Screening the metallothionein III gene in sporadic amyotrophic lateral sclerosis

Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders

Volumn 6, Issue 2, 2005, Pages 115-117

  Morahan, Julia M ^a,b   Yu, Bing ^a,b   Trent, Ronald J ^a,b   Pamphlett, Roger ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

^b ROYAL PRINCE ALFRED HOSPITAL   (Australia)

Author keywords

Amyotrophic lateral sclerosis; Genetic susceptibility; Metallothionein III (MT3)

Indexed keywords

ALANINE; CYSTEINE; DNA; METALLOTHIONEIN III;

5' UNTRANSLATED REGION; ADULT; AMYOTROPHIC LATERAL SCLEROSIS; ARTICLE; CONTROLLED STUDY; DISEASE PREDISPOSITION; DNA EXTRACTION; FEMALE; GENE FREQUENCY; GENE MUTATION; GENE SEQUENCE; GENETIC PREDISPOSITION; GENOTYPE; HAPLOTYPE; HUMAN; INTRON; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEIN ANALYSIS; SCREENING; SINGLE NUCLEOTIDE POLYMORPHISM;

EID: 21344451665     PISSN: 14660822     EISSN: 1471180X     Source Type: Journal    
DOI: 10.1080/14660820410021249a     Document Type: Article

References (13)

1. Miles AT, Hawksworth GM, Beattie JH, Rodilla V. Induction, regulation, degradation, and biological significance of mammalian metallothioneins. Crit Rev Biochem Mol Biol. 2000;35:35-70.
2. Cleveland DW, Rothstein JD. From Charcot to Lou Gehrig: deciphering selective motor neuron death in ALS. Nat Rev Neurosci. 2001;2:806-19.
3. Gong YH, Elliott JL. Metallothionein expression is altered in a transgenic murine model of familial amyotrophic lateral sclerosis. Exp Neurol. 2000;162:27-36.
4. Nagano S, Satoh M, Sumi H, Fujimura H, Tohyama C, Yanagihara T, et al. Reduction of metallothioneins promotes the disease expression of familial amyotrophic lateral sclerosis mice in a dose-dependent manner. Eur J Neurosci. 2001;13:1363-70.
5. Hidalgo J, Aschner M, Zatta P, Vasak M. Roles of the metallothionein family of proteins in the central nervous system. Brain Res Bull. 2001;55:133-45.
6. Ishigaki S, Niwa J, Ando Y, Yoshihara T, Sawada K, Doyu M, et al. Differentially expressed genes in sporadic amyotrophic lateral sclerosis spinal cords: screening by molecular indexing and subsequent cDNA microarray analysis. FEBS Lett. 2002;531:354-8.
7. Brooks BR, Miller RG, Swash M, Munsat TL. El Escorial revisited: revised criteria for the diagnosis of amyotrophic lateral sclerosis. Amyotroph Lateral Scler Other Motor Neuron Disord. 2000;1:293-9.
8. Gut IG. Automation in genotyping of single nucleotide polymorphisms. Hum Mutat. 2001;17:475-92.
9. Sillevis Smitt PA, van Beek H, Baars AJ, Troost D, Louverse ES, Krops-Hermus AC, et al. Increased metallothionein in the liver and kidney of patients with amyotrophic lateral sclerosis. Arch Neurol. 1992;49:721-4.
10. Sillevis Smitt PA, Blaauwgeers HG, Troost D, de Jong JM. Metallothionein immunoreactivity is increased in the spinal cord of patients with amyotrophic lateral sclerosis. Neurosci Lett. 1992;144:107-10.
11. Blaauwgeers HG, Anwar Chand M, van den Berg FM, Vianney de Jong JM, Troost D. Expression of different metallothionein messenger ribonucleic acids in motor cortex, spinal cord and liver from patients with amyotrophic lateral sclerosis. J Neurol Sci. 1996;142:39-44.
12. Olsen MK, Roberds SL, Ellerbrock BR, Fleck TJ, McKinley DK, Gurney ME. Disease mechanisms revealed by transcription profiling in SOD1-G93A transgenic mouse spinal cord. Ann Neurol. 2001;50:730-40.
13. Sillevis Smitt PA, Mulder TP, Verspaget HW, Blaauwgeers HG, Troost D, de Jong JM. Metallothionein in amyotrophic lateral sclerosis. Biol Signal. 1994;3:193-7.