Self-selected macronutrient diet affects energy and glucose metabolism in brown fat-ablated mice

Obesity Research

Volumn 11, Issue 12, 2003, Pages 1536-1544

  Ortmann, Sylvia ^a   Prinzler, Julia ^a   Klaus, Susanne ^a  

^a GERMAN INSTITUTE OF HUMAN NUTRITION   (Germany)

Author keywords

Diabetes; Diet induced obesity; Energy expenditure; Insulin resistance; Macronutrient choice diet

Indexed keywords

CARRIER PROTEIN; ION CHANNEL; MEMBRANE PROTEIN; MITOCHONDRIAL PROTEIN; MITOCHONDRIAL UNCOUPLING PROTEIN;

ANIMAL; ARTICLE; BASAL METABOLIC RATE; BODY COMPOSITION; BODY WEIGHT; BROWN ADIPOSE TISSUE; CARBOHYDRATE DIET; EATING; ENERGY METABOLISM; FAT INTAKE; FEEDING BEHAVIOR; FEMALE; GLUCOSE BLOOD LEVEL; INSULIN RESISTANCE; MALE; METABOLISM; MOUSE; PHYSIOLOGY; PROTEIN INTAKE; PSYCHOLOGICAL ASPECT; TRANSGENIC MOUSE;

ADIPOSE TISSUE, BROWN; ANIMALS; BASAL METABOLISM; BLOOD GLUCOSE; BODY COMPOSITION; BODY WEIGHT; CARRIER PROTEINS; DIETARY CARBOHYDRATES; DIETARY FATS; DIETARY PROTEINS; EATING; ENERGY METABOLISM; FEEDING BEHAVIOR; FEMALE; INSULIN RESISTANCE; ION CHANNELS; MALE; MEMBRANE PROTEINS; MICE; MICE, TRANSGENIC; MITOCHONDRIAL PROTEINS;

EID: 2142690211     PISSN: 10717323     EISSN: None     Source Type: Journal    
DOI: 10.1038/oby.2003.205     Document Type: Article

References (20)

1. Lowell BB, Susulic SV, Hamann A, et al. Development of obesity in transgenic mice after genetic ablation of brown adipose tissue. Nature. 1993;366:740-2.
2. Hamann A, Benecke H, Le Marchand-Brustel Y, Susulic VS, Lowell BB, Flier JS. Characterization of insulin resistance and NIDDM in transgenic mice with reduced brown fat. Diabetes. 1995;44:1266-73.
3. Hamann A, Flier JS, Lowell BB. Decreased brown fat markedly enhances susceptibility to diet-induced obesity, diabetes, and hyperlipidemia. Endocrinology. 1996;137:21-9.
4. Hamann A, Busing B, Kausch C, et al. Chronic leptin treatment does not prevent the development of obesity in transgenic mice with brown fat deficiency. Diabetologia. 1997;40:810-5.
5. Klaus S, Münzberg H, Trüloff C, Heldmaier G. Physiology of transgenic mice with brown fat ablation: obesity is due to lowered body temperature. Am J Physiol. 1998;274:R287-93.
6. Cittadini A, Mantzoros CS, Hampton TG, et al. Cardiovascular abnormalities in transgenic mice with reduced brown fat: an animal model of human obesity. Circulation. 1999;100:2177-83.
7. Melnyk A, Himms-Hagen J. Temperature-dependent feeding: lack of role for leptin and defect in brown adipose tissue-ablated obese mice. Am J Physiol. 1998;274:R1131-5.
8. Smith BK, Andrews PK, West DB. Macronutrient diet selection in thirteen mouse strains. Am J Physiol Regul. 2000;278 R797-805.
9. Koegler FH, Schaffhauser RO, Mynatt RL, York DA, Bray GA. Macronutrient diet intake of the lethal yellow agouti (Ay/a) mouse. Physiol Behav. 1999;67:809-12.
10. Romsos DR, Ferguson D. Self-selected intake of carbohydrate, fat, and protein by obese (ob/ob) and lean mice. Physiol Behav. 1982;28:301-5.
11. Bartness TJ, Rowland NE. Diet selection and metabolic fuels in three models of diabetes mellitus. Physiol Behav. 1983;31:539-45.
12. Tepper BJ, Kanarek RB. Dietary self-selection patterns of rats with mild diabetes. J Nutr. 1985;115:699-709.
13. Veyrat-Durebex C, Boghossian S, Alliot J. Age-related changes in adaptive mechanisms of macronutrient self-selection: evidence for a sexual dimorphism. Mech Ageing Dev. 1998;103:223-34.
14. Daenzer M, Ortmann S, Klaus S, Metges CC. Prenatal high protein exposure affects adiposity and energy expenditure in young rats. J Nutr. 2002;132:142-4.
15. Rothwell N, Stock M. A role for brown adipose tissue in diet-induced thermogenesis. Nature. 1979;281:31-3.
16. Rothwell N, Stock M Brown adipose tissue and diet-induced thermogenesis. In: Trayhurn P, Nicholls DG, eds. Brown Adipose Tissue. London: E. Arnold; 1986, pp. 299-338.
17. Kozak LP, Koza RA. Mitochondria uncoupling proteins and obesity: molecular and genetic aspects of UCP1. Int J Obes Relat Metab Disord. 1999;23(Suppl 6):S33-7.
18. Nibbelink M, Moulin K, Arnaud E, Duval C, Penicaud L, Casteilla L. Brown fat UCP1 is specifically expressed in uterine longitudinal smooth muscle cells. J Biol Chem. 2001;276:47291-5.
19. Shabalina I, Wiklund C, Bengtsson T, Jacobsson A, Cannon B, Nedergaard J. Uncoupling protein-1: involvement in a novel pathway for beta-adrenergic, cAMP-mediated intestinal relaxation. Am J Physiol. 2002;283:G1107-16.
20. Smith Richards BK, Belton BN, Poole AC, et al. QTL analysis of self-selected macronutrient diet intake: fat, carbohydrate, and total kilocalories. Physiol Genomics. 2002;11:205-17.