Differences in the DNA sequences in the upstream attenuator region of erm(A) in clinical isolates of Streptococcus pyogenes and their correlation with macrolide/lincosamide resistance

Antimicrobial Agents and Chemotherapy

Volumn 49, Issue 7, 2005, Pages 3070-3072

  Doktor, Stella Z ^a,b   Shortridge, Virginia ^a,c  

^a ABBOTT LABORATORIES   (United States)

^b Dept R4MJ ^*  (United States)

^c BIOMÉRIEUX   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CLINDAMYCIN; ERYTHROMYCIN; LINCOSAMIDE; MACROLIDE; TELITHROMYCIN;

ARTICLE; BACTERIAL GENE; BACTERIUM ISOLATE; CORRELATION ANALYSIS; DNA SEQUENCE; EMM GENE; ERMA GENE; GENE DELETION; GENE INSERTION; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; NUCLEOTIDE SEQUENCE; POINT MUTATION; PRIORITY JOURNAL; REGULATOR GENE; STREPTOCOCCUS PYOGENES;

ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BASE SEQUENCE; DRUG RESISTANCE, BACTERIAL; GENE EXPRESSION REGULATION, BACTERIAL; HUMANS; MACROLIDES; METHYLTRANSFERASES; MICROBIAL SENSITIVITY TESTS; MUTATION; PROTEIN SORTING SIGNALS; STREPTOCOCCUS PYOGENES;

EID: 21444435539     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.49.7.3070-3072.2005     Document Type: Article

References (13)

1. Beall, B., R. Facklam, and T. Thompson. 1996. Sequencing emm-specific PCR products for routine and accurate typing of group A streptococci. J. Clin. Microbiol. 34:953-958.
2. Clinical and Laboratory Standards Institute. 2005. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically, 6th ed., vol. M7-A6. Approved standard. Performance standards for antimicrobial susceptibility testing; 15th informational supplement. M100-S15. Clinical and Laboratory Standards Institute (NCCLS), Wayne, Pa.
3. Doktor, S., J. M. Beyer, R. K. Flamm, and V. D. Shortridge. 2005. A comparison between emm typing and ribotyping using three restriction enzymes to characterize clinical isolates of Streptococcus pyogenes. J. Clin. Microbiol. 43:150-155.
4. Fines, M., M. Gueudin, A. Ramon, and R. Leclerq. 2001. In vitro selection of resistance to clindamycin related to alterations in the attenuator of the erm(TR) gene of Streptococcus pyogenes UCN1 inducibly resistant to erythromycin. J. Antimicrob. Chemother. 48:411-416.
5. Schmitz, F.-J., J. Pertridou, N. Astfalk, K. Kohrer, S. Scheuring, and S. Schwarz. 2002. Molecular analysis of constitutively expressed erm(C) genes selected in vitro by incubation in the presence of the noninducers quinupristin, telithromycin or ABT-773. Microb. Drug Resist. 8:171-177.
6. Schmitz, F.-J., J. Pertridou, N. Astfalk, S. Scheuring, K. Kohrer, J. Verhoef, A. Fluit, and S. Schwarz. 2001. Structural alterations in the translational attenuator of constitutively expressed erm(A) genes in Staphylococcus aureus. Antimicrob. Agents Chemother. 45:1603-1604.
7. Seppälä, H., M. Skurnik, H. Soini, M. Roberts, and P. Huovinen. 1998. A novel erythromycin resistance methylase gene (ermTR) in Streptococcus pyogenes. Antimicrob. Agents Chemother. 42:257-262.
8. Shortridge, V. D., G. Doern, A. Brueggemann, J. Beyer, and R. Flamm. 1999. Prevalence of macrolide resistance mechanisms in Streptococcus pneumoniae isolates from a multicenter antibiotic resistance surveillance study conducted in the United States in 1994-1995. Clin. Infect. Dis. 29:1186-1188.
9. Shortridge, V. D., R. Flamm, N. Ramer, J. Beyer, and S. Tanaka. 1996. Novel mechanism of macrolide resistance in Streptococcus pneumoniae. Diagn. Microbiol. Infect. Dis. 26:73-78.
10. Shortridge, V. D., P. Zhong, P. Cao, J. M. Beyer, L. S. Almer, N. C. Ramer, S. Z. Doktor, and R. K. Flamm. 2002. Comparison of in vitro activities of ABT-773 and telithromycin against macrolide-susceptible and -resistant streptocci and staphylococci. Antimicrob. Agents Chemother. 46:783-786.
11. Weisblum, Bernard. 1995. Insights into Erythromycin Action from Studies of Its Activity as Inducer of Resistance. Antimicrob. Agents Chemother. 39:797-805.
12. Werckenthin, C., and S. Schwarz. 2000. Molecular analysis of the transnational attenuator of a constitutively expressed erm(A) gene from Staphylococcus intermedius. J. Antimicrobial. Chemother. 46:785-788.
13. Werckenthin, C., S. Schwarz, and H. Westh. 1999. Structural alterations in the translational attenuator of constitutively expressed ermC genes. Antimicrob. Agents Chemother. 43:1681-1685.