Oxidative mitochondrial DNA damage and deletion in hepatocytes of rejecting liver allografts in rats: Role of TNF-α

Hepatology

Volumn 42, Issue 1, 2005, Pages 208-215

  Nagakawa, Yuichi ^a   Williams, George Melville ^a   Zheng, Qizhi ^a   Tsuchida, Akihiko ^b   Aoki, Tatsuya ^b   Montgomery, Robert A ^a   Klein, Andrew S ^a,c   Sun, Zhaoli ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b TOKYO MEDICAL UNIVERSITY   (Japan)

^c CEDARS SINAI MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; MESSENGER RNA; MITOCHONDRIAL DNA; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL DEATH; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOPLASM; DNA DAMAGE; DOSE RESPONSE; GENE DELETION; GENE MUTATION; GRAFT SURVIVAL; INFLAMMATORY CELL; LIVER CELL; LIVER CELL CULTURE; LIVER GRAFT REJECTION; LIVER SINUSOID; LIVER TRANSPLANTATION; MALE; NICK END LABELING; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT;

ANIMALS; DNA DAMAGE; DNA, MITOCHONDRIAL; GRAFT REJECTION; HEPATOCYTES; LIVER TRANSPLANTATION; MODELS, ANIMAL; MUTATION; OXIDATIVE STRESS; RATS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 21344461433     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1002/hep.20755     Document Type: Article

References (31)

1. Yamaguchi Y, Ichiguchi O, Matsumura F, Akizuki E, Matsuda T, Okabe K, et al. Enhanced expression of cytokine-induced neutrophil chemoattractant in rat hepatic allografts during acute rejection. HEPATOLOGY 1997; 26:1546-1552.
2. Warle MC, Farhan A, Metselaar HJ, Hop WC, van der Plas AJ, Kap M, et al. In vitro cytokine production of TNFalpha and IL-13 correlates with acute liver transplant rejection. Hum Immunol 2001;62:1258-1265.
3. Goossens V, Grooten J, De Vos K, Fiers W. Direct evidence for tumor necrosis factor-induced mitochondrial reactive oxygen intermediates and their involvement in cytotoxicity. Proc Natl Acad Sci U S A 1995;92: 8115-8119.
4. Garcia-Ruiz C, Colell A, Mari M, Morales A, Fernandez-Checa JC. Direct effect of ceramide on the mitochondrial electron transport chain leads to generation of reactive oxygen species: role of mitochondrial glutathione. J Biol Chem 1997;272:11369-11377
5. Corda S, Laplace C, Vicaut E, Duranteau J. Rapid reactive oxygen species production by mitochondria in endothelial cells exposed to tumor necrosis factor-alpha is mediated by ceramide. Am J Respir Cell Mol Biol 2001;24: 762-768.
6. Fraga CG, Shigenaga MK, Park JW, Degan P, Ames BN. Oxidative damage to DNA during aging: 8-hydroxy-2′-deoxyguanosine in rat organ DNA and urine. Proc Natl Acad Sci U S A 1990;87:4533-4537
7. Merriwether DA, Clark AG, Ballinger SW, Schurr TG, Soodyall H, Jenkins T, et al. The structure of human mitochondrial DNA variation. J Mol Evol 1991;33:543-555
8. Richter C, Park JW, Ames BN. Normal oxidative damage to mitochondrial and nuclear DNA is extensive. Proc Natl Acad Sci U S A 1988;85: 6465-6467.
9. Cahill A, Stabley GJ, Wang X, Hoek JB. Chronic ethanol consumption causes alterations in the structural integrity of mitochondrial DNA in aged rats. HEPATOLOGY 1999;30:881-888.
10. Suzuki S, Hinokio Y, Komatu K, Ohtomo M, Onoda M, Hirai S, et al. Oxidative damage to mitochondrial DNA and its relationship to diabetic complications. Diabetes Res Clin Pract 1999;45:161-168.
11. de la Monte SM, Luong T, Neely TR, Robinson D, Wands JR. Mitochondrial DNA damage as a mechanism of cell loss in Alzheimer's disease. Lab Invest 2000;80:1323-1335.
12. Warita H, Hayashi T, Murakami T, Manabe Y, Abe K. Oxidative damage to mitochondrial DNA in spinal motoneurons of transgenic ALS mice. Brain Res Mol Brain Res 2001;89:147-152.
13. Kakimoto M, Inoguchi T, Sonta T, Yu HY, Imamura M, Etoh T, et al. Accumulation of 8-hydroxy-2′-deoxyguanosine and mitochondrial DNA deletion in kidney of diabetic rats. Diabetes 2002;51:1588-1595.
14. Lin PH, Lee SH, Su CP, Wei YH. Oxidative damage to mitochondrial DNA in atrial muscle of patients with atrial fibrillation. Free Radic Biol Med 2003;35:1310-1318.
15. Sun Z, Wada T, Maemura K, Uchikura K, Hoshino S, Diehl AM, et al. Hepatic allograft-derived Kupffer cells regulate T cell response in rats. Liver Transpl 2003;9:489-497.
16. Seglen PO. Hepatocyte suspensions and cultures as tools in experimental carcinogenesis. J Toxicol Environ Health 1979;5:551-560.
17. Fukagawa NK, Li M, Liang P, Russell JC, Sobel BE, Absher PM. Aging and high concentrations of glucose potentiate injury to mitochondrial DNA. Free Radic Biol Med 1999;27:1437-1443.
18. Yowe DL, Ames BN. Quantitation of age-related mitochondrial DNA deletions in rat tissues shows that their pattern of accumulation differs from that of humans. Gene 1998;209:23-30.
19. Nagakawa Y, Nomoto S, Kato Y, Montgomery RA, Williams GM, Klein AS, et al. Over-expression of AIF-1 in liver allografts and peripheral blood correlates with acute rejection after transplantation in rats. Am J Transplant 2004;4:1949-1957.
20. Bass DA, Parce JW, Dechatelet LR, Szejda P, Seeds MC, Thomas M. Flow cytometric studies of oxidative product formation by neutrophils: a graded response to membrane stimulation. J Immunol 1983;130:1910-1917.
21. Cathcart R, Schwiers E, Ames BN. Detection of picomole levels of hydroperoxides using a fluorescent dichlorofluorescein assay. Anal Biochem 1983;134:111-116.
22. Zhu H, Bannenberg GL, Moldeus P, Schertzer HG. Oxidation pathways for the intracellular probe 2′,7′-dichlorofluorescin. Arch Toxicol 1994;68: 582-587.
23. Schulze-Osthoff K, Bakker AC, Vanhaesebroeck B, Beyaert R, Jacob WA, Fiers W. Cytotoxic activity of tumor necrosis factor is mediated by early damage of mitochondrial functions: evidence for the involvement of mitochondrial radical generation. J Biol Chem 1992;267:5317-5323.
24. Gross A, Yin XM, Wang K, Wei MC, Jockel J, Milliman C, et al. Caspase cleaved BID targets mitochondria and is required for cytochrome c release, while BCL-XL prevents this release but not tumor necrosis factor-R1/Fas death. J Biol Chem 1999;274:1156-1163.
25. Cauwels A, Janssen B, Waeytens A, Cuvelier C, Brouckaert P. Caspase inhibition causes hyperacute tumor necrosis factor-induced shock via oxidative stress and phospholipase A2. Nat Immunol 2003;4:387-393.
26. Gadaleta MN, Rainaldi G, Lezza AMS, Milella F, Fracasso F, Cantatore P. Mitochondrial DNA copy number and mitochondrial DNA deletion in adult and senescent rats. Mutat Res 1992;275:181-193.
27. Edris W, Burgen B, Stine OC, Filburn CR. Detection and quanti ration by competitive PCR on an age-associated increase in a 4.8-kb deletion in rat mitochondrial DNA. Mutat Res 1994;316:69-78.
28. Holt IJ, Harding AE, Morgan-Hughes JA. Deletions of muscle mitochondrial DNA in patients with mitochondrial myopathies. Nature 1988;331: 717-719.
29. Lestienne P, Ponsot G. Kearns-Sayre syndrome with muscle mitochondrial DNA deletion [Letter]. Lancet 1988;1:885.
30. Wallace DC, Zheng XX, Lott MT, Shoffner JM, Hodge JA, Kelley RI, et al. Familial mitochondrial encephalomyopathy (MERRF): genetic, pathophysiological, and biochemical characterization of a mitochondrial DNA disease. Cell 1988;55:601-610.
31. Moraes CT, DiMauro S, Zeviani M, Lombes A, Shanske S, Miranda AF, et al. Mitochondrial DNA deletions in progressive external opthalmoplegia and Kearns-Sayre syndrome. N Engl J Med 1989;320:1293-1299.