Biol. Psychiatry 4 2003 69 73
12. S.V. Faraone, A.D. Skol, D.W. Tsuang, S. Bingham, K.A. Young, S. Prabhudesai, S.L. Haverstock, F. Mena, A.S. Menon, D. Bisset, J. Pepple, F. Sautter, C. Baldwin, D. Weiss, J. Collins, T. Keith, M. Boehnke, M.T. Tsuang, and G.D. Schellenberg Linkage of choromosome 13q32 to schizophrenia in a large veterans affairs cooperative study sample Am. J. Med. Genet. 114 2002 598 604
13. B.M. Fontoura, G. Blobel, and N.R. Yaseen The nucleoporin Nup98 is a site for GDP/GTP exchange on ran and termination of karyopherin beta 2-mediated nuclear import J. Biol. Chem. 275 2000 31289 31296
14. M.Z. Haider, and M.A. Zahid No evidence for an association between the 5-hydroxytryptamine 5-HT2a receptor gene and schizophrenia in Kuwaiti Arabs Psychiatry Clin. Neurosci. 56 2002 465 467
15. Z. Hawi, M.V. Myakishey, R.E. Straub, A. O'Neill, K.S. Kendler, D. Walsh, and M. Gill No association or linkage between the 5-HT2a/T102C polymorphism and schizophrenia in Irish families Am. J. Med. Genet. 74 1997 370 373
16. L. He, T. Li, C. Melville, S. Liu, G.Y. Feng, N.F. Gu, H. Fox, D. Shaw, G. Breen, X. Liu, P. Sham, J. Brown, D. Collier, and D. St Clair 102T/C polymorphism of serotonin receptor type 2A gene is not associated with schizophrenia in either Chinese or British populations Am. J. Med. Genet. 88 1999 95 98
17. H. Herken, M.E. Erdal, N. Erdal, and S. Aynacioglu T102C polymorphisms at the 5-HT2A receptor gene in Turkish schizophrenia patients: a possible association with prognosis Neuropsychobiology 47 2003 27 30
18. Y. Hu, G.Z. Ju, J. Wei, S.Z. Liu, S.P. Shi, Y.Q. Yu, Q. Xu, Y. Shen, and G.P. Hemmings A genetic association between the KPNB3 locus and schizophrenia in a Chinese population Schizophr. Res. 67 Suppl. 2004 55 (Abstract)
19. Y. Inayama, H. Yoneda, T. Sakai, T. Ishida, Y. Nonomura, Y. Kono, R. Takahata, J. Koh, J. Sakai, A. Takai, Y. Inada, and H. Asaba Positive association between a DNA sequence variant in the serotonin 2A receptor gene and schizophrenia Am. J. Med. Genet. 67 1996 103 105
20. M. Korostishevsky, M. Kaganovich, A. Cholostoy, M. Ashkenazi, Y. Ratner, D. Dahary, J. Bernstein, U. Bening-Abu-Shach, E. Ben-Asher, D. Lancet, M. Ritsner, and R. Navon Is the G72/G30 locus associated with schizophrenia? Single nucleotide polymorphisms, haplotype, and gene expression analysis Biol. Psychiatry 56 2004 169 176
21. A.P. Kouzmenko, A. Scaffidi, A.M. Pereira, W.L. Hayes, D.L. Copolov, and B. Dean No correlation between A(-1438) G polymorphism in 5-HT2A receptor gene promoter and the density of frontal cortical 5-HT2A receptors in schizophrenia Hum. Hered. 49 1999 103 105
22. D.F. Levinson, P. Holmans, R.E. Straub, M.J. Owen, D.B. Wildenauer, P.V. Gejman, A.E. Pulver, C. Laurent, K.S. Kendler, D. Walsh, N. Norton, N.M. Williams, S.G. Schwab, B. Lerer, B.J. Mowry, A.R. Sanders, S.E. Antonarakis, J.-L. Blouin, J.-F. Deleuze, and J. Mallet Multicenter linkage study of schizophrenia candidate regions on chromosomes 5q, 6q, 10p, and 13q: schizophrenia linkage collaborative group III Am. J. Hum. Genet. 67 2000 652 663
23. M.W. Lin, P. Sham, H.G. Hwu, D. Collier, R. Murray, and J.F. Powell Suggestive evidence for linkage of schizophrenia to markers on chromosome 13 in Caucasian but not Oriental populations Hum. Genet. 3 1997 417 420
24. J. Moroianu Distinct nuclear import and export pathways mediated by members of the karyopherin beta family J. Cell. Biochem. 70 1998 231 239
25. S. Nakielny, and G. Dreyfuss Transport of proteins and RNAs in and out of the nucleus Cell 96 1999 677 690
26. V.L. Nimgaonkar, X.R. Zhang, J.S. Brar, M. DeLeo, and R. Ganguli 5-HT2 receptor gene locus: association with schizophrenia or treatment response not detected Psychiatr. Genet. 6 1996 23 27
27. K. Ohara, M. Nagai, K. Tani, T. Tsukamoto, and K. Ohara Schizophrenia and the serotonin-2A receptor promoter polymorphism Psychiatry Res. 85 1999 221 224
28. J. Schumacher, R.A. Jamra, J. Freudenberg, T. Becker, S. Ohlraun, A.C. Otte, M. Tullius, S. Kovalenko, A.V. Bogaert, W. Maier, M. Rietschel, P. Propping, M.M. Nothen, and S. Cichon Examination of G72 and D-amino-acid oxidase as genetic risk factors for schizophrenia and bipolar affective disorder Mol. Psychiatry 9 2004 203 207
29. A. Serretti, C. Cusin, C. Lorenzi, E. Lattuada, R. Lilli, and E. Smeraldi Serotonin-2A receptor gene is not associated with symptomatology of schizophrenia Am. J. Med. Genet. 96 2000 84 87
30. S.H. Shaw, M. Kelly, A.B. Smith, G. Shields, P.J. Hopkins, J. Loftus, S.H. Laval, A. Vita, M. De Hert, L.R. Cardon, T.J. Crow, R. Sherrington, and L.E. DeLisi A genome-wide search for schizophrenia susceptibility genes Am. J. Med. Genet. 81 1998 364 376
31. T. Shinkai, O. Ohmori, H. Kojima, T. Terao, T. Suzuki, and K. Abe Negative association between T102C polymorphism of the 5-HT2a receptor gene and schizophrenia in Japan Hum. Hered. 48 1998 212 215
32. M. Verga, F. Macciardi, S. Cohen, S. Pedrini, and E. Smeraldi No association between schizophrenia and the serotonin receptor 5HTR2a in an Italian population Am. J. Med. Genet. 74 1997 21 25
33. X. Wang, G. He, N. Gu, J. Yang, J. Tang, Q. Chen, X. Liu, Y. Shen, X. Qian, W. Lin, Y. Duan, G. Feng, and L. He Association of G72/G30 with schizophrenia in the Chinese population Biochem. Biophys. Res. Commun. 319 2004 1281 1286
34. J. Wei, and G.P. Hemmings The KPNB3 locus is associated with schizophrenia Neurosci. Lett. 368 2004 323 326
35. J. Williams, P. McGuffin, M.M. Nöthen, M.J. Owen the EMASS Collaborative Group Meta-analysis of association between the 5-HT2a receptor T102C polymorphism and schizophrenia Lancet 349 1997 1221
36. J. Williams, G. Spurlock, P. McGuffin, J. Mallet, M.M. Nöthen, M. Gill, H. Aschauer, P.-O. Nylander, F. Macciardi, and M.J. Owen Association between schizophrenia and T102C polymorphism of the 5-hydroxytryptamine type 2a-receptor gene Lancet 347 1996 1294 1296
37. N.R. Yaseen, and G. Blobel Cloniing and characterization of human karyopherin β3 Proc. Natl. Acad. Sci. U.S.A. 94 1997 4451 4456
38. E. Yoshihara, K. Nakamura, M. Itoh, K. Ameno, Y. Takeuchi, I. Ijiri, and K. Iwahashi The human serotonin receptor gene (HTR2) MspI polymorphism in Japanese schizophrenic and alcoholic patients Neuropsychobiology 41 2000 124 126
39. X.N. Zhang, S.D. Jiang, X.H. He, and L.N. Zhang 102T/C SNP in the 5-hydroxytryptamine receptor 2A (HTR2A) gene and schizophrenia in two southern Han Chinese populations: lack of association Am. J. Med. Genet. 126B 2004 16 18
40. F. Zou, C. Li, S. Duan, Y. Zheng, N. Gu, Y. Feng, Y. Xing, J. Shi, and L. He A family-based study of the association between the G72/G30 genes and schizophrenia in the Chinese population Schizophr. Res. 73 2005 257 261