Heparin-coated cardiopulmonary bypass circuits reduce circulating complement factors and interleukin-6 in paediatric heart surgery

Scandinavian Cardiovascular Journal

Volumn 34, Issue 1, 2000, Pages 33-40

  Olsson, Christian ^a   Siegbahn, Agneta ^a   Henze, Axel ^a   Nilsson, Bo ^a   Venge, Per ^a   Joachimsson, Per Olof ^a   Thelin, Stefan ^a  

^a UPPSALA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Biocompatibility; Cardiopulmonary bypass; Complement; Heart surgery; Heparin; Inflammatory response; Interleukins; Paediatric

Indexed keywords

ACUTE PHASE PROTEIN; COMPLEMENT; COMPLEMENT COMPONENT C3A; CYTOKINE; HEPARIN; INTERLEUKIN 6;

ARTICLE; BIOCOMPATIBILITY; CARDIOPULMONARY BYPASS; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEVICE; GRANULOCYTE; HEART SURGERY; HUMAN; INFLAMMATION; PEDIATRIC SURGERY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL;

EID: 0034041743     PISSN: 14017431     EISSN: None     Source Type: Journal    
DOI: 10.1080/14017430050142378     Document Type: Article

References (32)

1. Steinberg JB, Kapelanski DP, Olson JD, Weiler JM. Cytokine and complement levels in patients undergoing cardiopulmonary bypass. J Thorac Cardiovasc Surg 1993; 106: 1008-16.
2. Borowiec JW, Hagman L, Tötterman TH, Pekna M, Venge P, Thelin S. Circulating cytokines and granulocyte-derived enzymes during complex heart surgery. Scand J Thorac Cardiovasc Surg 1995; 29: 167-74.
3. Kirklin JK, Westaby S, Blackstone EH, Kirklin JW, Chenoweth DE, Pacifico AD. Complement and the damaging effects of cardiopulmonary bypass. J Thorac Cardiovasc Surg 1983; 86: 845-57.
4. Ernofsson M, Thelin S, Siegbahn A. Monocyte tissue factor expression, cell activation, and thrombin formation during cardiopulmonary bypass: a clinical study. J Thorac Cardiovasc Surg 1997; 113: 576-84.
5. Seghaye MC, Duchateau J, Grabitz RG, et al. Complement activation during cardiopulmonary bypass in infants and children. Relation to postoperative multiple system organ failure. J Thorac Cardiovasc Surg 1993; 106: 978-87.
6. Butler J, Pathi VL, Paton RD, et al. Acute-phase response to cardiopulmonary bypass in children weighing less than 10 kilograms. Ann Thorac Surg 1996; 62: 538-42.
7. Finn A, Naik S, Klein N, Levinsky RJ, Strobel S, Elliott M. Interleukin-8 release and neutrophil degranulation after pediatric cardiopulmonary bypass. J Thorac Cardiovasc Surg 1993; 105: 234-41.
8. Saatvedt K, Lindberg OR, Geiran S, et al. Complement activation and release of tumour necrosis factor alpha, interleukin-2, interleukin-6 and soluble tumour necrosis factor and interleukin-2 receptors after cardiopulmonary bypass in children. Scand J Clin Lab Invest 1995; 55: 359-67.
9. Bagge L, Thelin S, Hultman J, Nilsson L, Thorelius J, Hillström PA. Heparin-coated CPB-sets increase biocompatibility and reduce endothelial cell damage in pigs. J Cardiothorac Anesth 1989; 3 (Suppl 5): 84.
10. Videm V, Mollnes TE, Garred P, Svennevig JL. Biocompatibility of extracorporeal circulation: in vitro comparison of heparin coated and uncoated oxygenator circuits. J Thorac Cardiovasc Surg 1991; 101: 654-60.
11. Steinberg BM, Grossi EA, Schwartz DS, et al. Heparin bonding of bypass circuits reduces cytokine release during cardiopulmonary bypass. Ann Thorac Surg 1995; 60: 5252-9.
12. Fosse E, Moen O, Johnson E, et al. Reduced complement and granulocyte activation with heparin-coated cardiopulmonary bypass. Ann Thorac Surg 1994; 58: 472-7.
13. Svenmarker S, Sandström E, Karlsson T, et al. Clinical effects of the heparin coated surface in cardiopulmonary bypass. Eur J Cardiothorac Surg 1997: 11: 957-64.
14. Redmond JM, Gillinov AV, Stuart RS, et al. Heparin-coated bypass reduce pulmonary injury. Ann Thorac Surg 1993; 56: 474-8.
15. Ashraf S, Tian Y, Cowan D, Entress A, Martin PG, Watterson KG. Release of proinflammatory cytokines during pediatric cardiopulmonary bypass: heparin-bonded versus nonbonded oxygenators. Ann Thorac Surg 1997; 64: 1790-4.
16. Schreurs HH, Wijers MJ, Gu J, et al. Heparin-coated bypass circuits: effects on inflammatory response in pediatric cardiac operations. Ann Thorac Surg 1998; 66: 166-71.
17. Nilsson-Ekdahl K, Nilsson B, Pekna M, Nilsson UR. Generation of iC3 on the interphase between blood and gas. Scand J Immunol 1992; 35: 85-91.
18. Mollnes TE, Lea T, Fröland SS, Harboe M. Quantification of the terminal complement complex in human plasma by an enzyme-linked immunosorbent assay based on monoclonal antibodies against neoantigen on the complex. Scand J Immunol 1985; 22: 703-10.
19. Olofsson T, Olsson I, Venge P. Myeloperoxidase and lactoferrin of blood neutrophils and plasma in chronic granulocytic leukemia. Scand J Haematol 1977; 18: 113-20.
20. Chenoweth DE, Cooper SW, Hugli TE, Stewart RW, Blackstone EH, Kirklin JW. Complement activation during cardiopulmonary bypass: evidence for generation of C3a and C5a anaphylatoxins. N Engl J Med 1981; 304: 497-503.
21. Mollnes TE, Videm V, Riesenfeld J, et al. Complement activation and bioincompatibility. The terminal complement complex for evaluation, and surface modification with heparin for improvement of biomaterials. Clin Exp Immunol 1991; 88 (Suppl 1): 21-6.
22. Bjork J, Hugli TE, Smedsgaard G. Microvasculature effect of anaphylatoxins C3a and C5a. J Immunol 1985; 134: 1115-9.
23. Balkwill FR, Burke F. The cytokine network. Immunol Today 1989; 10: 299-304.
24. de Waal Malefyt RW, Abrams J, Bennett B, Figdor CG, de Vries JE. Interleukin 10 (IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes. J Exp Med 1991; 174: 1209-20.
25. Venge P. The monitoring of inflammation by specific cellular markers. Scand J Clin Lab Invest 1994; 54 (Suppl 219): 47-54.
26. Aronen M, Leijala M, Meri S. Value of C-reactive protein in reflecting the magnitude of complement activation in children undergoing open heart surgery. Int Care Med 1990; 16: 128-32.
27. Boisclair MD, Lane DA, Philippou H, et al. Mechanisms of thrombin generation during surgery and cardiopulmonary bypass. Blood 1993; 82: 3350-7.
28. Scholz W, McClurg MR, Cardenas GJ, et al. C5a-mediated release of interleukin 6 by human monocytes. Clin Immunol Immunopathol 1990; 57: 297-307.
29. Butler J, Parker D, Pillai R, Westaby S, Shale DJ, Rocker GM. Effect of cardiopulmonary bypass on systemic release of neutrophil elastase and tumor necrosis factor. J Thorac Cardiovasc Surg 1993; 105: 25-30.
30. Andrew M, Mitchell L, Vegh P, Ofosu F. Thrombin regulation in children differs from adults in the absence and presence of heparin. Thromb Haemost 1994; 72: 836-42.
31. Ernofsson M, Thelin S, Siegbahn A. Thrombin generation during cardiopulmonary bypass using heparin-coated or standard circuits. Scand J Thorac Cardiovasc Surg 1995; 29: 157-65.
32. Chan AKC, Leaker M, Burrows FA, et al. Coagulation and fibrinolytic profile of pediatric patients undergoing cardiopulmonary bypass. Thromb Haemost 1997; 77: 270-7 (Erratum appears in Thromb Haemost 1997; 77: 1047).