Metabolism of the nephrotoxicant N-(3,5-dichlorophenyl)succinimide in rats: Evidence for bioactivation through alcohol-O-glucuronidation and O-sulfation

Chemical Research in Toxicology

Volumn 18, Issue 6, 2005, Pages 991-1003

  Cui, Donghui ^a,b   Ranking, Gary O ^c   Harvison, Peter J ^a  

^a UNIVERSITY OF THE SCIENCES   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

^c MARSHALL UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; ALCOHOL; N (3,5 DICHLOROPHENYL)SUCCINIMIDE;

AMINOLYSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOTRANSFORMATION; CHEMICAL REACTION; CONJUGATION; CONTROLLED STUDY; DRUG METABOLISM; ELECTROSPRAY MASS SPECTROMETRY; GLUCURONIDATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROLYSIS; LIVER CELL; MALE; NONHUMAN; RAT; SULFATION;

ANIMALS; BIOTRANSFORMATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FUNGICIDES, INDUSTRIAL; GLUCURONIDES; KIDNEY; MALE; MICROSOMES, LIVER; RATS; RATS, INBRED F344; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SUCCINIMIDES; SULFATES;

EID: 21144455582     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx0496587     Document Type: Article

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