Enantioselectivity of α-Benzyl-α-methyl-γ -butyrolactone-Mediated Modulation of Anticonvulsant Activity and GABA A Receptor Function

Journal of Pharmacology and Experimental Therapeutics

Volumn 309, Issue 2, 2004, Pages 677-683

  Gonzales, Eric B ^a   Bell Horner, Cathy L ^a   De La Cruz, Maria Antonette M ^b   Ferrendelli, James A ^c   Covey, Douglas F ^b   Dillon, Glenn H ^a  

^a UNIVERSITY OF NORTH TEXAS HEALTH SCIENCE CENTER   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; ALKYL GROUP; ALPHA BENZYL ALPHA METHYL GAMMA BUTYROLACTONE; ANTICONVULSIVE AGENT; GAMMA BUTYROLACTONE DERIVATIVE; LACTONE DERIVATIVE; PENTETRAZOLE; PICROTOXIN; RECOMBINANT RECEPTOR; TERT BUTYLBICYCLOPHOSPHOROTHIOATE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTICONVULSANT ACTIVITY; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG BINDING SITE; DRUG POTENCY; DRUG RECEPTOR BINDING; ENANTIOMER; ENANTIOSELECTIVITY; FEMALE; HUMAN; HUMAN CELL; IC 50; MEMBRANE CURRENT; MOUSE; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; RECEPTOR UPREGULATION; SEIZURE;

4-BUTYROLACTONE; ANIMALS; ANTICONVULSANTS; BICYCLO COMPOUNDS, HETEROCYCLIC; CONVULSANTS; GABA MODULATORS; LACTONES; MALE; MOLECULAR CONFORMATION; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GABA-A; SULFUR RADIOISOTOPES;

EID: 2142810127     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.103.063008     Document Type: Article

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