The mechanism underlying the contractile effect of a chemotactic peptide, formyl-Met-Leu-Phe on the guinea-pig Taenia coli

British Journal of Pharmacology

Volumn 145, Issue 3, 2005, Pages 353-363

  Kawata, Hiroshi ^a   Hirano, Katsuya ^a   Nishimura, Junji ^a   Kubo, Chiharu ^a   Kanaide, Hideo ^a,b  

^a KYUSHU UNIVERSITY   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

Author keywords

Ca 2+ sensitivity; fMLP; Gastrointestinal smooth muscle

Indexed keywords

1 [2 (4 METHOXYPHENYL) 2 [3 (4 METHOXYPHENYL)PROPOXY]ETHYL] 1H IMIDAZOLE; 2 (2,6 DIHYDROXYHEXYL) 6 (3 HYDROXY 1,5 UNDECADIENYL)PYRIDINE; 4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; 6 (4 CARBOXYPHENYLTHIO) 5 HYDROXY 7,9,11,14 ICOSATETRAENOIC ACID; ACETYLSALICYLIC ACID; ARACHIDONIC ACID DERIVATIVE; ATROPINE; CALCIUM ION; CARBACHOL; CHEMOTACTIC PEPTIDE; CHENODEOXYCHOLIC ACID; DILTIAZEM; FAMOTIDINE; FORMYLMETHIONYLLEUCYLPHENYLALANINE; FORMYLMETHIONYLLEUCYLPHENYLALANINE RECEPTOR; FORMYLPEPTIDE RECEPTOR INHIBITOR; ICATIBANT; ICATIBANT[DEARGININE]; INDOMETACIN; LEUKOTRIENE RECEPTOR BLOCKING AGENT; LIPOXYGENASE INHIBITOR; MEPYRAMINE; NOLPITANTIUM; NORDIHYDROGUAIARETIC ACID; OXYGENASE INHIBITOR; PHENINDIONE; POTASSIUM ION; PRANLUKAST; PROTEIN INHIBITOR; RECEPTOR; RECEPTOR BLOCKING AGENT; RHO KINASE INHIBITOR; SAREDUTANT; UNCLASSIFIED DRUG; VERLUKAST;

ANIMAL TISSUE; ARTICLE; CALCIUM CELL LEVEL; CALCIUM DEPLETION; CALCIUM TRANSPORT; COLON TENIA; CONCENTRATION RESPONSE; CONTROLLED STUDY; DEPOLARIZATION; DRUG EFFECT; DRUG MECHANISM; EXTRACELLULAR CALCIUM; GUINEA PIG; INTESTINE CONTRACTION; MALE; MUSCLE FORCE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; CALCIUM; CHEMOTACTIC FACTORS; COLON; DOSE-RESPONSE RELATIONSHIP, DRUG; GUINEA PIGS; MALE; MUSCLE CONTRACTION; N-FORMYLMETHIONINE LEUCYL-PHENYLALANINE;

EID: 21244497861     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0706181     Document Type: Article

References (42)

1. AMANO, M., ITO, M., KIMURA, K., FUKATA, Y., CHIHARA, K., NAKANO, T., MATSUURA, Y. & KAIBUCHI, K. (1996). Phosphorylation and activation of myosin by Rho-associated kinase (Rho-kinase). J. Biol. Chem., 271, 20246-20249.
2. ARMOUR, C.L., BLACK, J.L., JOHNSON, P.R., VINCENC, K.S. & BEREND, N. (1986). Formyl peptide-induced contraction of human airways in vitro. J. Appl. Physiol., 60, 141-146.
3. BAO, L., GERARD, N.P., EDDY JR, R.L., SHOWS, T.B. & GERARD, C. (1992). Mapping of genes for the human C5a receptor (C5AR), human FMLP receptor (FPR), and two FMLP receptor homologue orphan receptors (FPRH1, FPRH2) to chromosome 19. Genomics, 13, 437-440.
4. BECKER, E.L., FOROUHAR, F.A., GRUNNET, M.L., BOULAY, F., TARDIF, M., BORMANN, B.J., SODJA, D., YE, R.D., WOSKA, J.R. & MURPHY, P.M. (1998). Broad immunocytochemical localization of the formyl peptide receptor in human organs, tissues, and cells. Cell Tissue Res., 292, 129-135.
5. BOUKILI, M.A., BUREAU, M., LAGENTE, V., LEFORT, J., LELLOUCH-TUBIANA, A., MALANCHERE, E. & VARGAFTIG, B.B. (1986). Pharmacological modulation of the effects of N-formyl-L-methionyl-L-leucyl-L-phenylalanine in guinea-pigs: involvement of the arachidonic acid cascade. Br. J. Pharmacol., 89, 349-359.
6. CHEN, X., YANG, D., SHEN, W., DONG, H.F., WANG, J.M., OPPENHEIMEIM, J.J. & HOWARD, M.Z. (2000). Characterization of chenodeoxycholic acid as an endogenous antagonist of the G-coupled formyl peptide receptors. Inflamm. Res., 49, 744-755.
7. CROWELL, R.E., VAN EPPS, D.E. & REED, W.P. (1989). Responses of isolated pulmonary arteries to synthetic peptide F-Met-Leu-Phe. Am. J. Physiol., 257, H107-H112.
8. GAO, J.L., CHEN, H., FILIE, J.D., KOZAK, C.A. & MURPHY, P.M. (1998). Differential expansion of the N-formyl peptide receptor gene cluster in human and mouse. Genomics, 51, 270-276.
9. 4 receptor that is regulated by interleukin (IL)-13 and interferon γ and inhibits tumor necrosis factor α-induced IL-8 release. J. Exp. Med., 187, 1285-1294.
10. HAEGGSTROM, J.Z. & WETTERHOLM, A. (2002). Enzymes and receptors in the leukotriene cascade. Cell. Mol. Life Sci., 59, 742-753.
11. HAMEL, R., FORD-HUTCHINSON, A.W., LORD, A. & CIRINO, M. (1984). Bronchoconstriction induced by N-formyl-methionyl-leucyl-phenylalanine in the guinea pig; involvement of arachidonic acid metabolites. Prostaglandins, 28, 43-56.
12. HIRANO, K., DERKACH, D.N., HIRANO, M., NISHIMURA, J. & KANAIDE, H. (2003). Protein kinase network in the regulation of phosphorylation and dephosphorylation of smooth muscle myosin light chain. Mol. Cell. Biochem., 248, 105-114.
13. HIRANO, K., KANAIDE, H., ABE, S. & NAKAMURA, M. (1990). Effects of diltiazem on calcium concentrations in the cytosol and on force of contractions in porcine coronary arterial strips. Br. J. Pharmacol., 101, 273-280.
14. 4 in guinea-pig Taenia coli. Br. J. Pharmacol., 133, 529-538.
15. IZUMI, T., YOKOMIZO, T., OBINATA, H., OGASAWARA, H. & SHIMIZU, T. (2002). Leukotriene receptors: classification, gene expression, and signal transduction. J. Biochem., 132, 1-6.
16. i in smooth muscle strips using front-surface fluorimetry. In: Methods in Molecular Biology, ed. Lambert, D.G. pp. 269-277. Totowa, NJ: Humana Press.
17. KEITOKU, M., KOHZUKI, M., KATOH, H., FUNAKOSHI, M., SUZUKI, S., TAKEUCHI, M., KARIBE, A., HORIGUCHI, S., WATANABE, J., SATOH, S., NOSE, M., ABE, K., OKAYAMA, H. & SHIRATO, K. (1997). FMLP actions and its binding sites in isolated human coronary arteries. J. Mol. Cell. Cardiol., 29, 881-894.
18. KERR, S.W., YU, R., STEARNS, C.D., HAYNES, N.A. & WINQUIST, R.J. (1998). Characterization of the polymorphonuclear leukocyte-induced vasoconstriction in isolated human umbilical veins. J. Pharmacol. Exp. Ther., 287, 640-647.
19. KIMURA, K., ITO, M., AMANO, M., CHIHARA, K., FUKATA, Y., NAKAFUKU, M., YAMAMORI, B., FENG, J., NAKANO, T., OKAWA, K., IWAMATSU, A. & KAIBUCHI, K. (1996). Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase). Science, 273, 245-248.
20. LACY, M., JONES, J., WHITTEMORE, S.R., HAVILAND, D.L., WETSEL, R. A. & BARNUM, S. R. (1995). Expression of the receptors for the C5a anaphylatoxin, interleukin-8 and FMLP by human astrocytes and microglia. J. Neuroimmunol., 61, 71-78.
21. LE, Y., YANG, Y., CUI, Y., YAZAWA, H., GONG, W., QIU, C. & WANG, J.M. (2002). Receptors for chemotactic formyl peptides as pharmacological targets. Int. Immunopharmacol., 2, 1-13.
22. LE, Y.Y., HU, J.Y., GONG, W.H., SHEN, W.P., LI, B.Q., DUNLOP, N.M., HALVERSON, D.O., BLAIR, D.G. & WANG, J.M. (2000). Expression of functional formyl peptide receptors by human astrocytoma cell lines. J. Neuroimmunol., 111, 102-108.
23. MAGGI, C.A., SANTICIOLI, P., DEL BIANCO, E. & GIULIANI, S. (1992). Local motor responses to bradykinin and bacterial chemotactic peptide formyl-methionyl-leucyl-phenylalanine (FMLP) in the guinea-pig isolated renal pelvis and ureter. J. Urol., 148, 1944-1950.
24. MARASCO, W.A., FANTONE, J.C. & WARD, P.A. (1982). Spasmogenic activity of chemotactic N-formylated oligopeptides: identity of structure-function relationships for chemotactic and spasmogenic activities. Proc. Natl. Acad. Sci. U.S.A., 79, 7470-7473.
25. MARASCO, W.A., PHAN, S.H., KRUTZSCH, H., SHOWELL, H.J., FELTNER, D.E., NAIRN, R., BECKER, E.L. & WARD, P.A. (1984). Purification and identification of formyl-methionyl-leucyl-phenylalanine as the major peptide neutrophil chemotactic factor produced by Escherichia coli. J. Biol. Chem., 259, 5430-5439.
26. MARTEL-PELLETIER, J., LAJEUNESSE, D., REBOUL, P. & PELLETIER, J.P. (2003). Therapeutic role of dual inhibitors of 5-LOX and COX, selective and non-selective non-steroidal anti-inflammatory drugs. Ann. Rheum. Dis., 62, 501-509.
27. 1 receptor via intracellular calcium mobilization in smooth muscle cells. Br. J. Pharmacol., 138, 707-715.
28. MCCOY, R., HAVILAND, D.L., MOLMENTI, E.P., ZIAMBARAS, T., WETSEL, R.A. & PERLMUTTER, D.H. (1995). N-formyl peptide and complement C5a receptors are expressed in liver cells and mediate hepatic acute phase gene regulation. J. Exp. Med., 182, 207-217.
29. MERRITT, J.E., ARMSTRONG, W.P., BENHAM, C.D., HALLAM, T.J., JACOB, R., JAXA-CHAMIEC, A., LEIGH, B.K., MCCARTHY, S.A., MOORES, K.E. & RINK, T.J. (1990). SK&F 96365, a novel inhibitor of receptor-mediated calcium entry. Biochem. J., 271, 515-522.
30. MINAMINO, T., KITAKAZE, M., NODE, K., FUNAYA, H., INOUE, M., HORI, M. & KAMADA, T. (1996). Adenosine inhibits leukocyte-induced vasoconstriction. Am. J. Physiol., 271, H2622-H2628.
31. PANARO, M.A. & MITOLO, V. (1999). Cellular responses to FMLP challenging. Immunopharmacol. Immunotoxicol., 21, 397-419.
32. PROSSNITZ, E.R. & YE, R.D. (1997). The n-formyl peptide receptor - a model for the study of chemoattractant receptor structure and function. Pharmacol. Ther., 74, 73-102.
33. QUEHENBERGER, O., PROSSNITZ, E.R., CAVANAGH, S.L., COCHRANE, C.G. & YE, R.D. (1993). Multiple domains of the N-formyl peptide receptor are required for high-affinity ligand binding. Construction and analysis of chimeric N-formyl peptide receptors. J. Biol. Chem., 268, 18167-18175.
34. SCHIFFMANN, E., CORCORAN, B.A. & WAHL, S.M. (1975a). N-formylmethionyl peptides as chemoattractants for leucocytes. Proc. Natl. Acad. Sci. U.S.A., 72, 1059-1062.
35. SCHIFFMANN, E., SHOWELL, H.V., CORCORAN, B.A., WARD, P.A., SMITH, E. & BECKER, E.L. (1975b). The isolation and partial characterization of neutrophil chemotactic factors from Escherichia coli. J. Immunol., 114, 1831-1837.
36. SHORE, S.A., STIMLER-GERARD, N.P., SMITH, E. & DRAZEN, J.M. (1987). A formyl peptide contracts guinea pig lung: role of arachidonic acid metabolites. J. Appl. Physiol., 63, 2450-2459.
37. SOMLYO, A.P., WU, X., WALKER, L.A. & SOMLYO, A.V. (1999). Pharmacomechanical coupling: the role of calcium, G-proteins, kinases and phosphatases. Rev. Physiol. Biochem. Pharmacol., 134, 201-234.
38. SOZZANI, S., SALLUSTO, F., LUINI, W., ZHOU, D., PIEMONTI, L., ALLAVENA, P., VAN DAMME, J., VALITUTTI, S., LANZAVECCHIA, A. & MANTOVANI, A. (1995). Migration of dendritic cells in response to formyl peptides, C5a, and a distinct set of chemokines. J. Immunol., 155, 3292-3295.
39. STREK, M.E., WHITE, S.R., HSIUE, T.R., KULP, G.V., WILLIAMS, F.S. & LEFF, A.R. (1993). Effect of mode of activation of human eosinophils on tracheal smooth muscle contraction in guinea pigs. Am. J. Physiol., 264, L475-81.
40. UEHATA, M., ISHIZAKI, T., SATOH, H., ONO, T., KAWAHARA, T., MORISHITA, T., TAMAKAWA, H., YAMAGAMI, K., INUI, J., MAEKAWA, M. & NARUMIYA, S. (1997). Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension. Nature, 389, 990-994.
41. WANG, Z.G. & YE, R.D. (2002). Characterization of two new members of the formyl peptide receptor gene family from 129S6 mice. Gene, 299, 57-63.
42. YE, R.D., CAVANAGH, S.L., QUEHENBERGER, O., PROSSNITZ, E.R. & COCHRANE, C.G. (1992). Isolation of a cDNA that encodes a novel granulocyte N-formyl peptide receptor. Biochem. Biophys. Res. Commun., 184, 582-589.