Fatty acid extract from cod-liver oil: Activity against herpes simplex virus and enhancement of transdermal delivery of acyclovir in-vitro

Pharmacy and Pharmacology Communications

Volumn 4, Issue 6, 1998, Pages 287-291

  Loftsson, T ^a   Thormar, H ^a   Olafsson J H ^a   Gunnarsdottir T M ^a   Hjaltason, B ^b   Gudmundsson, G ^b  

^a UNIVERSITY OF ICELAND   (Iceland)

^b Lýsi Hf   (Iceland)

Author keywords

[No Author keywords available]

Indexed keywords

ACICLOVIR; ANTIVIRUS AGENT; COD LIVER OIL; DRUG VEHICLE; FATTY ACID; PROPYLENE GLYCOL;

ANIMAL TISSUE; ANTIVIRAL ACTIVITY; ARTICLE; CREAM; FEMALE; HERPES SIMPLEX VIRUS 1; MOUSE; NONHUMAN; NUDE MOUSE; OINTMENT; TRANSDERMAL DRUG ADMINISTRATION; VIRUS INFECTIVITY;

EID: 0031805551     PISSN: 14608081     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (14)

1. Aungst, B. J. (1995) Fatty acids as skin permeation enhancers. In: Maibach, H. I., Smith, E. W. (eds) Percutaneous Penetration Enhancers. CRC Press, Boca Raton, pp 277-287
2. Bendas, B., Neubert, R., Wohlrab, W. (1995) Propylene glycol. In: Maibach, H. I., Smith, E. W. (eds) Percutaneous Penetration Enhancers. CRC Press, Boca Raton, pp 61-77
3. Cooper, R. C., Patel, D. C. (1990) Practical considerations for topical drug formulations with and without enhancers. In: Osborne, D. W., Amann, A. H. (eds) Topical Drug Delivery Formulations. Marcel Dekker, New York, pp 1-12
4. Hjaltason, B. (1989) New frontiers in the processing and utilization of fish oil. In: Somogyi, J. C., Müller, H. R. (eds) Nutritional Impact of Food Processing. Bibl. Nutr. Dieta. Basel, Karger, pp 96-106
5. Kabara, J. J., Swieczkowski, D. M., Conley, A. J., Truant, J. P. (1972) Fatty acids and derivatives as antimicrobial agents. Antimicrob. Agents Chemother. 2: 23-28
6. Khulusi, S., Ahmed, H. A., Patel, P., Mendall, M. A., Northfield, T. C. (1995) The effect of unsaturated fatty acids on Helicobacter pylori in vitro. J. Med. Microbiol. 42: 276-282
7. Kristl, A., Mrhar, A., Kozjek, F. (1993) The ionisation properties of acyclovir and deoxyacyclovir. Int. J. Pharm. 99: 79-82
8. Loftsson, T., Gudmundsdóttir, T. K., Fridriksdóttir, H., Sigurdardóttir, A. M., Thorkelsson, J., Gudmundsson, G., Hjaltason, B. (1995) Fatty acids from cod-liver oil as skin penetration enhancers. Pharmazie 50: 188-190
9. Loftsson, T., Gunnarsdóttir, T., Fridriksdóttir, H., Gudmundsdóttir, T. K., Ólafsson, J. H., Haraldsson, G. G., Gudmundsson, G., Hjaltason, B. (1997) Effect of various marine lipids on transdermal drug delivery - in vitro evaluation. Boll. Chim. Farmaceutico 136: 640-645
10. Martin, A. R. (1991) Anti-infective agents. In: Delgado, J. N., Remers, W. A. (eds) Wilson and Gisvold's Textbook of Organic Medicinal and Pharmaceutical Chemistry. 9th edn, J. B. Lippincott, Philadelphia, pp 129-189
11. Spoehr, H. A., Smith, J. H. C., Strain, H. H., Milner, H. W., Hardin, G. J. (1949) Fatty Acid Antibacterials from Plants. Carnegie Institution, Washington D.C.
12. Thormar, H., Isaacs, C. E., Brown, H. R., Barshatzky, M. R., Pessolano, T. (1987) Inactivation of enveloped viruses and killing of cells by fatty acids and monoglycerides. Antimicrob. Agents Chemother. 31: 27-31
13. Vergin, H., Kikuta, C., Mascher, H., Metz, R. (1995) Pharmacokinetics and bioavailability of different formulations of acyclovir. Arzenm. Forsch. 45: 508-515
14. Volpato, N. M., Santi, P., Colombo, P. (1995) Iontophoresis enhances the transport of acyclovir through nude mouse skin by electrorepulsion and electroosmosis. Pharm. Res. 12: 1623-1627