The diacylglycerol lipase inhibitor RHC-80267 potentiates the relaxation to acetylcholine in rat mesenteric artery by anti-cholinesterase action

European Journal of Pharmacology

Volumn 517, Issue 1-2, 2005, Pages 97-102

  Ghisdal, Philippe ^a   Vandenberg, Greet ^a   Hamaide, Marie Christine ^a   Wibo, Maurice ^a   Morel, Nicole ^a  

^a UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

Author keywords

Acetylcholine; Cholinesterase; Diacylglycerol lipase; Endothelium dependent relaxation; Mesenteric artery; RHC 80267

Indexed keywords

1,6 HEXAMETHYLENEDICARBAMIC ACID BIS(CYCLOHEXANONE OXIME) ESTER; ACETYLCHOLINE; CARBACHOL; CHOLINESTERASE; CHOLINESTERASE INHIBITOR; CROMAKALIM; DIACYLGLYCEROL DERIVATIVE; GLYCEROL 2 ACETATE 1 OLEATE; LIPOPROTEIN LIPASE; N ACETYL S NITROSOPENICILLAMINE; NEOSTIGMINE; NITRIC OXIDE DONOR; NITRIC OXIDE SYNTHASE; NORADRENALIN; PHOSPHOLIPASE A2 INHIBITOR; POTASSIUM CHANNEL STIMULATING AGENT; POTASSIUM CHLORIDE; PROTEIN KINASE C INHIBITOR;

ANIMAL TISSUE; ARTERY CONSTRICTION; ARTICLE; BLOOD VESSEL WALL; BRAIN HOMOGENATE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG POTENTIATION; ENZYME ACTIVITY; ENZYME INHIBITION; IC 50; MALE; MESENTERIC ARTERY; NONHUMAN; PRIORITY JOURNAL; RAT; VASODILATATION;

ACETYLCHOLINE; ANIMALS; BIOLOGICAL FACTORS; CHOLINESTERASE INHIBITORS; CHOLINESTERASES; CROMAKALIM; CYCLOHEXANONES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; ENDOTHELIUM, VASCULAR; ENZYME INHIBITORS; LIPOPROTEIN LIPASE; MALE; MESENTERIC ARTERIES; NAPHTHALENES; NEOSTIGMINE; NITRIC OXIDE; NITRIC OXIDE DONORS; NITRIC OXIDE SYNTHASE; NITROARGININE; NOREPINEPHRINE; PENICILLAMINE; PHOSPHOLIPASES A; PROTEIN KINASE C; RATS; RATS, INBRED WKY; VASOCONSTRICTOR AGENTS; VASODILATION; VASODILATOR AGENTS;

EID: 21344471959     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2005.05.036     Document Type: Article

References (24)

1. R.J. Altiere, D.C. Travis, and D.C. Thompson Characterization of acetylcholinesterase in rabbit intrapulmonary arteries Am. J. Physiol. 267 1994 L745 L752
2. F. Amenta, C. Cavallotti, E. Ceccarelli, and F. Evangelisti Cholinergic nerves in the mesentery Acta Histochem. 69 1981 125 131
3. D. Amin, C.A. Sutherland, A.S. Khandwala, I.S. Jamall, and A.L. Kapoor Inhibition of the effects of thrombin on guinea pig platelets by the diacylglycerol lipase inhibitor RHC 80267 Thromb. Res. 44 1986 75 84
4. G.M. Bores, F.P. Huger, W. Petko, A.E. Mutlib, F. Camacho, D.K. Rush, D.E. Selk, V. Wolf, R.W. Kosley Jr., L. Davis, and H.M. Vargas Pharmacological evaluation of novel Alzheimer's disease therapeutics: acetylcholinesterase inhibitors related to galanthamine J. Pharmacol. Exp. Ther. 277 1996 728 738
5. W.Y. Choy, Y.F. Wong, Y.W. Kwan, A.L. Au, W.H. Lau, K. Raymond, and J.Z. Zuo Role of mitogen-activated protein kinase pathway in acetylcholine-mediated in vitro relaxation of rat pulmonary artery Eur. J. Pharmacol. 434 2002 55 64
6. M.L. Cohen, A.S. Landry, S.K. Hemrick, and R.W. Fuller Norepinephrine, monoamine oxidase, and acetylcholinesterase in the rat jugular vein compared with other blood vessels Can. J. Physiol. Pharm. 57 1979 1246 1250
7. M. Feletou, and P.M. Vanhoutte Endothelium-dependent hyperpolarization of canine coronary smooth muscle Br. J. Pharmacol. 93 1988 515 524
8. I. Fleming Cytochrome P450 epoxygenases as EDHF synthase(s) Pharmacol. Res. 49 2004 525 533
9. P. Ghisdal, and N. Morel Cellular target of voltage and calcium-dependent K(+) channel blockers involved in EDHF-mediated responses in rat superior mesenteric artery Br. J. Pharmacol. 134 2001 1021 1028
10. P. Ghisdal, T. Godfraind, and N. Morel Effect of nitro-l-arginine on electrical and mechanical responses to acetylcholine in the superior mesenteric artery from stroke-prone hypertensive rat Br. J. Pharmacol. 128 1999 1513 1523
11. Y. Iwanaga, N. Miyashita, K. Morikawa, A. Mizumoto, Y. Kondo, and Z. Itoh A novel water-soluble dopamine-2 antagonist with anticholinesterase activity in gastrointestinal motor activity. Comparison with domperidone and neostigmine Gastroenterology 99 1990 401 408
12. C.J. Kirkpatrick, F. Bittinger, R.E. Unger, J. Kriegsmann, H. Kilbinger, and I. Wessler The non-neuronal cholinergic system in the endothelium: evidence and possible pathobiological significance Jpn. J. Pharmacol. 85 2001 24 28
13. R.J. Konrad, C.D. Major, and B.A. Wolf Diacylglycerol hydrolysis to arachidonic acid is necessary for insulin secretion from isolated pancreatic islets: sequential actions of diacylglycerol and monoacylglycerol lipases Biochemistry 33 1994 13284 13294
14. M. Mason-Garcia, S. Clejan, J.S. Tou, and B.S. Beckman Signal transduction by the erythropoietin receptor: evidence for the activation of phospholipases A2 and C Am. J. Physiol 262 1992 C1197 C1203
15. S. Moncada, and J.R. Vane Pharmacology and endogenous roles of prostaglandin endoperoxides, thromboxane A2, and prostacyclin Pharmacol. Rev. 30 1978 293 331
16. T. Moriyama, R. Urade, and M. Kito Purification and characterization of diacylglycerol lipase from human platelets J. Biochem. 125 1999 1077 1085 (Tokyo)
17. K. Nishimaru, Y. Tanaka, H. Tanaka, and K. Shigenobu Pharmacological evidence for involvement of phospholipase D, protein kinase C, and sodium-calcium exchanger in alpha-adrenoceptor-mediated negative inotropy in adult mouse ventricle J. Pharm. Sci. 92 2003 196 202
18. R.M. Palmer, A.G. Ferrige, and S. Moncada Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor Nature 327 1987 524 526
19. J. Shinoda, A. Suzuki, Y. Oiso, and O. Kozawa Involvement of phosphatidylcholine hydrolysis by phospholipase D in extracellular ATP-induced arachidonic acid release in aortic smooth muscle cells Arterioscler. Thromb. Vasc. Biol. 17 1997 295 299
20. 2+ oscillations by diacylglycerol in human myometrial cells Cell Calcium 36 2004 157 164
21. C.A. Sutherland, and D. Amin Relative activities of rat and dog platelet phospholipase A2 and diglyceride lipase. Selective inhibition of diglyceride lipase by RHC 80267 J. Biol. Chem. 257 1982 14006 14010
22. H. Suzuki, Y. Kito, H. Fukuta, and Y. Yamamoto Effects of RHC-80267, an inhibitor of diacylglycerol lipase, on excitation of circular smooth muscle of the guinea-pig gastric antrum J. Smooth Muscle Res. 38 2002 153 164
23. S.G. Taylor, and A.H. Weston Endothelium-derived hyperpolarizing factor: a new endogenous inhibitor from the vascular endothelium Trends Pharmacol. Sci. 9 1988 272 274
24. K. Venkatachalam, F. Zheng, and D.L. Gill Regulation of canonical transient receptor potential (TRPC) channel function by diacylglycerol and protein kinase C J. Biol. Chem. 278 2003 29031 29040