AREA UNDER THE CURVE;
ARTICLE;
CHLORINATION;
CONTROLLED STUDY;
DEACETYLATION;
DRUG BLOOD LEVEL;
DRUG FECES LEVEL;
DRUG HALF LIFE;
DRUG METABOLISM;
DRUG URINE LEVEL;
FECES LEVEL;
HORMONE BLOOD LEVEL;
HORMONE METABOLISM;
HORMONE URINE LEVEL;
HUMAN;
HYDROXYLATION;
MALE;
NONHUMAN;
NORMAL HUMAN;
SPECIES DIFFERENCE;
Effects of a new steroidal antiandrogen TZP-4238 on hormone-induced canine prostatic hyperplasia
Y. Takezawa, Y. Fukabori, H. Yamanaka, M. Mieda, S. Honma, and M. Kushitani Effects of a new steroidal antiandrogen TZP-4238 on hormone-induced canine prostatic hyperplasia Prostate 21 1992 315 329
Effects of a new steroidal antiandrogen TZP-4238 (17α-acetoxy-6- chloro-2-oxa-4,6-pregnadiene-3,20-dione) on spontaneous development of canine benign prostatic hyperplasia
Y. Takezawa, K. Suzuki, Y. Fukabori, H. Yamanaka, S. Honma, and M. Mieda Effects of a new steroidal antiandrogen TZP-4238 (17α-acetoxy-6-chloro-2- oxa-4,6-pregnadiene-3,20-dione) on spontaneous development of canine benign prostatic hyperplasia Prostate 7 1992 321 328
Effect of antiandrogen TZP-4238 on the prostatic androgen receptor and prostatic androgen in rat
S. Honma, K. Suzuki, Y. Takezawa, K. Minato, Y. Fukabori, and H. Yamanaka Effect of antiandrogen TZP-4238 on the prostatic androgen receptor and prostatic androgen in rat Folia Endocrinol 70 1994 925 940
Antiandrogenic activity and endocrinological profile of a novel anti androgen, TZP-4238, in the rat
M. Mieda, M. Ohta, T. Saito, H. Takahashi, E. Shimazawa, and K. Miyasaka Antiandrogenic activity and endocrinological profile of a novel anti androgen, TZP-4238, in the rat Endocrinol J 41 1994 445 452
Identification and antiandrogenic activity of the metabolites of 17α-acetoxy-6-chloro-4,6-pregnadiene-3,20-dione (chloromadinone acetate) in the rat, rabbit, dog and man
S. Honma, S. Iwamura, K. Iizuka, A. Kambegawa, and K. Shibata Identification and antiandrogenic activity of the metabolites of 17α-acetoxy-6-chloro-4,6-pregnadiene-3,20-dione (chloromadinone acetate) in the rat, rabbit, dog and man Chem Pharm Bull 25 1977 2019 2031
The metabolic fate of anti-androgen, Osaterone acetate (TZP-4238) (1) absorption, excretion and plasma level of TZP-4238 in male mice and male rats
S. Honma, K. Minato, T. Hoshino, Y. Kawabe, and M. Mieda The metabolic fate of anti-androgen, Osaterone acetate (TZP-4238) (1) absorption, excretion and plasma level of TZP-4238 in male mice and male rats Pharmacomerics 47 1994 317 335
Pharmacokinetics and biliary excretion of osaterone acetate, a new steroidal antiandrogen, in dogs
K. Minato, N. Koizumi, S. Honma, K. Tsukamoto, and S. Iwamura Pharmacokinetics and biliary excretion of osaterone acetate, a new steroidal antiandrogen, in dogs Drug Metab Dispos 30 2 2002 167 172
Antiandrogen. I. 2-azapregnane and 2-oxapregnane steroids
K. Shibata, S. Takegawa, N. Koizumi, N. Yamakoshi, and E. Shimazawa Antiandrogen. I. 2-azapregnane and 2-oxapregnane steroids Chem Pharm Bull 40 1992 935 941
Three-month repeated oral dose toxicity study of osaterone acetate (TZP-4238), an antiandrogen, in Beagle dogs
N. Kuwayama, T. Nakayama, M. Murakoshi, M. Isobe, A. Sato, and K. Eguchi Three-month repeated oral dose toxicity study of osaterone acetate (TZP-4238), an antiandrogen, in Beagle dogs Pharamacometrics 47 1994 235 261
The effect of antiandrogen TZP-4238 on corticosteroid hormone in the dog
Y. Ohta, K. Minato, T. Hoshino, N. Hirabayashi, and S. Honma The effect of antiandrogen TZP-4238 on corticosteroid hormone in the dog Folia Endocrinol 70 1994 913 924
C.E. Gomez-Sanchez, M.Y. Zhou, E.N. Cozza, H. Morita, M.F. Foecking, and E.P. Gomez-Sanchez Aldosterone biosynthesis in the rat brain Endocrinology 138 8 1997 3369 3373
(1997)Endocrinology, vol.138, Issue.8, pp. 3369-3373
Regulation of aldosterone synthase in human vascular endothelial cells by angiotensin II and adrenocortiocotropin
Y. Takeda, I. Miyamori, T. Yoneda, H. Hatakeyama, S. Inaba, and K. Furukawa Regulation of aldosterone synthase in human vascular endothelial cells by angiotensin II and adrenocortiocotropin J Clin Endocrinol Metab 81 1996 2797 2800
Y. Takeda, T. Yoneda, M. Demura, I. Miyamori, and H. Mabuchi Sodium-induced cardiac aldosterone synthesis causes cardiac hypertrophy Endocrinology 141 5 2000 1901 1904
(2000)Endocrinology, vol.141, Issue.5, pp. 1901-1904
Glucocorticoid production in the murine thymus Eur
O. Lechner, G.J. Wiegers, A.J. Oliveira-dos-Santos, H. Dietrich, H. Recheis, and M. Waterman Glucocorticoid production in the murine thymus Eur J Immunol 30 2000 337 346
Characterizations of mouse hepatic microsomal monooxygenase catalyzing 11β-hydroxylation of osaterone acetate
K. Minato, N. Koizumi, S. Honma, S. Iwamura, and K. Tsukamoto Characterizations of mouse hepatic microsomal monooxygenase catalyzing 11β-hydroxylation of osaterone acetate Biochem Pharmacol 58 2 1999 335 341
Human and rodent type 1 11beta-hydroxysteroid dehydrogenase are 7beta-hydroxycholesterol dehydrogenases involved in oxysterol metabolism
M. Hult, B. Elleby, N. Shafgat, S. Svensson, A. Rane, and H. Jornvall Human and rodent type 1 11beta-hydroxysteroid dehydrogenase are 7beta-hydroxycholesterol dehydrogenases involved in oxysterol metabolism Cell Mol Life Sci 61 2004 992 999
Characterization of 11β-hydroxysteroid dehydrogenases in feline kidney and liver
L. Schipper, B. Spee, J. Routhuizen, F. Woutersen-van Nijnanten, and J. Fink-Gremmels Characterization of 11β-hydroxysteroid dehydrogenases in feline kidney and liver Biochimica et Biophysica Acta 1688 2004 68 77
Urinary and biliary metabolites of 17α-acetoxy-6-chloro-4.6- pregnadiene-3 20-dione in rabbit
T. Abe, and A. Kambegawa Urinary and biliary metabolites of 17α-acetoxy-6-chloro-4.6-pregnadiene-3 20-dione in rabbit Chem Pharm Bull 22 1974 2824 2829
Mechanism for the oxidative defluorination of flnisolide
P.J. Teitelbaum, N.I. Chu, D. Cho, L. Tokes, J.W. Patterson, and P.J. Wagner Mechanism for the oxidative defluorination of flnisolide J Pharmacol Exp Ther 218 1981 16 22
Oxidative dehalogenation of 2-fluoro-17 alpha-ethyloestradiol in vivo a distal structure-metabolism relationship of 17 alpha-ethynylation
P. Morgan, J.L. Maggs, P.C. Page, and B.K. Park Oxidative dehalogenation of 2-fluoro-17 alpha-ethyloestradiol in vivo A distal structure-metabolism relationship of 17 alpha-ethynylation Biochem Pharmacol 44 9 1992 1717 1724
The release and purification of sialic acids from glycoconjugates: Methods to minimize the loss and migration of O-acetyl groups
A. Varki, and S. Diaz The release and purification of sialic acids from glycoconjugates: Methods to minimize the loss and migration of O-acetyl groups Anal Biochem 137 1984 236 247
Characterization of the enzymatic 7-O-acetylation of sialic acids and evidence for enzymatic O-acetyl migration from C-7 to C-9 in bovine submandibular gland
V. Valdamme-Feldhaus, and R. Schuer Characterization of the enzymatic 7-O-acetylation of sialic acids and evidence for enzymatic O-acetyl migration from C-7 to C-9 in bovine submandibular gland J Biochem 124 1998 111 121
