Inhibitory effect of conjugated eicosapentaenoic acid on mammalian DNA polymerase and topoisomerase activities and human cancer cell proliferation

Biochemical Pharmacology

Volumn 70, Issue 3, 2005, Pages 453-460

  Yonezawa, Yuko ^a   Hada, Takahiko ^b   Uryu, Keisuke ^b   Tsuzuki, Tsuyoshi ^c   Eitsuka, Takahiro ^c   Miyazawa, Teruo ^c   Murakami Nakai, Chikako ^a,d   Yoshida, Hiromi ^a   Mizushina, Yoshiyuki ^a  

^a KOBE GAKUIN UNIVERSITY   (Japan)

^b Bizen Chemical Co Ltd   (Japan)

^c TOHOKU UNIVERSITY   (Japan)

^d NATIONAL CENTER FOR GLOBAL HEALTH AND MEDICINE   (Japan)

Author keywords

Apoptosis; Cell proliferation; Conjugated eicosapentaenoic acid (cEPA); Cytotoxicity; DNA polymerase; DNA replication; Enzyme inhibitor

Indexed keywords

CONJUGATED EICOSAPENTAENOIC ACID; CYCLIN A; CYCLIN E; DNA; DNA POLYMERASE; DNA TOPOISOMERASE; ICOSAPENTAENOIC ACID; THYMIDINE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER CELL; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CELL PROLIFERATION; CELL STRAIN HL 60; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DNA REPLICATION; DRUG EFFECT; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; IN VIVO STUDY; LD 50; LEUKEMIA CELL LINE; MAMMAL; MITOSIS INHIBITION; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMYELOCYTIC LEUKEMIA;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; CELL PROLIFERATION; DNA TOPOISOMERASES; DNA-DIRECTED DNA POLYMERASE; EICOSAPENTAENOIC ACID; ENZYME INHIBITORS; GROWTH INHIBITORS; HL-60 CELLS; HUMANS; LEUKEMIA, PROMYELOCYTIC, ACUTE;

EID: 21344432832     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2005.05.008     Document Type: Article

References (38)

1. A. Kornberg, and T.A. Baker DNA replication 2nd ed. 1992 W.D. Freeman and Co. New York p. 197-225 [Chapter 6]
2. J.C. Wang DNA topoisomerases Annu Rev Biochem 65 1996 635 691
3. Y. Mizushina, H. Yagi, N. Tanaka, T. Kurosawa, H. Seto, and K. Katsumi Screening of inhibitor of eukaryotic DNA polymerases produced by microorganisms J Antibiot (Tokyo) 49 1996 491 492
4. Y. Mizushina, N. Tanaka, H. Yagi, T. Kurosawa, M. Onoue, and H. Seto Fatty acids selectively inhibit eukaryotic DNA polymerase activities in vitro Biochim Biophys Acta 1308 1996 256 262
5. Y. Mizushina, S. Yoshida, A. Matsukage, and K. Sakaguchi The inhibitory action of fatty acids on DNA polymerase β Biochim Biophys Acta 1336 1997 509 521
6. Y. Mizushina, F. Sugawara, A. Iida, and K. Sakaguchi Structural homology between DNA binding sites of DNA polymerase beta and DNA topoisomerase II J Mol Biol 304 2000 385 395
7. E. Fernandez, L. Chatenoud, C. La Vecchia, E. Negri, and S. Franceschi Fish consumption and cancer risk Am J Clin Nutr 70 1999 85 90
8. M.A. Lindner A fish oil diet inhibits colon cancer in mice Nutr Cancer 15 1991 1 11
9. Reddy BS, Burill C, Rigotty J., Effect of diets high in omega-3 and omega-6 fatty acids on initiation and postinitiation stages of colon carcinobenesis. Cancer Res;191:487-91.
10. M. Hirose, A. Masuda, N. Ito, K. Kamano, and H. Okuyama Effects of dietary perilla oil, soybean oil and safflower oil on 7,12-dimethylbenz(α) anthracene (DMBA) and 1,2-dimethylhydrazine (DMH)-induced mammary gland and colon carcinogenesi in female SD rats Carcinogenesis 11 1990 731 735
11. M. Iigo, T. Nakagawa, Y. Iwahori, M. Asamoto, K. Yazawa, and E. Araki Inhibtory effects of docosahexaenoic acid on colon carcinoma 26 metastasis to the lung Br J Cancer 75 1997 650 655
12. S. Iwamoto, H. Senzaki, Y. Kiyozuka, E. Ogura, H. Takada, and K. Hioki Effects of fatty acids on liver metastasis of ACL15 rat colon cancer cells Nutr Cancer 31 1998 143 150
13. Y.L. Ha, N.K. Grimm, and M.W. Pariza Anticarcinogens from fried ground beef: heat-altered derivatives of linoleic acid Carcinogenesis 8 1987 1881 1887
14. H.S. Park, J.H. Ryu, Y.L. Ha, and J.H. Park Dietary conjugated linoleic acid (CLA) induces apoptosis of colonic mucosa in 1,2-dimethylhydrazine-treated rats: a possible mechanism of the anticarcinogenic effect by CLA Br J Nutr 86 2001 549 555
15. T.D. Shultz, B.P. Chew, W.R. Seaman, and L.O. Luedecke Inhibitory effect of conjugated dienoic derivatives of linoleic acid and β-carotene on the in vitro growth of human cancer cells Cancer Lett 63 1992 125 133
16. G.S. Kelly Conjugated linoleic acid: a review Alern Med Rev 6 2001 367 382
17. A. Lopez, and W.H. Gerwick Two new icosapentaenoic acids from the temperate red seaweed Ptilota filicina J. Agardh. Lipids 22 1987 190 194
18. M.V. Mikhailova, D.L. Bemis, M.L. Wise, W.H. Gerwick, J.N. Norris, and R.S. Jacobs Structure and biosynthesis of novel conjugated polyene fatty acids from the marine green alga Anadyomene stellata Lipids 30 1995 583 589
19. Y. Yonezawa, T. Tsuzuki, T. Eitsuka, T. Miyazawa, T. Hada, and K. Uryu Inhibitory effect of conjugated eicosapentaenoic acid on human DNA topoisomerases I and II Arch Biochem Biophys 435 2005 197 206
20. Association of Official Analytical Chemists Acids (poly-unsaturated) in oil and fats K. Helrich Official methods of analysis of the association of official analytical chemists 1990 Association of Official Analytical Chemists Arlington 960 963
21. G.A.J. Pitt, and R.A. Morton Prog Chem Fats Other Lipids 4 1957 227 278
22. K. Tamai, K. Kojima, T. Hanaichi, S. Masaki, M. Suzuki, and H. Umekawa Structural study of immunoaffinity-purified DNA polymerase α-DNA primase complex from calf thymus Biochim Biophys Acta 950 1988 263 273
23. T. Date, M. Yamaguchi, F. Hirose, Y. Nishimoto, K. Tanihara, and A. Matsukage Expression of active rat DNA polymerase β in Escherichia coli Biochemistry 27 1988 2983 2990
24. M. Oshige, R. Takeuchi, R. Ruike, K. Kuroda, and K. Sakaguchi Subunit protein-affinity isolation of Drosophila DNA polymerase catalytic subunit Protein Expr Purif 35 2004 248 256
25. K. Sakaguchi, Y. Hotta, and H. Stern Chromatin-associated DNA polymerase activity in meiotic cells of lily and mouse Cell Struct Funct 5 1980 323 334
26. K.T. Koizumi, T. Murate, M. Suzuki, C.G. Simbulan, M. Nakagawa, and M. Takemura Inhibition of DNA primase by sphingosine and its analogues parallels with their growth suppression of cultured human leukemic cells Biochem Mol Biol Int 41 1997 1179 1189
27. C. Nakayama, and M. Saneyoshi Inhibitory effects of 9-β-d- xylofuranosyladenine 5′-triphosphate on DNA-dependent RNA polymerase I and II from cherry salmon (Oncorhynchus masou) J Biochem (Tokyo) 97 1985 1385 1389
28. D.A. Soltis, and O.C. Uhlenbeck Isolation and characterization of two mutant forms of T4 polynucleotide kinase J Biol Chem 257 1982 11332 11339
29. B.C. Lu, and K. Sakaguchi An endo-exonuclease from meiotic tissues of the basidiomycete Coprinus cinereus J Biol Chem 266 1991 21060 21066
30. L.F. Lui, and K.G. Miller Eukaryotic DNA topoisomerases: two forms of type I DNA topoisomerases from HeLa cell nuclei Proc Natl Acad Sci USA 78 1981 3487 3491
31. T. Mosmann Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays J Immunol Methods 65 1983 55 63
32. Heintel D, Kroemer E, Kienle D, Schwarzinger I, Gleiss A, Schwarzmeier J, et al. German CLL Study Group. High expression of activation-induced cytidine deaminase (AID) mRNA is associated with unmutated IGVH gene status and unfavourable cytogenetic aberrations in patients with chronic lymphocytic leukaemia. Leukemia 2004;18:756-62.
33. S. Ikegami, T. Taguchi, M. Ohashi, M. Oguro, H. Nagano, and Y. Mano Aphidicolin prevents mitotic cell division by interfering with the activity of DNA polymerase-α Nature 275 1978 458 460
34. S. Izuta, M. Saneyoshi, T. Sakurai, M. Suzuki, K. Kojima, and S. Yoshida The 5′-triphosphates of 3′-azido-3′-deoxythymidine and 2′, 3′-dideoxynucleosides inhibit DNA polymerase gamma by different mechanisms Biochem Biophys Res Commun 179 1991 776 783
35. C. Murakami-Nakai, N. Maeda, Y. Yonezawa, I. Kuriyama, S. Kamisuki, and S. Takahashi The effects of dehydroaltenusin, a novel mammalian DNA polymerase α inhibitor, on cell proliferation and cell cycle progression Biochim Biophys Acta 1674 2004 193 199
36. K. Nishida, M. Seto, and R. Ishida Different susceptibilities of postmitotic checkpoint-proficient and -deficient Balb/3T3 cells to ICRF-193, a catalytic inhibior of DNA topoisomerase II Jpn J Cancer Res 92 2001 193 202
37. R.A. Woo, and R.Y. Poon Cyclin-dependent kinases and S phase control in mammalian cells Cell Cycle 2 2003 316 324
38. J. Pines, and T. Hunter Isolation of a human cyclin cDNA: evidence for cyclin mRNA and protein regulation in the cell cycle and for interaction with p34cdc2 Cell 58 1989 833 846