Short-term administration of supraphysiological recombinant human growth hormone (GH) does not increase maximum endurance exercise capacity in healthy, active young men and women with normal GH-insulin-like growth factor I axes

Journal of Clinical Endocrinology and Metabolism

Volumn 90, Issue 6, 2005, Pages 3268-3273

  Berggren, Annika ^a   Ehrnborg, Christer ^a   Rosén, Thord ^a   Ellegård, Lars ^a   Bengtsson, Bengt Åke ^a   Caidahl, Kenneth ^a,b,c  

^a SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

^c KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

HUMAN GROWTH HORMONE; OXYGEN; PLACEBO; SOMATOMEDIN C; CARBON DIOXIDE;

ADULT; AMBULATORY MONITORING; ANALYSIS OF VARIANCE; ARTICLE; BICYCLE; BLOOD PRESSURE; CLINICAL TRIAL; COMMUNITY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORRELATION FUNCTION; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG MEGADOSE; ELECTROCARDIOGRAPHY; ENDURANCE; EXERCISE; EXTRACELLULAR FLUID; FEMALE; FLUID RETENTION; HEART RATE; HUMAN; INTRACELLULAR FLUID; LOW DRUG DOSE; MALE; MUSCLE MASS; NORMAL HUMAN; OUTCOMES RESEARCH; OXYGEN CONSUMPTION; PERFORMANCE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; REST; ST SEGMENT; TRAINING; UNIVERSITY HOSPITAL; WEIGHT GAIN; BLOOD; BODY WATER; COMPARATIVE STUDY; METABOLISM; PHYSIOLOGY; PRESSURE; REFERENCE VALUE;

BLOOD PRESSURE; BODY WATER; CARBON DIOXIDE; DOUBLE-BLIND METHOD; EXERCISE; FEMALE; HUMAN GROWTH HORMONE; HUMANS; INSULIN-LIKE GROWTH FACTOR I; MALE; OXYGEN; OXYGEN CONSUMPTION; PARTIAL PRESSURE; PHYSICAL ENDURANCE; PLACEBOS; REFERENCE VALUES;

EID: 21244453198     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2004-1209     Document Type: Article

References (40)

1. Cuneo RC, Salomon F, Wiles CM, Hesp R, Sonksen PH 1991 Growth hormone treatment in growth hormone-deficient adults. II. Effects on exercise performance. J Appl Physiol 70:695-700
2. Cuneo RC, Salomon F, Wiles CM, Hesp R, Sonksen PH 1991 Growth hormone treatment in growth hormone-deficient adults. I. Effects on muscle mass and strength. J Appl Physiol 70:688-694
3. Johannsson G, Grimby G, Sunnerhagen KS, Bengtsson BA 1997 Two years of growth hormone (GH) treatment increase isometric and isokinetic muscle strength in GH-deficient adults. J Clin Endocrinol Metab 82:2877-2884
4. Jorgensen JO, Pedersen SA, Thuesen L, Jorgensen J, Ingemann-Hansen T, Skakkebaek NE, Christiansen JS 1989 Beneficial effects of growth hormone treatment in GH-deficient adults. Lancet 1:1221-1225
5. Christiansen JS, Jorgensen JO, Pedersen SA, Muller J, Jorgensen J, Moller J, Heickendorf L, Skakkebaek NE 1991 GH-replacement therapy in adults. Horm Res 36(Suppl 1):66-72
6. Johannsson G, Bengtsson BA, Andersson B, Isgaard J, Caidahl K 1996 Long-term cardiovascular effects of growth hormone treatment in GH-deficient adults. Preliminary data in a small group of patients. Clin Endocrinol (Oxf) 45:305-314
7. Eliakim A, Brasel JA, Mohan S, Barstow TJ, Berman N, Cooper DM 1996 Physical fitness, endurance training, and the growth hormone-insulin-like growth factor I system in adolescent females. J Clin Endocrinol Metab 81:3986-3992
8. Kelly PJ, Eisman JA, Stuart MC, Pocock NA, Sambrook PN, Gwinn TH 1990 Somatomedin-C, physical fitness, and bone density. J Clin Endocrinol Metab 70:718-723
9. Poehlman ET, Copeland KC 1990 Influence of physical activity on insulin-like growth factor-I in healthy younger and older men. J Clin Endocrinol Metab 71:1468-1473
10. Eliakim A, Brasel JA, Barstow TJ, Mohan S, Cooper DM 1998 Peak oxygen uptake, muscle volume, and the growth hormone-insulin-like growth factor-I axis in adolescent males. Med Sci Sports Exerc 30:512-517
11. Dall R, Longobardi S, Ehrnborg C, Keay N, Rosen T, Jorgensen JO, Cuneo RC, Boroujerdi MA, Cittadini A, Napoli R, Christiansen JS, Bengtsson BA, Sacca L, Baxter RC, Basset RE, Sonksen PH 2000 The effect of four weeks of supraphysiological growth hormone administration on the insulin-like growth factor axis in women and men. GH-2000 Study Group. J Clin Endocrinol Metab 85:4193-4200
12. Falk KJ, Angelhed JE, Bjuro TI 1982 Real-time processing of multiple-lead exercise electrocardiograms. Med Prog Technol 8:159-174
13. Falk KJ, Angelhed JE, Bjuro TI 1982 A program for processing of multiple-lead exercise ECGs in real time. Comput Programs Biomed 14:133-144
14. Merilainen PT 1989 Sensors for oxygen analysis: paramagnetic, electrochemical, polarographic, and zirconium oxide technologies. Biomed Instrum Technol 23:462-466
15. Merilainen PT 1990 A differential paramagnetic sensor for breath-by-breath oximetry. J Clin Monit 6:65-73
16. Bengtsson J, Bake B, Johansson A, Bengtson JP 2001 End-tidal to arterial oxygen tension difference as an oxygenation index. Acta Anaesthesiol Scand 45:357-363
17. Beaver WL, Wasserman K, Whipp BJ 1986 A new method for detecting anaerobic threshold by gas exchange. J Appl Physiol 60:2020-2027
18. Gudivaka R, Schoeller DA, Kushner RF, Bolt MJ 1999 Single- and multifrequency models for bioelectrical impedance analysis of body water compartments. J Appl Physiol 87:1087-1096
19. Bidlingmaier M, Wu Z, Strasburger CJ 2001 Doping with growth hormone. J Pediatr Endocrinol Metab 14:1077-1083
20. Lange KH, Larsson B, Flyvbjerg A, Dall R, Bennedou M, Rasmussen MH, Orskov H, Kjaer M 2002 Acute growth hormone administration causes exaggerated increases in plasma lactate and glycerol during moderate to high intensity bicycling in trained young men. J Clin Endocrinol Metab 87:4966-4975
21. Irving BA, Patrie JT, Anderson SM, Watson-Winfield DD, Frick KI, Evans WS, Veldhuis JD, Weltman A 2004 The effects of time following acute growth hormone administration on metabolic and power output measures during acute exercise. J Clin Endocrinol Metab 89:4298-4305
22. Macintyre JG 1987 Growth hormone and athletes. Sports Med 4:129-142
23. Clarkson PM, Thompson HS 1997 Drugs and sport. Research findings and limitations. Sports Med 24:366-384
24. Pritzlaff-Roy CJ, Widemen L, Weltman JY, Abbott R, Gutgesell M, Hartman ML, Veldhuis JD, Weltman A 2002 Gender governs the relationship between exercise intensity and growth hormone release in young adults. J Appl Physiol 92:2053-2060
25. Weltman A, Weltman JY, Hartman ML, Abbott RD, Rogol AD, Evans WS, Veldhuis JD 1994 Relationship between age, percentage body fat, fitness, and 24-hour growth hormone release in healthy young adults: effects of gender. J Clin Endocrinol Metab 78:543-548
26. Haydar ZR, Blackman MR, Tobin JD, Wright JG, Fleg JL 2000 The relationship between aerobic exercise capacity and circulating IGF-I levels in healthy men and women. J Am Geriatr Soc 48:139-145
27. Deyssig R, Frisch H, Blum WF, Waldhor T 1993 Effect of growth hormone treatment on hormonal parameters, body composition and strength in athletes. Acta Endocrinol (Copenh) 128:313-318
28. Yarasheski KE, Campbell JA, Smith K, Rennie MJ, Holloszy JO, Bier DM 1992 Effect of growth hormone and resistance exercise on muscle growth in young men. Am J Physiol 262:E261-E267
29. Yarasheski KE, Zachweija JJ, Angelopoulos TJ, Bier DM 1993 Short-term growth hormone treatment does not increase muscle protein synthesis in experienced weight lifters. J Appl Physiol 74:3073-3076
30. Wallace JD, Cuneo RC, Bidlingmaier M, Lundberg PA, Carlsson L, Boguszewski CL, Hay J, Healy ML, Napoli R, Dall R, Rosen T, Strasburger CJ 2001 The response of molecular isoforms of growth hormone to acute exercise in trained adult males. J Clin Endocrinol Metab 86:200-206
31. Healy ML, Gibney J, Russell-Jones DL, Pentecost C, Croos P, Sonksen PH, Umpleby AM 2003 High dose growth hormone exerts an anabolic effect at rest and during exercise in endurance-trained athletes. J Clin Endocrinol Metab 88:5221-5226
32. Merola B, Longobardi S, Sofia M, Pivonello R, Micco A, Di Rella F, Esposito V, Colao A, Lombardi G 1996 Lung volumes and respiratory muscle strength in adult patients with childhood- or adult-onset growth hormone deficiency: effect of 12 months' growth hormone replacement therapy. Eur J Endocrinol 135:553-558
33. Nass R, Huber RM, Klauss V, Muller OA, Schopohl J, Strasburger CJ 1995 Effect of growth hormone (hGH) replacement therapy on physical work capacity and cardiac and pulmonary function in patients with hGH deficiency acquired in adulthood. J Clin Endocrinol Metab 80:552-557
34. Woodhouse LJ, Asa SL, Thomas SG, Ezzat S 1999 Measures of submaximal aerobic performance evaluate and predict functional response to growth hormone (GH) treatment in GH-deficient adults. J Clin Endocrinol Metab 84:4570-4577
35. Thomas SG, Esposito JG, Ezzat S 2003 Exercise training benefits growth hormone (GH)-deficient adults in the absence or presence of GH treatment. J Clin Endocrinol Metab 88:5734-5378
36. Werlang Coelho C, Rebello Velloso C, Resende de Lima Oliveira Brasil R, Vaisman M, Gil Soares de Araujo C 2002 Muscle power increases after resistance training in growth-hormone-deficient adults. Med Sci Sports Exerc 34:1577-1581
37. Jorgensen JO, Moller J, Alberti KG, Schmitz O, Christiansen JS, Orskov H, Moller N 1993 Marked effects of sustained low growth hormone (GH) levels on day-to-day fuel metabolism: studies in GH-deficient patients and healthy untreated subjects. J Clin Endocrinol Metab 77:1589-1596
38. Christ ER, Cummings MH, Westwood NB, Sawyer BM, Pearson TC, Sonksen PH, Russell-Jones DL 1997 The importance of growth hormone in the regulation of erythropoiesis, red cell mass, and plasma volume in adults with growth hormone deficiency. J Clin Endocrinol Metab 82:2985-2990
39. Karila TA, Karjalainen JE, Mantysaari MJ, Viitasalo MT, Seppala TA 2003 Anabolic androgenic steroids produce dose-dependant increase in left ventricular mass in power atheletes, and this effect is potentiated by concomitant use of growth hormone. Int J Sports Med 24:337-343
40. Moor JW, Khan MI 2 March 2005 Growth hormone abuse and bodybuilding as aetiological factors in the development of bilateral internal laryngocoeles. A case report. Eur Arch Otorhinolaryngol 10.1007/500y05.004-0861-6