Fatty acids in Botryococcus braunii accelerate topical delivery of flurbiprofen into and across skin

International Journal of Pharmaceutics

Volumn 276, Issue 1-2, 2004, Pages 163-173

  Fang, Jia You ^a   Chiu, Hsien Chih ^a   Wu, Jiunn Tzong ^b   Chiang, Yin Ru ^b   Hsu, Shu Hui ^c  

^a CHANG GUNG UNIVERSITY   (Taiwan)

^b INSTITUTE OF PLANT AND MICROBIAL BIOLOGY   (Taiwan)

^c CHIA NAN UNIVERSITY OF PHARMACY AND SCIENCE   (Taiwan)

Author keywords

Botryococcus braunii; Enhancers; Fatty acids; Flurbiprofen; Topical delivery

Indexed keywords

FATTY ACID; FLURBIPROFEN; LINOLEIC ACID; OLEIC ACID; PALMITIC ACID; PROSTAGLANDIN E2;

ALGA; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BOTRYOCOCCUS BRAUNII; CONTROLLED STUDY; DRUG ABSORPTION; DRUG DELIVERY SYSTEM; EXPERIMENTAL MODEL; HUMAN; HUMAN CELL; KERATINOCYTE; NONHUMAN; PRIORITY JOURNAL; PROSTAGLANDIN RELEASE; SKIN FIBROBLAST; SKIN PENETRATION; SKIN SECRETION; SKIN WATER LOSS;

ADMINISTRATION, TOPICAL; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CELLS, CULTURED; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG DELIVERY SYSTEMS; FATTY ACIDS; FIBROBLASTS; FLURBIPROFEN; HUMANS; MALE; PLANT EXTRACTS; RATS; RATS, WISTAR; SKIN ABSORPTION;

EID: 2142707138     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2004.02.026     Document Type: Article

References (21)

1. Aaronson S., Berner T., Gold K., Kushner L., Patni N.J., Repak A., Rubin D. Some observations on the green planktonic alga, Botryococcus braunii and its bloom form. J. Plankton Res. 5:1983;693-700
2. Ahlgren G., Gustafsson I., Boberg M. Fatty acid content and chemical composition of freshwater microalgae. J. Phycol. 28:1992;37-50
3. Aungst B.J. Structure/effect studies of fatty acid isomers as skin penetration enhancers and skin irritants. Pharm. Res. 6:1989;244-247
4. Barry B.W. Lipid-protein-partitioning theory of skin penetration enhancement. J. Control. Release. 15:1991;237-248
5. Chi S.C., Park E.S., Kim H. Effect of penetration enhancers on flurbiprofen permeation through rat skin. Int. J. Pharm. 126:1995;267-274
6. Fang J.Y., Hwang T.L., Fang C.L., Chiu H.C. In vitro and in vivo evaluations of the efficacy and safety of skin permeation enhancers using flurbiprofen as a model drug. Int. J. Pharm. 255:2003a;153-166
7. Fang J.Y., Hwang T.L., Leu Y.L. Effect of enhancers and retarders on percutaneous absorption of flurbiprofen from hydrogels. Int. J. Pharm. 250:2003b;313-325
8. Fang J.Y., Leu Y.L., Wang Y.Y., Tsai Y.H. In vitro topical application and in vivo pharmacodynamic evaluation of nonivamide hydrogels using Wistar rat as an animal model. Eur. J. Pharm. Sci. 15:2002;417-423
9. Finnin B.C., Morgan T.M. Transdermal penetration enhancers: applications, limitations, and potential. J. Pharm. Sci. 88:1999;955-958
10. Gwak H.S., Chun I.K. Effect of vehicles and penetration enhancers on the in vitro percutaneous absorption of tenoxicam through hairless mouse skin. Int. J. Pharm. 236:2002;57-64
11. Laureillard J., Largeau C., Casadevall E. Oleic acid in the biosynthesis of the resistant biopolymers of Botryococcus braunii. Phytochemistry. 27:1988;2095-2098
12. Lawrence J.N. Application of in vitro human skin models to dermal irritancy: a brief overview and future prospects. Toxicol. In Vitro. 11:1997;305-312
13. Loftsson T., Gudmundsdóttir T.K., Fridriksdóttir H., Sigurdaróttir A.M., Thorkelsson J., Gudmundsson G., Hjaltason B. Fatty acids from cod-liver oil as skin penetration enhancers. Pharmazie. 50:1995;188-190
14. Loftsson T., Thormar H., Ólafsson J.H., Gunnarsdóttir T.M., Hjaltason B., Gudmundsson G. Fatty acid extract from cod-liver oil: activity against herpes simplex virus and enhancement of transdermal delivery of acyclovir in-vitro. Pharm. Pharmacol. Commun. 4:1998;287-291
15. Morimoto Y., Hatanaka T., Sugibayashi K., Omiya H. Prediction of skin permeability of drugs: comparison of human and hairless rat skin. J. Pharm. Pharmacol. 44:1992;634-639
16. Moser K., Kriwet K., Naik A., Kalia Y.N., Guy R.H. Passive skin penetration enhancement and its quantification in vitro. Eur. J. Pharm. Biopharm. 52:2001;103-112
17. Takeuchi Y., Yasukawa H., Yamaoka Y., Taguchi K., Fukushima S., Shimouaka Y., Nishinaga H., Morimoto Y. Behavior of propylene glycol in dermis after treatment of rat intact skin surface with fatty acids, fatty amines or Azone dissolved in propylene glycol. Biol. Pharm. Bull. 18:1995;304-309
18. Warner K.S., Li S.K., Higuchi W.I. Influences of alkyl group chain length and polar head group on chemical skin permeation enhancement. J. Pharm. Sci. 90:2001;1143-1153
19. Yamada M., Uda Y., Tanigawara Y. Mechanism of enhancement of percutaneous absorption of molsidomine by oleic acid. Chem. Pharm. Bull. 35:1987;3399-3406
20. Yamaguchi K., Nakano H., Murakami M., Konosu S., Nakayama O., Kanda M., Nakamura A., Iwamoto H. Lipid composition of a green alga, Botryococcus braunii. Agric. Biol. Chem. 51:1987;493-498
21. Zhao K., Singh J. Mechanisms of in vitro percutaneous absorption enhancement of tamoxifen by enhancers. J. Pharm. Sci. 89:2000;771-780