A novel 3-step enantioselective synthesis of pyrenylalanine with subsequent incorporation into opioid, CCK, and melanotropin ligands

Biochemical and Biophysical Research Communications

Volumn 318, Issue 2, 2004, Pages 335-340

  Alves, Isabel ^a   Cowell, Scott ^b   Lee, Yeon Sun ^b   Tang, Xuejun ^d   Davis, Peg ^c   Porreca, Frank ^c   Hruby, Victor J ^a,b  

^a UNIVERSITY OF ARIZONA   (United States)

^b University of Arizona   (United States)

^c UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

^d CB Research and Development   (United States)

Author keywords

Cholecystokinin; Enantioselective amino acid synthesis; Melanocortin; Opioid; Pyrenylalanine

Indexed keywords

ALANINE DERIVATIVE; CHOLECYSTOKININ; INTERMEDIN; LIGAND; OPIATE; PEPTIDE; PYRENE DERIVATIVE; PYRENYLALANINE; UNCLASSIFIED DRUG;

ARTICLE; ASYMMETRIC SYNTHESIS; CRYSTALLIZATION; ENANTIOSELECTIVITY; LIPOPHILICITY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; QUANTUM YIELD; SIGNAL TRANSDUCTION; SYNTHESIS;

ALANINE; AMINO ACID SEQUENCE; CHOLECYSTOKININ; CYCLIC AMP; ENKEPHALIN, D-PENICILLAMINE (2,5)-; GUANOSINE TRIPHOSPHATE; HUMANS; LIGANDS; MELANOCYTE-STIMULATING HORMONES; MOLECULAR STRUCTURE; NARCOTICS; OLIGOPEPTIDES; PROTEIN BINDING; PYRENES; RECEPTORS, MELANOCORTIN; RECEPTORS, OPIOID, DELTA; STEREOISOMERISM;

EID: 2142827076     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbrc.2004.04.033     Document Type: Article

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